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Antitumor Effect of Apcin on Endometrial Carcinoma via p21-Mediated Cell Cycle Arrest and Apoptosis

Current Medical Science 2024年第3期44卷 623-632页

作者： Ke NI Zi-li LI zhi-yong hu Li HONG Department of Obstetrics and Gynecology Renmin Hospital of Wuhan UniversityWuhan430060China Institute of Reproductive Health Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China

Objective Endometrial carcinoma(EC)is a prevalent gynecological malignancy characterized by increasing incidence and mortality *** underscores the critical need for novel therapeutic *** such potential target is cell division cycle 20(CDC20),which has been implicated in *** study investigated the effect of the CDC20 inhibitor Apcin on EC and elucidated the underlying mechanism *** The effects of Apcin on EC cell proliferation,apoptosis,and the cell cycle were evaluated using CCK8 assays and flow *** sequencing(RNA-seq)was subsequently conducted to explore the underlying molecular mechanism,and Western blotting and coimmunoprecipitation were subsequently performed to validate the *** studies were performed to evaluate the antitumor effects in *** analysis was also conducted to identify CDC20 as a potential therapeutic target in *** Treatment with Apcin inhibited proliferation and induced apoptosis in EC cells,resulting in cell cycle *** associated with apoptosis and the cell cycle were activated following treatment with ***,Apcin treatment led to the upregulation of the cell cycle regulator p21,which was verified to interact with CDC20 and consequently decrease the expression of downstream cyclins in EC *** vivo experiments confirmed that Apcin treatment significantly impeded tumor *** CDC20 expression was observed in EC tissue than in nonmalignant tissue,and increased CDC20 expression in EC patients was associated with shorter overall survival and progress free *** CDC20 is a novel molecular target in EC,and Apcin could be developed as a candidate antitumor drug for EC treatment.

关键词： endometrial carcinoma CDC20 apoptosis cell cycle arrest p21 BBC3

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Energy-efficient virtual machine consolidation algorithm in cloud data centers

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Journal of Central South University 2017年第10期24卷 2331-2341页

作者： ZHOU Zhou hu zhi-gang YU Jun-yang School of Software Central South University School of Information Technology Deakin University

Cloud data centers consume a multitude of power leading to the problem of high energy consumption. In order to solve this problem, an energy-efficient virtual machine(VM) consolidation algorithm named PVDE(prediction-based VM deployment algorithm for energy efficiency) is presented. The proposed algorithm uses linear weighted method to predict the load of a host and classifies the hosts in the data center, based on the predicted host load, into four classes for the purpose of VMs migration. We also propose four types of VM selection algorithms for the purpose of determining potential VMs to be migrated. We performed extensive performance analysis of the proposed algorithms. Experimental results show that, in contrast to other energy-saving algorithms, the algorithm proposed in this work significantly reduces the energy consumption and maintains low service level agreement(SLA) violations.

关键词： cloud computing energy consumption linear weighted method virtual machine consolidation virtual machine selection algorithm

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Spectroscopic Properties and Three-photon Absorption Induced Optical Limiting of Series of Novel Nonlinear Chromophores

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Chinese Journal of Chemical Physics 2008年第3期21卷 227-232页

作者： Fu-quan Guo Xiao-lao Sun Hao Liang zhi-yuan hu Qi-jin Zhang Hai Ming Department of Materials Engineering Luoyang Institute of Science and Technology Luoyang 471023 China Department of Chemical Engineering Huizhou University Guangdong 516007 China Department of Polymer Science and Engineering University of Science and Technology of China Hefei 230026 China Department of Physics University of Science and Technology of China Hefei 230026 China

Three novel nonlinear chromophores with symmetric D-π-D molecular structure and extended conjugated length were synthesized. Solvatochromism analysis shows great symmetric intramolecular charge transfer occurring in chromophores by the enhancement in the dipole moment between the ground and excited states. The properties of optical power limiting induced by three-photon absorption （3PA） are demonstrated. Large 3PA coefficients and the corresponding molecular cross sections as high as 10^-74 cm^6s^2 were obtained for nanosecond laser pulses at 1.06μm from nonlinear transmission measurements.

