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Journal of Genetics and Genomics 2016年第11期43卷 631-638页

作者： zhi chang chen Hong Liao Root Biology Center Fujian Agriculture and Forestry University

Aluminum （AI） toxicity and phosphorous （P） deficiency are two major limiting factors for plant growth on acidic soils. Thus, the physiological mechanisms for AJ tolerance and P acquisition have been intensively studied. A commonly observed trait is that plants have developed the ability to utilize organic acid anions （OAs; mainly malate, citrate and oxalate） to combat AI toxicity and P deficiency. OAs secreted by roots into the rhizosphere can externally chelate Al^3＋ and mobilize phosphate （Pi）, while OAs synthesized in the cell can internally sequester Al^3＋ into the vacuole and release free Pi for metabolism. Molecular mechanisms involved in OA synthesis and transport have been described in detail. Ensuing genetic improvement for AI tolerance and P efficiency through increased OA exudation and/or synthesis in crops has been achieved by transgenic and marker-assisted breeding. This review mainly elucidates the crucial roles of OAs in plant Al tolerance and P efficiency through summarizing associated physiological mechanisms, molecular traits and genetic manipulation of crops.

关键词： Organic acid anions Al toxicity P defidency Acidic soils

Two central circadian oscillators OsPRR59 and OsPRR95 modulate magnesium homeostasis and carbon fixation in rice

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Molecular Plant 2022年第10期15卷 1602-1614页

作者： Chun-Qu chen Xin-Yue Tian Jian Li Shuang Bai Zhuo-Yan Zhang Yuan Li Hong-Rui Cao zhi-chang chen Root Biology Center Fujian Agriculture and Forestry UniversityFuzhou 350002China College of Biological and Environmental Engineering Binzhou UniversityBinzhou 256603China

Photosynthesis,which provides oxygen and energy for all living organisms,is circadian ***-associated metabolism must tightly coordinate with the circadian clock to maximize the efficiency of the light-energy capture and carbon ***,the molecular basis for the interplay of photosynthesis and the circadian clock is not fully understood,particularly in crop ***,we report two central oscillator genes of circadian clock,OsPRR95 and OsPRR59 in rice,which function as transcriptional repressors to negatively regulate the rhythmic expression of OsMGT3 encoding a chloroplast-localized Mg2+***3-dependent rhythmic Mg fluctuations modulate carbon fixation and consequent sugar output in rice ***,sugar triggers the increase of superoxide,which may act as a feedback signal to positively regulate the expression of OsPRR95 and *** together,our results reveal a negative-feedback loop that strengthens the crosstalk between photosynthetic carbon fixation and the circadian clock,which may improve plan adaptation and performance in fluctuating environments.

关键词： OsPRR OsMGT3 photosynthesis magnesium rice

Metal nutrition and transport in the process of symbiotic nitrogen fixation

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Plant Communications 2024年第4期5卷 36-51页

作者： Yuan Li Qian Liu Dan-Xun Zhang Zhuo-Yan Zhang Ao Xu Yuan-Long Jiang zhi-chang chen Haixia Institute of Science and Technology Fujian Agriculture and Forestry UniversityFuzhou 350002China These authors contributed equally to this article.

Symbiotic nitrogenfixation(SNF)facilitated by the interaction between legumes and rhizobia is a well-documented and eco-friendly alternative to chemical nitrogen *** plants obtainfixed nitrogen from rhizobia by providing carbon and mineral *** mineral nutrients,which are mostly in the form of metal ions,are implicated in various stages of the SNF *** review describes the functional roles played by metal ions in nodule formation and nitrogenfixation and specifically addresses their trans-port mechanisms and associated transporters within root *** research directions and poten-tial strategies for enhancing SNF efficiency are also discussed.

关键词： metal ion transport legume nodule nitrogenfixation

Activation of γ-aminobutyric Acid （A） Receptor Protects Hippocampus from Intense Exercise-induced Synapses Damage and Apoptosis in Rats

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Chinese Medical Journal 2015年第17期128卷 2330-2339页

作者： Yi Ding Lan Xie Cun-Qing chang zhi-Min chen Hua Ai Institution of Sports Medicine Peking University Third Hospital Beijing 100191 China

