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七氟醚或丙泊酚复合瑞芬太尼用于小儿经喉罩纤维支气管镜检查的比较

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中国内镜杂志 2016年第2期22卷 53-56页

作者：王珊珊张志捷祁宾冯伟静江苏省淮安市淮阴医院麻醉科江苏淮安223300 南京医科大学附属淮安第一医院麻醉科江苏淮安223302 南京医科大学附属淮安第一医院儿科江苏淮安223302

目的观察和比较七氟醚或丙泊酚复合瑞芬太尼麻醉在小儿经喉罩纤维支气管镜(FOB)检查中的临床效果。方法 60例拟行FOB检查的患儿随机分为两组,每组30例:七氟醚复合瑞芬太尼组(S组)和丙泊酚复合瑞芬太尼组(P组)。S组采用七氟醚复合瑞芬太... 详细信息

目的观察和比较七氟醚或丙泊酚复合瑞芬太尼麻醉在小儿经喉罩纤维支气管镜(FOB)检查中的临床效果。方法 60例拟行FOB检查的患儿随机分为两组,每组30例:七氟醚复合瑞芬太尼组(S组)和丙泊酚复合瑞芬太尼组(P组)。S组采用七氟醚复合瑞芬太尼的静吸复合麻醉方式,P组采用丙泊酚复合瑞芬太尼的全凭静脉麻醉方式。两组均置入喉罩并保留自主呼吸,经喉罩行FOB检查。记录入室后安静时(T0:基础值)、镜检前(T1)、镜检进行2 min(T2)时平均动脉压(MAP)、心率(HR)、脉氧饱和度(Sp O)2、呼气末二氧化碳(PETCO2)和脑电双频指数(BIS),评估麻醉效果,并记录镜检时间、苏醒时间和不良反应发生情况。结果 P组T1时HR、MAP和Sp O2明显低于S组、PETCO2明显高于S组;T2时MAP、HR和PETCO2明显高于S组、Sp O2明显低于S组(P<0.05)。S组麻醉效果优良率明显高于P组(P<0.05)。S组短暂呼吸抑制、检查中断率明显低于P组(P<0.05)。结论经喉罩吸入七氟醚复合静脉瑞芬太尼用于小儿FOB检查,较丙泊酚复合瑞芬太尼的全凭静脉麻醉方式更为安全、有效。

关键词：七氟醚丙泊酚瑞芬太尼喉罩纤维支气管镜小儿

Nanomaterials-mediated lysosomal regulation:a robust protein-clearance approach for the treatment of Alzheimer’s disease

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Neural Regeneration Research 2025年第2期20卷 424-439页

作者： Mengqi Hao Jianjian Chu Tinglin zhang Tong Yin Yuankai Gu Wendanqi Liang Wenbo Ji Jianhua Zhuang Yan Liu jie Gao You Yin Department of Neurology Second Affiliated Hospital of Naval Medical University(Shanghai Changzheng Hospital)ShanghaiChina School of Health Science and Engineering University of Shanghai for Science and TechnologyShanghaiChina Changhai Clinical Research Unit Shanghai Changhai HospitalNaval Medical UniversityShanghaiChina Department of Clinical Pharmacy Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Neurology Shanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina

Alzheimer’s disease is a debilitating,progressive neurodegenerative disorder characterized by the progressive accumulation of abnormal proteins,including amyloid plaques and intracellular tau tangles,primarily within the ***,crucial intracellular organelles responsible for protein degradation,play a key role in maintaining cellular *** studies have suggested a link between the dysregulation of the lysosomal system and pathogenesis of neurodegenerative diseases,including Alzheimer’s *** the normal physiological function of lysosomes hold the potential to reduce the pathological burden and improve the symptoms of Alzheimer’s ***,the efficacy of drugs in treating Alzheimer’s disease is limited,with major challenges in drug delivery efficiency and ***,nanomaterials have gained widespread use in Alzheimer’s disease drug research owing to their favorable physical and chemical *** review aims to provide a comprehensive overview of recent advances in using nanomaterials(polymeric nanomaterials,nanoemulsions,and carbon-based nanomaterials)to enhance lysosomal function in treating Alzheimer’s *** review also explores new concepts and potential therapeutic strategies for Alzheimer’s disease through the integration of nanomaterials and modulation of lysosomal *** conclusion,this review emphasizes the potential of nanomaterials in modulating lysosomal function to improve the pathological features of Alzheimer’s *** application of nanotechnology to the development of Alzheimer’s disease drugs brings new ideas and approaches for future treatment of this disease.

