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Parallel difference schemes with interface extrapolation terms for quasi-linear parabolic systems

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Science China Mathematics 2007年第2期50卷 253-275页

作者： Guang-wei YUAN xu-deng HANG zhi-qiang SHENG Laboratory of Computational Physics Institute of Applied Physics and Computational MathematicsBeijing 100088China

In this paper some new parallel difference schemes with interface extrapolation terms for a quasi-linear parabolic system of equations are constructed. Two types of time extrapolations are proposed to give the interface values on the interface of sub-domains or the values adjacent to the interface points, so that the unconditional stable parallel schemes with the second accuracy are formed. Without assuming heuristically that the original boundary value problem has the unique smooth vector solution, the existence and uniqueness of the discrete vector solutions of the parallel difference schemes constructed are proved. Moreover the unconditional stability of the parallel difference schemes is justified in the sense of the continuous dependence of the discrete vector solution of the schemes on the discrete known data of the original problems in the discrete W2(2,1) (Q△) norms. Finally the convergence of the discrete vector solutions of the parallel difference schemes with interface extrapolation terms to the unique generalized solution of the original quasi-linear parabolic problem is proved. Numerical results are presented to show the good performance of the parallel schemes, including the unconditional stability, the second accuracy and the high parallelism.

关键词： parallel difference scheme interface extrapolation quasi-linear parabolic system unconditional stability convergence 65M06 65M12 65M55

Identification of a novel splice site mutation in the DNAAF4 gene of a Chinese patient with primary ciliary dyskinesia

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Asian Journal of Andrology 2023年第6期25卷 713-718页

作者： Yang xu Jing Wang Ji-Hai Liu Qing-qiang Gao Bing Wang zhi-Peng xu Department of Andrology Nanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolNanjing 210008China

Primary ciliary dyskinesia(PCD)is a rare hereditary orphan condition that results in variable phenotypes,including *** 50 gene variants are reported in the scientific literature to cause PCD,and among them,dynein axonemal assembly factor 4(DNAAF4)has been recently ***4 has been implicated in the preassembly of a multiunit dynein protein essential for the normal function of locomotory cilia as well as *** the current study,a single patient belonging to a Chinese family was recruited,having been diagnosed with PCD and *** affected individual was a 32-year-old male from a nonconsanguineous *** also had abnormal spine structure and spinal cord bends at angles diagnosed with *** reports,laboratory results,and imaging data were ***-exome sequencing,Sanger sequencing,immunofluorescence analysis,hematoxylin-eosin staining,and in silico functional analysis,including protein modeling and docking studies,were *** results identified DNAAF4 disease-related variants and confirmed their *** analysis through whole-exome sequencing identified two pathogenic biallelic variants in the affected *** identified variants were a hemizygous splice site c.784-1G>A and heterozygous 20.1 Kb deletion at the DNAAF4 locus,resulting in a truncated and functionless DNAAF4 *** analysis indicated that the inner dynein arm was not present in the sperm flagellum,and sperm morphological analysis revealed small sperm with twisted and curved flagella or lacking *** current study found novel biallelic variants causing PCD and asthenoteratozoospermia,extending the range of DNAAF4 pathogenic variants in PCD and associated with the etiology of *** findings will improve our understanding of the etiology of PCD.

关键词： DNAAF primary ciliary dyskinesia scoliosis splice site

ID effects on beam dynamics in the SSRF-U storage ring

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Nuclear Science and Techniques 2023年第11期34卷 140-154页

作者： Li‑Yuan Tan Shun‑qiang Tian Xin‑Zhong Liu xu Wu Wen‑zhi Zhang Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China University of Chinese Academy of Sciences Beijing 100049China Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201204China

This paper introduces the proposed insertion device(ID)scheme for the Shanghai Synchrotron Radiation Facility *** on this scheme,the influences of the ID radiation on the intra-beam scattering emittance and energy spread were *** distortion caused by the IDs was comprehensively examined and compensated using both local and global ***,a frequency map analysis method was used to identify potentially dangerous resonance *** addition,the dynamic aperture,energy acceptance,and Touschek lifetime were calculated after considering high-order magnetic field errors to ensure that the ID effect did not affect the operation of the storage ring.

