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Chemical modification of barite for improving the performance of weighting materials for water-based drilling fluids

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Petroleum Science 2024年第1期21卷 551-566页

作者： Li-Li Yang Ze-Yu Liu Shi-bo Wang Xian-Bo He Guan-Cheng jiang jie Zhang MOE Key Laboratory of Petroleum Engineering State Key Laboratory of Petroleum Resources and ProspectingChina University of Petroleum(Beijing)Changping DistrictBeijing102249China MOE Key CNPC Drilling Research Institute Changping DistrictBeijing102206China

With increasing drilling depth and large dosage of weighting materials,drilling fluids with high solid content are characterized by poor stability,high viscosity,large water loss,and thick mud cake,easier leading to reservoir damage and wellbore *** this paper,micronized barite(MB)was modified(mMB)by grafting with hydrophilic polymer onto the surface through the free radical polymerization to displace conventional API barite *** suspension stability of water-based drilling fluids(WBDFs)weighted with API barite:mMB=2:1 in 600 g was significantly enhanced compared with that with API barite/WBDFs,exhibiting the static sag factor within 0.54 and the whole stability index of *** viscosity and yield point reached the minimum,with a reduction of more than 40%compared with API barite only at the same *** multi-stage filling and dense accumulation of weighting materials and clays,filtration loss was decreased,mud cake quality was improved,and simultaneously it had great reservoir protection performance,and the permeability recovery rate reached 87%.In addition,it also effectively improved the lubricity of *** sticking coefficient of mud cake was reduced by 53.4%,and the friction coefficient was ***,mMB can serve as a versatile additive to control the density,rheology,filtration,and stability of WBDFs weighted with API barite,thus regulating comprehensive performance and achieving reservoir protection *** work opened up a new path for the productive drilling of extremely deep and intricate wells by providing an efficient method for managing the performance of high-density WBDFs.

关键词： Drilling fluids Weighting materials Filtration control Reservoir protection Stability property

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Novel PIKfyve/Tubulin Dual-target Inhibitor as a Promising Therapeutic Strategy for B-cell Acute Lymphoblastic Leukemia

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Current Medical Science 2024年第2期44卷 298-308页

作者： Zhen LU Qian LAI zhi-feng LI Meng-ya ZHONG Yue-long jiang Li-ying FENG jie ZHA Jing-wei YAO Yin LI Xian-ming DENG Bing XU Department of Hematology The First Affiliated Hospital of Xiamen University and Institute of HematologySchool of MedicineXiamen UniversityXiamen361005China Key Laboratory of Xiamen for Diagnosis and Treatment of Hematological Malignancy Xiamen361005China Department of Oncology The First Affiliated Hospital of Jinan UniversityJinan UniversityGuangzhou510630China State Key Laboratory of Cellular Stress Biology Innovation Center for Cell Signaling NetworkSchool of Life SciencesXiamen UniversityXiamen361003China

Objective:In B-cell acute lymphoblastic leukemia(B-ALL),current intensive chemotherapies for adult patients fail to achieve durable responses in more than 50%of cases,underscoring the urgent need for new therapeutic regimens for this patient *** present study aimed to determine whether HZX-02-059,a novel dual-target inhibitor targeting both phosphatidylinositol-3-phosphate 5-kinase(PIKfyve)and tubulin,is lethal to B-ALL cells and is a potential therapeutic for B-ALL ***:Cell proliferation,vacuolization,apoptosis,cell cycle,and in-vivo tumor growth were *** addition,Genome-wide RNA-sequencing studies were conducted to elucidate the mechanisms of action underlying the anti-leukemia activity of HZX-02-059 in ***:HZX-02-059 was found to inhibit cell proliferation,induce vacuolization,promote apoptosis,block the cell cycle,and reduce in-vivo tumor *** of the p53 pathway and suppression of the phosphoinositide 3-kinase(PI3K)/AKT pathway and the downstream transcription factors c-Myc and NF-κB were responsible for these ***:Overall,these findings suggest that HZX-02-059 is a promising agent for the treatment of B-ALL patients resistant to conventional therapies.

