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Chinese Chemical Letters 2006年第7期17卷 969-972页

作者： zhi bo chen bo Xun ZHANG Zhong Xiu HUANG Qing Lin PENG Jia chen Yu WANG Jian Guo ZHANG Guang zhi JIANG Wen Shu LI Lan Ying LIU College of Life Science Jilin University Changchun 130023 State Key Laboratory of Electroanalytical Chemistry Chinese Academy of SciencesChangchun Institute of Applied Chemistry Changchun 130022

A novel mimic was synthesized by modifying hyaluronic acid （HA） with tellurium, whose function is similar to that of glutathione peroxidase （GPX）. The structure of TeHA was characterized by means of IR and NMR, the target-Te was located at -CH2OH of the N-acetyl-D- glucosamine of HA. The H202 reducing activity of TeHA, by glutathione （GSH）, was 163.6 U/μmol according to Wilson＇s method. In contrast to other mimics, TeHA displayed the highest activity. Moreover, TeHA accepted many hydroperoxides as its substrates, such as H2O2, cumenyl hydroperoxide （CuOOH） and tert-butyl hydroperoxide （t-BuOOH）, and CuOOH was the optimal substrate of TeHA. A ping-pong mechanism was observed in the steady-state kinetic studies of the reactions catalyzed by TeHA.

关键词： Hyaluronic acid tellurium glutathione peroxidase synthesis kinetics.

Dual-functional microneedle with programmatic regulation of macrophage for autoimmune psoriasis treatment

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Nano Research 2024年第8期17卷 7436-7448页

作者： Ze Qiang Zhao bo zhi chen Jia Li Gan Yun Hao Feng Ling Liang Lingyun Yu Zi Yi Wang Samin Abbaszadeh Mohammad-Ali Shahbazi Ruixing Yu Xin Dong Guo State Key Laboratory of Organic-Inorganic Composites Beijing University of Chemical TechnologyBeijing 100029China Beijing Laboratory of Biomedical Materials College of Materials Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029China China-Japan Friendship Hospital Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100029China Department of Dermatology China-Japan Friendship HospitalBeijing 100029China Department of Pharmaceutical Biomaterials School of PharmacyZanjan University of Medical SciencesZanjan 45139-56184Iran Department of Biomaterials and Biomedical Technology University Medical Center GroningenUniversity of GroningenAntonius Deusinglaan 19713 AV GroningenThe Netherlands W.J.Kolff Institute for Biomedical Engineering and Materials Science University of GroningenAntonius Deusinglaan 19713 AV GroningenThe Netherlands

Modulating the immune microenvironment to establish sustained positive feedback within immune pathways represents a promising avenue for the treatment of ***,the precise and efficient delivery of therapeutic systems to the subcutaneous basal layer to modulate immune disorders is a major challenge in the treatment of autoimmune *** this project,we introduce a dual-functional microneedle(DF-MN)designed to combine MNs with multiple release kinetics and immunotherapy,the programmed treatment is achieved through segmented design of the MN structure,realizing the unification of rapid and long-lasting treatment of autoimmune *** vivo imaging results showed that GelMA@M-CSF showed fluorescent signals after 5 days of delivery to subcutaneous tissues,whereas HA@IL-13 showed minimal fluorescent signals after 2 *** multistage release behavior of MNs and the diffusion mechanism of drugs were explained at the molecular level,in combination with coarse-grained molecular ***,DF-MN can successfully induce macrophage reprogramming in vitro and ameliorate overall symptoms in a psoriasis mice model,suggesting that it has the potential to be an effective strategy for the treatment of psoriasis and portends to be a transformative platform for the treatment of other autoimmune diseases.

