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Synthesis of Phenoxazinone Derivatives and Antiproliferative Activities on Wild-type and Drug-resistant Tumor Cells

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Chinese Chemical Letters 2006年第9期17卷 1141-1144页

作者： Ji Wu RUAN zhi shu huang Jin Feng huang Cui Juan DU Shi Liang huang zhi SHI Li Wu FU Lian Quan GU School of Pharmaceutical Sciences Zhongshan University Guangzhou 510080 Cancer Center Sun Yet-sen UniVersity Guangziaou 510060

A series of novel phenoxazinone derivatives （1-6） were designed and synthesized for evaluating their antitumor activities. The antiproliferative activities of the prepared compounds against representative human neoplastic cell lines were evaluated by MTF assay. The results showed that most of them inhibited cell proliferation in a submicromolar to rnicromolar range. These compounds were also evaluated against KBv200 and MCF-7/Adr cell lines, which overexpress the MDR/P-glycoprotein drug efflux pump responsible for drug resistance, and had a more potential for resisting MDR than their lead compound APO.

关键词： Antitumor phenoxazinones iminoquinones multidrug-resistance.

A facile and efficient method for hydroxylation of azabenzanthrone compounds

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Chinese Chemical Letters 2011年第1期22卷 41-44页

作者： Fang Xian Ning Xiang Weng Shi Liang huang Li Jun Gu zhi shu huang Lian Quan Gu School of Pharmaceutical sciences Sun Yat-Sen University Guangzhou 51006 China

A novel and facile method of introducing 4-hydroxyl group into the aromatic ring of azabenzanthrone compounds was carried out by reacting azabenzanthrone compounds with hydrazine hydrate or hydroxylamine hydrochloride and sodium hydroxide in diethylene glycol （DEG） solvent. The mechanism of reaction may involve an amino intermediate and follow a hydroxyl substitution process.

关键词： Azabenzanthrone Hydroxylation Hydrazine hydrate Hydroxylamine hydrochloride Sodium hydroxide

A new approach to the facile synthesis of 2-substituted-quinazolin-4(3H)-ones

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Chinese Chemical Letters 2011年第8期22卷 951-953页

作者： Bin Wang Zeng Li Xiao Ning Wang Jia Heng Tan Lian Quan Gu zhi shu huang School of Pharmaceutical Sciences Sun Yat-sen University Guanzhou 510006 China Department of Chemistry and Lithe Science Xiangnan University Chenzhou 423000 China

A new approach to the facile synthesis of 2-substituted-quinazolin-4（3H）-ones and its derivatives using the condensation reaction of substituted 2-aminobenzamide and orthoesters is reported.

关键词： Quinazolin-4(3H)-ones Synthesis Aminobenzamide Orthoester

Unexpected Synthesis of 2,2'-[1-(4-Methoxyphenoxy)propane-2,2-diyl]bis(5-methoxy-3-methylbenzofuran)

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Chinese Chemical Letters 2005年第12期16卷 1581-1583页

作者： Yu Dong SHEN Hai Qiang WU Lin Kun AN zhi shu huang Xian Zhang BU Lian Quan GU School of Chemistry and Chemical Engineering Sun Yat-sen University Guangzhou 510275 School of Pharmaceutical Sciences Sun Yat-sen University Guangzhou 510080

A new bisbenzofuran analogue Ⅶ was achieved unexpectedly in one step procedure from 1-（4-methoxyphenoxy）acetone Ⅰ by using Amberlyst 15 resin as catalyst in excellent yield. The structure was elucidated by spectro... 详细信息

关键词： Benzofuran Amberlyst 15 resin cyclization

Synthesis of 2,2'-(Substituted Arylmethylene)bis(1,6,6-trimethyl- 6,7,8,9-tetrahydrophenanthro[1,2-b]furan-10,11-dione) Derivatives

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Chinese Chemical Letters 2005年第11期16卷 1451-1454页

作者： Jiang Ke QIN Xian Zhang BU Yu Fang WANG zhi Yun DU Xing Yuan WANG zhi shu huang Lin MA Lin Kun AN Lian Quan GU School of Pharmaceutical Sciences Sun Yat-sen University Guangzhou 510080 School of Chemistry and Chemical Engineering Sun Yat-sen University Guangzhou 510275

The reactions of tanshinone IIA with aromatic aldehydes have been investigated and several 2, T-（substituted arylmethylene） bis （1,6,6-trimethyl-6,7,8,9-tetrahydrophenanthro[1,2-b]- furan- 10, 11-dione） derivative... 详细信息

关键词： Tanshinone IIA aromatic aldehydes reaction.

