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Thermodynamic study on the interaction between anti-tumor drug tegafur and human serum albumin

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Chinese Chemical Letters 2007年第7期18卷 891-894页

作者： Lin Wei Li Dong Dong Wang De zhi Sun min liu You Ying Di Hua Chao Yan College of Chemistry and Chemical Engineering Liaocheng University Liaocheng 252059 China

The changes of thermodynamic properties of the system on interaction between tegafur and human serum albumin （HSA） and the changes of secondary structure units of HSA in the system at 298.15 K have been investigated by the Nano-Watt-Scale isothermal titration calorimetry （ITC）, the Langmuirs binding model and the circular dichroism （CD） spectrometry.

关键词： Tegafur Human serum albumin Isothermal titration calorimetry Circular dichroism

Leukocyte cell-derived chemotaxin 2(LECT2)regulates liver ischemia-reperfusion injury

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Liver Research 2024年第3期8卷 165-171页

作者： Meng-Qi Dong Yuan Xie zhi-Liang Tang Xue-Wen Zhao Fu-Zhen Lin Guang-Yu Zhang zhi-Hao Huang zhi-min liu Yuan Lin Feng-Yong liu Wei-Jie Zhou State Key Laboratory of Organ Failure Research Department of General SurgeryGuangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal TumorNanfang HospitalSouthern Medical UniversityGuangzhouGuangdongChina Department of Hepato-Biliary-Pancreatic and Hernia Surgery The First People's Hospital of ZhaoqingZhaoqingGuangdongChina Department of Interventional Radiology Senior Department of OncologyFifth Medical Center of PLA General HospitalBeijingChina

Background and aim Hepatic ischemia–reperfusion injury(IRI)is a significant challenge in liver transplantation,trauma,hypovolemic shock,and hepatectomy,with limited effective interventions *** study aimed to investigate the role of leukocyte cell-derived chemotaxin 2(LECT2)in hepatic IRI and assess the therapeutic potential of Lect2-short hairpin RNA(shRNA)delivered through adeno-associated virus(AAV)*** and methods This study analyzed human liver and serum samples from five patients undergoing the Pringle ***2-knockout and C57BL/6J mice were *** IRI was induced by clamping the hepatic *** included recombinant human LECT2(rLECT2)and ***2 expression levels and serum biomarkers including alanine aminotransferase(ALT),aspartate aminotransferase(AST),creatinine,and blood urea nitrogen(BUN)were *** analysis of liver necrosis and quantitative reverse-transcription polymerase chain reaction were *** Serum and liver LECT2 levels were elevated during hepatic *** LECT2 protein and mRNA levels increased post ***2-knockout mice had reduced weight loss;hepatic necrosis;and serum ALT,AST,creatinine,and BUN ***2 treatment exacerbated weight loss,hepatic necrosis,and serum biomarkers(ALT,AST,creatinine,and BUN).AAV-Lect2-shRNA treatment significantly reduced weight loss,hepatic necrosis,and serum biomarkers(ALT,AST,creatinine,and BUN),indicating therapeutic *** Elevated LECT2 levels during hepatic IRI increased liver *** knockout or shRNA-mediated knockdown of Lect2 reduced liver damage,indicating its therapeutic ***-mediated Lect2-shRNA delivery mitigated hepatic IRI,offering a potential new treatment strategy to enhance clinical outcomes for patients undergoing liver-related surgeries or trauma.

