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甘肃岷县红三叶病害及其对红三叶生长和品质的影响

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草地学报 2024年第5期32卷 1303-1313页

作者：郑荣春南志标段廷玉兰州大学草种创新与草地农业生态系统全国重点实验室兰州大学草地农业科技学院甘肃兰州730020

‘岷山’红三叶(Trifolium pratense ***)是适宜于岷县地区生长的优良豆科牧草品种。前期的调研发现该地区红三叶田间病害发病较重,限制了红三叶的生产,而目前尚缺少该地区病害的系统研究。本研究调查了‘岷山’红三叶在岷县田间的主要... 详细信息

‘岷山’红三叶(Trifolium pratense ***)是适宜于岷县地区生长的优良豆科牧草品种。前期的调研发现该地区红三叶田间病害发病较重,限制了红三叶的生产,而目前尚缺少该地区病害的系统研究。本研究调查了‘岷山’红三叶在岷县田间的主要病害及发生规律,并研究了匍柄霉叶斑病对红三叶生长和品质的影响。该地区红三叶主要田间病害为匍柄霉叶斑病(Stemphylium sarcniforme)、小光壳叶斑病(Leptosphaerulina trifolii)和长隔孢叶斑病(Longiseptatispora meliloti)。其中红三叶匍柄霉叶斑病最为严重,最高发病率26.67%,病情指数8.20。匍柄霉叶斑病显著影响了红三叶的产量和品质,导致鲜重显著下降20.14%、叶绿素含量显著下降20.93%及引起各项营养指标的不同变化。本研究明确了岷县地区红三叶主要病害的发生情况及发病最为严重的匍柄霉叶斑病对红三叶生物量和品质的影响,为该地区的红三叶病害防控提供依据。

关键词： ‘岷山’红三叶田间病害致病性生长指标牧草品质

Alzheimer’s disease early diagnostic and staging biomarkers revealed by large-scale cerebrospinal fluid and serum proteomic profiling

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The Innovation 2024年第1期5卷 118-126页

作者： Qing-Qing Tao Xue Cai Yan-Yan Xue Weigang Ge Liang Yue Xiao-Yan Li Rong-Rong Lin Guo-Ping Peng Wenhao Jiang Sainan Li Kun-Mu zheng Bin Jiang Jian-Ping Jia Tiannan Guo zhi-Ying Wu Department of Neurology and Research Center of Neurology in the Second Affiliated Hospital and Key Laboratory of Medical Neurobiology of Zhejiang Province Zhejiang University School of MedicineHangzhou 310009China Liangzhu Laboratory Zhejiang UniversityHangzhou 311100China Westlake Laboratory of Life Sciences and Biomedicine Key Laboratory of Structural Biology of Zhejiang ProvinceSchool of Life SciencesWestlake UniversityHangzhou 310024China Institute of Basic Medical Sciences Westlake Institute for Advanced StudyHangzho 310024China Department of Neurology First Affiliated HospitalZhejiang University School of MedicineHangzhou 310009China Department of Neurology First Affiliated HospitalSchool of MedicineXiamen UniversityXiamen 361009China Innovation Center for Neurological Disorders and Department of Neurology Xuanwu HospitalCapital Medical UniversityNational Clinical Research Center for Geriatric DiseasesBeijing 100053China MOE Frontier Science Center for Brain Science and Brain-machine Integration School of Brain Science and Brain MedicineZhejiang UniversityHangzhou 310058China CAS Center for Excellence in Brain Science and Intelligence Technology Shanghai 200031China

