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Diagnostic significance of serum levels of serum amyloid A,procalcitonin,and high-mobility group box 1 in identifying necrotising enterocolitis in newborns

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World Journal of Gastrointestinal Surgery 2024年第7期16卷 2003-2011页

作者： Li-Ming Guo zhi-Hui jiang Hong-Zhen Liu Lei Zhang Department of General Surgery Qingdao Women and Children’s HospitalQingdao 266000Shandong ProvinceChina Department of Pediatric Surgery Children's Hospital Affiliated to Shandong UniversityJinan 250022Shandong ProvinceChina Department of Pediatric Surgery Jinan Children's HospitalJinan 250022Shandong ProvinceChina Department of Pediatric Surgery Qilu Hospital of Shandong University(Qingdao)Qingdao 260010Shandong ProvinceChina

BACKGROUND Necrotising enterocolitis(NEC)is a critical gastrointestinal emergency affecting premature and low-birth-weight *** amyloid A(SAA),procalcitonin(PCT),and high-mobility group box 1(HMGB1)have emerged as potential biomarkers for NEC due to their roles in inflammatory response,tissue damage,and immune *** To evaluate the diagnostic value of SAA,PCT,and HMGB1 in the context of NEC in *** The study retrospectively analysed the clinical data of 48 newborns diagnosed with NEC and 50 healthy newborns admitted to the ***,radiological,and laboratory findings,including serum SAA,PCT,and HMGB1 Levels,were collected,and specific detection methods were *** diagnostic value of the biomarkers was evaluated through statistical analysis,which was performed using chi-square test,t-test,correlation analysis,and receiver operating characteristic(ROC)*** The study demonstrated significantly elevated levels of serum SAA,PCT,and HMGB1 Levels in newborns diagnosed with NEC compared with healthy *** correlation analysis indicated strong positive correlations among serum SAA,PCT,and HMGB1 Levels and the presence of *** analysis revealed promising sensitivity and specificity for serum SAA,PCT,and HMGB1 Levels as potential diagnostic *** combined model of the three biomarkers demonstrating an extremely high area under the curve(0.908).CONCLUSION The diagnostic value of serum SAA,PCT,and HMGB1 Levels in NEC was *** biomarkers potentially improve the early detection,risk stratification,and clinical management of critical *** findings suggest that these biomarkers may aid in timely intervention and the enhancement of outcomes for neonates affected by NEC.

关键词： Serum amyloid A Procalcitonin High-mobility group box 1 Necrotising enterocolitis in newborns Serum biomarkers

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High Speed Sintering:Assessing the Influence of Energy Input on Microstructure and Mechanical Properties of Polyether Block Amide(PEBA)Parts

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Chinese Journal of Polymer Science 2024年第5期42卷 675-682,I0004,I0010页

作者： jiang-Tao Sun zhi-Yong Fan Yi-Wei Mao Wei Li Wei Zhu Dao-Sheng Cai Qing-Song Wei State Key Laboratory of Materials Processing and Die&Mould Technology Huazhong University of Science and TechnologyWuhan430074China State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan430074China National Engineering Research Centre for High Efficiency Grinding Hunan UniversityChangsha410082China Wuhan EasyMFG Technology CO. LTDWuhan430074China

High speed sintering,a new powder-bed fusion additive manufacturing technology,utilizes infrared lights(IR)to intensely heat and melt polymer *** presence of defects such as porosity,which is associated with particle coalescence,is highly dependdent on the level of energy *** study investigate the influcence of energy input on porosity and its subsequent effects on the mechanical properties and microstructures of PEBA *** parts were manufactured with a variety of lamp powers,resulting in a range of energy input levels spanning from low to ***,they underwent testing using Archimedes’method,followed by tensile *** porosity,mechanical characteristics,and energy input exhibit a strong correlation;inadequate energy input was the primary cause of pore *** the reduced IR light power resulted in the following outcomes:porosity,ultimate tensile strength,and elongation of 1.37%,7.6 MPa,and 194.2%,*** the energy input was further increased,the porosity was reduced to as low as 0.05%and the ultimate tensile strength and elongation were increased to their peak values of 233.8%and 9.1 MPa,respectively.