关键词： B-cell acute lymphoblastic leukemia dual-target inhibitor NF-kB c-Myc PI3K/AKT p53

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Quantitative prediction model for the depth limit of oil accumulation in the deep carbonate rocks:A case study of Lower Ordovician in Tazhong area of Tarim Basin

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Petroleum Science 2024年第1期21卷 115-124页

作者： Wen-Yang Wang Xiong-Qi Pang Ya-Ping Wang Zhang-Xin Chen Fu-jie jiang Ying Chen State Key Laboratory of Lithospheric Evolution Institute of Geology and GeophysicsChinese Academy of SciencesBeijing100029China State Key Laboratory of Petroleum Resources and Prospecting China University of Petroleum(Beijing)Beijing102249China College of Geosciences China University of Petroleum(Beijing)Beijing102249China Research Institute of Exploration and Development PetroChina Southwest Oil&Gas Field CompanyChengdu610041SichuanChina Chemical and Petroleum Engineering Schulich School of EngineeringUniversity of CalgaryCalgaryT2N 1N4Canada

With continuous hydrocarbon exploration extending to deeper basins,the deepest industrial oil accumulation was discovered below 8,200 m,revealing a new exploration ***,the extent to which oil exploration can be extended,and the prediction of the depth limit of oil accumulation(DLOA),are issues that have attracted significant attention in petroleum *** it is difficult to characterize the evolution of the physical properties of the marine carbonate reservoir with burial depth,and the deepest drilling still cannot reach the ***,the DLOA cannot be predicted by directly establishing the relationship between the ratio of drilling to the dry layer and the *** this study,by establishing the relationships between the porosity and the depth and dry layer ratio of the carbonate reservoir,the relationships between the depth and dry layer ratio were obtained *** depth corresponding to a dry layer ratio of 100%is the *** on this,a quantitative prediction model for the DLOA was finally *** results indicate that the porosity of the carbonate reservoir,Lower Ordovician in Tazhong area of Tarim Basin,tends to decrease with burial depth,and manifests as an overall low porosity reservoir in deep *** critical porosity of the DLOA was 1.8%,which is the critical geological condition corresponding to a 100%dry layer ratio encountered in the *** depth of the DLOA was 9,000 *** study provides a new method for DLOA prediction that is beneficial for a deeper understanding of oil accumulation,and is of great importance for scientific guidance on deep oil drilling.

关键词： Deep layer Tarim Basin Hydrocarbon accumulation Depth limit of oil accumulation Prediction model

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Preparation of vanadium-based electrode materials and their research progress in solid-state flexible supercapacitors

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Rare Metals 2024年第2期43卷 431-454页

作者： Rui-jie Zhu jiang Liu Chao Hua Hao-Yu Pan Yi-Jun Cao Meng Li Zhongyuan Critical Metals Laboratory Zhengzhou UniversityZhengzhou450001China School of Chemical Engineering Zhengzhou UniversityZhengzhou450001China

Solid-state flexible supercapacitors(SCs)have many advantages of high specific capacitance,excellent flexibility,fast charging and discharging,high power density,environmental friendliness,high safety,light weight,ductility,and long cycle *** are the ideal choice for the development of flexible energy storage technology in the future,and provide a good prospect for energy storage *** present,solid-state flexible SCs are widely used for portable electronic equipment and wearable energy storage equipment,the research of them has become the focus of a growing number of *** material is the key part of SCs and always determines the electrochemical performance of *** has been a hotspot and focus of ***-based compounds are considered to be a promising electrode material for SCs because of variable valence,open structure,high theoretical capacity,and low ***,this study first gives an overview of solid-state flexible SCs,then reviews the current research status of vanadium-based electrode materials in solid-state flexible SCs,and proposes some strategies to solve some problems of vanadium-based electrode materials.

