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China Foundry 2024年第2期21卷 101-115页

作者： Hao-ran Zhou Hao Yang Huai-qian Li Ying-chun Ma Sen Yu Jian shi Jing-chang Cheng Peng Gao Bo Yu zhi-quan miao Yan-peng Wei National Key Laboratory of Advanced Casting Technologies Shenyang Research Institute of Foundry Co.Ltd.CAMShenyang 110022China Department of Mechanical Engineering Tsinghua UniversityBeijing 100084China Key Laboratory of Space Physics Beijing 100076China School of Materials Science and Engineering Nanyang Technological University639798Singapore

Additive manufacturing technology is highly regarded due to its advantages,such as high precision and the ability to address complex geometric challenges.However,the development of additive manufacturing process is constrained by issues like unclear fundamental principles,complex experimental cycles,and high costs.Machine learning,as a novel artificial intelligence technology,has the potential to deeply engage in the development of additive manufacturing process,assisting engineers in learning and developing new techniques.This paper provides a comprehensive overview of the research and applications of machine learning in the field of additive manufacturing,particularly in model design and process development.Firstly,it introduces the background and significance of machine learning-assisted design in additive manufacturing process.It then further delves into the application of machine learning in additive manufacturing,focusing on model design and process guidance.Finally,it concludes by summarizing and forecasting the development trends of machine learning technology in the field of additive manufacturing.

关键词： additive manufacturing machine learning material design process optimization intersection of disciplines embedded machine learning

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基于超构透镜的微型头戴式荧光显微镜设计

中国光学（中英文） 2024年第3期17卷 512-520页

作者：张智淼王承邈谢冕林雨韩业明邓永波郭长亮付强中国科学院长春光学精密机械与物理研究所吉林长春130033 中国科学院大学北京100049 清华大学生命学院北京100084 北京大学未来技术学院北京100871

微型头戴式荧光显微镜可以对自由移动活体动物大脑中的神经活动进行实时成像,是近些年兴起的脑科学研究新仪器。然而,目前大多数微型荧光显微镜为了做到更小巧、更轻便,视场都比较小,这使得可用于观测的神经细胞数量受限,虽然有大视场... 详细信息

微型头戴式荧光显微镜可以对自由移动活体动物大脑中的神经活动进行实时成像,是近些年兴起的脑科学研究新仪器。然而,目前大多数微型荧光显微镜为了做到更小巧、更轻便,视场都比较小,这使得可用于观测的神经细胞数量受限,虽然有大视场系统的报道,但重量都比较大,对动物的自由行为会产生一定的影响。为了提高微型荧光显微镜成像性能,同时降低其重量,光学系统采用超轻、超薄、成像质量高的超构透镜。本文首先推导了双曲相位超构透镜的像差公式,并以此为指导,完成了一款视场为4 mm×4 mm、NA为0.14的微型荧光显微镜设计,实现了7种初级像差的校正。装配完成的样机重量仅为4.11 g,全视场范围内分辨率为7.8μm,对自由移动小鼠大脑中的神经活动进行成像观测能够达到单细胞分辨率。

关键词：微型荧光显微镜超构透镜光学设计神经科学像差理论

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基于蒙特卡罗法的不均匀锈蚀钢筋力学性能评估

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吉林大学学报（工学版） 2024年第4期54卷 1007-1015页

作者：刘一凡缪志伟申晨耿祥东东南大学土木工程学院南京211189

本文基于符合锈蚀钢筋形貌特征的截面积概率分布函数,并考虑锈坑处相邻截面的相关性,建立了不均匀锈蚀钢筋的三维有限元模型,通过蒙特卡罗模拟批量开展数值拉伸试验,定量研究不同锈蚀率下钢筋力学性能的退化情况。与已有的试验结论对比... 详细信息

本文基于符合锈蚀钢筋形貌特征的截面积概率分布函数,并考虑锈坑处相邻截面的相关性,建立了不均匀锈蚀钢筋的三维有限元模型,通过蒙特卡罗模拟批量开展数值拉伸试验,定量研究不同锈蚀率下钢筋力学性能的退化情况。与已有的试验结论对比显示,该方法能较好地估计锈蚀钢筋的力学性能,尤其是钢筋的变形能力。本文研究了锈蚀钢筋不同本构和标距长度对力学性能的影响,结果表明:钢筋的强屈比是影响其变形能力的主要因素,不同的标距长度将会显著影响锈蚀钢筋极限应变的计算结果。