Background： Our previous study has confirmed that one bout of exhaustion （Ex） can cause hippocampus neurocyte damage, excessive apoptosis, and dysfunction, its initial reason is intracellular calcium overload in hippocampus triggered by N-methyl-D-aspartic acid receptor （NMDAR） over-activation. NMDAR activation can be suppressed by y-aminobutyric acid （A） receptor （GABAAR）. Whether GABAAR can prevent intense exercise-induced hippocampus apoptosis, damage, or dysfunction will be studied in this study. Methods： According to dose test, rats were randomly divided into control （Con）, Ex, muscimol （MUS, 0.1 mg/kg） and bicuculline （BIC, 0.5 mg/kg） groups, then all rats underwent once swimming Ex except ones in Con group only underwent training, lntracellular free calcium concentration （[Ca2＋]i） was measured by Fura-2-acetoxymethyl ester; glial fibrillary acidic protein （GFAP） and synaptophysin （SYP） immunofluorescence were also performed; apoptosis were displayed by dUTP nick end labeling （TUNEL） stain; endoplasmic reticulum stress-induced apoptosis pathway was detected by Western blotting analysis; Morris water maze was used to detect learning ability and spatial memory. Results： The appropriate dose was 0.1 mg/kg for MUS and 0.5 mg/kg for BIC. Ex group showed significantly increased [Ca^2＋]i and astrogliosis; TUNEL positive cells and levels of GFAP, B cell lymphoma-2 （Bcl-2） associated X protein （Bax）, caspase-3, caspase-12 cleavage, CCAAT/enhancer binding protein homologous protein （CHOP）, and p-Jun amino-terminal kinase （p-JNK） in Ex group also raised significantly compared to Con group, while SYP, synapse plasticity, and Bcl-2 levels in Ex group were significantly lower than those in Con group. These indexes were back to normal in MUS group. BIC group had the highest levels of [Ca^2＋]i, astrogliosis, TUNEL positive cell, GFAP, Bax, caspase-3, caspase-12 cleavage, CHOP, and p-JNK, it also gained the lowest SYP, synapse plasticity, and Bcl-2 levels among all groups. Wat

关键词： Endoplasmic Reticulum Stress-induced Apoptosis γ-aminobutyric Acid (A) Receptor Hippocampus Intense Exercise Synapse Plasticity

多源异构数据环境下基于模糊积分融合的公租房退出方法

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运筹与管理 2017年第7期26卷 193-199页

作者：常志朋陈立荣安徽工业大学商学院安徽马鞍山243002 内蒙古大学计算机学院内蒙古呼和浩特010021

为有效解决公租房退出问题,提出一种基于多源异构数据的模糊积分融合退出方法,该退出方法首先给出一种多源异构数据的同构化方法,然后针对常用模糊测度确定方法原理复杂、计算困难的问题,提出一种原理简单、易于计算的模糊测度确定方法... 详细信息

为有效解决公租房退出问题,提出一种基于多源异构数据的模糊积分融合退出方法,该退出方法首先给出一种多源异构数据的同构化方法,然后针对常用模糊测度确定方法原理复杂、计算困难的问题,提出一种原理简单、易于计算的模糊测度确定方法,该模糊测度确定方法利用单个属性的相对重要程度和两两属性之间的交互度计算单个属性的全局重要程度,最后,根据模糊测度的单调性和有界性通过专家逐级打分计算各子属性集的重要程度。实例验证表明所提出的退出方法可行、有效。

关键词：多源异构模糊积分模糊测度公租房

Tranylcypromine upregulates Sestrin 2 expression to ameliorate NLRP3-related noise-induced hearing loss

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Neural Regeneration Research 2025年第5期20卷 1483-1494页

作者： Xihang chen zhifeng chen Menghua Li Weiwei Guo Shuolong Yuan Liangwei Xu chang Lin Xi Shi Wei chen Shiming Yang Senior Department of Otolaryngology Head and Neck Surgery Chinese PLA General HospitalChinese PLA Medical SchoolBeijingChina State Key Laboratory of Hearing and Balance Science BeijingChina National Clinical Research Center for Otolaryngologic Diseases BeijingChina Key Laboratory of Hearing Science Ministry of EducationBeijingChina Beijing Key Laboratory of Hearing Impairment Prevention and Treatment BeijingChina Department of Otorhinolaryngology Head and Neck Surgery The First Affiliated Hospital of Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Otolaryngology Head and Neck Surgery The 940th Hospital of Joint Logistics Support Force of Chinese PLALanzhouGansu ProvinceChina Key Laboratory of Tropical Biological Resources of Ministry of Education School of Pharmaceutical SciencesHainan UniversityHaikouHainan ProvinceChina Academician Workstation of Hainan University School of Pharmaceutical SciencesYazhou BaySanyaHainan ProvinceChina