关键词： Alzheimer’s disease autophagy dysfunction lysosomal acidification lysosomal system nanomaterials neurodegenerative diseases

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核磁共振成像教学实验

物理实验 2004年第8期24卷 3-7页

作者：臧充之彭培芝张洁天吕斯骅北京大学物理学院基础物理实验教学中心北京100871

利用超小型核磁共振成像仪 ,完成了核磁共振空间编码成像的一系列实验 .研究了超小型核磁共振成像仪的性能 ,并对 2种观赏植物、动物骨骼、蛔虫、蚯蚓等生物样品进行了核磁共振成像以及T1加权和氢核密度加权成像 .

关键词：核磁共振核磁共振成像加权成像

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一种共享型校园图书馆管理系统的设计与实现

广东交通职业技术学院学报 2018年第3期17卷 89-92页

作者：李月谢志杰张凯周江广东交通职业技术学院广东广州510650

随着共享经济的发展,越来越多的实体加入到共享的范围。图书共享是共享经济下诞生的新事物,文章通过对传统图书借阅方式及管理软件的分析,结合共享经济下校园内图书共享的需求现状,提出了一种基于微信公众号平台的校园图书共享平台设计... 详细信息

随着共享经济的发展,越来越多的实体加入到共享的范围。图书共享是共享经济下诞生的新事物,文章通过对传统图书借阅方式及管理软件的分析,结合共享经济下校园内图书共享的需求现状,提出了一种基于微信公众号平台的校园图书共享平台设计及实现方法,详细阐述了校园共享图书管理系统的功能需求、系统架构及实现方式,并对系统应用前景进行了展望。

关键词：共享图书系统设计软件架构系统应用

Enhanced memristor performance via coupling effect of oxygen vacancy and ferroelectric polarization

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Journal of Materials Science & Technology 2024年第4期171卷 139-146页

作者： zhi Yun Yue zhi Dong zhang Zhan jie Wang Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China School of Materials Science and Engineering Shenyang University of TechnologyShenyang 110870China

As a new type of nonvolatile memory,the resistive memristor has broad application prospects in in-formation storage and neural computing based on its excellent resistive switching(RS)*** present,it is still a great challenge to improve both ferroelectric polarization and leakage current to achieve a high RS on/offratio of ferroelectric ***,epitaxial Pb(Zr_(0.40)Ti_(0.60))O_(3)(PZT)thin films with low content Ca doping were deposited on the Nb:SrTiO_(3)substrate to prepare PCZT/NSTO het-erostructures and their RS behaviors were *** research findings show that compared with pure PZT film,the ferroelectric polarization of 1-mol%-Ca-doped PZT film is slightly improved,while the leak-age current is increased by three orders of ***,the RS on/offratio reaches 2.5×10^(5),about three orders of magnitude higher than pure PZT *** theoretical analysis reveals that the RS behavior of PCZT/NSTO heterostructures is controlled by the PCZT/NSTO interfacial barrier and the space charge-limited current *** results demonstrate that the ferroelectricity and electricity of ferroelectric thin films can be improved simultaneously by doping low-content Ca ions to increase the RS performance,which provides a good reference for the development of high-performance ferroelectric memristor devices.