关键词： microneedle psoriasis M2 macrophage immunoregulation

CRITICAL EXAMINATION OF WETLANDS ECOSYSTEM SERVICE IN SHANGHAI, CHINA

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湿地科学 2005年第4期3卷 279-285页

作者： Zhao Bin Yang Feng-Hui Gao Yu Ma zhi-Jun Li bo chen Jia-Kuan Key Laboratory for Biodiversity Science and Ecological Engineering Ministry of Chinese Education Institute of Biodiversity Science Fudan University Shanghai 200433 China

Wetlands provide many important services to human society, but are at the same time ecologically sensitive and adaptive systems, and are under heavy pressure. As a wetland city, Shanghai city has various types of natural wetlands (chiefly, includes coastal, riverine, lacustrine, and reservoir and pond wetlands), which account for 23.5% of total areas. Meanwhile, Shanghai is a metropolitan city, being confronted with the pressure of port expansion and urban and industrial sprawl, just like the other megalopolises in the world. Based on our earlier study on estimating the ecological service values of wetlands in Shanghai, this paper analyzed the ecological functions of the wetland city, such as nutrient cycling, water regulation and supply, food supply, disturbance control, water treatment, habitats and refugia, aesthetic, education and culture, tidal flats and potential land resources. Unfortunately, the wetland function was being degraded and the ecosystem service was discounted accordingly because of over-reclamation, over-fishing, water pollution, and rapid urbanization in the city. It’s therefore recommended that, to improve the environment of Shanghai ciry, and make the ecosystems sustainable function appropriately, the effective wetland management strategies should be taken.

关键词：生态系统生态功能湿地上海

In Vitro Bacteriostatic Activity of Five Chinese Herbal Medicines against Two Common Pathogens of Scylla serrata

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Animal Husbandry and Feed Science 2010年第8期2卷 17-20页

作者： XIE Li-ling ZHAO Shui-ling chenG Kai LI zhi-rong chen bo Biology College Shantou University Shantou 515063 China

[ Objective] To investigate the in vitro bacteriostatic activity of Chinese herbal medicines （ rhubarb, Baikal skullcap root, honeysuckle, eucommia bark and Chinese date） and their compounds against two common pathogens of Scylla serrata （ Vibrio parahaemolyticus and Aeromonas hydrophila）. [Method] Drug sensitivity of the bacteria was determined by paper method. Minimum inhibitory concentration （MIC） and minimum bactericidal concentration （MBC） were determined by dilution method and plate method, respectively. [Result] The bacteriostatic order of single medicines on V. parahaemolyticus were Baikal skullcap root 〉 honeysuckle 〉 rhubarb 〉 Chinese date 〉 eucommia bark. The bacteriostatic order of the compounds were A =B = C 〉 D. Among these medicines, the Baikal skullcap root and the compounds A, B, C and D had better bactericidal effects on V. parahaemolyticus. The bacteriostatic order of single medicines on A. hydrophila was rhubarb 〉 Baikal skullcap root 〉 honeysuckle 〉 Chinese date 〉 eucommia bark. The bacteriostatic order of the compounds were A 〉 B 〉 C = D, while the rhubarb and the compound C had better bactericidal effects on A. hydrophila. [ Conclusion] The Chinese herbal medicines including rhubarb, Baikal skullcap root, honeysuckle, eucommia bark and Chinese date have good bacteriostatic effects on V. parahaemolyticus and A. hydrophila, and they can be used to treat bacterial infection in Scylla serrata.

关键词： Chinese herbal medicine Vibdo parahaemolyticus Aeromonas hydrophila Bacteriostatic activity

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工业废弃地生态恢复中的植被重建技术

水土保持学报 2004年第3期18卷 160-163,199页

作者：包志毅陈波浙江大学园艺系浙江杭州310029

随着社会经济的发展,各种生产建设活动产生了为数众多的工业废弃地。特别是在城市地区,随着经济结构的转变,城市内的传统产业向外迁移,在城市中留下大量的工业废弃地。这些废弃地的资源枯竭和生态系统退化问题十分突出,必须对其进行生... 详细信息

随着社会经济的发展,各种生产建设活动产生了为数众多的工业废弃地。特别是在城市地区,随着经济结构的转变,城市内的传统产业向外迁移,在城市中留下大量的工业废弃地。这些废弃地的资源枯竭和生态系统退化问题十分突出,必须对其进行生态恢复。为此,阐述了各种工业废弃地生态恢复中的植被重建问题,主要对土壤基质改良、植物种类选择和植物种植技术3个环节进行了分析。