Noise-induced hearing loss is the primary non-genetic factor contributing to auditory ***,there are currently no effective pharmacological interventions for patients with noise-induced hearing ***,we present evidence suggesting that the lysine-specific demethylase 1 inhibitor–tranylcypromine is an otoprotective agent that could be used to treat noise-induced hearing loss,and elucidate its underlying regulatory *** established a mouse model of permanent threshold shift hearing loss by exposing the mice to white broadband noise at a sound pressure level of 120 d B for 4 *** found that tranylcypromine treatment led to the upregulation of Sestrin2(SESN2)and activation of the autophagy markers light chain 3B and lysosome-associated membrane glycoprotein 1 in the cochleae of mice treated with *** noise exposure group treated with tranylcypromine showed significantly lower average auditory brainstem response hearing thresholds at click,4,8,and 16 k Hz frequencies compared with the noise exposure group treated with *** findings indicate that tranylcypromine treatment resulted in increased SESN2,light chain 3B,and lysosome-associated membrane glycoprotein 1 expression after noise exposure,leading to a reduction in levels of 4-hydroxynonenal and cleaved caspase-3,thereby reducing noise-induced hair cell ***,immunoblot analysis demonstrated that treatment with tranylcypromine upregulated SESN2 expression via the autophagy *** treatment also reduced the production of NOD-like receptor family pyrin domaincontaining 3(NLRP3)*** conclusion,our results showed that tranylcypromine treatment ameliorated cochlear inflammation by promoting the expression of SESN2,which induced autophagy,thereby restricting NLRP3-related inflammasome signaling,alleviating cochlear hair cell loss,and protecting hearing *** findings suggest that inhibiting lysine-specific demethylase 1 is a

关键词： 4-hydroxynonenal apoptosis autophagy cleaved caspase-3 inflammation NOD-like receptor family pyrin domain-containing 3(NLRP3) noise-induced hearing loss oxidative stress Sestrin2 tranylcypromine

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, China )

生物化学与生物物理学报 1997年第4期 53-58页

作者：易继财徐凤彩华南农业大学生物技术学院

采用脱氨再生几丁质凝胶亲和层析从萝卜叶中获得了ＰＡＧＥ圆盘电泳均一的溶菌酶，并通过微量蒸发扩散法获得其结晶。用ｐＨ动力学研究方法和化学修饰法对该酶的活性中心进行了初步研究，实验结果表明：－ＣＯＯＨ（Ｇｌｕ／Ａｓｐ）基... 详细信息

采用脱氨再生几丁质凝胶亲和层析从萝卜叶中获得了ＰＡＧＥ圆盘电泳均一的溶菌酶，并通过微量蒸发扩散法获得其结晶。用ｐＨ动力学研究方法和化学修饰法对该酶的活性中心进行了初步研究，实验结果表明：－ＣＯＯＨ（Ｇｌｕ／Ａｓｐ）基团、Ｔｒｐ及Ｈｉｓ残基可能为酶活性所必需。采用对Ｔｙｒ、Ｃｙｓ、Ａｒｇ、Ｓｅｒ／Ｔｈｒ残基专一的修饰剂对酶作用后，酶活性基本上不受影响。同时，酶活性受到组胺和ＧｌｃＮＡｃ抑制。讨论了萝卜溶菌酶与鸡蛋清溶菌酶和木瓜溶菌酶的活性中心的相互差异。

关键词：萝卜溶菌酶活性中心化学修饰

Lightweight Al-Nb-Ti-V-Cr high entropy alloys with high hardness and enhanced mechanical properties via doping Co

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China Foundry 2025年

作者： Fang-dong Xu De-zhi chen Rui-run chen Bin Gan Jing-yue Yu National Key Laboratory for Precision Hot Processing of Metals Harbin Institute of Technology Suzhou Laboratory

To develop high-hardness and high-strength lightweight high entropy alloys （LHEAs）,a series of CoxAlNbTiVCr alloys were *** phase constitution,distribution,and crystal structure of the Laves phase in alloys can be altered by adjusting the composition of HEAs,which in turn influences their mechanical *** Nb Ti VCr （x=0,0.5,1,1.5,and 2,atomic ratio percentage） LHEAs were designed and prepared to characterize the microstructure and tailor the mechanical *** introduction of Co changes the microstructure of LHEAs from a single B2 structure to a mixture dendrite structure,which consists of B2 phase,C14 and C15 Laves *** the C14 and C15 Laves phases exhibit coupled *** parameters including mixing enthalpy (ΔHmix),valence electron concentration （VEC）,atomic radius size （δ）,mixing entropy （ΔS）,and electronegativity difference （Δχ） are used to predict the formation of B2 and Laves phase in *** the Co content increases from 0 to 1.5at.%,Laves phase volume fraction gradually increases,which leads to an enhancement in the compressive strength from 1,520.8 MPa to 1,844.4 ***1.5Al Nb Ti VCr alloy exhibits the maximum Vickers hardness of 699.4 *** improvement of mechanical properties mainly originates from solid solution strengthening and second phase strengthening.