关键词： Hepatic ischemia-reperfusion injury(IRI) Leukocyte cell-derived chemotaxin 2 (LECT2) Adeno-associated virus(AAV)

Outcomes in patients with Fournier’s gangrene originating from the anorectal region with a particular focus on those without perineal involvement

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Gastroenterology Report 2019年第3期7卷 212-217,I0003页

作者： Hong-Cheng Lin Zu-Qing Chen Hua-Xian Chen Qiu-Lan He zhi-min liu zhi-Yang Zhou Rong Shi Dong-Lin Ren Department of Coloproctology The Sixth Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong 510655China Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases GuangzhouGuangdong 510655China Guangdong Institute of Gastroenterology GuangzhouGuangdong 510655China Department of Colorectal Surgery People’s Hospital Affiliated to Fujian University of Traditional ChineseFuzhouFujian 350004China Department of Anaesthesiology The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong 510080China Department of Radiology the Sixth Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong 510655China

Background and aim:Fournier’s gangrene(FG)is a fulminant infection in the external genital region and *** present study explored the clinical features of FG originating from the anorectal region,from primary conditions such as anal fistulas and ***:A retrospective analysis was performed in order to identify the factors associated with clinical outcomes in FG patients derived from two hospitals—the Sixth Affiliated Hospital of Sun Yat-sen University and People’s Hospital Affiliated to Fujian University of Traditional Chinese—over the period from May 2013 to April ***:Sixty FG patients were included in this *** common causative microorganisms cultured were Escherichia coli *** and perirectal regional involvement was evident in 52 and 59 cases,respectively,although the perineum was unaffected in 7 cases(12%),as confirmed by imaging examination and surgical *** with early radical debridement and broad-spectrum antibiotic therapy is effective with an acceptably sepsis mortality(1.7%).Ten patients underwent protective *** patient underwent an orchidectomy and required urinary ***:FG originating from the anorectal region can be rapidly progressive and *** can spread superiorly to the genital region without the involvement in perineal *** aggressive surgical debridement of nonviable tissue is essential for satisfactory outcomes and a protective colostomy is not mandatory.

关键词： Fournier’s gangrene perianal abscess anal fistula protective colostomy

High sensitivity C-reactive protein and cardfiac resynchronization therapy in patients with advanced heart failure

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Journal of Geriatric Cardiology 2014年第4期11卷 296-302页

作者： Chi CAI Wei HUA Li-Gang DING Jing WANG Ke-Ping CHEN Xin-Wei YANG zhi-min liu Shu ZHANG Cardiac Arrhythmia Center Fuwai Hospital Beilishi road No. 167 Xicheng district Beijing 100037 China

Background The data on the prognostic values of high sensitivity C-reactive protein （hsCRP） levels in patients with advanced symp-tomatic heart failure （HF） receiving cardiac resynchronization therapy （CRT） are scarce. The aim of present study was to investigate the association of serum hsCRP levels with left ventricle reverse remodeling after six months of CRT as well as long-term outcome. Methods A total of 232 CRT patients were included. The assessment of hsCRP values, clinical status and echocardiographic data were performed at baseline and after six months of CRT. Long-term follow-up included all-cause mortality and hospitalizations for HF. Results During the mean follow-up periods of 31.3 ± 31.5 months, elevated hsCRP （〉3 mg/L） prior to CRT was associated with a significant 2.39-fold increase （P=0.006） in the risk of death or HF hospitalizations. At 6-month follow-up, patients who responded to CRT showed significant reductions or maintained low in hsCRP levels （–0.5 ± 4.1 mg/L reduction） compared with non-responders （1.7 ± 6.1 mg/L increase, P=0.018）. Com-pared with patients in whom 6-month hsCRP levels were reduced or remained low, patients in whom 6-month hsCRP levels were increased or maintained high experienced a significantly higher risk of subsequent death or HF hospitalizations （Log-rank P〈0.001）. The echocardio-graphic improvement was also better among patients in whom 6-month hsCRP levels were reduced or remained low compared to those in whom 6-month hsCRP levels were raised or maintained high. Conclusions Our findings demonstrated that measurement of baseline and follow-up hsCRP levels may be useful as prognostic markers for timely potential risk stratification and subsequent appropriate treatment strategies in patients with advanced HF undergoing CRT.

