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A multi-mechanism numerical simulation model for CO_(2)-EOR and storage in fractured shale oil reservoirs

Petroleum Science 2024年第3期21卷 1814-1828页

作者： Yuan-Zheng Wang Ren-Yi Cao zhi-Hao jia Bin-Yu Wang Ming Ma Lin-Song Cheng College of Petroleum Engineering China University of Petroleum(Beijing)Beijing102249China John&Willie Leone Department of Energy&Mineral Engineering The Pennsylvania State UniversityUniversity Park16802PA.USA

Under the policy background and advocacy of carbon capture,utilization,and storage(CCUS),CO_(2)-EOR has become a promising direction in the shale oil reservoir *** multi-scale pore structure distribution and fracture structure lead to complex multiphase flow,comprehensively considering multiple mechanisms is crucial for development and CO_(2) storage in fractured shale *** this paper,a multi-mechanism coupled model is developed by *** to the traditional Eclipse300 and MATLAB Reservoir Simulation Toolbox(MRST),this model considers the impact of pore structure on fluid phase behavior by the modified Peng—Robinson equation of state(PR-EOS),and the effect simultaneously radiate to Maxwell—Stefan(M—S)diffusion,stress sensitivity,the nano-confinement(NC)***,a modified embedded discrete fracture model(EDFM)is used to model the complex fractures,which optimizes connection types and half-transmissibility calculation approaches between non-neighboring connections(NNCs).The full implicit equation adopts the finite volume method(FVM)and Newton—Raphson iteration for discretization and *** model verification with the Eclipse300 and MRST is *** results show that the interaction between the mechanisms significantly affects the production performance and storage *** effect of molecular diffusion may be overestimated in oil-dominated(liquid-dominated)shale *** well spacing and injection gas rate are the most crucial factors affecting the production by sensitivity ***,the potential gas invasion risk is *** model provides a reliable theoretical basis for CO_(2)-EOR and sequestration in shale oil reservoirs.

关键词： CO_(2)-EOR CO_(2)storage Shale oil reservoir Complex fracture model Multiple mechanisms

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N6-methyladenosine methylation regulates the tumor microenvironment of Epstein-Barr virus-associated gastric cancer

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2555-2570页

作者： Yu Zhang Fang Zhou Ming-Yu Zhang Li-Na Feng jia-Lun Guan Ruo-Nan Dong Yu-Jie Huang Su-Hong Xia jia-zhi Liao Kai Zhao Department of Gastroenterology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030Hubei ProvinceChina Institute of Liver and Gastrointestinal Diseases Hubei Key Laboratory of Hepato-Pancreato-Biliary DiseasesTongji Hospital of Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030Hubei ProvinceChina Department of Pharmacy Wuhan Fourth HospitalWuhan 430030Hubei ProvinceChina

BACKGROUND N6-methyladenosine(m6A)methylation modification exists in Epstein-Barr virus(EBV)primary infection,latency,and lytic *** also modifies EBV latent genes and lytic ***-associated gastric cancer(EBVaGC)is a distinctive molecular subtype of *** hypothesized EBV and m6A methylation regulators interact with each other in EBVaGC to differentiate it from other types of *** To investigate the mechanisms of m6A methylation regulators in EBVaGC to determine the differentiating factors from other types of *** First,The Cancer Gene Atlas and Gene Expression Omnibus databases were used to analyze the expression pattern of m6A methylation regulators between EBVaGC and EBV-negative GC(EBVnGC).Second,we identified Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)functional enrichment of m6A-related differentially expressed *** quantified the relative abundance of immune cells and inflammatory factors in the tumor microenvironment(TME).Finally,cell counting kit-8 cell proliferation test,transwell test,and flow cytometry were used to verify the effect of insulin-like growth factor binding protein 1(IGFBP1)in EBVaGC cell *** m6A methylation regulators were involved in the occurrence and development of *** with EBVnGC,the expression levels of m6A methylation regulators Wilms tumor 1-associated protein,RNA binding motif protein 15B,CBL proto-oncogene like 1,leucine rich pentatricopeptide repeat containing,heterogeneous nuclear ribonucleoprotein A2B1,IGFBP1,and insulin-like growth factor 2 binding protein 1 were significantly downregulated in EBVaGC(P<0.05).The overall survival rate of EBVaGC patients with a lower expression level of IGFBP1 was significantly higher(P=0.046).GO and KEGG functional enrichment analyses showed that the immunity pathways were significantly activated and rich in immune cell infiltration in *** with EBVnGC,the infiltration of activated CD4+T cells,activated CD8+T cel

