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Journal of Hainan Medical University 2018年第9期24卷 71-74页

作者： Yuan-Li Kuang Zheng Wang zhi-liang Yang zhi-Ming Tan Department of General Surgery The People's Hospital of kaizhou District ChongqingChongqing 405400China

Objective:To investigate the effects of laparoscopic normal hepatectomy and partial open hepatectomy on inflammatory factors, stress hormones and immune function in patients with intrahepatic ***: A total of 90 patients with intrahepatic cholelithiasis were randomly divided into control group and the observation group. The patients in the control group were treated with partial hepatectomy. Patients in observation group were treated with laparoscopic normal hepatectomy. The levels of inflammatory factors, stress hormones and immune function were compared in two groups before and after ***: Before treatment, there was no significant difference in the levels of neutrophile granulocyte, CRP, WBC, COR, E, CD3+, CD4+, CD8+ and NK cells between the two groups. After treatment, the levels of CD3+, CD4+ and NK cells in the observation group were significantly higher than those in the control group, moreover, these levels after treatment were obviously lower than before treatment;The levels of neutrophile granulocyte, CRP, WBC, COR, E and CD8+ in the observation group were significantly lower than those in the control group, and these levels were significantly higher than before ***: Compared with partial open hepatectomy, laparoscopic normal hepatectomy can effectively reduce the inflammatory factors and stress hormone levels, improve the immune function of the body, and have a certain clinical value.

关键词： Intrahepatic cholelithiasis Open partial hepatectomy Laparoscopic standardized partial hepatectomy Inflammatory factors Stress hormone Immune function

Coronary bifurcation lesions treated with double kissing crush technique compared to classical crush technique： serial intravascular ultrasound analysis

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Chinese Medical Journal 2013年第7期126卷 1247-1251页

作者： SHAN Shou-jie YE Fei LIU zhi-zhong TIAN Nai-liang ZHANG Jun-jie CHEN Shao-liang Department of Cadiology Nanjing First Hospital Affiliated to Nanjing Medical University Nanjing Jiangsu 210006 China

Background The double kissing （DK） crush technique is a modified version of the crush technique. It is specifically designed to increase the success rate of the final kissing balloon post-dilatation, but its efficacy and safety remain unclear. Methods Data were obtained from the DKCRUSH-I trial, a prospective, randomized, multi-center study to evaluate safety and efficacy. Post-procedural and eight-month follow-up intravascular ultrasound （IVUS） analysis was available in 61 cases. Volumetric analysis using Simpson＇s method within the Taxus stent, and cross-sectional analysis at the five sites of the main vessel （MV） and three sites of the side branch （SB） were performed. Impact of the bifurcation angle on stent expansion at the carina was also evaluated. Results Stent expansion in the SB ostium was significantly less the DK crush group （（72.27±11.46）%）（P=0.04）. For the MV, the n the classical crush group （（53.81±13.51）%） than in ncidence of incomplete crush was 41.9% in the DK group and 70.0% in the classical group （P=0.03）. The percentage of neointimal area at the ostium had a tendency to be smaller in the DK group compared with the classical group （（16.4±19.2）% vs. （22.8±27.1）%, P=0.06）. The optimal threshold of post-procedural minimum stent area （MSA） to predict follow-up minimum lumen area （MLA）〈4.0 mm2 at the SB ostium was 4.55 mm2, yielding an area under the curve of 0.80 （95% confidence interval： 0.61 to 0.92）. Conclusion Our data suggest that the DK crush technique is associated with improved quality of the final kissing balloon inflation （FKBI） and had smaller optimal cutoff value of post-procedural MSA at the SB ostium.

关键词： coronary disease drug-eluting stents bifurcation lesion crush technique intravascular ultrasound

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浅埋坚硬特厚煤层综放开采顶煤冒放结构分析

煤炭学报 2016年第2期41卷 359-366页

作者：解兴智赵铁林煤炭科学研究总院开采设计研究分院北京100013 天地科技股份有限公司开采设计事业部北京100013

为深入研究浅埋坚硬特厚煤层综放开采顶煤冒放结构特征,以主采3号煤层的榆阳地区千树塔煤矿作为研究背景,采用数值模拟、理论分析和现场实测等综合方法对坚硬顶煤冒放结构进行了研究,得出靠近工作面两端头位置坚硬顶煤容易形成"悬臂"结... 详细信息