关键词： Cardiac resynchronization therapy Clinical outcome Heart failure High sensitivity C-reactive protein

Identification of molecular biomarkers for the diagnosis of gastric cancer and lymph-node metastasis

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Gastroenterology Report 2019年第1期7卷 57-66,I0002页

作者： Sharvesh Raj Seeruttun Wing Yan Cheung Wei Wang Cheng Fang zhi-min liu Jin-Qing Li Ting Wu Jun Wang Chun Liang zhi-Wei Zhou Department of Gastric Surgery Sun Yat-sen University Cancer CenterGuangzhouGuangdong 510060P.R.China State Key Laboratory of Oncology in South China GuangzhouGuangdong 510060P.R.China Collaborative Innovation Center for Cancer Medicine GuangzhouGuangdong 510060P.R.China Division of Life Science Center for Cancer Research and State Key Lab for Molecular NeuroscienceHong Kong University of Science and TechnologyHong KongP.R.China Fok Ying Tung Research Institute Hong Kong University of Science and TechnologyHong KongP.R.China Biomedical Research Institute Shenzhen-Peking University-Hong Kong University of Science and Technology Medical CenterShenzhenGuangdong 518036P.R.China

Background and objective:Biomarkers are important tools for prompt diagnosis of *** study aimed to identify reliable biomarkers for clinical applications in the diagnosis of gastric cancer and lymph-node(LN)***:Between 1 December 2014 and 31 December 2015,we prospectively collected samples of gastric-cancer tissues,corresponding matched-pair normal gastric mucosa,and their peri-gastric metastatic and non-metastatic LNs to identify quantitatively reliable genes using quantitative real-time polymerase chain *** quantity(RQ)was used to calculate the mRNA expression levels of our target *** were calculated using one-way analysis of variance(ANOVA)and Tukey’s multiple comparison *** graphs were plotted using GraphPad ***:Of nine assessed genes,the mRNA levels of inhibin beta A(INHBA)and secreted phosphoprotein 1(SPP1)were most consistently highly expressed in tumor tissues by 15.4-and 15.6-fold,respectively,as compared with normal tissues(P<0.001),with 91.3%sensitivity and 95.7%specificity(receiver operating characteristic[ROC]curve area=0.974)for the former and 82.6%sensitivity and 87.0%specificity(ROC curve area=0.924)for the *** analysis revealed no differentiating significance of SPP1 mRNA expression between metastatic and non-metastatic LNs(P=0.470).In contrast,the INHBA mRNA level was up-regulated 4.1-fold in metastatic LNs(P<0.001),with 80.0%sensitivity and 81.5%specificity(ROC curve area=0.857),and was also able to successfully differentiate between more severe disease conditions,T3 and T4(P=0.003),M0 and M1(P=0.043)and different histological variants(intestinal type vs diffuse type,P=0.019).Conclusions:Our results showed that INHBA was the most optimally reliable biomarker for diagnosing gastric cancer and LN metastasis.

关键词： Diagnosis gastric cancer lymph node metastasis molecular biomarker

Plasma big endothelin-1 is an effective predictor for ventricular arrythmias and end-stage events in primary prevention implantable cardioverter-defibrillator indication patients

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Journal of Geriatric Cardiology 2020年第7期17卷 427-433页

作者： Xiao-Yao LI Shuang ZHAO Xiao-Han FAN Ke-Ping CHEN Wei HUA zhi-min liu Xiao-Di XUE Bin ZHOU Shu ZHANG Arrhythmia Center State Key Laboratory of Cardiovascular DiseaseFuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

