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Long-term tadalafil once daily in Chinese men with erectile dysfunction:a 2-year final analysis of a post-marketing,multicenter,randomized,open-label trial

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Asian Journal of Andrology 2024年第3期26卷 282-287页

作者： Hui Jiang Lian-Ming zhao Su Yan Ji-Hong Liu zhao-Hui Zhu Jin-Dan Luo Yu-Tian Dai Fu-Biao Li Hao-Cheng Lin zhi-Chao zhang Department of Urology Peking University First HospitalBeijing 100000China Department of Urology Peking University Third HospitalBeijing 100191China Department of Urology Peking Union Medical College HospitalBeijing 100730China Department of Urology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Urology Union Hospital of Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Urology The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Departmentof Andrology Nanjing Drum Tower HospitalNanjing 210008China Department of Andrology The First Hospital of Jilin UniversityChangchun 130021China Andrology Center Department of UrologyPeking University First HospitalBeijing 100034China

The long-term safety and effectiveness of once-daily tadalafil is crucial,but limited data are available in Chinese patients witherectile dysfunction(ED).In this post-marketing,multicenter,randomized,open-label trial with 2-year follow-up,635 ED caseswere randomized to receive daily oral tadalafil 2.5 mg or 5 mg for 3 months,of whom 580 continued once-daily tadalafil 5 mg for21 ***-emergent adverse events in the 12-month and 24-month period were similar,with the most common beingviral upper respiratory tract infection,upper respiratory tract infection,and *** improvement from baseline inthe International Index of Erectile Function-Erectile Function(IIEF-EF)score was detected at month 12(least squares mean[LSM]change:7.9,95%confidence interval[CI]:7.5–8.4,P<0.001)and was maintained to month 24(LSM change:8.6,95%CI:8.1–9.0,P<0.001).The proportions of patients regaining normal erectile function(IIEF-EF score≥26)were 43.7%and 48.0%at months 12 and 24,*** Assessment Questionnaire results showed improved erection function in 97.5%ofpatients and improved ability to engage in sexual activity in 95.9%of patients at month 12;these values were 96.1%and 95.0%at month 24,*** quality of sexual life score based on the Sexual Life Quality Questionnaire(SLQQ)was increased by52.2%at month 12 and by 55.3%at month 24(both P<0.001).The treatment satisfaction score determined by SLQQ(mean±standard deviation)was 62.4±21.0 at month 12 versus 65.9±20.2 at month ***-year daily application of tadalafil 5mg in Chinese men with ED showed a favorable safety profile and durable improvement in sexual performance and satisfaction.

关键词： clinical trial erectile dysfunction long-term safety once-daily dosing tadalafil

Mechanical behavior and damage constitutive model of sandstone under hydro-mechanical (H-M) coupling

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International Journal of Mining Science and Technology 2024年第6期34卷 837-853页

作者： Tao Tan Chunyang zhang Yanlin zhao Xiaoshuang Li School of Resources and Environmental Engineering Wuhan University of TechnologyWuhan 430070China State Key Laboratory of Safety and Health in Metal Mines Maanshan 243000China Sinosteel Maanshan General Institute of Mining Research Co. Ltd.Maanshan 243000China School of Resource&Environment and Safety Engineering Hunan University of Science and TechnologyXiangtan 411201China School of Urban Construction Changzhou UniversityChangzhouJiangsu 213164China