关键词：结构工程蒙特卡罗法不均匀锈蚀有限元模型力学性能

Microstructure and corrosion behavior of Zr–1.0Cr–0.4Fe–xMo alloys

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Rare Metals 2015年第2期34卷 118-124页

作者： Tian-Guo Wei Lu Zhang zhi miao Hong Liu Bai-Feng Luan Wen Wang Chong-Sheng Long Reactor Fuel and Materials Key Laboratory Nuclear Power Institute of China Nuclear and Radiation Safety Ministry of Environmental Protection Institute of Material Science and Technology Chongqing University

Possibility of using Mo as an alloying element in Zr-based alloys was attractive in terms of microstructure refinement and mechanical properties strengthening. In this research, Zr–1.0Cr–0.4Fe–xMo（0, 0.2, 0.4, and 0.6） alloys with different Mo contents were prepared by vacuum arcmelting method, the microstructure and the corrosion resistance of these alloys were investigated. Addition of Mo has a refinement effect on the microstructure; with the increase of Mo content, the a-laths in the as-cast samples and the grain size in the annealed samples decrease. Zr–1.0Cr–0.4Fe–xMo alloys have large numbers of fine second-phase particles（SPPs） in the matrix, the area fraction of the SPPs is more than 10 %. With the increase of Mo content, the population density of the SPPs increases significantly, while the average diameter of the SPPs decreases. Mo addition also affects the texture; the intensity of basal pole texture aligning normal direction decreases with the increase of Mo content in the alloys.Compared with Zr-4 and Zr–1Nb, Zr–1.0Cr–0.4Fe–xMo alloys have excellent corrosion resistance in 500 ℃/10.3 MPa steam. The corrosion rates of Mo-containing alloys are higher than that of Mo-free alloy, which is mainly attributed to the solute Mo atoms in the Zr matrix.Change of the SPPs features due to the increase of Mo content alleviates the degradation of corrosion resistance in some degree, but it is not the dominant factor.

关键词： Zr-based alloys Mo addition Microstructures Second-phase particles Corrosion behavior

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北盘江大桥推荐桥位安龙岸边坡稳定性分析

科学技术与工程 2024年第10期24卷 4222-4228页

作者：李和志葛莎贺建清梅松华叶智淼湖南城建职业技术学院市政与路桥工程系湘潭411104 湖南科技大学土木工程学院湘潭411201 中南电建集团中南勘测设计研究院有限公司长沙410014

根据工程地质分析,北盘江大桥推荐桥位安龙岸边坡施加工程荷载后,存在滑动破坏的可能性。为判断安龙岸边坡的稳定性,分别采用Slide.v6007、Phase2 V9.0边坡稳定分析计算软件和FLAC 3D软件对安龙岸边坡进行二维和三维稳定性计算分析。计... 详细信息

根据工程地质分析,北盘江大桥推荐桥位安龙岸边坡施加工程荷载后,存在滑动破坏的可能性。为判断安龙岸边坡的稳定性,分别采用Slide.v6007、Phase2 V9.0边坡稳定分析计算软件和FLAC 3D软件对安龙岸边坡进行二维和三维稳定性计算分析。计算分析显示,安龙岸边坡稳定性计算安全系数大于安全系数设计标准,从理论分析来看该边坡处于稳定状态,并且有一定的安全裕度。相对于二维分析的计算安全系数,三维分析的计算安全系数要大。安龙岸边坡稳定性分析结论为北盘江大桥推荐桥位的初步设计提供了较为合理的依据。

关键词：边坡稳定性二维分析三维分析安全系数

基于炎症网络的“柴胡清上汤”治疗前庭神经炎的临床研究

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中国实用医药 2024年第12期19卷 138-141页

作者：李得平苗治国郑州市中医院 450002

目的探讨基于炎症网络的“柴胡清上汤”治疗前庭神经炎的临床疗效。方法选取60例前庭神经炎患者为研究对象,采取随机分组方式分为对照组(30例)与观察组(30例)。对照组患者接受常规内科治疗,观察组患者在常规内科治疗基础上采用“柴胡... 详细信息