Objective To investigate whether plasma big endothelin-1(ET-1) predicts ventricular arrythmias(VAs) and end-stage events in primary prevention implantable cardioverter-defibrillator(ICD) indication patigents. Methods In total, 207 patients fulfilling the inclusion criteria from Fuwai Hospital between January 2013 and December 2015 were retrospectively analyzed. The cohort was divided into three groups according to baseline plasma big ET-1 tertiles: tertile 1( 0.7 pmol/L, n = 70). The primary endpoints were VAs. The secondary endpoints were end-stage events comprising all-cause mortality and heart transplantation. Results During a mean follow-up period of 25.6 ± 13.9 months, 38(18.4%) VAs and 78(37.7%) end-stage events occurred. Big ET-1 was positively correlated with NYHA class(r = 0.165, P = 0.018), serum creatinine concentration(Scr;r = 0.147, P = 0.034), high-sensitivity C-reactive protein(hs-CRP;r = 0.217, P = 0.002), Lg NT-pro BNP(r = 0.463, P < 0.001), left ventricular end diastolic diameter(LVEDD;r = 0.234, P = 0.039) and negatively correlated with left ventricular ejection fraction(LVEF;r =-0.181, P = 0.032). Kaplan-Meier analysis showed that elevated big ET-1 was associated with increased risk of VAs and end-stage events(P < 0.05). In multivariate Cox regression models, big ET-1 was an independent risk factor for VAs(hazard ratio(HR) = 3.477, 95% confidence interval(CI): 1.352–8.940, P = 0.010, tertile 2 vs. tertile 1;HR = 4.112, 95% CI: 1.604–10.540, P = 0.003, tertile 3 vs. tertile 1) and end-stage events(HR = 2.804, 95% CI: 1.354–5.806, P = 0.005, tertile 2 vs. tertile 1;HR = 4.652, 95% CI: 2.288–9.459, P < 0.001, tertile 3 vs. tertile 1). Conclusions In primary prevention ICD indication patients, plasma big ET-1 levels can predict VAs and end-stage events and may facilitate ICD-implantation risk stratification.

关键词： Big endothelin-1 End-stage events Implantable cardioverter-defibrillator implantation Primary prevention Ventricular arrythmias

Contrast Dose and Radiation Dose Reduction in Abdominal Enhanced Computerized Tomography Scans with Single-phase Dual-energy Spectral Computerized Tomography Mode for Children with Solid Tumors

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Chinese Medical Journal 2017年第7期130卷 823-831页

作者： Tong Yu Jun Gao zhi-min liu Qi-Feng Zhang Yong liu Ling Jiang Yon Peng Imaging Center Beijing Children's Hospital Capital Medical University Beijing 100045 China

Background：Contrast dose and radiation dose reduction in computerized tomography （CT） scan for adult has been explored successfully,but there have been few studies on the application of low-concentration contrast in pediatric abdominal CT *** was a feasibility study on the use of dual-energy spectral imaging and adaptive statistical iterative reconstruction （ASiR） for the reduction of radiation dose and iodine contrast dose in pediatric abdominal CT patients with solid ***：Forty-five patients with solid tumors who had initial CT （Group B） and follow-up CT （Group A） after chemotherapy were *** initial diagnostic CT scan （Group B） was performed using the standard two-phase enhanced CT with 320 mgI/ml concentration contrast,and the follow-up scan （Group A） was performed using a single-phase enhanced CT at 45 s after the beginning of the 270 mgI/ml contrast injection using spectral *** percent ASiR was used for the images in Group B and monochromatic images with energy levels ≥60 keV in Group *** addition,filtered back-projection （FBP） reconstruction was used for monochromatic images 〈60 keV in Group *** total radiation dose,total iodine load,contrast injection speed,and maximum injection pressure were compared between the two *** 40 keV and 60 keV spectral CT images of Group A were compared with the images of Group B to evaluate overall image ***：The total radiation dose,total iodine load,injection speed,and maximum injection pressure for Group A were decreased by 19%,15%,34.4%,and 18.3%,*** optimal energy level in spectral CT for displaying the abdominal vessels was 40 *** this level,the CT values in the abdominal aorta and its three branches,the portal vein and its two branches,and the inferior vena cava were all greater than 340 hounsfield unit （HU）.The abdominal organs of Groups A and B had similar degrees of absolute and relative enhancement （t =0.36 and-1.716 for liver,0.153 and-1.546