关键词： N6-methyladenosine methylation Tumor microenvironment Epstein-Barr virus Gastric cancer Insulin-like growth factor binding protein 1

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Study on the preservation effects of the amputated forelimb by machine perfusion at physiological temperature

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Chinese Journal of Traumatology 2024年第2期27卷 114-120页

作者： Sheng-Feng Chen Bo-Yao Yang Tie-Yuan Zhang Xiang-Yu Song zhi-Bo jia Lei-jia Chen Meng-Yi Cui Wen-Jing Xu jiang Peng Guizhou Medical University Guiyang550025China Medical School of PLA Beijing100048 China Beijing Key Lab of Regenerative Medicine in Orthopedics Key Laboratory of Musculoskeletal Trauma and War Injuries PLADepartment of OrthopedicsThe Fourth Medical CenterChinese PLA General HospitalBeijing100048China Hebei North Universiy Zhangjiakou075000Hebei ProvinceChina

Purpose:Ischemia and hypoxia are the main factors limiting limb replantation and *** cold storage(SCS),a common preservation method for tissues and organs,can only prolong limb ischemia time to 4-6 *** normothermic machine perfusion(NMP)is a promising method for the preservation of tissues and organs,which can extend the preservation time in vitro by providing continuous oxygen and *** study aimed to evaluate the difference in the efficacy of the 2 limb preservation ***:The 6 forelimbs from beagle dogs were divided into 2 *** the SCS group(n=3),the limbs were preserved in a sterile refrigerator at 4°C for 24 h,and in the NMP group(n=3),the perfusate prepared with autologous blood was used for the oxygenated machine perfusion at physiological temperature for 24 h,and the solution was changed every 6 *** effects of limb storage were evaluated by weight gain,perfusate biochemical analysis,enzyme-linked immunosorbent assay,and histological *** statistical analyses and graphs were performed using GraphPad Prism 9.0 one-way or two-way analysis of *** p value of less than 0.05 was considered to indicate statistical ***:In the NMP group,the weight gained percentage was 11.72%±4.06%;the hypoxia-inducible factor-1αcontents showed no significant changes;the shape of muscle fibers was normal;the gap between muscle fibers slightly increased,showing the intercellular distance of(30.19±2.83)μm;and the vascularα-smooth muscle actin(α-SMA)contents were lower than those in the normal blood *** creatine kinase level in the perfusate of the NMP group increased from the beginning of perfusion,decreased after each perfusate change,and remained stable at the end of perfusion showing a peak level of 4097.6 U/*** lactate dehydrogenase level of the NMP group increased near the end of perfusion and reached the peak level of 374.4 U/*** the SCS group,the percentage of weight gain was 0.18%±0.10%,a

关键词： Traumatic amputation Machine perfusion Static cold storage Limb replantation

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Charge regulation by ferromagnetic metal/LiF spin-polarized interface for high-performance Li metal anodes

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Rare Metals 2024年第3期43卷 995-1005页

作者： Ming-Yang Feng Shuang Zhou Yi-Fang Zhang Ya-Ping Wang Chun-Yan Fu jian-Wen Li Yuan-Lang Wan zhi-jia Zhang Yong jiang An-Qiang Pan State Key Laboratory of Powder Metallurgy School of Materials Science and EngineeringCentral South UniversityChangsha410083China State Key Laboratory of Separation Membranes and Membrane Processes Tianjin Key Laboratory of Advanced Fibers and Energy StorageSchool of Material Science and EngineeringTiangong UniversityTianjin300387China School of Materials Science and Engineering Hebei University of TechnologyTianjin300130China