关键词： Ferroelectric memristor Ca-doped PZT Ferroelectric polarization Oxygen vacancies Resistive switching

倍他米松与医用生物蛋白胶在腰椎神经根减压术中的联合应用评价

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中国医院药学杂志 2017年第8期37卷 762-766页

作者：孙志杰张义龙刘正蓬王雅辉承德医学院附属医院脊柱外一科河北承德067000

目的:评价在神经根减压术中联合应用倍他米松和医用生物蛋白胶的疗效。方法:观察对象为腰椎神经根减压术术后的120例患者,根据术后处理方式的不同将患者分为4组:A组单纯手术组,B组单纯应用倍他米松组,C组单纯应用医用生物蛋白胶组,D组... 详细信息

目的:评价在神经根减压术中联合应用倍他米松和医用生物蛋白胶的疗效。方法:观察对象为腰椎神经根减压术术后的120例患者,根据术后处理方式的不同将患者分为4组:A组单纯手术组,B组单纯应用倍他米松组,C组单纯应用医用生物蛋白胶组,D组倍他米松联合应用医用生物蛋白胶组。观察各组术后直腿抬高试验角度、改良JOA评分、ODI评分、VAS评分、术后48 h内引流量,分析各组检查结果的差异。结果:术前患者年龄、病史时程、男女比例、直腿抬高试验角度、改良JOA评分、ODI评分、VAS评分、术后48 h内引流量均无统计学意义。术后各组患者直腿抬高试验角度在不同时期均有明显改善,差异有统计学意义(P<0.05)。术后4周,D组患者髋关节运动角度显著高于其他3组,差异有统计学意义[(75±23)°vs.(54±19)°,vs.(62±20)°,vs.(64±21)°,(P<0.05)];术后4周,D组患者膝关节运动角度显著低于其他3组,差异有统计学意义[(11±4)°vs.(16±6)°,vs.(13±5)°,vs.(14±5)°,(P<0.05)];术后4周,D组患者髋关节运动角度显著高于A组,差异有统计学意义[(74±21)°vs.(54±19)°,(P<0.05)]。术后患者症状也有显著改善:术后4周,D组患者改良JOA评分显著高于其他3组,差异有统计学意义[(22±7)vs.(16±6),vs.(18±5),vs.(18±5),(P<0.05)]。术后4周,D组患者ODI评分显著低于其他3组,差异有统计学意义[(9±2)vs.(18±3),vs.(13±2),vs.(15±3),(P<0.05)]。D组患者VAS评分显著低于其他3组,差异有统计学意义[(3.3±0.6)vs.(5.4±0.8),vs.(4.3±0.7),vs.(4.2±0.7),(P<0.05)]。D组患者术后48 h内引流量明显低于其他3组,差异有统计学意义[(316±41)vs.(457±51),vs.(420±56),vs.(391±48),(P<0.05)]。结论:联合应用倍他米松和医用生物蛋白胶能够在神经根减压术中收获比单用药物更好的疗效。

关键词：倍他米松医用生物蛋白胶腰椎神经减压术三维遮挡结构

Influence of the Spudcan Angle on the Ultimate Bearing Capacity of Jack-up Platform

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China Ocean Engineering 2018年第4期32卷 476-481页

作者： zhang Qi-yi LIU zhi-jie Department of Ocean Engineering College of EngineeringOcean University of ChinaQingdao 266100China Key Laboratory of Ocean Engineering of Shandong Province Qingdao 266100China

Jack-up platforms of the Ocean engineering structures always withstand the vertical gravity loads which are applied to the seabed by spudcan, so it is important to determine the bearing capacity and the penetration depth of the spudcan for its geometry. In fact, it is up to the deformation law and the failure modes of soil surrounding the spudcan which can calculate the ultimate bearing capacity of the spudcan foundation on the soil seabed. By using the finite element analysis software Abaqus, the deformation law of soil around the spudcan is analyzed in detail, and the failure modes of soil surrounding the spudcan foundation are achieved. At the same time, based on the limit equilibrium theory, by use of static permissible slip-line field, the ultimate bearing capacity of the spudcan foundation is analyzed and the lower limit solution is derived theoretically, and the effect of the spudcan angle on the ultimate bearing capacity is investigated. The numerical results are compared with those obtained by the theoretical formulas deduced in this paper. On the basis of the lower limit solutions in this paper, the effect of the spudcan angle on the ultimate bearing capacity is revealed, and a practical bearing capacity formula is given to take the effect of the spudcan angle into consideration.