关键词： Vanadium-based materials Flexible energy storage Specific capacitance Supercapacitors(SCs)

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Cryo-EM structure of cannabinoid receptor CB1-β-arrestincomplex

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Protein & Cell 2024年第3期15卷 230-234页

作者： Yuxia Wang Lijie Wu Tian Wang Junlin Liu Fei Li Longquan jiang Zhongbo Fan Yanan Yu Na Chen Qianqian Sun Qiwen Tan Tian Hua zhi-jie Liu iHuman Institute ShanghaiTech UniversityShanghai 201210China School of Life Science and Technology ShanghaiTech UniversityShanghai 201210China Institute of Molecular and Clinical Medicine Kunming Medical UniversityKunming 650500China

Dear Editor,G protein-coupled receptors(GPCRs)play a vital role in regulating almost every aspect of human physiology,making up more than one-third of marketed drug targets(Santos et al.,2017).GPCRs orchestrate their signalling through interactions with three distinct downstream protein families:G proteins,G protein-coupled receptor kinases(GRKs),and arrestins(Santos et al.,2017).While G protein-mediated signalling is initiated upon GPCR stimulation,activated GPCRs return to their basal levels through a GRK-and arrestin-regulated desensitization process(Santos et al.,2017).In addition to modulating receptor desensitization,β-arrestin also regulates downstream events that are distinct from classical G protein signalling(Ahn et al.,2020).

关键词： stimulation return

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Cytochrome P45026A1 Contributes to the Maintenance of Neuropathic Pain

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Neuroscience Bulletin 2024年第3期40卷 293-309页

作者： De-Li Cao Ling-jie Ma Bao-Chun jiang Qiang Gu Yong-Jing Gao Institute of Pain Medicine and Special Environmental Medicine Co-innovation Center of NeuroregenerationNantong UniversityNantong226019China Nantong University Medical School Nantong226001China Department of Pain Management The Affiliated Hospital of Nantong UniversityNantong226001China

The cytochrome P450 proteins(CYP450s)have been implicated in catalyzing numerous important biological reactions and contribute to a variety of ***26A1,a member of the CYP450 family,carries out the oxidative metabolism of retinoic acid(RA),the active metabolite of vitamin *** we report that CYP26A1 was dramatically upregulated in the spinal cord after spinal nerve ligation(SNL).CYP26A1 was mainly expressed in spinal neurons and *** analysis displayed that the content of all-trans-RA(at-RA),the substrate of CYP26A1,was reduced in the spinal cord on day 7 after *** of CYP26A1 by siRNA or inhibition of CYP26A1-mediated at-RA catabolism by talarozole relieved the SNL-induced mechanical allodynia during the maintenance phase of neuropathic *** also reduced SNL-induced glial activation and proinflammatory cytokine production but increased anti-inflammatory cytokine(IL-10)*** RA receptors RARα,RXRβ,and RXRγwere expressed in spinal neurons and glial *** promoter of Il-10 has several binding sites for RA receptors,and at-RA directly increased Il-10 mRNA expression in ***,intrathecal IL-10 attenuated SNL-induced neuropathic pain and reduced the activation of astrocytes and ***,the inhibition of CYP26A1-mediated at-RA catabolism alleviates SNL-induced neuropathic pain by promoting the expression of IL-10 and suppressing glial ***26A1 may be a potential therapeutic target for the treatment of neuropathic pain.