The interfacial characteristics of the Li metal anode(LMA)play a crucial role in its overall *** various materials being applied to modify the interface,a comprehensive understanding of their specific mechanisms remains to be ***,we have prepared carbon cloth(CC)frameworks with their surfaces modified using ferromagnetic metal/LiF heterogeneous films(T^(M)-LiF-CC)as the substrate for LMA,which exhibit superior electrochemical *** ferromagnetic Co as a representative example,our study demonstrates that the enhanced performance of Co-LiF-CC,compared to bare CC,is attributed to the spinpolarized interface contributed by the Co/LiF *** and LiF play individual roles in redistributing electrons and Li^(+)to promote homogeneous Li *** nanoparticles play a crucial role in generating strong surface capacitance by storing electrons in spin-split bands,while LiF,with low surface diffusion barriers,ensures fast transportation of Li^(+).The Co-LiF-CC@Li electrodes deliver long lives of 7400 and 3600 h at 1 and 2 mA·cm^(-2)in symmetric cells,respectively;moreover,they enable full batteries with high and durable capacities,particularly when the N/P ratios are low(3.3 or even 1.7).

关键词： Lithium metal anode Interfacial charge Ferromagnetic metal Lithium fluoride Spin polarization

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Cassiterite U-Pb dating of the Yelonggou pegmatite-type lithium deposit in western Sichuan and its metallogenic age constraints

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China Geology 2024年第1期7卷 153-156页

作者： Xiang-yuan Yue Qian Zhang Jun-jun Zhang Wei Zhang Jing Zhang zhi-quan jia Li-ping Luo Institute of Multipurpose Utilization of Mineral Resources Chinese Academy of Geological SciencesChengdu610041China Shandong Lunan Geology and Exploration Institute(No.2 Brigade of Shandong BGMR) Jining272100China Sichuan Shudao Advanced Material Science Group Co.Ltd. Chengdu610041China No.3 Geological Brigade of Sichuan Province Chongzhou611230China

*** Pegmatite hosts important resource of rare metals,e.g.,lithium(Li)and beryllium(Be).In recent years,increasingly more studies were dedicated to characterize and unravel the formation of pegmatite-type deposits,for which accurate dating of pegmatite formation and mineralization is *** Songpan-Ganzi orogenic belt is a major rare metal metallogenic belt in China,hosting many important pegmatite-type Li deposits,including the Lijiagou,Dangba,jiajika,Yelonggou,Cuola,and *** age data(mica Ar-Ar and zircon/cassiterite U-Pb)from these Li deposits are sparse,ranging from 210 to 152 ***,obtaining reliable zircon U-Pb dates can be a challenge due to the strong decidualization in *** a result,the formation and mineralization ages of these rare metal pegmatites remain controversial,which hampers the development of pegmatite-type metallogenic model for the Songpan-Ganzi orogenic belt.

关键词： dating metallogenic zircon

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Suppression of MyD88 disturbs gut microbiota and activates the NLR pathway and hence fails to ameliorate DsS-inducedcolitis

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Precision Clinical Medicine 2024年第2期7卷 146-158页

作者： Jun-hua Li Yu Chen Zheng-hao Ye Li-ping Chen jia-xin Xu jian Han Lin Xie Shuai Xing De-an Tian Ursula Seidler jia-zhi Liao Fang Xiao Department of Nephrology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Gastroenterology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Institute of Organ Transplantation Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Gastroenterology Hepatology and EndocrinologyHannover Medical SchoolHannover 30625Germany

Background:Myeloid differentiation factor 88(MyD88)is the core adaptor for Toll-like receptors defending against microbial invasion and initiating a downstream immune response during microbiota-host ***,the role of MyD88 in the pathogenesis of inflammatory bowel disease is *** study aims to investigate the impact of MyD88 on intestinal inflammation and ***:MyD88 knockout(MyD88^(-/-))mice and the MyD88 inhibitor(TJ-M2010-5)were used to investigate the impact of MyD88 on acute dextran sodium sulfate(Dss)-induced *** activity index,colon length,histological score,and inflammatory cytokines were examined to evaluate the severity of *** transcriptome analysis and 16S rDNA sequencing were used to detect the potential ***:In an acute DSS-colitis model,the severity of colitis was not alleviated in MyD88^(-/-)mice and TJ-M2010-5-treated mice,despite significantly lower levels of NF-kB activation being exhibited compared to control ***,16S rDNA sequencing and RNA transcriptome analysis revealed a higher abundance of intestinal Proteobacteria and an up-regulation of the nucleotide oligomerization domain-like receptors(NLRs)signaling pathway in colitis mice following MyD88 *** blockade of the NLRs signaling pathway or elimination of gut microbiota with broad-spectrum antibiotics in DsS-induced colitis mice treated with TJ-M2010-5 ameiorated the disease severity,which was not improved solely by MyD88 *** treatment with broad-spectrum antibiotics,downregulation of the NLR signaling pathway was ***:Our study suggests that the suppression of MyD88 might be associated with unfavorable changes in the composition of gut microbiota,leading to NLR-mediated immune activation and intestinal inflammation.