目的探讨基于炎症网络的“柴胡清上汤”治疗前庭神经炎的临床疗效。方法选取60例前庭神经炎患者为研究对象,采取随机分组方式分为对照组(30例)与观察组(30例)。对照组患者接受常规内科治疗,观察组患者在常规内科治疗基础上采用“柴胡清上汤”治疗。对比两组患者治疗前后中性粒细胞与淋巴细胞比率(NLR)、血小板与淋巴细胞比率(PLR)、C反应蛋白(CRP)、眩晕残障评分、双温试验以及头脉冲试验。结果两组患者治疗14、90 d后的NLR、PLR、CRP水平与治疗前相比均有所降低,数据对比具有明显统计学意义(P0.05)。结论前庭神经炎患者采用“柴胡清上汤”治疗可降低炎症反应,改善眩晕、耳鸣、恶心呕吐等临床症状,促进前庭功能恢复,整体预后良好,更能减少因前庭神经炎所致的慢性头晕发生几率,所以,值得临床大力推广与广泛应用。

关键词：前庭神经炎柴胡清上汤炎症临床疗效

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杀线虫抑菌剂研究进展

化肥设计 2024年第1期62卷 9-12,29页

作者：邓文星解田苗志伟南开大学化学学院元素有机化学国家重点实验室天津300071 赤峰瑞阳化工有限公司内蒙古赤峰024000

杀线虫抑菌剂在农药中占比很小,但是非常重要。随着呋喃丹、克百威、二溴氯丙烷等农药品种的禁限用,市场上可供选择的杀线虫抑菌剂屈指可数,因此,研发低毒高效的杀线虫抑菌剂具有重要的应用前景。综述了国内外常用杀线虫抑菌剂的合成方... 详细信息

杀线虫抑菌剂在农药中占比很小,但是非常重要。随着呋喃丹、克百威、二溴氯丙烷等农药品种的禁限用,市场上可供选择的杀线虫抑菌剂屈指可数,因此,研发低毒高效的杀线虫抑菌剂具有重要的应用前景。综述了国内外常用杀线虫抑菌剂的合成方法,为杀线虫抑菌剂的开发提供参考。

关键词：杀线虫抑菌剂合成方法研究进展

Shear band evolution and acoustic emission characteristics of sandstone containing non-persistent flaws

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第2期16卷 497-513页

作者： Shuting miao Peng-zhi Pan Chuanqing Zhang Lei Huo State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhan430071China University of Chinese Academy of Sciences Beijing100049China CASIC Research Institute of Intelligent Decision Engineering Wuhan430040China

Direct shear tests were conducted on sandstone specimens under different constant normal stresses to study the coalescence of cracks between non-persistent flaws and the shear sliding characteristics of the shear-formed fault.Digital image correlation and acoustic emission(AE)techniques were used to monitor the evolution of shear bands at the rock bridge area and microcracking behaviors.The experimental results revealed that the shear stresses corresponding to the peak and sub-peak in the stressdisplacement curve are significantly affected by the normal stress.Strain localization bands emerged at both the tip of joints and the rock bridge,and their extension and interaction near the peak stress caused a surge in the AE hit rate and a significant decrease in the AE b value.Short and curvilinear strain bands were detected at low normal stress,while high normal stress generally led to more microcracking events and longer coplanar cracks at the rock bridge area.Furthermore,an increase in normal stress resulted in a higher AE count rate and more energetic AE events during friction sliding along the shearformed fault.It was observed that the elastic energy released during the crack coalescence at the prepeak stage was much greater than that released during friction sliding at the post-peak stage.More than 75%of AE events were located in the low-frequency band(0e100 kHz),and this proportion continued to rise with increasing normal stress.Moreover,more AE events of low AF value and high RA value were observed in specimens subjected to high normal stress,indicating that greater normal stress led to more microcracks of shear nature.

关键词： Shear band evolution Acoustic emission(AE) Crack coalescence Normal stress Shear sliding

Effects of Biologics on Mental Health and Health-Related Quality of Life in Patients With Psoriasis:A Repeated Cross-Sectional Survey in Chinese Population

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International Journal of Dermatology and Venereology 2023年第4期6卷 207-213页

作者： Jie Liu Xuan Wang Xiao-Ling Yu zhi-miao Lin Li-Yan Yuan Bin Yang Dermatology Hospital Southern Medical UniversityGuangzhouGuangdong 510091China School of Public Health Southern Medical UniversityGuangzhouGuangdong 510515China.

