检索结果-南通市图书馆

Changes in posterior corneal elevation after small incision lenticule extraction for different myopic diopters

在线全文

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2024年第3期17卷 491-498页

作者： Xiao-Tong Sun Yang Zhang Xiao-Kun mei nan-nan Zheng Ling-zhi Niu Xiao-Li Qu Ai-Ping Song Jian Zhuo Department of Ophthalmology the First Affiliated Hospital of Shandong First Medical UniversityShandong Provincial Qianfoshan HospitalJinan 250014Shandong ProvinceChina

●AIM:To study the changes and effect factors of posterior corneal surface after small incision lenticule extraction(SMILE)with different myopic diopters.●METHODS:Ninety eyes of 90 patients who underwent SMILE were included in this retrospective *** were allocated into three groups based on the preoperative spherical equivalent(SE):low myopia(SE≥-3.00 D),moderate myopia(-3.00 D>SE>-6.00 D)and high myopia(SE≤-6.00 D).Posterior corneal surfaces were measured by a Scheimpflug camera preoperatively and different postoperative times(1wk,1,3,6mo,and 1y).Posterior mean elevation(PME)at 25 predetermined points of 3 concentric circles(2-,4-,and 6-mm diameter)above the best fit sphere was analyzed.●RESULTS:All surgeries were completed uneventfully and no ectasia was found through the *** difference of myopia group was significant at the 2-mm ring at 1 and 3mo postoperatively(1mo:P=0.017;3mo:P=0.018).The effect of time onΔPME was statistically significant(2-mm ring:P=0.001;4-mm ring:P<0.001;6-mm ring:P<0.001).The effect of different corneal locations onΔPME was significant except 1wk postoperatively(1mo:P=0.000;3mo:P=0.000;6mo:P=0.001;1y:P=0.001).Posterior corneal stability was linearly correlated with SE,central corneal thickness,ablation depth,residual bed thickness,percent ablation depth and percent stromal bed thickness.●CONCLUSION:The posterior corneal surface changes dynamically after *** protrusion is observed on the posterior corneal surface in patients with different degrees of myopia within one year after *** has good stability,accuracy,safety and predictability.

关键词： myopia posterior corneal elevation corneal ectasia small incision lenticule extraction

Spatiotemporal variation of ecological environment quality and extreme climate drivers on the Qinghai-Tibetan Plateau

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Mountain Science 2023年第8期20卷 2282-2297页

作者： SUN Tao YANG Yan-mei WANG Ze-gen YONG zhi-wei XIONG Jun-nan MA Guo-li LI Jie LIU Ao School of Civil Engineering and Geomatics Southwest Petroleum UniversityChengdu 610500China School of Geoscience and Technology Southwest Petroleum UniversityChengdu 610500China State Key Laboratory of Resources and Environmental Information System Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBeijing 100101China

Protecting the ecological security of the Qinghai-Tibet Plateau(QTP)is of great importance for global ecology and *** the past few decades,climate extremes have posed a significant challenge to the ecological environment of the ***,there are few studies that explored the effects of climate extremes on ecological environment quality of the QTP,and few researchers have made quantitative ***,this paper proposed the Ecological Environmental Quality Index(EEQI)for analyzing the spatial and temporal variation of ecological environment quality on the QTP from 2000 to 2020,and explored the effects of climate extremes on EEQI based on Geographically and Temporally Weighted Regression(GTWR)*** results showed that the ecological environment quality in QTP was poor in the west,but good in the *** 2000 and 2020,the area of EEQI variation was large(34.61%of the total area),but the intensity of EEQI variation was relatively low and occurred mainly by a slightly increasing level(EEQI change range of 0.05-0.1).The overall ecological environment quality of the QTP exhibited spatial and temporal fluctuations,which may be attributed to climate *** spatial heterogeneity was observed in the effects of the climate extremes on ecological environment ***,the effects of daily temperature range(DTR),number of frost days(FD0),maximum 5-day precipitation(RX5day),and moderate precipitation days(R10)on ecological environment quality were positive in most ***,there were significant temporal differences in the effects of consecutive dry days(CDD),consecutive wet days(CWD),R10,and FD0 on ecological environment *** differences may be attributed to variances in ecological environment quality,climate extremes,and vegetation types across different *** conclusion,the impact of climate extremes on ecological environment quality exhibits complex *** findings will assist managers in iden