关键词：

“One stone, two birds”: Salt template enabling porosity engineering and single metal atom coordinating toward high-performance zinc-ion capacitors

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Journal of Energy Chemistry 2025年第1期100卷 637-645页

作者： Chunliu Zhu Huanyu Liang Ping Li chenglong Qiu Jingyi Wu Jingwei chen Weiqian Tian Yue Zhu zhi Li Huanlei Wang School of Materials Science and Engineering Ocean University of China Department of Chemical and Materials Engineering University of Alberta

Zinc-ion hybrid capacitors （ZIHCs） have received increasing attention as energy storage devices owing to their low cost,high safety,and environmental ***,their progress has been hampered by low energy and power density,as well as unsatisfactory long-cycle stability,mainly due to the lack of suitable electrode *** this context,we have developed manganese single atoms implanted in nitrogen-doped porous carbon nanosheets （MnSAs/NCNs） using a metal salt template method as cathodes for *** metal salt serves a dual purpose in the synthesis process:It facilitates the uniform dispersion of Mn atoms within the carbon matrix and acts as an activating agent to create the porous *** applied in ZIHCs,the MnSAs/NCNs electrode demonstrates exceptional performance,including a high capacity of 203 m Ah g-1,an energy density of 138 Wh kg-1at 68 W kg-1,and excellent cycle stability with 91%retention over 10,000 *** calculations indicate that the introduced Mn atoms modulate the local charge distribution of carbon materials,thereby improving the electrochemical *** work demonstrates the significant potential of carbon materials with metal atoms in zinc-ion hybrid capacitors,not only in enhancing electrochemical performance but also in providing new insights and methods for developing high-performance energy storage devices.

关键词： Zinc ion hybrid capacitors Cathodes Carbon materials Heteroatoms Single atoms

Deciphering fungal metabolon coupling tandem inverse-electrondemand Diels-Alder reaction and semipinacol rearrangement for the biosynthesis of spiro polycyclic alkaloids

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Science China Chemistry 2025年第1期68卷 288-296页

作者： Shuai Liu Wen-Qiang Xu Ying-Tong Di Man-cheng Tang Ding-Kang chen Ming-Ming Cao Yao-Wen chang Hong-Yu Tang Chun-Mao Yuan Jun-Bo Yang zhi-Li Zuo Han Guo Zi-Fei Xu Ying Zeng Yun-Dong Wu Xiao-Jiang Hao Key Laboratory of Phytochemistry and Natural Medicines (Chinese Academy of Sciences) Kunming Institute of Botany Chinese Academy of Sciences University of Chinese Academy of Sciences Lab of Computational Chemistry and Drug Design State Key Laboratory of Chemical Oncogenomics Peking University Shenzhen Graduate School Shenzhen Bay Laboratory State Key Laboratory of Microbial Metabolism School of Life Sciences & Biotechnology Shanghai Jiao Tong University State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical University Molecular Biology Experimental Center Germplasm Bank of Wild Species in Southwest China Kunming Institute of Botany Chinese Academy of Sciences Yunnan Key Laboratory for Wild Plant Resources Kunming Institute of Botany Chinese Academy of Sciences Research Unit of Chemical Biology of Natural Anti-Virus Products Chinese Academy of Medical Sciences

In the intricate process of natural product biosynthesis, a metabolon can enhance metabolic flux by associating sequential enzymes. A fungal metabolon, comprising of flavin-dependent monooxygenase Spe F and P450 monooxygenase Spe G, is identified in the biosynthesis of spiro polycyclic alkaloids(+)-notoamide B and its diastereomer(+)-versicolamide B. Using notoamide E as a substance, Spe F/Spe G metabolon can control the stereoselectivity of its 2,3-epoxidation, followed by hydrogen atom ion at C-17 to generate reactive epoxide tau-m A with dienyl iminium unit. Subsequently,(+)-notoamide B and(+)-versicolamide B are produced via tandem nonenzymatic inverse-electron-demand Diels-Alder reaction and semipinacol rearrangement. This provides the first example of metabolon in the biosynthesis of spiro-prenylated indole alkaloids.

关键词： metabolon Diels-Alder reaction semipinacol rearrangement biosynthesis notoamides spiro polycyclic alkaloids