Amyloid-b,tau pathology,and biomarkers of neurodegeneration make up the core diagnostic biomarkers of Alzheimer disease(AD).However,these proteins represent only a fraction of the complex biological processes underlying AD,and individuals with other brain diseases in which AD pathology is a comorbidity also test positive for these diagnostic *** ADspecific early diagnostic and disease staging biomarkers are *** this study,we performed tandem mass tag proteomic analysis of paired cerebrospinal fluid(CSF)and serum samples in a discovery cohort comprising 98 *** biomarkers were validated by parallel reaction monitoring–based targeted proteomic assays in an independent multicenter cohort comprising 288 *** quantified 3,238 CSF and 1,702 serum proteins in the discovery cohort,identifying 171 and 860 CSF proteins and 37 and 323 serum proteins as potential early diagnostic and staging biomarkers,*** the validation cohort,58 and 21 CSF proteins,as well as 12 and 18 serum proteins,were verified as early diagnostic and staging biomarkers,*** 19-protein CSF and an 8-protein serum biomarker panels were built by machine learning to accurately classify mild cognitive impairment(MCI)due to AD from normal cognition with areas under the curve of 0.984 and 0.881,*** 19-protein CSF biomarker panel also effectively discriminated patients with MCI due to AD from patients with other neurodegenerative ***,we identified 21 CSF and 18 serum stage-associated proteins re-flecting AD *** findings provide a foundation for developing bloodbased tests for AD screening and staging in clinical practice.

关键词： cerebrospinal Alzheimer fluid

PRaG 3.0 therapy for human epidermal growth factor receptor 2-positive metastatic pancreatic ductal adenocarcinoma:A case report

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World Journal of Gastroenterology 2024年第9期30卷 1237-1249页

作者： Yue-Hong Kong Mei-Ling Xu Jun-Jun Zhang Guang-Qiang Chen zhi-Hui Hong Hong Zhang Xiao-Xiao Dai Yi-Fu Ma Xiang-Rong Zhao Chen-Yang Zhang Rong-zheng Chen Peng-Fei Xing Li-Yuan Zhang Center for Cancer Diagnosis and Treatment The Second Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina Department of Radiotherapy&Oncology The Second Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina Institution of Radiotherapy&Oncology Soochow UniversitySuzhou 215000Jiangsu ProvinceChina Department of Radiology The Second Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina Department of Nuclear Medicine The Second Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina Department of Clinical Laboratory The Second Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina Department of Pathology The Second Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina

BACKGROUND Pancreatic ductal adenocarcinoma(PDAC)is a highly fatal disease with limited effective treatment especially after first-line *** human epidermal growth factor receptor 2(HER-2)immunohistochemistry(IHC)positive is associated with more aggressive clinical behavior and shorter overall survival in *** SUMMARY We present a case of multiple metastatic PDAC with IHC mismatch repair proficient but HER-2 IHC weakly positive at diagnosis that didn’t have tumor regression after first-line nab-paclitaxel plus gemcitabine and PD-1 inhibitor treatment.A novel combination therapy PRaG 3.0 of RC48(HER2-antibody-drug conjugate),radio-therapy,PD-1 inhibitor,granulocyte-macrophage colony-stimulating factor and interleukin-2 was then applied as second-line therapy and the patient had confirmed good partial response with progress-free-survival of 6.5 months and overall survival of 14.2 *** had not developed any grade 2 or above treatment-related adverse events at any *** of peripheral CD8^(+) Temra and CD4^(+) Temra were increased during first two activation cycles of PRaG 3.0 treatment containing radiotherapy but deceased to the baseline during the maintenance cycles containing no *** PRaG 3.0 might be a novel strategy for HER2-positive metastatic PDAC patients who failed from previous first-line approach and even PD-1 immunotherapy but needs more data in prospective trials.

