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Two new steroidal glycosides from the root of Cynanchum auriculatum

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Chinese Chemical Letters 2011年第1期22卷 77-80页

作者： Hong Li Teng Yu Lu Jun Li Guang Zhong Yang zhi nan mei Guangxi Institute of Minority Medicine Nanning 530001 China College of Pharmacy South Central University for Nationalities Wuhan 430074 China

Two new steroidal glycosides named cyanoauriculoside A （1） and B （2）, have been isolated from the roots of Cynanchum auriculatum Royle ex Wight. The structure of cyanoauriculoside A （1） was determined to be 20-O-acetyl-penupogenin-3-O-β-D- glucopyranosyl-（ 1 →4）-β-D-glucopyranosyl-（ 1 →4）-α -L-cymaropyranosyl- （ 1 →4）-β-D-cymaropyranosyl- （ 1 →4）-α-L-diginopyranosyl-（1→4）-β-D-cymaropyranoside. Cyanoauriculoside B （2） was characterized as 20-O-acetylpenupogenin-3-O-β-D-gluco- pyranosyl-（ 1 →4）-α-L-cymaropyranosyl-（ 1 →4）-β-D-cymaropyranosyl-（ 1 →4）-α-L-diginopyranosyl-（ 1 →4）-β-D-cymaropyranoside. The structures of these compounds were elucidated based on the chemical and spectroscopic evidence.

关键词： Cynanchum auriculatum Steroidal glycoside Cyanoauriculosides A and B

Phenolic glycosides from Boschniakia himalaica

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Chinese Chemical Letters 2012年第5期23卷 579-582页

作者： Jin Fu Wan Jing Quan Yuan zhi nan mei Xin Zhou Yang Yunnan Baiyao Group Co.LTD Kunming 650032China College of Pharmacy South-Central University for NationalitiesWuhan 430074China Guangxi Institute of Medicinal Plants Nanning 530023China

Two new phenylethanoid glycosides,himalosides A（1） and B（2）,were isolated from the whole plant of Boschniakia himalaica, together with four known *** structures were elucidated on the basis of spectral and chemical *** A（1） and（＋）-lariciresinol 4＇-O-β-D-glucopyranoside（4） exhibited antibacterial activity with the MIC values at 50 and 25μg/mL against Staphylococcus aureus and ***,respectively.

关键词： Boschniakia himalaica Phenylethanoids Phenolic glycosides Antibacterial

Antitumor effects of Chi-Shen extract from Salvia miltiorrhiza and Paeoniae radix on human hepatocellular carcinoma cells

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Acta Pharmacologica Sinica 2007年第8期28卷 1215-1223页

作者： Sheng HU Shi-min CHEN Xiao-kuan LI Rui QIN zhi-nan mei~1 Institute of Materia Media,South-Central University for Nationalities,Wuhan 430074,China Institute of Materia Media South-Central University for NationalitiesWuhan430074China

Aim:To investigate the antihepatocellular carcinoma effects of Chi-Shen extract(CSE)from the water-soluble compounds of Salvia miltiorrhiza and ***:The effect of CSE on the growth of HepG2 cells(hepatocellularcarcinoma cell line)was studied by 3-(4,5)-2,5-diphenyltetrazolium bromide *** were detected through acridine orange(AO)and ethylene dibromide(EB)staining and DNA fragmentation *** effect of CSE on the cell cycle ofHepG2 cells was studied by the propidium iodide staining *** activationof caspases-3,-8 and-9 was examined by immunoassay *** transcription ofthe Bcl-2 family and p53 was detected by ***:Our data revealed thatCSE strongly induced HepG2 cell death in a dose-and time-dependent ***-induced cell death was considered to be apoptotic by observing the typicalapoptotic morphological change by AO/EB staining and DNA fragmentation *** induction of HepG2 cell death was caused by an induction of apoptosis forthe sub-G1proportion increase,the downregulation of Bcl-2,the upregulation ofBax and p53,and the activation of the caspases-3 and -9 ***:These results clearly demonstrated that CSE was able to inhibit the proliferation ofHepG2 cells and cause ***,the anticancer effects of CSE wererelated to the Bcl-2 family pathway and the activation of caspases-3 and-9 inHepG2 cells.

