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Inhibitory effects of cariporide on LPC-induced expression of ICAM-1 and adhesion of monocytes to smooth muscle cells in vitro

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Acta Pharmacologica Sinica 2006年第10期27卷 1326-1332页

作者： zhi li tao song gui-zhen liu li-ying liu~2 department of pharmacology,pharmaceutical college,central south university,{3.,China department of pharmacology Pharmaceutical College Central South University Changsha 410078 China

Aim:To explore the effects of cariporide on the expression of intercellular adhe-sion molecule-1(ICAM-1)and the adhesion of monocytes to vascular smoothmuscle cells(SMC)in ***:Monocytes were isolated from humanperipheral blood by the Ficoll-Hypaque *** expression of ICAM-1 inSMC was detected by *** adhesion of monocytes to SMC was stimu-lated by lysophosphatidylcholine(LPC).The adhesion ratio of monocytes wasassayed by measuring protein *** intracellular pH([pH]i)of SMC wasmeasured with 2’,7’-bis(2-carboxyethyl)-5,6-carboxyfluorescein(BCECF).Results:Preincubation of SMC with LPC alone(5 μg/mL)for 4 h markedly enhanced theexpression of ICAM-1 in SMC and the rate of the adhesion of monocytes to SMCin a concentration-dependent and time-related *** simultaneously alsoinduced an increase of[pH]ivalue in *** concentration-dependentlyreduced the adhesion ratio of monocytes to SMC and the expression of ICAM-1in SMC induced by *** inhibitory effects of cariporide on the expression ofICAM-1 in SMC and the adhesion of monocytes to SMC also were associatedwith blocking LPC-induced elevation of the[pH]ivalue in ***:LPC-induced monocyte-SMC adhesion may be mediated via activation of theNa~+/H~+(NHE)*** action mechanism of cariporide may be related withinhibition of activation of the Na~+/H~+ exchanger of plasma membranes and ICAM-1expression on the surface of SMC induced by LPC.

关键词： Na~+/H~+ exchanger cariporide lysophosphatidylcholine intercellular adhesion molecule-l monocyte smooth muscle cells

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