关键词： High speed sintering Additive manufacturing Energy input Powder bed fusion PEBA

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Deliberate self-harm among pediatric psychiatric inpatients in China:A single-center retrospective study

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World Journal of Psychiatry 2024年第3期14卷 398-408页

作者： Xing-zhi jiang Huan-Huan Li Zhen-Zhen Yu Chen Wang Department of Child and Adolescent Psychiatry Shenzhen Kangning HospitalShenzhen Mental Health CenterShenzhen Key Laboratory for Psychological Healthcare and Shenzhen Institute of Mental HealthShenzhen 518020Guangdong ProvinceChina Department of Psychiatry Xiamen Xianyue HospitalXiamen 361012Fujian ProvinceChina Department of Geriatric Medicine Dalian Medical UniversityDalian 116000Liaoning ProvinceChina Department of Neurology The Second Affiliated Hospital of Xiamen Medical CollegeXiamen 361000Fujian ProvinceChina Department of Neurology and Department of Neuroscience The First Affiliated Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamen 361000Fujian ProvinceChina

BACKGROUND For children and adolescents,deliberate self-harm(DSH)is becoming a mental health problem of *** several studies on the prevalence and factors of DSH in the world,there is little information on DSH among children and adolescents in *** study explores the prevalence,types,associated risk factors and tendency of DSH in pediatric psychiatric inpatients in *** To understand the situation of DSH among hospitalized children and adolescents and its related *** In this study,we retrospectively studied 1414 hospitalized children and adolescents with mental illness at Xiamen Mental Health Center from 2014 to 2019,extracted the demographic and clinical data of all patients,and analyzed clinical risk factors of *** A total of 239(16.90%)patients engaged in at least one type of DSH in our ***(n=115,48.12%)was the most common type of ***(n=171,71.55%)were more likely to engage in DSH than males(n=68,28.45%).DSH was positively associated with depressive disorders[OR=3.845(2.196-6.732);P<0.01],female[OR=2.536(1.815-3.542);P<0.01],parental marital status[OR=5.387(2.254-12.875);P<0.01]and negative family history of psychiatric illness[OR=7.767(2.952-20.433);P<0.01],but not with occupation,substance use and history of physical *** Our findings suggest that for patients with depression,females,an abnormal marriage of parents,and no history of mental illness,attention should be paid to the occurrence of DSH.

关键词： Deliberate self-harm Children Adolescent Psychiatric inpatients Retrospective study

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Real-world effectiveness and safety of Janus kinase 1 inhibitors for the treatment of moderate-to-severe atopic dermatitis:a single-center,prospective study in China

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Frontiers of Medicine 2024年第4期18卷 752-756页

作者： Yihui Chen Qiaozhi Cao Cong Peng Bingjing Zhou Yu jiang Xiang Chen jie Li Department of Dermatology Xiangya HospitalCentral South UniversityChangsha410008China Hunan Key Laboratory of Skin Cancer and Psoriasis Xiangya HospitalCentral South UniversityChangsha410008China National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangsha410008China Furong Laboratory Changsha410008China

Dear Editor,Upadacitinib and abrocitiniboareselective,smallmolecule Janus kinase 1(JAK1)inhibitors approved in China for the treatment of moderate-to-severe atopic dermatitis(AD)[1].The favorable efficacy and tolerable safety of upadacitinib and abrocitinib have been determined in several clinical trials[2-5].However,realworld data,especially in Asian populations,are ***,we conducted a prospective,24-week,real-life observational study to assess the effectiveness and safety of abrocitinib and upadacitinib for the treatment of moderate-to-severe AD in a Chinese patient *** patients with moderate-to-severe AD(IGA score 3-4)in the Department of Dermatology.