关键词： SSRF-U Insertion devices Emittance Beam dynamic

Novel pricing model for spectrum leasing in secondary spectrum market

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The Journal of China Universities of Posts and Telecommunications 2010年第5期17卷 12-19页

作者： WANG Lei xu Xing-kun xu Wen-jun HE zhi-qiang LIN Jia-ru Key Laboratory of Universal Wireless Communications Ministry of Education Beijing University of Posts and Telecommunications Beijing 100876 China

According to the property rights model of cognitive radio,primary users who own the spectral resource have the right to lease or trade part of it to secondary users in exchange for appropriate *** this paper,an implementation of this framework is investigated,where a primary link can lease the owned spectrum to secondary nodes in exchange for cooperation （relaying）.A novel pricing model is proposed that enables the trading between spectrum and *** on the demand of secondary nodes,the primary link attempts to maximize its quality of service （QoS） by setting the price of *** the price asked by primary link,the secondary nodes aim to obtain most profits by deciding the amount of spectrum to buy and then pay for it by cooperative *** investigated model is conveniently cast in the framework of seller/buyer （Stackelberg） *** and numerical results show that our pricing model is effective and practical for spectrum leasing based on trading spectral resource for cooperation.

关键词： cognitive radio property rights cooperative transmission spectrum leasing secondary spectrum market

Palladium-catalyzed alkynylative[5+1]carboannulation of 1,3-diarylprop-2-yn-1-yl acetates with terminal alkynes enabled by C-H functionalization

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Organic Chemistry Frontiers 2022年第5期9卷 1389-1394页

作者： Jiang-Xi Yu Li-Jun Wu zhi-qiang Wang zhi-Feng xu Jin-Heng Li Key Laboratory of Functional Meta-Organic Compounds of Hunan Province Key Laboratory of Functional Organometallic Materials(University of Hunan Province)Hengyang Normal UniversityHengyang 421008China College of Sciences Central South University of Forestry and TechnologyChangsha410004China Key Laboratory of Jiangxi Province for Persistent Pollutants Control and Resources Recycle Nanchang Hangkong UniversityNanchang 330063China School of Chemistry and Chemical Engineering Henan Normal UniversityXinxiangHenan 475004China

A new method for the synthesis of 3-ethynyl-1-methylene-1,2-dihydronaphthalenes via copper-pro-moted palladium-catalyzed intermolecular alkynylative[5+1]carboannulation of 1-arylphenyl-prop-2-yn-1-yl acetates involving C–H functionalization is *** terminal alkyne molecules serve as an alkynylation reagent and a one-carbon unit to enable alkynylative[5+1]carboannulation with excellent selectivity control,broad substrate scope and good tolerance of functional groups.

关键词： catalyzed Palladium palladium

河南省26例甲型副伤寒沙门菌聚集性病例的病原学研究及溯源分析

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中国人兽共患病学报 2016年第12期32卷 1122-1125页

作者：赵嘉咏张白帆穆玉姣苏佳黄学勇夏胜利谢志强许汴利河南省疾病预防控制中心郑州450016

目的分析2015年3-7月份河南省登封市分离自临床诊断为副伤寒聚集性病例的甲型副伤寒（*** A）沙门菌病原学特征及分子流行病学关联。方法采集副伤寒病例患者的静脉血8~10mL,双相血培养瓶37℃培养4~7d,沙门菌科玛嘉选择性培养基分离培养... 详细信息

目的分析2015年3-7月份河南省登封市分离自临床诊断为副伤寒聚集性病例的甲型副伤寒（*** A）沙门菌病原学特征及分子流行病学关联。方法采集副伤寒病例患者的静脉血8~10mL,双相血培养瓶37℃培养4~7d,沙门菌科玛嘉选择性培养基分离培养,系统生化鉴定,丹麦SSI分型血清进行沙门菌O抗原及H1/2相鞭毛诱导血清凝集试验。根据PulseNet China病原体分子分型网络实验室公布的沙门菌脉冲场凝胶电泳（PFGE）操作指南与美国临床实验室标准化协会（CLSI）沙门菌K-B法药敏测试方案对其进行XbaI/BlnI双酶切PFGE分子分型与聚类分析及8类13种抗生素药敏测试。结果从29例病人血培养物中共分离到26株甲型副伤寒沙门菌,其经XbaI与BlnI限制性双酶切和PFGE电泳后带型完全一致（PTYA1）;药敏测试结果显示24株甲型副伤寒沙门菌耐药表型一致。结论病原学诊断及PFGE分子分型结果证实了26例甲型副伤寒沙门菌感染病例间可能存在高度的聚集性与分子流行病学关联,为进一步的追踪溯源和调查取证提供了技术支撑。

关键词：甲型副伤寒沙门菌聚集性病例药敏测试 PFGE

Review:Advances in research of stress-assisted corrosion fatigue problem

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第2期8卷 221-227页

作者： TANG zhi-bo LI qiang Division of Engineering Zhejiang Ocean University Zhoushan 316004 China

Ceramic materials are notable for their rigidity, insulation and resistance to hostile environment, Nevertheless, if a stressed ceramic component is exposed to chemical attack, it may suffer from a form of delayed fracture known as static fatigue. From the point of view of a designer, it is clearly desirable to determine the behavior of sub-critical crack growth; the crack path and crack growth rate, as a function of material properties and loading conditions are of particular interest. This paper presents a review of advances in stress assisted corrosion problem in history and its corresponding numerical approaches in the last decades, and finally, comes uo with consideration and crucial suggestions for future work.