关键词： microbiota innate immunity myeloid differentiation factor 88,MyD88 inhibitor NOD-like receptor inflammatory bowel disease

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矿渣-白泥固化黄土的力学性能与微观机理

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中国公路学报 2024年第6期37卷 181-192页

作者：薛志佳罗江晏长根张营张英立贾小龙长安大学公路学院陕西西安710064 成都市市政工程设计研究院有限公司四川成都610023 宁夏交通建设股份有限公司宁夏银川750002

为探究矿渣与白泥固废材料应用于黄土路基加固的可行性,并解决传统石灰固化黄土强度较低以及生产污染大的问题,制备了矿渣-白泥胶凝材料,随后使用不同掺量(0%、5%、10%、15%)的矿渣-白泥胶凝材料对黄土进行固化,结合基本物理化学性质,... 详细信息

为探究矿渣与白泥固废材料应用于黄土路基加固的可行性,并解决传统石灰固化黄土强度较低以及生产污染大的问题,制备了矿渣-白泥胶凝材料,随后使用不同掺量(0%、5%、10%、15%)的矿渣-白泥胶凝材料对黄土进行固化,结合基本物理化学性质,探究了固化黄土的无侧限抗压强度以及耐久性(干湿和冻融)的变化规律,并通过XRD、TG/DTG和SEM揭示了其微观机理。试验结果表明:矿渣-白泥胶凝材料中矿渣占比越高强度增长潜力越大,但矿渣占比超过70%时,会导致试样无法成型;适当增加其中的白泥占比,可以提高pH值以及早期强度,综合成本来看其最佳配比为60∶40;未浸水条件下,10%掺量时矿渣-白泥固化黄土28 d无侧限抗压强度为4.9 MPa,相比于石灰固化黄土提高2.2倍,水稳定系数提高0.45倍,满足路基填料强度要求;矿渣-白泥胶凝材料可以显著提高黄土的耐久性,10%与15%掺量时固化黄土经14次冻融后强度和质量变化均小于2%,固化黄土的强度随干湿循环次数先增加后降低,并且12次干湿循环后强度均高于28 d强度。微观测试表明:白泥能促进矿渣的水化作用,矿渣-白泥胶凝材料的主要水化产物为CSH等凝胶,CSH凝胶的胶结作用是固化黄土强度和耐久性提升的主要来源,而填充效果起到次要作用。

关键词：路基工程固化黄土力学强度测试矿渣-白泥耐久性

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Dosimetric risk factors for radiation esophagitis in patients with breast cancer following regional nodal radiation

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World Journal of Clinical Cases 2024年第17期12卷 2995-3003页

作者： Mei-Chen Ji zhi-jia Li Ke Li Yun-Xiao Wang Bo Yang Lin-Lin Lv Ying Su zhi-Wei Zhang Zhong-Chao Huo Qing Qi Yong-Chang Lu zhi-Qiang Cui Yan-Bao Liu Oncology Center The Affiliated Hospital of Hebei University of EngineeringHandan 056002Hebei ProvinceChina General Surgery Department Handan First HospitalHandan 056002Hebei ProvinceChina Department of Breast Surgery The Affiliated Hospital of Hebei University of EngineeringHandan 056002Hebei ProvinceChina School of Clinical Medicine Hebei University of EngineeringHandan 056002Hebei ProvinceChina