关键词： dermatitis prospective treatment

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Mechanical behaviors of backfill-rock composites: Physical shear test and back-analysis

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第3期16卷 807-827页

作者： jie Xin Quan jiang Fengqiang Gong Lang Liu Chang Liu Qiang Liu Yao Yang Pengfei Chen State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhan430071China University of Chinese Academy of Sciences Beijing100049China School of Civil Engineering Southeast UniversityNanjing211189China Energy School Xi’an University of Science and TechnologyXi’an710054China

The shear behavior of backfill-rock composites is crucial for mine safety and the management of surface *** exposing the shear failure mechanism of backfill-rock composites,we conducted shear tests on backfill-rock composites under three constant normal loads,compared with the unfilled *** investigate the macro-and meso-failure characteristics of the samples in the shear tests,the cracking behavior of samples was recorded by a high-speed camera and acoustic emission *** parallel with the experimental test,the numerical models of backfill-rock composites and unfilled rock were established using the discrete element method to analyze the continuous-discontinuous shearing *** on the damage mechanics and statistics,a novel shear constitutive model was proposed to describe mechanical *** results show that backfill-rock composites had a special bimodal phenomenon of shearing load-deformation curve,*** first shearing peak corresponded to rock break and the second shearing peak induced by the broken of aeolian sand-cement/fly ash paste ***,the shearing characteristic curves of the backfill-rock composites could be roughly divided into four stages,*** shear failure of the specimens experienced:stage I:stress concentration;stage II:crack propagation;stage III:crack coalescence;stage IV:shearing *** numerical simulation shows that the existence of aeolian sand-cement/fly ash paste backfill inevitably altered the coalescence type and failure mode of the specimens and had a strengthening effect on the shear strength of backfillrock *** on damage mechanics and statistics,a shear constitutive model was proposed to describe the shear fracture characteristics of specimens,especially the bimodal ***,the micro-and meso-mechanisms of shear failure were discussed by combining the micro-test and numerical *** research can advance the better understanding of the shear behavior of

关键词： Physical simulation Backfill-rock composites Shear failure Cracking Shear constitutive model

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Elaborate Design of Two Novel Fluorescent Zinc-based Metal-Organic Frameworks for Highly Efficient Tetracycline Antibiotics Detection

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Chemical Research in Chinese Universities 2024年第3期40卷 499-507页

作者： TAO He JI Chengshan ZHANG Jian YIN Yuanyuan JIA Wenwen jiang Xin XU jie YANG Yulin MIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage School of Chemistry and Chemical EngineeringHarbin Institute of TechnologyHarbin 150001P.R.China

The abuse of tetracycline antibiotics has caused great harm to human health and *** inexpensive,convenient and sensitive methods for the detection of tetracycline antibiotics is highly ***,based on the H_(4)ddp ligand[H_(4)ddp=3-(3,5-dicarboxyphenyl)pyridine-2,6-dicarboxylic acid],two novel zinc-based metal-organic frameworks(MOFs){[Zn_(3)(ddp)_(2)(H_(2)O)_(4)]·3H_(2)O}n(Zn1-ddp)and{[Zn_(3)(ddp)_(2)(H_(2)O)_(4)]·3H_(2)O}n(Zn2-ddp)were successfully designed by delicate structural *** Zn1-ddp and Zn2-ddp exhibited excellent water and chemical stability and showed excellent fluorescence quenching performance for tetracycline ***,the more advanced framework structure and better fluorescent performance make Zn1-ddp more sensitive than Zn2-ddp in fluorescent detection with a detection limit of 0.29µmol/L for tetracycline(TC),0.09µmol/L for doxycycline(DOX),0.10µmol/L for minocycline(MIN)and metacycline(MEL),0.19µmol/L for chlortetracycline(CTC),and 0.67µmol/L for oxytetracycline(OTC)among tetracycline *** fluorescence quenching mechanism of Zn1-ddp and Zn2-ddp for tetracycline antibiotics detection was deeply *** reasons for the superior detection performance of Zn1-ddp over Zn2-ddp were also analyzed in depth through Fourier transform infrared spectrophotometry(FTIR),X-ray photoelectron spectroscopy(XPS)analysis and framework structure *** developed method opens up a new perspective for antibiotics detection based on zinc-based MOFs.