为深入研究浅埋坚硬特厚煤层综放开采顶煤冒放结构特征,以主采3号煤层的榆阳地区千树塔煤矿作为研究背景,采用数值模拟、理论分析和现场实测等综合方法对坚硬顶煤冒放结构进行了研究,得出靠近工作面两端头位置坚硬顶煤容易形成"悬臂"结构。由悬臂顶煤内部应力解析和模拟得到顶煤不同的破断长度对其垮落放出有着重要影响,当其破断长度小于放煤口水平投影宽度时,垮落放出相对较为容易;当其破断长度大于放煤口水平投影宽度时,垮落放出较为困难,并且增加处理大块煤的时间,该结论解释了坚硬顶煤垮落放出困难的宏观结构因素。

关键词：浅埋坚硬特厚煤层综放开采冒放结构

Identification of SPP1 as an extracellular matrix signature for metastatic castration-resistant prostate cancer

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中国药理学与毒理学杂志 2019年第10期 760-761页

作者： PANG Xiao-cong xie Ran ZHANG Zhuo LIU Qian-xin WU Shi-liang CUI Yi-min Department of Pharmacy Peking University First Hospital Department of Urology Peking University First Hospital

OBJECTIVE Resistance to androgen deprivation therapy(ADT) is the main challenge for advanced fatal prostate cancer(PCa), which can gradually develop into metastatic castration-resistant prostate cancer(m CRPC). However, the pathologic mechanisms of m CRPC are still far from clear. Given the high incidence and mortality related to m CRPC, understanding the causes and pathogenesis of this condition as well as identifying potential biomarkers are of great *** In the research reported here, we integrated several gene expression profiles from hormone sensitive prostate cancer(HSPC) and m CRPC datasets to identify differentially expressed genes(DEGs), key biological pathways, and cellular components. K-nearest neighbor,logistic regression, naive Bayes, and random forest classifiers models were established to identify key regulated genes. Furthermore, organoid models were employed to validate the results in vitro. RESULTS We found that extracellular matrix(ECM) genes were significantly enriched, and further filtered them using Pearson correlation analysis and stepwise regression to find ECM signatures to differentiate between the HSPC and m CRPC phenotypes. Six ECM signatures were input into K-nearest neighbor, logistic regression, naive Bayes, and random forest classifiers models. Random forest algorithm with the six-gene prognostic signature showed best performance, which had high sensitivity and specificity for HSPC and m CRPC classification. Among the six ECM genes, SPP1 was identified as the key hub signature for PCa metastasis and drug resistance development; we found that both protein and m RNA expression levels of SPP1 were remarkably up-regulated in m CRPC compared with HSPC in organoid models and could regulate the androgen receptor signaling pathway. CONCLUSION Therefore, SPP1 is a potential novel biomarker and therapeutic target for m CRPC. Further understanding of the role of SPP1 in m CRPC development may help to explore effectively therapeutic

关键词： SPP1 castration-resistant prostate cancer extracellular matrix metastasis organoid model

IBVE/AANa/VAc无皂乳液的合成与性能

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胶体与聚合物 2024年第1期42卷 24-26,33页

作者：刘敏吴志俊邹婷婷钱鹏菲徐杨军谢磊张书香江苏科麦特科技发展有限公司江苏无锡214161 济南大学化学化工学院济南250022

本文以异丁基乙烯基醚、丙烯酸钠和醋酸乙烯酯为反应单体合成无皂乳液。研究了AANa的用量对乳液稳定性的影响,考察了VAc/IBVE的比例与聚合物性能的关系,同时分析了乳胶粒的形貌。结果表明,亲水性单体AANa对乳液的稳定性、粒径大小影响... 详细信息

本文以异丁基乙烯基醚、丙烯酸钠和醋酸乙烯酯为反应单体合成无皂乳液。研究了AANa的用量对乳液稳定性的影响,考察了VAc/IBVE的比例与聚合物性能的关系,同时分析了乳胶粒的形貌。结果表明,亲水性单体AANa对乳液的稳定性、粒径大小影响较大。调整反应单体VAc/IBVE的比例可以得到不同分子量、不同玻璃化转变温度的聚合物,该无皂乳液具有明显的核壳结构。

关键词：无皂乳液聚合丙烯酸钠醋酸乙烯酯异丁基乙烯基醚

一种基于知识表示的多步攻击规划问题描述模型

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电子学报 2013年第6期41卷 1101-1107页

作者：努尔布力解男男刘志宇胡亮柴胜新疆大学信息科学与工程学院新疆乌鲁木齐830046 新疆多语种信息技术重点实验室新疆乌鲁木齐830046 吉林大学计算机科学与技术学院吉林长春130012 公安部第一研究所北京100044