关键词： human hepatocellular carcinoma cells apoptosis Bcl-2 Bax caspase-3 Salvia miltiorrhiza Paeoniae radix

掺杂对TiC_(2)纳米片析氢反应的第一性原理研究

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原子与分子物理学报 2025年第3期42卷 29-34页

作者：孙楠楠赵翠莲潘美玲赵志超张宇河北水利电力学院基础部沧州061000 河北省数据中心相变热管理技术创新中心沧州061000

过渡金属二碳族化物单层作为一种廉价而丰富的材料,在制氢催化剂方面的应用越来越受到人们的关注.在这项工作中,基于第一性原理计算研究了掺杂二碳化钛单层的析氢还原.我们发现掺杂元素和浓度对单分子膜的催化能力有强烈的影响.结果表明... 详细信息

过渡金属二碳族化物单层作为一种廉价而丰富的材料,在制氢催化剂方面的应用越来越受到人们的关注.在这项工作中,基于第一性原理计算研究了掺杂二碳化钛单层的析氢还原.我们发现掺杂元素和浓度对单分子膜的催化能力有强烈的影响.结果表明,在高氢覆盖率内,O和V掺杂能有效的降低氢吸附的吉布斯自由能.低密度掺杂可以提高催化能力.我们进一步研究表明,由于V原子在二碳化钛(TiC_(2))单层中具有最低的负形成能,因此比其他过渡金属原子更容易取代Ti原子.期望掺钒TiC_(2)单分子膜能以更高的效率应用于水电解.

关键词：密度泛函理论 TiC_(2)单层片覆盖率掺杂

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Terpenes from Schisandra sphenanthera

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Terpenes from Schisandra sphenanthera

2010年全国中药学术研讨会

作者： Yan Jiang~a,zhi-nan mei~a,Guang -Zhong Yang~(*a),Mao-Chuan Liao~a,Yu Chen~b a Laboratory for Natural Product Chemistry,College of Pharmacy,South Central University for Nationalities,Wuhan 430074,P.R.China b College of Chemistry and Material Sciences,South Central University for Nationalities,Wuhan 430074,P.R.China

One novel highly oxygenated nortriterpenoid,schintrilactone C,and four known compounds,were isolated from the rattan of Schisandra *** structures were determined by analysis of 1D and 2D NMR spectroscopic *** C is the third example of Wuweiziartane-type skeleton nortriterpenoids,bearing a modified five-membered D ring and aδ-lactone E ring and a spirocyclic moiety at the C(13) side chain.

关键词： Schisandra sphenanthea Terpene Nortriterpenoid Schintrilactone

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新质人才需求背景下学校教育供给变革研究

教学与管理 2025年第1期 15-18页

作者：孟志远李永梅曲阜师范大学教育学院山东曲阜273165

新质生产力的蓬勃发展呼唤新质人才并为其培养提供了重要的时域与场域,面向新质人才需求的学校教育供给变革成为教育的基础性命题。当前面向新质人才需求的学校供给变革存在“传统型”供给主体与“新质型”主体需求、“标准化”供给内... 详细信息

新质生产力的蓬勃发展呼唤新质人才并为其培养提供了重要的时域与场域,面向新质人才需求的学校教育供给变革成为教育的基础性命题。当前面向新质人才需求的学校供给变革存在“传统型”供给主体与“新质型”主体需求、“标准化”供给内容与“个性化”内容需求、“统一性”供给方式与“数智化”方式需求之间的矛盾。鉴于此,提出面向新质人才需求的学校教育供给遵循从“人类教师主体”到“人机智能联合主体”、从“统一与他主内容”到“开放与自主内容”、从“前置性预设方式”到“发展性按需方式”的变革理路,以期为学校教育供给变革与新质人才培养提供一定的理论借鉴和实践启示。

关键词：学校教育供给变革新质人才需求新质生产力新质人才培养

Chemical constituents with free-radical-scavenging activities from the stem of Microcos paniculata

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Chemical constituents with free-radical-scavenging activitie...