Underground engineering often passes through water-rich fractured rock masses, which are prone to fracture and instability under the long-term coupling of in-situ stress field and pore water(P-W) pressure, ultimately threatening the stability of underground structures. In order to explore the mechanical properties of rocks under H-M coupling, the corresponding damage constitutive(D-C) model has become the focus of attention. Considering the inadequacy of the current research on rock strength parameters,energy evolution characteristics and D-C model under H-M coupling, the mechanical properties of typical sandstone samples are discussed based on laboratory tests. The results show that the variation of characteristic stresses of sandstone under H-M coupling conforms to the normalized attenuation equation and Mohr-Coulomb(M-C) criterion. The P-W pressure mechanism of sandstone exhibits a dynamic change from softening effect to H-M fracturing effect. The closure stress is mainly provided by cohesive strength, while the initiation stress, damage stress, and peak stress are jointly dominated by cohesive strength and friction strength. In addition, residual stress is attributed to the friction strength formed by the bite of the fracture surface. Subsequently, the energy evolution characteristics of sandstone under H-M coupling were studied, and it was found that P-W pressure weakened the energy storage capacity and energy dissipation capacity of sandstone, and H-M fracturing was an important factor in reducing its energy storage efficiency. Finally, combined with energy dissipation theory and statistical damage theory, two types of D-C models considering P-W pressure are proposed accordingly, and the model parameters can be determined by four methods. The application results indicate that the proposed and modified D-C models have high reliability, and can characterize the mechanical behavior of sandstone under H-M coupling, overcome the inconvenience of existing D-C models

关键词： H-M coupling Water-saturated sandstone Mechanical mechanism Energy evolution D-C model

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Hierarchical Spinning of Janus Textiles with Anisotropic Wettability for Wound Healing

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Research 2024年第1期2023卷 97-105页

作者： Han zhang Lingyu Sun Jiahui Guo Yuanjin zhao Department of Rheumatology and Immunology Nanjing Drum Tower HospitalSchool of Biological Science and Medical EngineeringSoutheast UniversityNanjingJiangsu 210096China Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine Vision and Brain Health)Wenzhou InstituteUniversity of Chinese Academy of SciencesWenzhouZhejiang 325001China

Wound healing and tissue repair are recognized as basic human health problems *** to accelerate the reparative process are focused on developing functional wound ***,we present novel Janus textiles with anisotropic wettability from hierarchical microfluidic spinning for wound *** hydrophilic hydrogel microfibers from microfluidics are woven into textiles for freeze-drying treatment,followed by the deposition of electrostatic spinning nanofibers composed of hydrophobic polylactic acid(PLA)and silver *** electrospun nanofiber layer can be well coupled with the hydrogel microfiber layer to generate Janus textiles with anisotropic wettability due to the roughness of the hydrogel textile surface and the incomplete evaporation of PLA solution when reaching the *** wound treatment with the hydrophobic PLA side contacting the wound surface,the wound exudate can be pumped from the hydrophobic to the hydrophilic side based on the wettability differential derived drainage *** this process,the hydrophobic side of the Janus textile can prevent excess fluid from infiltrating the wound again,preventing excessive moisture and preserving the breathability of the *** addition,the silver nanoparticles contained in the hydrophobic nanofibers could impart the textiles with good antibacterial effect,which further promote the wound healing *** features indicate that the described Janus fiber textile has great application potential in the field of wound treatment.

关键词： silver spinning healing

Multiphysical contact of functionally graded magneto-electroelastic material with imperfect bonding interface

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Friction 2024年第4期12卷 632-654页

作者： Yijin SUI Haibo zhang Jieliang zhao Wenzhong WANG School of Mechanical Engineering Beijing Institute of TechnologyBeijing 100081China

Three-dimensional(3D)frictional contact model of functionally graded magneto-electro-elastic(FGMEE)material with a conducting spherical punch under electromagnetic fields is *** types of imperfect bonding interface of layers,dislocation-like interface and force-like interface,are *** response functions(FRFs)for multilayered MEE material with imperfect interface subjected to unit mechanical,electric,and magnetic loads are *** FRFs are used with the semi-analytical method(SAM)to solve present multiphysical contact *** present model is verified by comparing with literatures and the finite element method(FEM)and used to study the contact problem of FGMEE film imperfectly bonded on homogenous MEE half-space under electromagnetic *** studies are conducted to reveal the effects of imperfect interfaces and also film properties including gradient index and thickness.

