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Endoscopic retrograde cholangiopancreatography for diagnosing and treating pediatric biliary and pancreatic diseases

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World Journal of Gastrointestinal Surgery 2023年第10期15卷 2272-2279页

作者： Xiu-min Qin Fei-Hong Yu Chuan-Kai Lv zhi-min liu Jie Wu Department of Gastroenterology Beijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthBeijing 100045China Department of Ultrasound Beijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthBeijing 100045China Department of Radiology Beijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthBeijing 100045China

BACKGROUND This study evaluated the safety and effectiveness of endoscopic retrograde cholangiopancreatography(ERCP)in pediatric patients with biliary and pancreatic diseases.A retrospective analysis was conducted on 57 ERCP procedures performed in 41 children,primarily for treating pancreatic *** overall success rate was 91.2%,with no major complications ***-ERCP pancreatitis(PEP)occurred in 8.8%of ***-up examinations over one year showed no recurrence of biliary or pancreatic ***,endoscopic treatment led to a significant increase in body mass index(BMI).These findings demonstrate the valuable role of ERCP in managing such *** To evaluate the safety and efficacy of ERCP for the management of biliary and pancreatic diseases in pediatric *** We conducted a retrospective analysis of data from children aged 1-18 years who underwent ERCP for biliary and pancreatic diseases at Beijing Children’s Hospital between January 2021 and December *** collected data included procedure time,endoscopic treatment,success rate,and postoperative *** Forty-one children underwent 57 ERCP procedures,including 14 with biliary duct disease and 27 with pancreatic *** mean age of the patients was 7.48±3.48 *** duct-related treatments were performed 18 times,and pancreatic disease treatments were performed 39 *** was primarily used to treat pediatric pancreatic diseases[68.4%(39/57)of the procedures].The overall success rate was 91.2%(52/57 patients).PEP was noted in five patients(8.8%,5/57),and no instances of bleeding,perforation,or cholangitis were *** patients were followed up for over one year,and no recurrence of biliary or pancreatic diseases was ***,BMI significantly increased after endoscopic treatment compared to that before treatment(P=0.001).CONCLUSION The high success rate and lack of major complications support the valuable role of ERCP in the

关键词： Pediatric Endoscopic retrograde cholangiopancreatography Choledocholithiasis Chronic pancreatitis Pancreatic ducts Postoperative complications

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Asperuloside Promotes Apoptosis of Cervical Cancer Cells through Endoplasmic Reticulum Stress-Mitochondrial Pathway

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Chinese Journal of Integrative Medicine 2024年第1期30卷 34-41页

作者： QI zhi-min WANG Xia liu Xia ZHAO Juan Medical Examination Center Hebei Province Hospital of Chinese MedicineShijiazhuang(050011)China Department of Gynaecology and Obstetrics Hebei Province Hospital of Chinese MedicineShijiazhuang(050011)China Experimental Center for Teaching Hebei Medical UniversityShijiazhuang(050017)China

Objective: To investigate the effects of asperuloside on cervical cancer based on endoplasmic reticulum(ER) stress and mitochondrial pathway. Methods: Different doses(12.5–800 μg/mL) of asperuloside were used to treat cervical cancer cell lines Hela and CaSki to calculate the half maximal inhibitory concentration(IC_(50)) of asperuloside. The cell proliferation was analyzed by clone formation assay. Cell apoptosis, intracellular reactive oxygen species(ROS) and mitochondrial membrane potential were determined by flow cytometry. The protein expressions of cleaved-caspase-3, Bcl-2, Bax, Cyt-c, cleaved-caspase-4 and glucose-regulated protein 78(GRP78) were analyzed by Western blot. And the inhibitor of ER stress, 4-phenyl butyric acid(4-PBA) was used to treat cervical cancer cells to further verify the role of ER stress in the apoptosis of cervical cancer cells induced by asperuloside. Results: Asperuloside of 325, 650, and 1300 μg/mL significantly inhibited the proliferation and promoted apoptosis of Hela and CaSki cells(P<0.01). All doses of asperuloside significantly increased intracellular ROS levels, reduced mitochondrial membrane potential, significantly reduced Bcl-2 protein expression level, and increased Bax, Cyt-c, GRP78 and cleaved-caspase-4 expressions(P<0.01). In addition, 10 mmol/L 4-PBA treatment significantly promoted cell proliferation and reduced apoptosis(P<0.05), and 650 μg/mL asperuloside could reverse 4-PBA-induced increased cell proliferation, decreased apoptosis and cleaved-caspase-3,-4 and GRP78 protein expressions(P<0.05). Conclusion: Our study revealed the role of asperuloside in cervical cancer, suggesting that asperuloside promotes apoptosis of cervical cancer cells through ER stress-mitochondrial pathway.