关键词： Nonlinear chromophores Solvatochromism Three-photon absorption Optical limiting

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XAFS applications in semiconductors

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Nuclear Science and Techniques 2006年第6期17卷 370-388页

作者： WEI Shi-Qiang SUN zhi-hu PAN zhi-Yun ZHANG Xin-Yi YAN Wen-Sheng ZHONG Wen-Jie National Synchrotron Radiation Laboratory University of Science and Technology of China Hefei 230029 China Department of Physics Surface Physics Laboratory （National Key laboratory） and Synchrotron Radiation Research Center Fudan University Shanghai 200433. China

X-ray absorption fine structure (XAFS) has experienced a rapid development in the last three decades and has proven to be a powerful structural characterization technique nowadays. In this review, the XAFS basic principles including the theory, the data analysis, and the experiments have been introduced in detail. To show its strength as a local structure probe, the XAFS applications in semiconductors are summarized comprehensively, that is, thin films, quantum wells and dots, dilute magnetic semiconductors, and so on. In addition, certain new XAFS-related techniques, such as in-situ XAFS, micro-XAFS, and time-resolved XAFS are also shown.

关键词： XAFS应用半导体 X射线吸收基本原理

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Morbidity and Mortality of Nosocomial Infection after Cardiovascular Surgery： A Report of 1606 Cases

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Current Medical Science 2018年第2期38卷 329-335页

作者： Wan-li JIANG Xiao-ping hu zhi-peng hu Zheng TANG Hong-bing WU Liang-hao CHEN zhi-wei WANG Ying-an JIANG Department of Cardiovascular Surgery Renmin Hospital of Wuhan UniversityWuhan 430060 China Department of Infectious Diseases Renmin Hospital of Wuhan UniversityWuhan 430060 China

Nosocomial infection （NI） is one of the most significant complications arising after open heart surgery, and leads to increased mortality, hospitalization time and health resource allocation. This study investigated the morbidity, mortality, and independent risk factors associated with NI following open heart surgery. We retrospectively surveyed the records of 1606 consecutive cardiovascular surgical patients to identify those that developed NI. The NI selection criteria were based on the Centers for Disease Control and Prevention （CDC） guidelines. The term NI encompasses surgical site infection （SSI）, central venous catheter-related infection （CVCRI）, urinary tract infection （UTI）, respiratory tract infection and pneumonia （RTIP）, as well as other types of infections. Of 1606 cardiovascular surgery patients, 125 developed NI （7.8%, 125/1606）. The rates of NI following surgery for congenital malformation, valve replacement, and coronary artery bypass graft were 2.6% （15/587）, 5.5% （26/473） and 13.6% （32/236）, respectively. The NI rate following surgical repair of aortic aneurysm or dissection was 16.8% （52/310）. Increased risk of NI was detected for patients with a prior preoperative stay 〉3 days （OR=2.11, 95% CI=1.39-3.20）, diabetes （OR=2.00, 95%=CI 1.26-3.20）, length of surgery 〉6 h （OR=2.26, 95% CI=1.47-3.47）, or postoperative cerebrovascular accident （OR=4.08, 95% CI=1.79-9.29）. Greater attention should be paid toward compliance with ventilator and catheter regulations in order to decrease NI morbidity and mortality following cardiovascular procedures.

关键词： nosocomial infection cardiovascular surgery morbidity mortality

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Atomic defects,functional groups and properties in MXenes

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Chinese Chemical Letters 2021年第1期32卷 339-344页

作者： Wenjun Cui zhi-Yi hu Raymond RUnocic Gustaaf Van Tendeloo Xiahan Sang State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China NRC(Nanostructure Research Centre) Wuhan University of TechnologyWuhan 430070China Center for Nanophase Materials Sciences Oak Ridge National LaboratoryOak RidgeTN 37831United States EMAT(Electron Microscopy for Materials Science) University of AntwerpAntwerpB-2020Belgium

MXenes,a new family of functional two-dimensional(2 D) materials,have shown great potential for an extensive variety of applications within the last *** defects and functional groups in MXenes are known to have a tremendous influence on the functional *** this review,we focus on recent progress in the characterization of atomic defects and functional group chemistry in MXenes,and how to control them to directly influence various properties(e.g.,electron transport,Li^(+) adsorption,hydrogen evolution reaction(HER) activity,and magnetism) of 2 D MXenes *** structural transformations such as oxidation and growth induced by atomic defects in MXenes are also *** review thus provides perspectives on property optimization through atomic defect engineering,and bottom-up synthesis methods based on defect-assisted homoepitaxial growth of MXenes.