关键词： frictional contact magneto-electro-elastic material imperfect interface functionally graded electromagnetic fields

Formal Verification of Data Modifications in Cloud Block Storage Based on Separation Logic

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Chinese Journal of Electronics 2024年第1期33卷 112-127页

作者： Bowen zhang zhao JIN Hanpin WANG Yongzhi CAO Key Laboratory of High Confidence Software Technologies (MOE) School of Computer Science Peking University School of Computer and Artificial Intelligence Zhengzhou University School of Computer Science and Cyber Engineering Guangzhou University

Cloud storage is now widely used, but its reliability has always been a major concern. Cloud block storage(CBS) is a famous type of cloud storage. It has the closest architecture to the underlying storage and can provide interfaces for other types. Data modifications in CBS have potential risks such as null reference or data *** verification of these operations can improve the reliability of CBS to some extent. Although separation logic is a mainstream approach to verifying program correctness, the complex architecture of CBS creates some challenges for verifications. This paper develops a proof system based on separation logic for verifying the CBS data modifications. The proof system can represent the CBS architecture, describe the properties of the CBS system state, and specify the behavior of CBS data modifications. Using the interactive verification approach from Coq, the proof system is implemented as a verification tool. With this tool, the paper builds machine-checked proofs for the functional correctness of CBS data modifications. This work can thus analyze the reliability of cloud storage from a formal perspective.

关键词： Cloud computing Behavioral sciences Reliability Formal verification

Kinetic model of vibration screening for granular materials based on biological neural network

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Particuology 2024年第5期88卷 98-106页

作者： Zhan zhao Yan zhang Fang Qin Mingzhi Jin School of Agricultural Engineering Jiangsu UniversityZhenjiang212013China Shandong Academy of Agricultural Machinery Sciences Ji'nan250100China

The kinetic model is the theoretical basis for optimizing the structure and operation performance of vibration screening *** this paper,a biological neurodynamic equation and neural connections were established according to the motion and interaction properties of the material under vibration *** material feeding to the screen and the material passing through apertures were considered as excitatory and inhibitory inputs,respectively,and the generated stable neural activity landscape was used to describe the material distribution on the 2D screen *** dynamic process of material vibration screening was simulated using discrete element method(DEM).By comparing the similarity between the material distribution established using biological neural network(BNN)and that obtained using DEM simulation,the optimum coefficients of BNN model under a certain screening parameter were determined,that is,one relationship between the BNN model coefficients and the screening operation parameters was *** screening parameters were randomly selected,and the corresponding relationships were established as a ***,with straw/grain ratio,aperture diameter,inclination angle,vibration strength in normal and tangential directions as inputs,five independent adaptive neuro-fuzzy inference systems(ANFIS)were established to predict the optimum BNN model coefficients,*** training results indicated that ANFIS models had good stability and *** flexibility and adaptability of the proposed BNN method was demonstrated by modeling material distribution under complex feeding conditions such as multiple regions and non-uniform rate.

关键词： Kinetic model Material distribution Vibration screening Biological neural network DEM simulation Adaptive neuro-fuzzy inference systems

Uncertain knowledge graph embedding:an effective method combining multi-relation and multi-path

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Frontiers of Computer Science 2024年第3期18卷 73-89页

作者： Qi LIU Qinghua zhang Fan zhao Guoyin WANG Key Laboratory of Tourism Multisource Data Perception and Decision Ministry of Culture and TourismChongqing University of Posts and TelecommunicationsChongqing 400065China Chongqing Key Laboratory of Computational Intelligence Chongqing University of Posts and TelecommunicationsChongqing 400065China Chongqing Key Laboratory of Big Data Intelligent Computing Chongqing University of Posts and TelecommunicationsChongqing 400065China