关键词： Water system Metal-organic framework Fluorescent detection Tetracycline antibiotic

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A 16-bit 18-MSPS flash-assisted SAR ADC with hybrid synchronous and asynchronous control logic

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Journal of Semiconductors 2024年第6期45卷 3-12页

作者： Junyao Ji Xinao Ji Ziyu Zhou zhichao Dai Xuhui Chen jie Zhang Zheng jiang Hong Zhang School of Microelectronics Xi'an Jiaotong UniversityXi'an 710049China Qingdao Hi-image Tech.Co.Ltd. Qingdao 266100China

This paper presents a 16-bit,18-MSPS(million samples per second)flash-assisted successive-approximation-register(SAR)analog-to-digital converter(ADC)utilizing hybrid synchronous and asynchronous(HYSAS)timing control logic based on an on-chip delay-locked loop(DLL).The HYSAS scheme can provide a longer settling time for the capacitive digital-to-analog converter(CDAC)than the synchronous and asynchronous SAR ***,the issue of incomplete settling or ringing in the DAC voltage for cases of either on-chip or off-chip reference voltage can be solved to a large *** addition,the fore-ground calibration of the CDAC’s mismatch is performed with a finite-impulse-response bandpass filter(FIR-BPF)based least-mean-square(LMS)algorithm in an off-chip FPGA(field programmable gate array).Fabricated in 40-nm CMOS process,the proto-type ADC achieves 94.02-dB spurious-free dynamic range(SFDR),and 75.98-dB signal-to-noise-and-distortion ratio(SNDR)for a 2.88-MHz input under 18-MSPS sampling rate.

关键词： SAR ADC control logic reference ringing DAC incomplete settling

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PACS gene family-related neurological diseases: limited genotypes and diverse phenotypes

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World Journal of Pediatrics 2024年第1期20卷 82-91页

作者： Han Zhang Kai Gao Shuang Wang Yue-Hua Zhang zhi-Xian Yang Ye Wu Yu-Wu jiang Department of Pediatrics Peking University First Hospital.No.1 Xi'an Men StreetWest DistrictBeijing 100034China Bejing Key Laboratory of Molecular Diagnosis and Study on Pediatric Genetic Diseases BeijingChina Children Epilepsy Center Peking University First HospitalBeijingChina Key Laboratory for Neuroscience Ministry of Education/National Health and Family Planning CommissionPeking UniversityBeijingChina Center of Epilepsy Beijing Institute for Brain DisordersBeijingChina

Background The PACS gene family has been demonstrated to be related to intracellular vesicular *** phenotypic manifestations caused by the pathogenic variants of PACS include epilepsy,intellectual disability/developmental delay,and malformations,such as facial *** We identified seven new cases with pathogenic or likely pathogenic PACS variants using next-generation *** information obtained from these patients was analyzed along with that obtained from previously reported *** With the inclusion of the newly diagnosed cases in this study,103 cases with PACS gene family-related neurological diseases were reported,of which 43 were PACS2-related cases and the remaining were PACSI-related *** patients had seizures,which have been reported to be effectively controlled by several types of anti-seizure medications(ASMs).The most efficacious and frequently prescribed ASMs included sodium valproate(43.3%,13/30),oxcarbazepine/carbamazepine(26.7%,8/30),and levetiracetam(20%,6/30).Almost all patients had intellectual disability/developmental *** most common pathogenic missense variants were PACSI ***203Trp and PACS2 *** addition,we report a patient carrying a likely pathogenic copy number variation(CNV)(de novo heterozygous deletion of chr14:105821380-106107443,286 kilobase,destroyed part of the furin-binding region domain and the protein structure after it)with more severe and refractory late-onset *** The clinical phenotypes of the different PACS heterozygous missense variants were *** pathogenic variant sites of PACSI and PACS2 were quite limited but located in different regions.A CNV destroying part of the PACS2 gene might also be *** findings may provide an important clue for further functional studies on the pathogenic mechanism of neurological disorders related to the PACS gene family.