网络入侵检测中,攻击的形式越来越多样化和复杂化,网络多步攻击成为当前攻击的主要形式.智能规划最早用于人工智能领域,将一个领域内的知识形成规划推理时的规划域,将待求解的问题对应于规划问题.将智能规划应用于多步攻击领域,用以对... 详细信息

网络入侵检测中,攻击的形式越来越多样化和复杂化,网络多步攻击成为当前攻击的主要形式.智能规划最早用于人工智能领域,将一个领域内的知识形成规划推理时的规划域,将待求解的问题对应于规划问题.将智能规划应用于多步攻击领域,用以对多步攻击进行识别,并以此为基础,提出一种基于知识表示的多步攻击规划问题描述模型,用以提供解决复杂网络攻击数据的形式化描述问题的一种探索.实验中规划问题采用PDDL语言进行描述,对所提模型进行可用性验证.

关键词：多步攻击智能规划安全规划问题 PDDL

胰十二指肠切除术术后出血列线图预测模型的建立和验证

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中国现代医学杂志 2024年第5期34卷 65-71页

作者：郑康鹏刘竞航唐鑫国徐琦樊钰亭徐良智刘天德梁博熊虎李文付晓伟方路南昌大学第二附属医院肝胆外科江西南昌330006

目的分析胰十二指肠切除术(PD)术后出血的危险因素,构建预测PD术后出血的列线图模型。方法回顾性分析2017年1月—2023年1月494例在南昌大学第二附属医院行PD患者的临床资料。将2017年1月—2020年12月收集的376例患者作为训练集,2021年1... 详细信息

目的分析胰十二指肠切除术(PD)术后出血的危险因素,构建预测PD术后出血的列线图模型。方法回顾性分析2017年1月—2023年1月494例在南昌大学第二附属医院行PD患者的临床资料。将2017年1月—2020年12月收集的376例患者作为训练集,2021年1月—2023年1月118例患者作为验证集。通过单因素分析、Lasso回归分析和多因素一般Logistic回归分析筛选预测因素并构建列线图预测模型。通过受试者工作特征曲线下面积(AUC)、校正曲线和决策曲线分析(DCA)评估模型的鉴别能力、一致性和临床效果。结果多因素一般Logistic回归分析结果显示,血管重建、术后胰瘘、术后胆瘘、腹腔感染和白蛋白为PD术后出血的独立风险因素(P<0.05)。由上述因素构建列线图预测模型在训练集的AUC为0.870(95%CI:0.820,0.920),验证集AUC为0.799(95%CI:0.691,0.907),提示模型诊断效能较好,在训练集和验证集中绘制出的校正曲线与标准曲线较为接近,提示模型一致性较好。绘制的DCA曲线也表明了明显的正向净收益。结论通过血管重建、术后胰瘘、术后胆瘘和腹腔感染和白蛋白构建的列线图预测模型能够很好识别出PD术后出血的高风险患者,具有很好的临床应用价值。

关键词：胰十二指肠切除术术后出血预测模型列线图

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水合物阻聚剂研究进展

石油科学通报 2024年第2期9卷 318-337页

作者：付顺康王智卫国锋梁璇玑陈玉川张烜玮姚海元许保珅宋尚飞史博会吴海浩宫敬天然气水合物国家重点实验室北京102249 中国石油大学(北京)油气管道输送安全国家工程实验室/石油工程教育部重点实验室/城市油气输配技术北京市重点实验室北京102249 国家石油天然气管网集团有限公司西气东输分公司上海710018 长庆工程设计有限公司西安710018 中国石油国际勘探开发有限公司北京100034 中国石油塔里木油田公司博大油气开发部阿克苏842300 中海油研究总院有限责任公司北京100028

相较于传统的水合物生成抑制方式,向管线中添加低剂量抑制剂的水合物风险控制策略,在深水多相集输领域防控水合物堵塞中具有显著的优势,备受国内外学术与工业界的青睐。阻聚剂是一种能在更为苛刻的高过冷度工况下,仍具有良好阻聚效果的... 详细信息