关键词： Contrast Dose Reduction Pediatric Radiation Dose Reduction Solid Tunlors

Association of time-varying changes in physical activity with cardiac death and all-cause mortality after ICD or CRT-D implantation

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Journal of Geriatric Cardiology 2022年第3期19卷 177-188页

作者： Xue-Rong SUN Chen-Di CHENG Bin ZHOU Shuang ZHAO Ke-Ping CHEN Wei HUA Yan-Gang SU Wei XU Fang WANG Xiao-Han FAN Yan DAI zhi-min liu Shu ZHANG Arrhythmia Center State Key Laboratory of Cardiovascular DiseaseFuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Cardiology Laboratory of Heart CenterZhujiang HospitalSouthern Medical UniversityGuangzhouChina Department of Cardiology Shanghai Institute of Cardiovascular DiseasesZhongshan HospitalFudan UniversityShanghaiChina Department of Cardiology Nanjing Drum Tower HospitalNanjingChina Department of Cardiology Shanghai First People's HospitalShanghai Jiao Tong University School of MedicineShanghaiChina

OBJECTIVE To evaluate the association of longitudinal changes in physical activity(PA)with long-term outcomes after im-plantable cardioverter-defibrillator(ICD)or cardiac resynchronization therapy defibrillator(CRT-D)*** Patients with ICD/CRT-D implantation from SUMMIT registry were retrospectively ***-de-rived PA changes over 12 months post implantation were obtained from the archived home monitoring *** primary end-points were cardiac death and all-cause *** secondary endpoints were the first ventricular arrthymia(VA)and first ap-propriate ICD *** In 705 patients,446(63.3%)patients showed improved PA over 12 months after *** a mean 61.5-month follow-up duration,99 cardiac deaths(14.0%)and 153 all-cause deaths(21.7%)*** to reduced/un-changed PA,improved PA over 12 months could result in significantly reduced risks of cardiac death(improved PA≤30 min:hazard ratio(HR)=0.494,95%CI:0.288−0.848;>30 min:HR=0.390,95%CI:0.235−0.648)and all-cause mortality(improved PA≤30 min:HR=0.467,95%CI:0.299−0.728;>30 min:HR=0.451,95%CI:0.304−0.669).No differences in the VAs or ICD shocks were observed across different groups of PA *** changes can predict the risks of cardiac death only in the low baseline PA group,but improved PA was associated with 56.7%,57.4%,and 62.3%reduced risks of all-cause mortality in the low,moderate,and high baseline PA groups,respectively,than reduced/unchanged *** Improved PA could protect aganist cardiac death and all-cause mortality,probably reflecting better clinical efficacy after ICD/CRT-D ***-intensity exercise training might be encouraged among patients with different baseline PA levels.

关键词： cardiac mortality implantation

Controlling the Molecular Weight and Molecular Weight Distribution using Compressed CO_2 Antisolvent

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Chinese Chemical Letters 2000年第10期11卷 933-934页

作者： Jun liu, zhi min liu, Bu Xing HAN, Jian WANG, Qing HUO, Fang Fang liu (Center For Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080 (Chemical Engineering College of Beijing United University, Beijing 100023) (Department of Chemical Engineering, University of Science and Technology of Hebei, Shijiazhuang 050018) Chinese Acad Sci Inst Chem Ctr Mol Sci Beijing 100080 Peoples R China Beijing United Univ Chem Engn Coll Beijing 100023 Peoples R China Univ Sci & Technol Hebei Dept Chem Engn Shijiazhuang 050018 Peoples R China

Effect of CO2 dissolved in tetrahydrofuran (THF) on the polymerization of styrene in THF was studied at 333.2 K and different pressures. It was found that the molecular weight (MW) and MW distribution of the polystyre... 详细信息

关键词： CO_2 antisolvent styrene polymerization