关键词：工业废弃地生态恢复植被重建技术经济结构

A Novel Self-Supervised Learning Network for Binocular Disparity Estimation

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 209-229页

作者： Jiawei Tian Yu Zhou Xiaobing chen Salman A.AlQahtani Hongrong chen bo Yang Siyu Lu Wenfeng Zheng Department of Computer Science and Engineering Major in Bio Artificial IntelligenceHanyang UniversityAnsan-si15577Republic of Korea School of Electrical and Computer Engineering Louisiana State UniversityBaton RougeLA 70803USA Department of Computer Engineering College of Computer and Information SciencesKing Saud UniversityRiyadh11574Saudi Arabia School of Automation University of Electronic Science and Technology of ChinaChengdu610054China

Two-dimensional endoscopic images are susceptible to interferences such as specular reflections and monotonous texture illumination,hindering accurate three-dimensional lesion reconstruction by surgical *** study proposes a novel end-to-end disparity estimation model to address these *** approach combines a Pseudo-Siamese neural network architecture with pyramid dilated convolutions,integrating multi-scale image information to enhance robustness against lighting *** study introduces a Pseudo-Siamese structure-based disparity regression model that simplifies left-right image comparison,improving accuracy and *** model was evaluated using a dataset of stereo endoscopic videos captured by the Da Vinci surgical robot,comprising simulated silicone heart sequences and real heart video *** results demonstrate significant improvement in the network’s resistance to lighting interference without substantially increasing ***,the model exhibited faster convergence during training,contributing to overall performance *** study advances endoscopic image processing accuracy and has potential implications for surgical robot applications in complex environments.

关键词： Parallax estimation parallax regression model self-supervised learning Pseudo-Siamese neural network pyramid dilated convolution binocular disparity estimation

Postnatal development of rat retina:a continuous observation and comparison between the organotypic retinal explant model and in vivo development

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Neural Regeneration Research 2025年第3期20卷 900-912页

作者： Baoqi Hu Rui Wang Hanyue Zhang Xiou Wang Sijia Zhou bo Ma Yan Luan Xin Wang Xinlin chen zhichao Zhang Qianyan Kang Department of Ophthalmology The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’anShaanxi ProvinceChina Department of Ophthalmology The First Affiliated Hospital of Northwest UniversityXi’anShaanxi ProvinceChina Institute of Neurobiology Xi’an Jiaotong University Health Science CenterXi’anShaanxi ProvinceChina

The organotypic retinal explant culture has been established for more than a decade and offers a range of unique advantages compared with in vivo experiments and cell ***,the lack of systematic and continuous comparison between in vivo retinal development and the organotypic retinal explant culture makes this model controversial in postnatal retinal development ***,we aimed to verify the feasibility of using this model for postnatal retinal development studies by comparing it with the in vivo *** this study,we showed that postnatal retinal explants undergo normal development,and exhibit a consistent structure and timeline with retinas in ***,we used SOX2 and PAX6 immunostaining to identify retinal progenitor *** then examined cell proliferation and migration by immunostaining with Ki-67 and doublecortin,***-67-and doublecortin-positive cells decreased in both in vivo and explants during postnatal retinogenesis,and exhibited a high degree of similarity in abundance and distribution between ***,we used Ceh-10 homeodomain-containing homolog,glutamate-ammonia ligase(glutamine synthetase),neuronal nuclei,and ionized calcium-binding adapter molecule 1 immunostaining to examine the emergence of bipolar cells,Müller glia,mature neurons,and microglia,*** timing and spatial patterns of the emergence of these cell types were remarkably consistent between in vivo and explant *** study showed that the organotypic retinal explant culture model had a high degree of consistency with the progression of in vivo early postnatal retina *** findings confirm the accuracy and credibility of this model and support its use for long-term,systematic,and continuous observation.