关键词： CYP26A1 Microglia Astrocytes ERK P38 IL-10 Neuropathic pain

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Experimental and numerical study on atmospheric-pressure air dielectric barrier discharge via 50 Hz/5000 Hz dual-frequency excitation

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High Voltage 2024年第2期9卷 391-402页

作者： Junwen He Bangfa Peng Guanglin Yu Ronggang Wang Nan jiang jie Li Yan Wu School of Electrical Engineering Dalian University of TechnologyDalianChina Canmax Technologies Co. Ltd.SuzhouChina

A dual-frequency(DF)dielectric barrier discharge,excited by the superposition of a 50 Hz low frequency(LF)and a 5000 Hz intermediate frequency(IF),is proposed to enhance *** effect of the LF voltage component on the breakdown behaviour of the DF discharge during different periods has been studied both experimentally and *** number of high-current pulses rises as the LF voltage *** statistical analysis shows that the number of the current pulse amplitude above 80 mA in the DF discharge reaches nearly 6 times that in the IF ***,the total discharge energy in the DF discharge is significantly higher than that in the IF *** simulation re-produces the temporal variation of the breakdown behaviours in the DF *** simulated results reveal that the maximal electric field strength of the breakdown process is greater in the DF discharge compared to the IF discharge during a half-period of ***,the comparison between the IF and DF discharges exhibits that the LF voltage regulates the accumulation of residual charged species on the dielectric surface after the breakdown by modulating the residual voltage between the air gap.

关键词： dielectric excitation excited

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BMP9 induces osteogenic differentiation through up-regulating LGR4 via the mTORC1/ Stat3 pathway in mesenchymal stem cells

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Genes & Diseases 2024年第3期11卷 468-483页

作者： jie Zhang Jinhai jiang Hang Liu Shiyu Wang Kaixin Ke Siyuan Liu Yue jiang Lu Liu Xiang Gao Baicheng He Yuxi Su Department of Pharmacology School of PharmacyChongqing Medical UniversityChongqing 400016China Key Laboratory of Biochemistry and Molecular Pharmacology of Chongqing Chongqing Medical UniversityChongqing 400016China Department of Orthopedics Second Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China orthopedics Department Children's Hospital of Chongqing Medical UniversityChongqing 400014China China International Science and Technology Cooperation Base of Child Development and Critical Disorders Jiangxi Hospital Affiliated Children's Hospital of Chongqing Medical UniversityJiangxi 330000China National Clinical Research Center for Child Health and Disorders China

Bone defects and non-union are prevalent in clinical orthopedy,and the outcomes of current treatments are often *** tissue engineering offers a promising approach to treating these conditions *** morphogenetic protein 9(BMP9)can commit mesenchymal stem cells to osteogenic lineage,and a knowledge of the underlying mechanisms may help advance the field of bone tissue ***-rich repeats con-taining G protein-coupled receptor 4(LGR4),a member of G protein-coupled receptors,is essential for modulating bone *** study is aimed at investigating the impact of LGR4 on BMP9-induced osteogenesis in mesenchymal stem cells as well as the underlying *** marrow stromal cells from BMp9-knockout mice exhibited diminished LGR4 expression,and exogenous LGR4 clearly restored the impaired osteogenic potency of the bone marrow stromal ***,LGR4 expression was increased by BMP9 in C3H10T1/2 ***4 augmented the benefits of BMP9-induced osteogenic markers and bone formation,whereas LGR4 inhibition restricted these ***,the BMP9-induced li-pogenic markers were increased by LGR4 *** protein levels of Raptor and p-Stat3 were elevated by *** knockdown or p-Stat3 suppression attenuated the osteoblastic markers and LGR4 expression brought on by ***4 significantly reversed the blocking ef-fect of Raptor knockdown or p-Stat3 suppression on the BMP9-induced osteoblastic *** interacts with p-Stat3,and p-Stat3 activates the LGR4 promoter *** conclusion,LGR4 boosts BMP9 osteoblastic potency in mesenchymal stem cells,and BMP9 may up-regulate LGR4 via the mTORC1/Stat3 signal activation.