Objective:Psoriasis is a chronic inflammatory systemic disease that severely impacts patients’ quality of life (QoL) and psychological health.While biologics have been shown to be effective in treating psoriatic lesions,thus improving QoL,real-life data regarding such effects remain scant.We administered a repeated cross-sectional survey to assess the effects of 8 weeks of biologics treatment on the QoL and mental health status of patients with moderate-to-severe plaque psoriasis.Methods:From March to May 2022,patients with moderate-to-severe plaque psoriasis were enrolled and treated with biologics in the outpatient clinic at the Dermatology Hospital of Southern Medical University.Assessments were performed before treatment and after 4 and 8 weeks of treatment with biologics.Psoriasis severity,QoL,and mental health status were evaluated using the Psoriasis Area and Severity Index (PASI),Dermatology Life Quality Index (DLQI),36-Item Short-form Health Survey (SF-36),and Hospital Anxiety and Depression Scale (HADS).A multivariate generalized estimating equations (GEE) analysis was used to account for repeated measures and to determine the effects of treatment duration and type of biological agent on relevant indicators.Results:Among the 78 enrolled patients,the ranges of pretreatment scores were 4.6 to 46.8 for the PASI,1 to 30 for the DLQI,31.5 to 100.0 for the physical component score (PCS) of the SF-36,16.6 to 100.0 for the mental component score (MCS) of the SF-36,0 to 15 for the HADS-A,and 0 to 17 for the HADS-D.After 8 weeks of biologics treatment,98.7% (77/78) of patients had obtained PASI 75.All assessed scores changed over time (GEE,P < 0.001).Moreover,there were group-by-time interaction effects for the DLQI score (GEE,P = 0.023) and PCS (GEE,P = 0.029).The HADS-A and HADS-D scores were both decreased at week 8 compared with pretreatment values.Correlation analyses revealed that higher DLQI scores were associated with lower levels of QoL and higher levels of anxiety or depression.Conclusion:Biologics are

关键词： psoriasis quality of life biologics Psoriasis Area and Severity Index Dermatology Life Quality Index 36-Item Short-form Health Survey Hospital Anxiety and Depression Scale

Curcumin inhibits the growth and invasion of gastric cancer by regulating long noncoding RNA AC022424.2

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1437-1452页

作者： Bin-Sheng Wang Chen-Li Zhang Xiang Cui Qiang Li Lei Yang zhi-Yun He Ze Yang miao-miao Zeng Nong Cao Department of General Surgery First Hospital of Lanzhou UniversityLanzhou 730000Gansu ProvinceChina School of Basic Medical Sciences Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Third Department of General Surgery First Hospital of Lanzhou UniversityLanzhou 730000Gansu ProvinceChina

BACKGROUND Gastric cancer,characterized by a multifactorial etiology and high heterogeneity,continues to confound researchers in terms of its pathogenesis.Curcumin,a natural anticancer agent,exhibits therapeutic promise in gastric cancer.Its effects include promoting cell apoptosis,curtailing tumor angiogenesis,and enhancing sensitivity to radiation and chemotherapy.Long noncoding RNAs(lncRNAs)have garnered significant attention as biomarkers for early screening,diagnosis,treatment,and drug response because of their remarkable specificity and sensitivity.Recent investigations have revealed an association between aberrant lncRNA expression and early diagnosis,clinical staging,metastasis,drug sensitivity,and prognosis in gastric cancer.A profound understanding of the intricate mechanisms through which lncRNAs influence gastric cancer develop-ment can provide novel insights for precision treatment and tailored management of patients with gastric cancer.This study aimed to unravel the potential of curcumin in suppressing the malignant behavior of gastric cancer cells by upregu-lating specific lncRNAs and modulating gastric cancer onset and progression.AIM To identify lncRNAs associated with curcumin treatment and investigate the role of lncRNA AC022424.2 in the effects of curcumin on gastric cancer cell apoptosis,proliferation,and invasion.Furthermore,these findings were validated in clinical samples.METHODS The study employed CCK-8 assays to assess the impact of curcumin on gastric cancer cell proliferation,flow cytometry to investigate its effects on apoptosis,and scratch and Transwell assays to evaluate its influence on the migration and invasion of BGC-823 and MGC-803 cells.Western blotting was used to gauge changes in the protein expression levels of CDK6,CDK4,Bax,Bcl-2,caspase-3,P65,and the PI3K/Akt/mTOR pathway in gastric cancer cell lines after curcumin treatment.Differential expression of lncRNAs before and after curcumin treatment was assessed using lncRNA sequencing and validated using quantitative reverse

关键词： Gastric cancer Curcumin Long noncoding RNA AC022424.2 Apoptosis Akt/PI3K pathway Lymph metastasis