关键词： Stress corrosion Finite element method (FEM) Fracture Static fatigue Meshless local Petrov-Galerkin (MLPG)

Deep-detection of formation boundary using transient multicomponent electromagnetic logging measurements

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Petroleum Science 2022年第3期19卷 1085-1098页

作者： Xi-Yong Yuan Shao-Gui Deng zhi-qiang Li Xiao-Mei Han xu-Fei Hu Key Laboratory of Deep Oil and Gas China University of Petroleum(East China)QingdaoShandong266580China Sinopec Matrix Corporation QingdaoShandong266000China China Research Institute of Radiowave Propagation XinxiangHenan453000China China University of Petroleum—Beijing at Karamay KaramayXinjiang834000China

The maximum distance at which an electromagnetic(EM)logging while drilling(LWD)tool detects an approaching boundary is defined as the depth of detection(DOD).Ultra-deep detection capability of the transient multicomponent EM logging measurement is investigated ***,we adopt sine and cosine transform to calculate the transient multicomponent *** to the cosine transform,sine transform is more accurate in solving late-time ***,a time-domain geosignal is introduced to sense the *** show that DOD of this transient EM measurement can be up to tens of meters,including directionally ***,by studying the decay characteristics of different components with time,cross component is confirmed to decay much faster than the coaxial/coplanar components in the formation coordinate system.A pseudo-inversion is thereby proposed to determine the dip angle of anisotropic stratified *** simulation results indicate that this algebraic method can determine the true dip at some particular *** is still stable and valid even when considering random measurement ***,we establish the linear relationship between the time at which the half-point of geosignal curve appears and the distance to boundary(DTB),which would assist in the quick determination of DTB.

关键词： Time-domain Logging while drilling Formation boundary Dip angle Distance to boundary

Deciphering the molecular mechanisms of Simiaowan in the treatment of hyperuricemia: in vivo and in silico approaches

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Traditional Medicine Research 2025年第2期10卷 37-54页

作者： Yong-Chang Zeng Jun-Hong Wu Dan-Dan xu Kang He Chang-Qing Liu Li-Fei Song Zheng-zhi Wu Qian-Qian Jiang Shao-Yu Liang Department of Neurology The First Affiliated Hospital of Shenzhen UniversityShenzhen 518020China Pharmaceutical Department The Affiliated TCM Hospital of Guangzhou Medical UniversityGuangzhou 510000China School of Pharmacy Guizhou University of Traditional Chinese MedicineGuiyang 550025China Guangzhou Zeli Medical Technology Co. Ltd.Guangzhou 510700China

Background:Simiaowan(SMW),a well-known traditional Chinese medicine,has been employed to treat hyperuricemia(HUA)and gout for ***,the bioactive components and underlying mechanisms have not been *** objective of this study was to identify the active components and potential mechanisms of SMW by integrating pharmacological experimentation,serum pharmacochemistry,network pharmacology and molecular ***:HUA rats modelling by high-fat/high-sugar diet and potassium oxonate/adenine oral administration were used to evaluate the pharmacodynamic effects of ***-Q-Exactive-MS/MS was employed to detect the bioactive components present in SMW-containing *** pharmacology and molecular docking were utilized to elucidate the potential targets and underlying ***:SMW effectively ameliorated HUA rats via the inhibition of uric acid(UA)production,promotion of UA excretion,improvement of lipid and glucose metabolic abnormalities,antioxidant,anti-inflammatory and anti-insulin resistance effects.A total of 73 compounds detected in SMW-containing serum were identified as potential active components,with alkaloids,flavonoids,organic acids,and terpenoids emerging as the primary active *** 203 corresponding targets were obtained as SMW anti-HUA/gout targets,which mainly participated in apoptosis,insulin resistance,TNF,PI3K-Akt,HIF-1,NF-κB,MAPK,IL-17 and TLR signaling *** docking indicated that active compounds(***,phellodendrine,quercetin,formononetin,ferulic acid)had superior binding abilities to the key targets(*** carrier family 22 member 12(URAT1),solute carrier family 22 member 6(OAT1),ATP-binding cassette sub-family G member 2(ABCG2),solute carrier family 2,facilitated glucose transporter member 9(GLUT9),xanthine dehydrogenase/oxidase(XDH),transcription factor p65(RELA),toll-like receptor 4(TLR4),prostaglandin G/H synthase 2(PTGS2),caspase-3(CASP3),insulin(INS)).Conclusion:S

关键词： hyperuricemia network pharmacology serum pharmacochemistry Simiaowan UPLC-Q-Exactive-MS/MS