关键词： asperuloside Chinese medicine cervical cancer endoplasmic reticulum stress mitochondrial damage apoptosis

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Gut microbial interactions based on network construction and bacterial pairwise cultivation

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Science China(Life Sciences) 2024年第8期67卷 1751-1762页

作者： min-zhi Jiang Chang liu Chang Xu He Jiang Yulin Wang Shuang-Jiang liu State Key Laboratory of Microbial Technology Shandong UniversityQingdao 266000China State Key Laboratory of Microbial Resources and Environmental Microbiology Research Center(EMRC)Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China

Association networks are widely applied for the prediction of bacterial interactions in studies of human gut ***,the experimental validation of the predicted interactions is challenging due to the complexity of gut microbiomes and the limited number of cultivated *** this study,we addressed this challenge by integrating in vitro time series network(TSN)associations and cocultivation of TSN taxon *** samples were collected and used for cultivation and enrichment of gut microbiome on YCFA agar plates for 13 *** cells were harvested for DNA extraction and metagenomic sequencing.A total of 198 metagenome-assembled genomes(MAGs)were *** dynamics of bacteria growing on the YCFA agar were used to infer microbial association *** experimentally validate the interactions of taxon pairs in networks,we selected 24 and 19 bacterial strains from this study and from the previously established human gut microbial biobank,respectively,for pairwise *** co-culture experiments revealed that most of the interactions between taxa in networks were identified as neutralism(51.67%),followed by commensalism(21.67%),amensalism(18.33%),competition(5%)and exploitation(3.33%).Genome-centric analysis further revealed that the commensal gut bacteria(helpers and beneficiaries)might interact with each other via the exchanges of amino acids with high biosynthetic costs,short-chain fatty acids,and/or *** also validated 12 beneficiaries by adding 16 additives into the basic YCFA medium and found that the growth of 66.7%of these strains was significantly *** approach provides new insights into the gut microbiome complexity and microbial interactions in association *** work highlights that the positive relationships in gut microbial communities tend to be overestimated,and that amino acids,short-chain fatty acids,and vitamins are contributed to the positive relationships.

关键词： human gut microbiome gut microbial pairwise interaction co-culture association network microbial community

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Normalized Solution for p-Kirchhoff Equation with a L2-supercritical Growth

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Acta Mathematicae Applicatae Sinica 2024年第2期40卷 414-429页

作者： zhi-min REN Yong-yi LAN School of Sciences Jimei UniversityXiamen 361005China

In this paper,we investigate the following p-Kirchhoff equation{∫R^(N)|u|^(2)dx=ρ,(a+b)∫RN(|Δu}^(p)+|u|^(p))dx)(-Δpu+|u|^(p-2u)=|u|^(s-2)u+μu,x∈R^(N),where a>0,b≥0,p>0 are constants,constants,p*=N-P/Np is the ... 详细信息

关键词： p-Kirchhoff equation normalized solution mountain-pass lemma

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Quantum Neural Network for Quantum Neural Computing

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Research 2024年第1期2023卷 71-80页

作者： min-Gang Zhou zhi-Ping liu Hua-Lei Yin Chen-Long Li Tong-Kai Xu Zeng-Bing Chen National Laboratory of Solid State Microstructures School of PhysicsCollaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210093China MatricTime Digital Technology Co.Ltd. Nanjing 211899China