关键词： Ecological environment quality Extreme climate Geographically and Temporally Weighted Regression Qinghai-Tibetan Plateau

BODIPY@Ir(Ⅲ)Complexes Assembling Organic nanoparticles for Enhanced Photodynamic Therapy

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Polymer Science 2018年第3期36卷 417-424页

作者： Yang Liu nan Song Li Chen zhi-Gang Xie Department of Chemistry Northeast Normal UniversityChangchun 130024China State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China

We present a new cyclometalated Ir(III)complexes IrBDP,which could self-assemble into organic nanoparticles(IrBDP NPs).IrBDP NPs show enhanced photodynamic effect and can be engulfed by HeLa cells for cell imaging as ... 详细信息

关键词： BODIPY Photodynamic therapy Iridium complex

Discovery of Novel Long-Chain Alkenyl Diacid Derivatives as ACLY Inhibitors

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Chemistry 2022年第22期40卷 2663-2670页

作者： Gao-Lei Song Lei Cao mei Zhang Yu-Rou Yang Jie Ma zhi-Fu Xie Jing-Ya Li Fa-Jun nan State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China University of Chinese Academy of Sciences No.19A Yuquan RoadBeijing 100049China Yantai Key Laboratory of nanomedicine&Advanced Preparations Yantai Institute of Materia MedicaYantaiShandong 264000China

ATP citrate lyase(ACLY)synthesizes cytosolic acetyl coenzyme A(acetyl-CoA),an essential biosynthetic precursor for lipid synthesis and the acetyl donor required for protein *** aberrant expression and activity of ACLY has been documented in multiple human ***-1002 is an indirect ACLY inhibitor,and it has recently been approved by the FDA as an additional therapeutic option in high-risk hypercholesterolemia patients unable to meet goals with standard *** this work,we identified a series of novel long-chain alkenyl diacids as potent direct ACLY inhibitors,and comprehensive structure-activity relationship analysis showed that compound 18f was the most potent ACLY inhibitor with an IC50 value of 1.5μmol/*** ester formation of 18f gave a new series of compounds such as 25f that maintained ACLY inhibitory activity and improved antitumor cell proliferation effects.

关键词： Alkenyl diacid derivatives Cancer ACLY inhibitors Acetyl-CoA Structure-activity relationships

Dandelion polyphenols protect against acetaminophen-induced hepatotoxicity in mice via activation of the Nrf-2/HO-1 pathway and inhibition of the JNK signaling pathway

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Natural Medicines 2020年第2期18卷 103-113页

作者： REN Yong-Shen ZHENG Yao DUAN Huan LEI Lei DENG Xin LIU Xin-Qiao mei zhi-nan DENG Xu-Kun School of Pharmaceutical Sciences South-Central University for NationalitiesWuhan 430074China