Deep-cryogenic-treatment-induced phase transformation in the Al-Zn-Mg-Cu alloy

2010年全国中药学术研讨会

作者： Hua Fan~1,Guang-Zhong Yang1,* Tong Zheng1,zhi-nan mei1,Xiang-ming Liu1,Yu Chen2, Su Chen1 1 College of Pharmacy,South Central University for Nationalities,Wuhan 430074,P.R.China 2 College of Chemistry and Material Sciences,South Central University for Nationalities,Wuhan 430074,P.R.China

The free-radical-scavenging activities of various solvent extracts of Microcos paniculata were evaluated through in vitro model systems,such as 1,1-diphenyl-2-picrylhydrazyl(DPPH), 2,2’-azino-bis-(3-ethylbenzothiazoline-6-sulfonate)(ABTS) and Co(Ⅱ) EDTA-induced luminol chemiluminescence by flow *** all these three systems the ethyl acetate(EtOAc) extract showed the highest free-radical-scavenging activity compared with the other three extracts. Free-radical-scavenging assay-guided chromatographic separation of the EtOAc extract,using a normal-phase and reverse-phase silica gel column chromatography yielded five compounds,a new triterpene named 3β-O-p-hydroxy-E-cinnamoyloxy-2α,23-dihydroxy-olean-12-en-28-oate(1), together with four known compounds,epicatechin(2),3-trans-feruloyl maslinic acid(3),maslinic acid(4) and sucrose(5),the above compounds were identified by spectroscopic *** them,Spectral data of compound 1 was presented for the first time,and all over compounds were isolated from Microcos Paniculata for the first ***,compound 2 presented as a powerful scavenger with significant free-radical-scavenging activity which is similar to that of standard antioxidant ascorbic acid and therefore may be a promising source of natural antioxidants.

关键词： Microcos paniculata free-radical-scavenging activities DPPH ABTS Co(Ⅱ) EDTA-induced luminol chemiluminescence by flow injection

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International Journal of Minerals,Metallurgy and Materials 2015年第1期22卷 68-77页

作者： Chun-mei Li nan-pu Cheng zhi-qian Chen Ning Guo Su-min Zeng School of Materials Science and Engineering Central South University School of Materials Science and Engineering Southwest University

An aluminum alloy （Al-Zn-Mg-Cu） subjected to deep cryogenic treatment （DCT） was systematically investigated. The results show that a DCT-induced phase transformation varies the microstructures and affects the mechanical properties of the Al alloy. Both Guinier-Preston （GP） zones and a metastableη′phase were observed by high-resolution transmission electron microscopy. The phenomenon of the second precipitation of the GP zones in samples subjected to DCT after being aged was observed. The viability of this phase transfor-mation was also demonstrated by first-principles calculations.

关键词： aluminum alloys cryogenic treatment phase transformation microstructure

Weighted Pseudo Asymptotically Periodic Mild Solutions of Evolution Equations

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Acta Mathematica Sinica,English Series 2015年第8期31卷 1215-1232页

作者： zhi nan XIA Department of Applied Mathematics Zhejiang University of Technology

In this paper, we propose a new class of functions called weighted pseudo S-asymptotically periodic function in the Stepanov sense and explore its properties in Banach space including composition theorems. Furthermore, the existence, uniqueness of the weighted pseudo S-asymptotically periodic mild solutions to partial evolution equations and nonautonomous semilinear evolution equations are investigated. Some interesting examples are presented to illustrate the main findings.

关键词： Sp-weighted pseudo S-asymptotic periodicity weighted pseudo S-asymptotic periodicity evolution equations mild solutions