关键词： Pancreatic ductal adenocarcinoma PRaG 3.0 therapy Human epidermal growth factor receptor 2 Novel combination therapy Case report

基于静力推覆分析的穿越地裂缝浅埋地铁车站地震破坏模式研究

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振动与冲击 2024年第1期43卷 54-63,70页

作者：熊仲明陈帜陈轩郑坤阿鑫西安建筑科技大学土木工程学院西安710055 陕西省岩土与地下空间工程重点实验室西安710055 青海省建筑建材科学研究院有限责任公司西宁810008 青海省高原绿色建筑与生态社区重点实验室西宁810008

以处于西安f4地裂缝场地的浅埋地铁车站为研究对象,通过开展振动台试验,探讨了地裂缝场地和结构的震害特征。同时,考虑场地地震响应的非一致性,采用静力推覆分析方法,分析了穿越地裂缝浅埋地铁车站的地震破坏模式。结果表明:针对地裂缝... 详细信息

以处于西安f4地裂缝场地的浅埋地铁车站为研究对象,通过开展振动台试验,探讨了地裂缝场地和结构的震害特征。同时,考虑场地地震响应的非一致性,采用静力推覆分析方法,分析了穿越地裂缝浅埋地铁车站的地震破坏模式。结果表明:针对地裂缝场地地下结构的Pushover分析方法能够较真实地反应地震作用下地裂缝场地的活动特征和地下结构的破坏特点。在水平地震作用下,趋于稳定状态的地裂缝上、下盘土体主要进行张合活动(相互挤压与分离)。其中,相互挤压会对结构中柱施加明显附加压弯作用。地裂缝场地土体的水平剪切变形是结构破坏的主要外在因素,而地裂缝活动造成的附加压弯作用会进一步增大中柱轴压比,降低中柱的变形能力,加速结构的地震破坏。在地裂缝场地特征变形作用下,结构底层中柱水平剪切变形能力相对较弱,且结构剪力表现出明显的空间分布规律,上盘结构底层中柱是结构的抗震关键构件。研究结果对该类结构的抗震设计具有重要参考价值。

关键词：地裂缝地铁车站静力推覆分析破坏模式

GNSS辅助风云三号卫星MERSI近红外通道的大气可降水量反演方法

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测绘学报 2024年第2期53卷 306-320页

作者：赵庆志马智姚宜斌杜正西安科技大学测绘科学与技术学院陕西西安710054 武汉大学测绘学院湖北武汉430079

大气水汽是对流层中的重要参数之一,已被广泛应用于短临天气预警和长期气候监测等领域。我国风云三号(FY-3)系列卫星搭载的中分辨率光谱成像仪可用于大气水汽监测,但反演大气可降水量(PWV)时存在大气透过率参数低估、水汽与大气透过率... 详细信息

大气水汽是对流层中的重要参数之一,已被广泛应用于短临天气预警和长期气候监测等领域。我国风云三号(FY-3)系列卫星搭载的中分辨率光谱成像仪可用于大气水汽监测,但反演大气可降水量(PWV)时存在大气透过率参数低估、水汽与大气透过率回归系数经验选取的缺陷,无法满足在短临降雨监测、数值同化等高精度PWV应用方面的需求。针对该问题,本文提出一种GNSS辅助FY-3卫星的高精度PWV反演方法。本文方法引入高精度实测GNSS PWV作为大气透过率计算模型的回归拟合参数,辅助FY-3 L1级数据精确估计PWV和大气透过率的模型回归系数;同时,该方法顾及季节和高程因素对FY-3-L1 PWV反演的影响,分季节反演PWV并引入数字高程模型修正由于部分大气透过率参数低估导致的FY-3 L1 PWV相对不准确的现象。选取中国区域2013—2014年FY-3A卫星的L1数据和中国地壳运动观测网络的260个GNSS测站数据进行试验。结果表明,本文提出的GNSS辅助FY-3系列卫星PWV反演方法优于传统方法(FY-3A-L2 PWV),其整体精度改善率为74.5%,可得到更加可靠、稳健性更强的PWV格网产品,对于其在短临降雨监测和数值同化等方面具有重要意义。

关键词： GNSS 风云三号卫星 PWV 大气透过率参数

Optical PAM-4/PAM-8 generation via dual-Raman process in Rydberg atoms

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Chinese Physics B 2024年第6期33卷 383-388页