We investigated the liver protective activity of dandelion polyphenols(DP)against acetaminophen(APAP;Paracetamol)-induced *** were acclimated for 1 week and randomly divided into the following groups(n=9 per group):Control,APAP,APAP+DP(100 mg·kg^–1),APAP+DP(200 mg·kg^–1),and APAP+DP(400 mg·kg^–1)*** were pretreated with DP(100,200,and 400 mg·kg^–1)by oral gavage for 7 d before being treated with 350 mg·kg^–1 APAP for 24 h to induced *** liver injury was observed,and hepatotoxicity was analyzed after 24 h by evaluation of biochemical markers,protein expressions levels,and liver *** with DP was able to restore serum liver characteristics(aspartate transaminase,AST;alanine aminotransferase,ALT;alkaline phosphatase,AKP),improve redox imbalance(superoxide dismutase,SOD;glutathione,GSH;malondialdehyde,MDA),and decrease inflammatory factors(tumor necrosis factor-α,TNF-α;interleukin-1β,IL-1β).Pretreatment with DP also significantly inhibited the expression levels of nitric oxide synthase(iNOS)and cyclooxygenase-2(COX-2).Furthermore,DP pretreatment could inhibit the apoptosis of liver cells caused by APAP through up-regulation of Bcl-2 and down-regulation of Bax and caspase-9 *** also down-regulated p-JNK protein expression levels to inhibit APAP-induced mitochondrial oxidative stress and up-regulated the expression of Nrf-2 and its target gene *** histopathological staining demonstrated that DP pretreatment could inhibit APAP-induced hepatocyte infiltration,congestion,and *** results demonstrate that DP pretreatment could protect against APAP-induced hepatic injury by activating the Nrf-2/HO-1 pathway and inhibition of the intrinsic apoptosis pathway.

关键词： Dandelion polyphenols APAP-induced liver injury Oxidative stress Anti-inflammation Anti-apoptosis JNK pathways Nrf-2/HO-1 pathways

Synthesis and Evaluation of Nicotinoylamino Acid Compounds as Radiosensitizer

在线全文

学校读者我要写书评

暂无评论

Chemical Research in Chinese Universities 2008年第4期24卷 496-500页

作者： QIN zhi-zhong ZHANG Feng-bao JIANG Tie-nan LI mei-jia WANG Rong-xian LI Yi-liang School of Chemical Engineering and Technology Tianjin University Tianjin 300072 P. R. China Institute of Radiation Medicine Peking Union Medical College Tianjin 300192 P. R. China

Nicotinoylamino acid compounds 4, 5, 9a, 9b, 9c, 10a and 10b were synthesized with nicotinoyl chloride or nicotinoyl azide as acetylating agents of amino acid esters or amino acids. The compounds were tested for their radiosensitizing activity in Leukemia cell line（L1210） and compared with nicotinamide; among them, compounds 9a and 9c showed significant radiosensitizing effects, the sensitizer enhancement ratio（SER） was 1.64 and 1.58, respectively, while nicotinamide did not show good radiosensitizing effect under the same conditions. Compound 9c was alone tested for radiosensitization in LA 795 cell-bearing T-739 mice, or hyperthermia and breathing carbogen（5%CO2＋95%O2） were together tested for radiosensitization. The results showed that radiation-induced growth delay was enhanced by 9c alone or by the combination of hypertheimia and carbogen. The tumor-bearing mice were irradiated locally by total 10 Gy, and the tumors grew to three times that of the original volume in an average of 5.8 d. The mice were given i.p. compound 9c at 1000 mg/kg 60 min before irradiation and treated at 43 ℃ for 30 min after irradiation or treated with breathing carbogen for 5 min before radiation or with hyperthmia（43 ℃） for 30 min after irradiation; the time required for the tumor to grow to three times the orginal volume was in an average of 12.9 and 13 d, respectively.

关键词： Radiosensitizer Nicotinoylamino acid compound Hyperthermia Carbogen

Development of Chinese duplex stainless steel in recent years

在线全文

学校读者我要写书评

暂无评论

Journal of Iron and Steel Research International 2017年第2期24卷 121-130页

作者： zhi-gang Song Han Feng Shao-mei Hu Institute for Special Steels Central Iron and Steel Research Institute Beijing 100081 China

The development in research, production, applications, and national standards of Chinese duplex stainless steel （DSS） in recent years was introduced in light of the worldwide development in the field of DSS. The results showed that the output of Chinese DSS increased greatly, and at the same time its grade gradually evolved into a collaborative developing series including the main grade type 2205 and other DSS types in recent years. Economical DSS and super DSS underwent rapid development, especially after 2010. In re- cent years, the application of Chinese DSS has been expanded further not only in traditional application ar- eas such as the petrochemical industry, but also in diverse new fields such as oil and gas transportation, chemical tanker manufacturing, nuclear power plants, and construction. Moreover, due to the increase in output and improvement in quality, as well as applications in Chinese projects, Chinese DSS has also been exported to the Middle East, Eastern Europe, and other regions.