BACKGROUND Radiation esophagitis(RE)is one of the most common clinical symptoms of regional lymph node radiotherapy for breast ***,there are fewer studies focusing on RE caused by hypofractionated radiotherapy(HFRT).AIM To analyze the clinical and dosimetric factors that contribute to the development of RE in patients with breast cancer treated with HFRT of regional lymph *** Between January and December 2022,we retrospectively analysed 64 patients with breast cancer who met our inclusion criteria underwent regional nodal intensity-modulated radiotherapy at a radiotherapy dose of 43.5 Gy/*** Of the 64 patients in this study,24(37.5%)did not develop RE,29(45.3%)developed grade 1 RE(G1RE),11(17.2%)developed grade 2 RE(G2RE),and none developed grade 3 RE or *** univariable logistic regression analysis found G2RE to be significantly correlated with the maximum dose,mean dose,relative volume 20-40,and absolute volume(AV)*** stepwise linear regression analyses found AV30 and AV35 to be significantly associated with G2RE(P<0.001).The optimal threshold for AV30 was 2.39 mL[area under the curve(AUC):0.996;sensitivity:90.9%;specificity:91.1%].The optimal threshold for AV35 was 0.71 mL(AUC:0.932;sensitivity:90.9%;specificity:83.9%).CONCLUSION AV30 and AV35 were significantly associated with *** thresholds for AV30 and AV35 should be limited to 2.39 mL and 0.71 mL,respectively.

关键词： Breast cancer Dosimetric parameters Radiation esophagitis Esophagitis Hypofractionated radiotherapy

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穿支皮瓣中Choke vessels的相关研究与展望

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中国矫形外科杂志 2024年第14期32卷 1309-1313页

作者：霍磊谭琪高加智谢佳宁山东第二医科大学临床医学院山东潍坊261053 潍坊市人民医院创伤骨科山东潍坊261000

Choke vessels作为连接穿支皮瓣中相邻血管体的桥梁,在提高穿支皮瓣存活率方面发挥重要作用。目前,如何提高穿支皮瓣存活率的研究重点是通过施加不同措施增加Choke vessels的供血而改善皮瓣血运。本文通过对Choke vessels在穿支皮瓣中... 详细信息

Choke vessels作为连接穿支皮瓣中相邻血管体的桥梁,在提高穿支皮瓣存活率方面发挥重要作用。目前,如何提高穿支皮瓣存活率的研究重点是通过施加不同措施增加Choke vessels的供血而改善皮瓣血运。本文通过对Choke vessels在穿支皮瓣中的研究进展进行回顾,分析不同干预措施对Choke vessels的影响,旨在为未来提高穿支皮瓣存活率的相关研究提供参考方向。

关键词：穿支皮瓣 Choke vessels 血管内皮生长因子(VEGF)

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浅谈微扰动技术在地铁改造项目中的应用

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建筑科技 2024年第5期8卷 147-150页

作者：贾智城盾隧安地下工程有限公司上海201108

根据中国城市轨道交通协会统计,截至2023年上半年,中国内地累计有57个城市投运城市轨道交通运营线路10 566 km,新增城市轨道交通运营线路长度236 km,预计下半年将开通运营线路600 km。随着运营线路的不断增长,部分既有地铁设施已经无法... 详细信息

根据中国城市轨道交通协会统计,截至2023年上半年,中国内地累计有57个城市投运城市轨道交通运营线路10 566 km,新增城市轨道交通运营线路长度236 km,预计下半年将开通运营线路600 km。随着运营线路的不断增长,部分既有地铁设施已经无法满足现行运营需求,或者与周边商业建筑规划不相协调,就需要通过地铁设施改造来提高地铁的运营效率和服务水平,为市民提供更加便捷和舒适的出行体验。由于地铁线路周边建构筑物繁多,再加上错综的地上地下管线,周边环境敏感复杂。为了减少对周边环境的扰动,且不影响地铁正常运营,结合上海轨道交通1号线莲花路站南站台改造工程中锚杆静压钢管桩施工技术,和上海轨道交通2号线静安寺站3号口改造项目中MJS施工技术和人工挖孔钢管桩施工技术,浅谈微扰动施工技术在地铁改造项目中的应用。

关键词：地铁改造项目微扰动施工技术锚杆静压钢管桩 MJS施工技术人工挖孔钢管桩

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