关键词： Developmental delay Epilepsy Intellectual disability PACSI PACS2

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Geant4 simulation of fast-electron bremsstrahlung imaging at the HL-3 tokamak

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Nuclear Science and Techniques 2024年第9期35卷 213-229页

作者： Shi-Kui Cheng Yi-Po Zhang Yue-jiang Shi jie Zhang Shuai Guan Hong-Bing Xu Qiu-Lei Yang College of Science Chongqing University of TechnologyChongqing 400054China Chongqing Key Laboratory of New Energy Storage Materials and Devices Chongqing 400054China Southwestern Institute of Physics Chengdu 610041China Hebei Key Laboratory of Compact Fusion Langfang 065001China ENN Science and Technology Development Co. Ltd.Langfang 065001China

To further research on high-parameter plasma,we plan to develop a two-dimensional hard X-ray(HXR)imaging system at the HL-3 tokamak to measure HXRs with energies ranging from 20 to 300 *** application of an array-structured detector ensures that this system can measure HXR-radiation spectra from the entire plasma cross ***,it is suitable for the study of fast-electron physics,such as radio-frequency wave current drives,fast electrons driving instabilities,and plasma disruptions in fusion *** this study,we develop a simulation for calculating fast-electron bremsstrahlung in the HL-3 tokamak based on the Monte Carlo simulation code Geant4,in which the plasma geometry and forward scattering of fast-electron bremsstrahlung are *** preliminary calculation results indicate that the HXR energy deposi-tion on the detector is symmetrically distributed,even though the plasma distribution is asymmetric owing to the toroidal *** simulation results are helpful in constructing the relationship between the energy deposition on the detector and parameter distribution on the plasma cross section during HL-3 *** is beneficial for the reconstruction of the fast-electron-distribution function and for optimizing the design of the HXR-imaging system.

关键词： Geant4 simulation HL-3 tokamak Fast-electron bremsstrahlung Hard X-ray imaging

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Lymph node-biomimetic scaffold boosts CAR-T therapy against solid tumor

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National Science Review 2024年第4期11卷 206-215页

作者： Ziyan Liao jie jiang Wei Wu Jiaqi Shi Yanfang Wang Yuejun Yao Tao Sheng Feng Liu Wei Liu Peng Zhao Feifei Lv jie Sun Hongjun Li Zhen Gu National Key Laboratory of Advanced Drug Delivery and Release Systems College of Pharmaceutical Sciences Zhejiang University Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province College of Pharmaceutical SciencesZhejiang University Liangzhu Laboratory Zhejiang University Bone Marrow Transplantation Center of the First Affiliated Hospital and Department of Cell Biology Zhejiang University School of Medicine Department of Medical Oncology The First Affiliated Hospital School of Medicine Zhejiang University Department of Laboratory Medicine The First Affiliated Hospital Zhejiang University School of Medicine Department of Hepatobiliary and Pancreatic Surgery The Second Affiliated HospitalSchool of MedicineZhejiang University Jinhua Institute of Zhejiang University MOE Key Laboratory of Macromolecular Synthesis and Functionalization of Ministry of Education Department of Polymer Science and EngineeringZhejiang University Department of General Surgery Sir Run Run Shaw Hospital School of Medicine Zhejiang University

The limited infiltration and persistence of chimeric antigen receptor(CAR)-T cells is primarily responsible for their treatment deficits in solid tumors. Here, we present a three-dimensional scaffold, inspired by the physiological process of T-cell proliferation in lymph nodes. This scaffold gathers the function of loading,delivery, activation and expansion for CAR-T cells to enhance their therapeutic effects on solid tumors. This porous device is made from poly(lactic-co-glycolic acid) by a microfluidic technique with the modification of T-cell stimulatory signals, including anti-CD3, anti-CD28 antibodies, as well as cytokines. This scaffold fosters a 50-fold CAR-T cell expansion in vitro and a 15-fold cell expansion in vivo. Particularly, it maintains long-lasting expansion of CAR-T cells for up to 30 days in a cervical tumor model and significantly inhibits the tumor growth. This biomimetic delivery strategy provides a versatile platform of cell delivery and activation for CAR-T cells in treating solid tumors.

关键词： drug delivery cell therapy bioinspired biomaterials cancer immunotherapy

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