关键词： Duplex stainless steelNitrogen alloyingHot ductilityPrecipitated phase

For robust big data analyses:a collection of 150 important pro-metastatic genes

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Cancer 2017年第3期36卷 112-120页

作者： Yan mei Jun-Ping Yang Chao-nan Qian State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer CenterGuangzhou 510060GuangdongP.R.China Department of Nasopharyngeal Carcinoma Sun Yat-sen University Cancer CenterGuangzhou 510060GuangdongP.R.China

Metastasis is the greatest contributor to cancer?related *** the era of precision medicine,it is essential to predict and to prevent the spread of cancer cells to significantly improve patient *** to the application of a variety of high?throughput technologies,accumulating big data enables researchers and clinicians to identify aggressive tumors as well as patients with a high risk of cancer ***,there have been few large?scale gene collection studies to enable metastasis?related *** the last several years,emerging efforts have identi?fied pro?metastatic genes in a variety of cancers,providing us the ability to generate a pro?metastatic gene cluster for big data *** carefully selected 285 genes with in vivo evidence of promoting metastasis reported in the *** genes have been investigated in different tumor *** used two datasets downloaded from The Cancer Genome Atlas database,specifically,datasets of clear cell renal cell carcinoma and hepatocellular carcinoma,for validation tests,and excluded any genes for which elevated expression level correlated with longer overall survival in any of the ***,150 pro?metastatic genes remained in our *** believe this collection of pro?metastatic genes will be helpful for big data analyses,and eventually will accelerate anti?metastasis research and clinical intervention.

关键词： Pro-metastatic gene Big data analysis Renal cancer Liver cancer

Paricalcitol in hemodialysis patients with secondary hyperparathyroidism and its potential benefits

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2021年第33期9卷 10172-10179页

作者： Xiu Chen Feng Zhao Wei-Juan Pan Jia-mei Di Wei-nan Xie Ling Yuan zhi Liu Department of Nephrology The First Affiliated Hospital of Anhui University of Science and Technology(The First People’s Hospital of Huainan)Huainan 232007Anhui ProvinceChina

BACKGROUND Secondary hyperparathyroidism(SHPT)is a common complication in patients with end-stage renal disease and it is also common in hemodialysis *** can increase bone fragility and calcification of blood vessels and soft tissues,which greatly increases the risk of *** To discuss the outcome,safety and other potential benefits of paricalcitol injection in hemodialysis patients with *** We recruited 40 patients who received hemodialysis at our hospital for chronic renal failure with SHPT between March and December *** received paricalcitol injection for 24 wk(starting dose,0.06–0.08μg/kg),three times per *** were followed up at the baseline(week 0),week 4,week 12 and week *** primary outcome indicator was the percentage of patients with a>30%decrease in intact parathyroid hormone(iPTH)levels at week 24 compared with the *** secondary outcome indicators included percentage decrease in iPTH levels at week 24,standard-reaching rate of iPTH(percentage of patients with iPTH down to 130–585 pg/mL),changes in serum levels of calcium(Ca),phosphate(P),Ca×P product,alkaline phosphatase(ALP),creatinine(Cre),hemoglobin(Hb),and C-reactive protein(CRP),and incidence of adverse events(AEs).RESULTS After 24 wk of treatment,iPTH levels decreased significantly(598.88±381.29 pg/mL vs 888.84±376.88 pg/mL,P0.05).After 24 wk of treatment,serum P levels decreased compared with the baseline(1.91±0.40 mmol/L vs 2.16±0.66 mmol/L)(t=2.830,P<0.05).Ca×P product decreased significantly compared with the baseline(56.38±13.22 mg2/dL

关键词： Paricalcitol Hemodialysis Secondary hyperparathyroidism Drug efficacy Drug safety