关键词： BMP9 LGR4 mTORC1 Osteogenic differentiation Stat3

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A High-Accuracy Curve Boundary Recognition Method Based on the Lattice Boltzmann Method and Immersed Moving Boundary Method

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Computer Modeling in Engineering & Sciences 2024年第9期140卷 2533-2557页

作者： jie-Di Weng Yong-Zheng jiang Long-Chao Chen Xu Zhang Guan-Yong Zhang Hunan Provincial Key Laboratory of Health Maintenance for Mechanical Equipment Hunan University of Science and TechnologyXiangtan411201China School of Mechanical Engineering Hunan Chemical Vocational Technology CollegeZhuzhou412000China

Applying numerical simulation technology to investigate fluid-solid interaction involving complex curved bound-aries is vital in aircraft design,ocean,and construction ***,current methods such as Lattice Boltzmann(LBM)and the immersion boundary method based on solid ratio(IMB)have limitations in identifying custom curved ***,IBM based on velocity correction(IBM-VC)suffers from inaccuracies and numerical ***,this study introduces a high-accuracy curve boundary recognition method(IMB-CB),which identifies boundary nodes by moving the search box,and corrects the weighting function in LBM by calculating the solid ratio of the boundary nodes,achieving accurate recognition of custom curve *** addition,curve boundary image and dot methods are utilized to verify *** findings revealed that IMB-CB can accurately identify the boundary,showing an error of less than 1.8%with 500 ***,the flow in the custom curve boundary and aerodynamic characteristics of the NACA0012 airfoil are calculated and compared to *** showed that IMB-CB yields lower lift and drag coefficient errors than IBM-VC,with a 1.45%drag coefficient *** addition,the characteristic curve of IMB-CB is very stable,whereas that of IBM-VC is *** the moving boundary problem,LBM-IMB-CB with discrete element method(DEM)is capable of accurately simulating the physical phenomena of multi-moving particle flow in complex curved *** research proposes a new curve boundary recognition method,which can significantly promote the stability and accuracy of fluid-solid interaction simulations and thus has huge applications in engineering.

关键词： Fluid-solid interaction curve boundary recognition method Lattice Boltzmann method immersed moving boundary method

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Identification of P-type plasma membrane H^(+)-ATPases in common wheat and characterization of TaHA7 associated with seed dormancy and germination

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Journal of Integrative Agriculture 2024年第7期23卷 2164-2177页

作者： Bingli jiang Wei Gao Yating jiang Shengnan Yan Jiajia Cao Litian Zhang Yue Zhang jie Lu Chuanxi Ma Cheng Chang Haiping Zhang Key Laboratory of Wheat Biology and Genetic Improvement on Southern Yellow&Huai River Valley Ministry of Agriculture and Rural Affairs/College of AgronomyAnhui Agricultural UniversityHefei 230036China

The P-type plasma membrane(PM)H^(+)-ATPases(HAs)are crucial for plant development,growth,and *** HAs have been thoroughly characterized in many different ***,despite their importance,the functions of HAs in germination and seed dormancy(SD)have not been validated in ***,we identified 28 TaHA genes(TaHA1-28)in common wheat,which were divided into five *** examination of gene expression in strong-and weak-SD wheat varieties led to the discovery of six candidate genes(TaHA7/-12/-14/-16/-18/-20).Based on a single nucleotide polymorphism(SNP)mutation(C/T)in the TaHA7 coding region,a CAPS marker(HA7)was developed and validated in 168 wheat varieties and 171 Chinese mini-core collections that exhibit diverse germination and SD *** further verified the roles of the two allelic variations of TaHA7 in germination and SD using wheat mutants mutagenized with ethyl methane sulphonate(EMS)in‘Jimai 22’and‘Jing 411’backgrounds,and in transgenic Arabidopsis ***7 appears to regulate germination and SD by mediating gibberellic acid(GA)and abscisic acid(ABA)signaling,metabolism,and *** results presented here will enable future research regarding the TaHAs in wheat.

关键词： wheat P-type plasma membrane H^(+)-ATPase seed dormancy abscisic acid gibberellin

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