Neural networks have achieved impressive breakthroughs in both industry and *** to effectively develop neural networks on quantum computing devices is a challenging open ***,we propose a new quantum neural network model for quantum neural computing using(classically controlled)single-qubit operations and measurements on real-world quantum systems with naturally occurring environment-induced decoherence,which greatly reduces the difficulties of physical *** model circumvents the problem that the state-space size grows exponentially with the number of neurons,thereby greatly reducing memory requirements and allowing for fast optimization with traditional optimization *** benchmark our model for handwritten digit recognition and other nonlinear classification *** results show that our model has an amazing nonlinear classification ability and robustness to ***,our model allows quantum computing to be applied in a wider context and inspires the earlier development of a quantum neural computer than standard quantum computers.

关键词： quantum thereby breakthrough

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OsPDR20 is an ABCG metal transporter regulating cadmium accumulation in rice

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Journal of Environmental Sciences 2024年第2期136卷 21-34页

作者： He Li Chao Li Di Sun zhi min Yang Department of Biochemistry and Molecular Biology College of Life SciencesNanjing Agricultural UniversityNanjing 210095China

Cadmium(Cd)is a non-essential toxic heavy metal,seriously posing high environmental risks to human *** genetic resources relevant to functional genes is important for understanding the metal absorption and accumulation in crops and bioremediation of Cd-polluted *** study investigated a functionally uncharacterized ATP binding cassette transporter G family(ABCG)gene encoding a Pleiotropic Drug Resistance 20(PDR20)type metal transporter which is localized to the plasma membrane of ***20 was transcriptionally expressed in almost all tissues and organs in lifespan and was strongly induced in roots and shoots of young rice under Cd *** expression of OsPDR20 in a yeast mutant ycf1 sensitive to Cd conferred cellular tolerance with less Cd *** of OsPDR20 by RNA interference(RNAi)moderately attenuated root/shoot elongation and biomass,with reduced chlorophylls in rice grown under hydroponic medium with 2 and 10μmol/L Cd,but led to more Cd accumulation.A field trial of rice grown in a realistic Cd-contaminated soil(0.40 mg/kg)showed that RNAi plants growth and development were also compromised compared to wild-type(WT),with smaller panicles and lower spikelet fertility but little effect on yield of ***,OsPDR20 suppression resulted in unexpectedly higher levels of Cd accumulation in rice straw including lower leaves and culm and *** results suggest that OsPDR20 is actively involved in Cd accumulation and homeostasis in rice *** increased Cd accumulation in the RNAi plants has the potential application in phytoremediation of Cd-polluted wetland soils.

关键词： Rice ABCG transporter Cadmium accumulation Phytoremediation

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Design of efficient thermoelectric generators

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Science China Materials 2024年第1期67卷 377-378页

作者： min liu Yanzhong Pei Interdisciplinary Materials Research Center School of Materials Science and EngineeringTongji UniversityShanghai 201804China

Thermoelectricity,which enables direct conversion between heat and electricity,undergoes impressive developments in recent decades,and is particularly promising for recovering low-grade heat of<600 K[1,2].Currently,only Bi2Te3-based thermoelectric devices are commercialized[3].However,the scarcity of tellurium(Te)(Fig.1a)is the main *** leads to numerous recent efforts on the development of efficient nonBi2Te3 thermoelectrics as potential alternatives,and successful examples(Fig.1b)include Mg3Sb2-alloys[2,3]and MgAgSb[1,2].