The Mechanism on Cyclization, Debenzylation and Oxidation of 1-[1-(Benzyloxy)-3-methylnaphthalen-4-yloxy]propan-2-one

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Chinese Chemical Letters 2006年第6期17卷 769-772页

作者： Shi Liang huang Yi LUO zhi shu huang Xian Zhang BU Pei Qing LIU Lin MA Yue Ming LI Albert S. C. CHAN Lian Quan GU School of Chemistry and Chemical Engineering Sun Yat-Sen University Guangzhou 510275 School of Pharmaceutical Science Sun Yat-Sen University Guangzhou 510275 Department of Applied Bioiogy ＆ Chemical Technology The Hong Kong Polytechnic University Kowloon Hong Kong

1-[1-（Benzyloxy）-3-methylnaphthalen-4-yloxy]propan-2-one （la） took place a cyclization, debenzylation and oxidation to form 9-substitued benzo[de]chromene-7,8-dione （2a） and 5-benzyl-9-substitued benzo[de]chrome... 详细信息

关键词： Mansonone F cyclization selenium dioxide sigmatropic rearrangement.

Simultaneous Bulk-and Surface-initiated Living Polymerization Studied with a Heterogeneous Stochastic Reaction Model

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Chinese Journal of Polymer Science 2024年第3期42卷 364-372,I0008页

作者： Jia-shu Ma zhi-Ning huang Jia-Hao Li Bang-Ping Jiang Yan-Da Liao Shi-Chen Ji Xing-Can Shen State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources(Ministry of Education of China)School of Chemistry and Pharmaceutical SciencesGuangxi Normal UniversityGuilin 541004China School of Computer Science and Engineering&School of Software Guangxi Normal UniversityGuilin 541004China

To better characterize the properties of surface-initiated polymers, simultaneous bulk-and surface-initiated polymerizations are usually carried out by assuming that the properties of the surface-initiated polymers resemble those of the bulk-initiated polymers. Through a Monte Carlo simulation using a heterogeneous stochastic reaction model, it was discovered that the bulk-initiated polymers exhibit a higher molecular weight and a lower dispersity than the corresponding surface-initiated polymers, which indicates that the equivalent assumption is invalid. Furthermore, the molecular weight distributions of the two types of polymers are also different, suggesting different polymerization mechanisms. The results can be simply explained by the heterogeneous distributions of reactants in the system. This study is helpful to better understand surface-initiated polymerization.

关键词： Surface-initiated polymerization Polymer brush Stochastic reaction model Heterogeneous polymerization Simultaneous polymerization

Synergistic Tuning of Nickel Cobalt Selenide@Nickel Telluride Core-Shell Heteroarchitectures for Boosting Overall Urea Electrooxidation and Electrochemical Supercapattery

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Energy & Environmental Materials 2024年第1期7卷 305-316页

作者： Diab Khalafallah Weibo huang Mingjia zhi Zhanglian Hong State Key Laboratory of Silicon Material School of Materials Science and Engineering Zhejiang University Mechanical Design and Materials Department Faculty of Energy EngineeringAswan University

Herein,we demonstrate the synthesis of bifunctional nickel cobalt selenide@nickel telluride(NixCo12-xSe@NiTe) core-shell heterostructures via an electrodeposition approach for overall urea electrolysis and *** 3D vertically orientated NiTe dendritic frameworks induce the homogeneous nucleation of 2D NixCo12-xSe nanosheet arrays along similar crystal directions and bring a strong interfacial binding between the integrated active components.

关键词： bifunctional NixCo12-xSe@NiTe core–shell electrodeposition heterointerfaces supercapacitors UOR

Predictive value of intracranial high-density areas in neurological function

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World Journal of Psychiatry 2024年第7期14卷 1080-1086页

作者： zhi-Juan Lu Jin-Xing Lai Jing-Ru huang shu-Hua Xie Zhao-Hui Lai Department of Neurology Ganzhou People’s HospitalGanzhou 341000Jiangxi ProvinceChina

BACKGROUND Intracranial high-density areas(HDAs)have attracted considerable attention for predicting clinical outcomes;however,whether HDAs predict worse neurological function and mental health remains controversial and unclear,which requires further *** this prospective study,96 patients with acute ischemic stroke(AIS)who accepted endovascular mechanical thrombectomy(EMT)were *** enrolled patients underwent cranial computed tomography(CT)examination within 24 hours after *** data in terms of National Institutes of Health Stroke Scale(NIHSS),the 3-month modified Rankin Scale(mRS),self-rating depression scale(SDS),and self-rating anxiety scale(SAS)scores were collected and compared between patients with HDAs and non-HDAs and between patients with good and poor clinical *** to patients without HDAs,patients with HDAs presented severe neurological deficits(admission NIHSS score:18±3 vs 19±4),were more likely to have post-stroke disabilities(mRS<3:35%vs 62%),and suffered more severe depression(SDS score:58±16 vs 64±13)and anxiety disorder(SAS score:52±8 vs 59±10).Compared to patients with a good prognosis,patients with a poor prognosis presented severe neurological deficits(admission NIHSS score:17±4 vs 20±3),were more likely to have HDAs on CT images(64%vs 33%),and suffered more severe depression(SDS score:55±19 vs 65±11)and anxiety(SAS score:50±8 vs 58±12).Multivariate analysis revealed that HDAs were independent nega-tive prognostic *** In conclusion,HDAs on CT images predicted poor prognosis and severe depressive and anxiety symptoms in patients with AIS who underwent EMT.

关键词： Acute ischemic stroke Endovascular mechanical thrombectomy High-density areas Depressive disorder Anxiety disorder