相较于传统的水合物生成抑制方式,向管线中添加低剂量抑制剂的水合物风险控制策略,在深水多相集输领域防控水合物堵塞中具有显著的优势,备受国内外学术与工业界的青睐。阻聚剂是一种能在更为苛刻的高过冷度工况下,仍具有良好阻聚效果的低剂量抑制剂,可保证多相混输流体内生成的水合物以浆液呈现可输送状态。本文重点阐述了影响阻聚剂性能的关键因素,梳理了阻聚剂存在体系内水合物生成及流动的宏微观特性。总体而言,阻聚剂的性能受加剂量、含水率、矿化度、pH、溶液乳化状态及应用工况过冷度等综合因素的影响;添加阻聚剂体系的水合物浆液内水合物生成量稳定适中、流动性越好,油气水混输系统内发生水合物堵塞的风险越低,其流动安全的保障可靠性越高。基于上述研究,本文总结了阻聚剂对水合物的作用机理,并给出了未来深入开展阻聚剂研究的建议。

关键词：水合物阻聚剂乳化吸附

A new bleb-independent surgery namely penetrating canaloplasty for corticosteroid-induced glaucoma: a prospective case series

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International Journal of Ophthalmology(English edition) 2022年第7期15卷 1077-1081页

作者： Jing-Jing Hu Hai-Shuang Lin Shao-Dan Zhang Wen-Qing Ye Juan Gu Yan-Qian xie Yi-Hua Tang Yuan-Bo liang The Eye Hospital School of Ophthalmology&OptometryWenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina Glaucoma Institute Wenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina

AIM: To report the outcomes of penetrating canaloplasty for corticosteroid-induced glaucoma in a case ***: Penetrating canaloplasty is a blebindependent filtering surger y unifying canaloplasty and trabeculectomy. In this study, the surger y was performed to restore the natural outflow through surgically expanded Schlemm’s canal and generated trabeculum ostium. A total of 10 eyes of 8 patients were treated with penetrating canaloplasty for corticosteroid-induced glaucoma. Intraocular pressure(IOP) and the number of glaucoma medications at postoperative 3, 6, 12, 18, 24,36, and 48mo were documented as primary *** after the surgery were recorded as secondary ***: Penetrating canaloplasty was accomplished successfully for all 10 eyes, with a mean follow-up of 20.4±13.0mo(range 6-48mo). The mean preoperative IOP and number of anti-glaucoma medications were 45.1±6.5 mm Hg and 3.3±0.5 respectively. The mean post-operative IOP at 3, 6, 12, 18, 24, 36, and 48mo were 15.8±6.0, 14.7±3.3,15.3±2.0, 15.6±2.6, 17.5±1.8, 16.5±4.9, and 14.0 mm *** number of anti-glaucoma medications at these time points were all 0. This surgery failed to control the IOP in 1 eye at 1mo after surgery. Hyphaema occurred in 3 eyes on the first day after surgery. Postoperative transient IOP increasing was encountered with in two eyes from 1wk to 1mo after surgery. Choroidal detachment developed in one eye but responded well to conservative ***: Penetrating canaloplasty is effective for corticosteroid-induced glaucoma without serious complications, making it a viable or preferred alternative option.

关键词： penetrating canaloplasty corticosteroid-induced glaucoma intraocular pressure bleb-independent filtering surgery

Effects of laparoscopic hepatectomy and laparoscopic radiofrequency ablation on immune function, pain related indexes and liver function in patients with hepatocellular carcinoma

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Journal of Hainan Medical University 2018年第6期24卷 47-50页

作者： Yuan-Li Kuang Zheng Wang zhi-liang Yang zhi-Ming Tan Department of General Surgery The People's Hospital of Kaizhou District ChongqingChongqing 405400China

Objective:To investigate the effects of laparoscopic hepatectomy and laparoscopic radiofrequency ablation on immune function, pain related indexes and liver function in patients with hepatocellular ***: Ninety-six patients with hepatocellular carcinoma were randomly divided into two groups: control group and observation group. The patients in the control group were treated with laparoscopic hepatectomy, and the patients in the observation group were treated with laparoscopic radiofrequency ablation. The immune function, pain index and liver function were compared between the two ***:There was no significant difference in the levels of CD3+, CD4+, CD8+, CD4+/CD8+, COR, NE, CRP, ALT and AST in two groups before treatment. After treatment, the levels of CD3+, CD4+and CD4+/CD8+ in the observation group were significantly higher than those in the control group. The levels of CD8+, COR, NE, CRP, ALT and AST in the observation group were significantly lower than those in the control ***: Compared with laparoscopic hepatectomy, laparoscopic radiofrequency ablation for hepatocellular carcinoma can improve the immune function and liver function, reduce pain, and has certain clinical value.

关键词： Hepatocellular carcinoma Laparoscopic hepatectomy Laparoscopic radiofrequency ablation Immune function Pain Liver function