作者：宋晓云尹政任冠宇韩明志杨艾红祁义红彭延东 Qingdao Key Laboratory of Terahertz Technology College of Electronic and Information EngineeringShandong University of Science and TechnologyQingdao 266590China School of Physics East China University of Science and TechnologyShanghai 200237China MIIT Key Laboratory of Complex-field Intelligent Exploration Beijing Institute of TechnologyBeijing 100081China

A scheme of optical four-level pulse amplitude modulation(PAM-4) is proposed based on dual-Raman process in Rydberg atoms. A probe field counter-propagates with a dual-Raman field which drives the ground and the excited states transition, respectively, and the Rydberg transition is driven by a microwave(MW) field. A gain peak appears in the probe transmission and is sensitive to the MW field strength. Optical PAM-4 can be achieved by encoding an MW signal and decoding the magnitude of a probe signal. Simulation results show that the differential nonlinearity and the integral nonlinearity of the proposed scheme can be reduced by 5 times and 6 times, respectively, compared with the counterparts of previous scheme, and the ratio of level separation mismatch is close to the ideal value 1. Moreover, the scheme is extended to optical PAM-8 signal, which may further improve the spectral efficiency.

关键词： Rydberg atoms PAM-4/PAM-8 dual-Raman process

Multiphysics simulation and optimization of the in-situ beneficiation process of ilmenite minerals from lunar regolith

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Science China Earth Sciences 2024年

作者： Peng ZHANG Xin LIU Guanghui LIU Wei DAI Hanzhe YANG Haibo zheng zhi WANG Ran NIU Yifan BAI Yang ZHANG Chengbao LIU Ge YANG Junwei YANG Guang ZHANG Technology and Engineering Center for Space Utilization Chinese Academy of Sciences Beijing Hegong Simulation Co. Ltd

The exploration and utilization of lunar resources have become the major objectives of future lunar exploration missions. The classified collection and processing of lunar minerals is the basic prerequisite for the in-situ exploration and utilization of lunar resources. In this study, we propose a scheme for in-situ separation of magnetic minerals from lunar soils using the dry magnetic separation method. The scheme can realize the purpose of separating magnetic minerals from lunar regolith by altering the motion trajectory of lunar regolith particles with different magnetic properties. Detailed modeling of the dry magnetic separation device is conducted, and the three-dimensional distribution of magnetic parameters is calculated and analyzed. Based on the characterization and analysis of the ChangE-5’s samples, the morphologies and physical parameters of lunar regolith particles are modeled and simulated. A discrete element simulation of the motion process of lunar regolith particles under multi-physical field conditions is performed, and the influences of key parameters on the beneficiation performance of lunar magnetic minerals are investigated. Our results indicate that optimal separation and beneficiation of lunar regolith particles can be achieved under specific conditions of magnetic field strength and drum speed. Additionally, we analyze the effects of lunar weak gravity conditions and the charged nature of lunar particles on the beneficiation process, showing that these factors can obviously enhance the beneficiation process of lunar ilmenites. This study demonstrates the feasibility of using the dry magnetic separation method for the beneficiation of magnetic minerals from lunar regolith, providing a theoretical basis for the scientific tasks of collecting, processing, and utilizing lunar mineral resources.

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Review of advanced oxidation processes for treating hospital sewage to achieve decontamination and disinfection

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Chinese Chemical Letters 2024年第1期35卷 140-152页

作者： Si-Ying Yu zhi-Hui Xie Xiaoyu Wu Yun-Zhe zheng Yang Shi Zhao-Kun Xiong Peng Zhou Yang Liu Chuan-Shu He zhi-Cheng Pan Kai-Jun Wang Bo Lai State Key Laboratory of Hydraulics and Mountain River Engineering College of Architecture and EnvironmentSichuan UniversityChengdu 610065China Sino-German Centre for Water and Health Research Sichuan UniversityChengdu 610065China State Key Joint Laboratory of Environment Simulation and Pollution Control School of EnvironmentTsinghua UniversityBeijing 100084China Water Safety and Water Pollution Control Engineering Technology Research Center in Sichuan Province Haitian Water GroupChengdu 610041China