关键词： bipolar cells differentiation in vivo microglia Müller glia organotypic retinal explant culture postnatal retina development proliferation retinal progenitor cells

植入型心律转复除颤器一级预防的卫生经济学模型分析

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中国卫生经济 2018年第4期37卷 83-87页

作者：曾治宇陈博张明东张澍北京大学公共卫生学院北京100191 波科国际医疗贸易(上海)有限公司医学部北京100125 中国医学科学院阜外医院心律失常诊治中心北京100037

目的:从社会支付的视角,对植入型心律转复除颤器ICD在我国的一级预防作一初步的成本-效用模型分析。方法:建立ICD一级预防的Markov模型,与不用ICD的对照组比较,输入相应的变量,计算ICD的增量成本—效果比(incremental cost-effectivenes... 详细信息

目的:从社会支付的视角,对植入型心律转复除颤器ICD在我国的一级预防作一初步的成本-效用模型分析。方法:建立ICD一级预防的Markov模型,与不用ICD的对照组比较,输入相应的变量,计算ICD的增量成本—效果比(incremental cost-effectiveness ratio,ICER),包括基线分析和概率分析,并作关键变量的敏感性分析。结果:基线分析单腔ICD一级预防在中国的ICER为171 304元/QALY。现代ICD因其长寿命、优化程控及远程监测的特点,可望将ICER降至100 187元/QALY,有望为中国每年节约2.13亿元。结论:ICD成本-效用分析的主要影响因素较多,敏感性分析提示选择高危人群,通过优化程控、远程监测等手段提高ICD的疗效及选用长寿命的器械可改善ICER。

关键词：植入型心律转复除颤器一级预防成本-效用分析

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青少年亲社会行为培养的社会工作介入途径

社会工作 2009年第18期 51-53页

作者：牛素枝陈勃南昌大学社会学系江西南昌330031

亲社会行为是道德行为的重要组成部分和最基础的行为表征,通过加强亲社会行为的培养,可以使青少年思想道德培养的认知效果更显著。社会工作采用个案工作、小组工作和社区工作的方法介入亲社会行为的培养,可以为青少年提供必要的帮助和支... 详细信息

亲社会行为是道德行为的重要组成部分和最基础的行为表征,通过加强亲社会行为的培养,可以使青少年思想道德培养的认知效果更显著。社会工作采用个案工作、小组工作和社区工作的方法介入亲社会行为的培养,可以为青少年提供必要的帮助和支持,为其亲社会行为的培养提供新的途径与方法。

关键词：青少年亲社会行为社会工作介入

Human-induced pluripotent stem cell-derived neural stem cell exosomes improve blood-brain barrier function after intracerebral hemorrhage by activating astrocytes via PI3K/AKT/MCP-1 axis

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Neural Regeneration Research 2025年第2期20卷 518-532页

作者： Conglin Wang Fangyuan cheng Zhaoli Han bo Yan Pan Liao Zhenyu Yin Xintong Ge Dai Li Rongrong Zhong Qiang Liu Fanglian chen Ping Lei Department of Geriatrics Tianjin Medical University General HospitalTianjinChina School of Medicine Nankai UniversityTianjinChina Tianjin Neurological Institute TianjinChina

Cerebral edema caused by blood-brain barrier injury after intracerebral hemorrhage is an important factor leading to poor ***-induced pluripotent stem cell-derived neural stem cell exosomes(hiPSC-NSC-Exos)have shown potential for brain injury repair in central nervous system *** this study,we explored the impact of hiPSC-NSC-Exos on blood-brain barrier preservation and the underlying *** results indicated that intranasal delivery of hiPSC-NSC-Exos mitigated neurological deficits,enhanced blood-brain barrier integrity,and reduced leukocyte infiltration in a mouse model of intracerebral ***,hiPSC-NSC-Exos decreased immune cell infiltration,activated astrocytes,and decreased the secretion of inflammatory cytokines like monocyte chemoattractant protein-1,macrophage inflammatory protein-1α,and tumor necrosis factor-αpost-intracerebral hemorrhage,thereby improving the inflammatory *** sequencing indicated that hiPSC-NSC-Exo activated the PI3K/AKT signaling pathway in astrocytes and decreased monocyte chemoattractant protein-1 secretion,thereby improving blood-brain barrier *** with the PI3K/AKT inhibitor LY294002 or the monocyte chemoattractant protein-1 neutralizing agent C1142 abolished these *** summary,our findings suggest that hiPSC-NSC-Exos maintains blood-brain barrier integrity,in part by downregulating monocyte chemoattractant protein-1 secretion through activation of the PI3K/AKT signaling pathway in astrocytes.

关键词： AKT astrocyte blood-brain barrier cerebral edema exosomes human-induced pluripotent stem cells intracerebral hemorrhage neural stem cells neuroinflammation PI3K