关键词： enable efficient electricity

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Synthesis of Long-Chain Oligomeric Donor and Acceptors via Direct Arylation for Organic Solar Cells

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Chinese Journal of Chemistry 2024年第5期42卷 523-532页

作者： Yu Wu Xin-Yu He Xu-min Huang Ling-Jun Yang Peng liu Na Chen Chang-zhi Li Shi-Yong liu Jiangxi Provincial Key Laboratory of Functional Molecular Materials Chemistry College of MaterialsMetallurgical and ChemistryJiangxi University of Science and TechnologyGanzhouJiangxi341000 China Department of Polymer Science and Engineering Zhejiang UniversityHangzhouZhejiang310027 China

The rapid synthesis of structurally complicated electron donors&acceptors still remains a major challenge in organic solar cells(OSC).In this work,we developed a highly efficient strategy to access long-chain oligomeric donor and acceptors for OSC applications.A series of cyclopentadithiophene(CPDT)and benzothiadiazole(BT)-basedπ-conjugated oligomers,i.e.,three oligomeric acceptors(BTDT)n-IC(n=1—3)and one long-chain oligomeric donor(BTDT)4-RD,are facilely synthesized by an atom-and step-economical,and labor-saving direct C—H arylation(DACH)reaction(i.e.,C—H/C—Br cross coupling).Note that(BTDT)4-RD involving five CPDT,four BT and two rhodamine(RD)building blocks is the longest oligomeric donor in the fullerene-free OSC devices ever *** dependence of the structure-property-performance correlation of(BTDT)n-IC(n=1—3)and(BTDT)4-RD on theπ-conjugation lengths is thoroughly investigated by opto-electrochemical measurements,bulk heterojunction(BHJ)OSC devices and ***(BTDT)1-IC:PBDB-T and(BTDT)4-RD:Y6 BHJs achieve power conversion efficiencies of 9.14%and 4.51%,*** findings demonstrate that DACH reaction is a powerful tool to tune the opto-electronic properties and device performances by regulating the lengths ofπ-conjugated oligomers with varied numbers of repeating units.

关键词： Long-chainπ-conjugated oligomer Organic solar cells Direct arylation Atom-economical synthesis Cyclopentadithiophene Benzothiadiazole C—H activation Conjugation Oligomers

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Synergic action of linear dispersion, second-order nonlinearity, and third-order nonlinearity in shaping the spectral profile of a femtosecond pulse transporting in a lithium niobate crystal

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Photonics Research 2024年第4期12卷 774-783页

作者： LIHONG HONG YUANYUAN liu zhi-YUAN LI State Key Laboratory of High Field Laser Physics Shanghai Institute of Optics and Fine MechanicsChinese Academy of SciencesShanghai 201800China School of Physics and Optoelectronics South China University of TechnologyGuangzhou 510640China

We present a detailed theoretical and numerical analysis on the temporal-spectral-spatial evolution of a highpeak-power femtosecond laser pulse in two sets of systems:a pure lithium niobate(LN)plate and a periodically poled lithium niobate(PPLN)*** develop a modified unidimensional pulse propagation model that considers all the prominent linear and nonlinear processes and carried out the simulation process based on an improved split-step Fourier transformation *** theoretically analyze the synergic action of the linear dispersion effect,the second-order nonlinearity(2nd-NL)second-harmonic generation(SHG)effect,and the third-order nonlinearity(3rd-NL)self-phase modulation(SPM)effect,and clarify the physical mechanism underlying the peculiar and diverse spectral broadening patterns previously reported in LN and PPLN thin plate *** analysis and discussion provides a deeper insight into the synergetic contribution of these linear and nonlinear effects brought about by the interaction of a femtosecond laser pulse with the LN nonlinear crystal and helps to draw a picture to fully understand these fruitful optical physical processes,phenomena,and laws.

关键词： pulse nonlinearity lithium

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Equivalence between the internal observability and equation

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Applied Mathematics(A Journal of Chinese Universities) 2024年第1期39卷 89-97页

作者： liu Wen-jun TU zhi-yu School of Mathematics and Statistics Nanjing University of Information Science and TechnologyNanjing 210044China

This paper is concerned with a third order in time linear Moore-Gibson-Thompson equation which describes the acoustic velocity potential in ultrasound wave *** by the work of Kaltenbacher,Lasiecka and Marchand(Control Cybernet.2011,40:971-988),we establish an observability inequality of the conservative problem,and then discuss the equivalence between the exponential stabilization of a dissipative system and the internal observational inequality of the corresponding conservative system.

关键词： Moore-Gibson-Thompson equation internal observability exponential stability

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