关键词： spudcan lower limit analysis ultimate bearing capacity failure modes Abaqus

Tracing Escaping Structure in the Northern Indo-China Peninsula by Openness and Remote Sensing

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Journal of Earth Science 2017年第1期28卷 147-160页

作者： jie zhang Qinglai Feng zhi zhang State Key Laboratory of Geological Processes and Mineral Resources China University of Geosciences Nanjing Center China Geological Survey School of Earth Sciences China University of GeosciencesWuhan

The Openness based on DEM emphasizes the terrain convexity and concavity. It facilitates the interpretation of detailed landforms on the Earth＇s surface. Compared with the layer stacking of ETM＋ with less three-dimensionality and visualizability and with indefinite details of linear images in the deep cutting or deep covered region, the Openness is used for accurate interpretation of tectonic geomorphic units and linear structures. In this paper, the ETM＋ images（741 RGB） and RRIM based on Openness combined with the field geological investigation are used to trace the escaping structure in SE Asia. The east boundary is Ailaoshan shear zone and the west boundary is Uttaradit-Dien Bien Phu fault, which together form the southwards extruding wedge block. The arc boundary surface of the southern Khorat Plateau is jutted to the north. The NW and NE sides of Khorat Plateau are traversed by Uttaradit-Dien Bien Phu fault and Thakhek-Da Nang fault, respectively, resulting in a blocked escaping structure. The SE margins of Truong Son structure belt and Song Ma structure belt are both arcs jutting to SE. These arc structures clamped by faults or related to the fault on one side indicating the material flow direction obviously, are the most specific manifestation of escaping structures. Moreover, these push units are extruded from south to north successively.

关键词： Openness Indo-China Peninsula escaping structure remote sensing.

Unraveling the mechanism of action of Shangxia Liangji formula for treating insomnia:a metabolomics and network pharmacology approach

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Traditional Medicine Research 2025年第2期10卷 16-29页

作者： Xia-jie Quan Hao Liang Yong-Hong Tang Li Jiang Xiong-Ying Ji Feng-Ying zhang Ping zhang Bo Ouyang Department of Information The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Neurology The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Gastroscopy The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Traditional Chinese Medicine The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China

Background:Insomnia is a prevalent clinical condition and Shangxia Liangji formula(SXLJF)is a well-established method of ***,the specific mechanism of action of SXLJF remains ***:The mouse model of insomnia was established by intraperitoneal injection of ***-two mice were randomly divided into a negative control group,model group,SXLJF group(18.72 g/kg/day),and positive control group(diazepam,2 mg/kg)and treated with the corresponding drugs for 7 consecutive *** open field test and pentobarbital-induced sleeping test were ***-MS-based untargeted metabolomics and network pharmacology were applied to explore the potential targets of SXLJF for treating ***,key targets were validated using ***:Behavioral tests demonstrated that SXLJF reduced the total distance,average velocity,central distance,and sleep latency,and prolonged sleep *** and network pharmacology revealed potential targets,signaling pathways,metabolic pathways,and metabolites associated with the anti-insomnia effects of ***,tyrosine hydroxylase(TH)and tyrosine metabolism emerged as crucial metabolic pathways and targets,***-qPCR results supported the role of TH in the mechanism of SXLJF in treating ***:In conclusion,TH and tyrosine metabolism may represent significant targets and pathways for SXLJF in treating insomnia.

关键词： Shangxia Liangji formula insomnia metabolomics network pharmacology tyrosine hydroxylase tyrosine metabolism