Uncertain Knowledge Graphs(UKGs)are used to characterize the inherent uncertainty of knowledge and have a richer semantic structure than deterministic knowledge *** research on the embedding of UKG has only recently begun,Uncertain Knowledge Graph Embedding(UKGE)model has a certain effect on solving this ***,there are still unresolved *** the one hand,when reasoning the confidence of unseen relation facts,the introduced probabilistic soft logic cannot be used to combine multi-path and multi-step global information,leading to information *** the other hand,the existing UKG embedding model can only model symmetric relation facts,but the embedding problem of asymmetric relation facts has not be *** address the above issues,a Multiplex Uncertain Knowledge Graph Embedding(MUKGE)model is proposed in this ***,to combine multiple information and achieve more accurate results in confidence reasoning,the Uncertain ResourceRank(URR)reasoning algorithm is ***,the asymmetry in the UKG is *** embed asymmetric relation facts of UKG,a multi-relation embedding model is ***,experiments are carried out on different datasets via 4 tasks to verify the effectiveness of *** results of experiments demonstrate that MUKGE can obtain better overall performance than the baselines,and it helps advance the research on UKG embedding.

关键词： knowledge representation uncertain knowledge graph multi-relation embedding uncertain reasoning

Examination of two-phase behaviors in porous media during pool boiling

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Science China(Technological Sciences) 2024年第6期67卷 1695-1713页

作者： zhang zhiHao GUAN ShuYa WU Rui zhao ChangYing School of Mechanical Engineering Shanghai Jiao Tong University

The enhancement of pool boiling heat transfer using porous media has been extensively *** the two-phase distribution and evolution in porous media are crucial to the heat transfer performance,including the critical heat flux(CHF)and heat transfer coefficient(HTC),direct observation of the two-phase flow inside the media is limited owing to the blockage of the direct view from the porous *** this study,pool boiling visualization experiments were conducted on porous samples with different throat widths in deionized *** results showed that the HTC increased with the throat ***,the growth-contraction cycle of the vapor region and the formation and drying of the wall liquid film inside the porous media were *** vapor region,including the maximum and minimum areas in the boiling cycle,was quantitatively ***,the relationship between the minimum gas-phase area and HTC peak was identified.A one-dimensional transient model was developed considering solid skeleton heat conduction,liquid film evaporation,and vapor region growth to quantitatively study the influence of heat flux on the internal two-phase *** model successfully captured the maximum gas-phase area,duration of boiling cycles,and HTC trends at specific heat *** results of this quantitative study provide insights into the internal two-phase distribution and evolution induced by pool boiling.

关键词： porous media two-phase behaviors pool boiling

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Traditional Chinese Medicine Integrated Responsive Microneedles for Systemic Sclerosis Treatment

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Research 2024年第1期2023卷 139-147页

作者： Xi Luan Xiaoxuan zhang Min Nie Yuanjin zhao Department of Rheumatology and Immunology Nanjing Drum Tower HospitalSchool of PharmacyClinical College of Traditional Chinese and Western MedicineNanjing University of Chinese MedicineNanjing 210023China State Key Laboratory of Bioelectronics School of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China

Traditional Chinese medicine,such as Tripterygium wilfordii and Paeonia lactiflora,has potential values in treating systemic sclerosis(SSc)and other autoimmune diseases,while their toxic side effect elimination and precise tropical drug delivery are still ***,we present multiple traditional Chinese medicine integrated photoresponsive black phosphorus(BP)microneedles(MNs)with the desired features for the SSc *** employing a template-assisted layer-by-layer curing method,such MNs with triptolide(TP)/paeoniflorin(Pae)needle tips and BP-hydrogel needle bottoms could be well *** combined administration of TP and Pae can not only provide anti-inflammatory,detoxification,and immunomodulatory effects to treat skin lesions in the early stage of SSc but also remarkably reduce the toxicity of single drug ***,the additive BPs possess good biocompatibility and near-infrared(NIR)responsiveness,imparting the MN photothermal-controlled drug release *** on these features,we have demonstrated that the traditional Chinese medicine integrated responsive MNs could effectively improve skin fibrosis and telangiectasia,reduce collagen deposition,and reduce epidermal thickness in the SSc mouse *** results indicated that the proposed Chinese medicine integrated responsive MNs had enormous potential in clinical therapy of SSc and other diseases.

关键词： needle precise template