Hospital sewage contains various harmful pharmaceutical contaminants(e.g.,antibiotics,anti-inflammatory agents,and painkillers)and pathogens(e.g.,bacteria,viruses,and parasites),whose direct discharge into the environment will induce diseases and pose a powerful threat to human health and safety,and environmental *** recent years,advanced oxidation processes(AOPs),particularly photocatalysis,electrocatalysis,and ozone catalysis have been developed as widespread and effective techniques for hospital sewage ***,there is a lack of systematic comparison and review of the prior studies on hospital sewage treatment using AOPs *** review elaborates on the mechanisms,removal efficiencies,and advantages/disadvantages of these AOPs systems for hospital wastewater decontamination and ***,some novel and potential technologies such as photo-electrocatalysis,electro-peroxone,Fenton/Fenton-like,and piezoelectric catalysis are also included and ***,we further summarize and compare the capacity of these AOPs to treat the actual hospital wastewater under the impact of the water matrix and pH,and estimate the economic cost of these technologies for practical ***,the future development directions of AOPs for hospital wastewater decontamination and disinfection have been ***,this study provides a comparison and overview of these AOP systems in an attempt to raise extensive concerns about hospital wastewater decontamination and disinfection technologies and guide researchers to discover the future directions of technologies optimization,which would be a crucial step forward in the field of hospital sewage treatment.

关键词： Hospital sewage treatment Advanced oxidation processes Pharmaceutical contaminants Disinfection Decontamination

Intramedullary nailing for irreducible spiral subtrochanteric fractures:A comparison of cerclage and non-cerclage wiring

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Chinese Journal of Traumatology 2024年第5期27卷 305-310页

作者： Yan-Hui Guo Zhan-Lin Song Hua-Yong zheng Jie Gao Yi-Yun Lin zhi Liu Lian-Hua Li Department of Orthopedics The Seventh Medical Center of Chinese People's Liberation Army General HospitalBeijing100048China Department of Orthopedics The Fourth Medical Center of Chinese People's Liberation Army General HospitalBeijing100048China

Purpose:Intramedullary nailing is the preferred internal fixation technique for the treatment of subtrochanteric fractures because of its biomechanical ***,no definitive conclusion has been reached regarding whether combined cable cerclage is required during intramedullary nailing *** study is performed to compare the clinical effects of intramedullary nailing with cerclage and non-cerclage wiring in the treatment of irreducible spiral subtrochanteric ***:Patients with subtrochanteric fractures admitted to our center from January 2013 to December 2021 were retrospectively *** patients were enrolled in the case-control study according to the inclusion and exclusion criteria and divided into the non-cerclage group and the cerclage *** patients'clinical data,including the operative time,intraoperative blood loss,hospital stay,reoperation rate,fracture union time,and Harris hip score,were compared between these 2 *** variables were compared using Chi-square or Fisher's exact *** variables with normal distribution were presented as mean±standard deviation and analyzed with Student's *** distributed variables were expressed as median(Q_(1),Q_(3))and assessed using the Mann-Whitney test.A p<0.05 was considered ***:In total,69 patients were included in the study(35 patients in the non-cerclage group and 34 patients in the cerclage group).The baseline data of the 2 groups were *** were no significant difference in the length of hospital stay(z=-0.391,p=0.696),operative time(z=-1.289,p=0.197),or intraoperative blood loss(z=-1.321,p=0.186).However,compared with non-cerclage group,the fracture union time was shorter(z=-5.587,p<0.001),the rate of nonunion was lower(χ^(2)=6.030,p=0.03),the anatomical reduction rate was higher(χ^(2)=5.449,p=0.03),and the Harris hip score was higher(z=-2.99,p=0.003)in the cerclage group,all with statistically significant dif

关键词： Hip fracture Subtrochanteric fracture Intramedullary nail Cerclage wiring