关键词： MXenes Atomic defects Surface functional groups Electron microscopy Functional properties

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Identification and Kinetics Study on the Transformation of Mevinolin in Acidic Alcohol Solution by High-performance Liquid Chromatography with Photodiode Array Detector or Mass Spectrometry

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Chemical Research in Chinese Universities 2006年第4期22卷 500-504页

作者： LI Yong-guo LIU Hong ZHANG Fang WANG Zheng-tao hu zhi-bi Key Laboratory of Standardization of Chinese Medicines of Ministry of Education Institute of Chinese Materia Medica Shanghai University of Traditional Chinese Medicine Shanghai 201203 P.R. China Shanghai R ＆ D Center for Standardization of Traditional Chinese Medicines Shanghai 201203 P.R. China State Key Laboratory of Drug Research Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai 201203 P. R. China

Mevinolin is one of the earlier statin drugs which is effective for the treatment of hypercholesterolemia, as an inhibitor of the HMG-CoA reductase. The transformations of mevinolin in acidic alcohol（ such as ethanol, methanol and isopropanol） solutions caused by solvent effects were revealed in the present article. The solvates, that is, mevinolinic methyl ester, mevinolinic ethyl ester and mevinolinic isopropyl ester, were identified by LC/PDA and LC/MS. The kinetics parameters of the transformations caused by solvent effects, such as the observed rate constant of mevinolin （kobs）, the maximum concentration（ Cmax ）, and its corresponding maximum time（ t time for the acid form to reach the maximum concentration） of mevinolinic acid, are discussed. The influencing factors, such as the kind of solvents, the acidic concentration, the initial mevinolin concentration, and the water content as well as temperature were investigated. Two kinds of comparative reactions, hydrolysis and alcoholysis, of mevinolin in solution were studied. This detailed study on the kinetics of mevinolin transformations is valuable and meaningful for the purification, preparation, injection manufacturing, extraction, storage, etc. , of mevinolin or other similar compounds. This work provides useful information for the quality control of mevinolin and mevinolin-like drugs as well.

关键词： Identification Kinetic study Solvates Mevinolin LC-PDA-ESI-MS

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Isolation and Structural Analysis of an Acidic Polysaccharide from Astragalus membranaceus （Fisch.） Bunge

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Journal of Integrative Plant Biology 2006年第11期48卷 1379-1384页

作者： Shun-Chun Wang Jun-Jie Shan Zheng-Tao Wang zhi-Bi hu Institute of Chinese Materia Medica Shanghai University of Traditional Chinese Medicine Shanghai 201203 China

A new water-soluble hetero-polysaccharlde, APSID3, was obtained from a hot-water extract of the roots of Astragalus membranaceus （Flsch.） Bunge by DEAE-Sepharose Fast Flow and Sephacryl S-300 chromatography. The molecular weight of APSID3 was estimated to be 5.79 × 10^5 Da. Based on a sugar composlUon analysis, methylatlon analysis, partial hydrolysis and 13C nuclear magnetic resonance experimentation, It was concluded that the minimal repeat unit of APSID3 was composed of one terminal arablnose, one 1,5-1Inked arabinose, one 1,3-1Inked rhamnose, one 1,3,4-1Inked rhamnose, five 1,4-1Inked methyl galacturonates and six 1,4-1inked methyl glucuronates.

关键词： Astragalus membranaceus hetero-polysaccharide isolation and purification structural analysis.

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A novel acidophile community populating waste ore deposits at an acid mine drainage site

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Journal of Environmental Sciences 2007年第4期19卷 444-450页

作者： HAO Chun-bo ZHANG Hong-xun BAI zhi-hui hu Qing ZHANG Bao-guo Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Beijing 100085 China.

Waste ore samples （pH 3.0） were collected at an acid mine drainage （AMD） site in Anhui, China. The present acidophillc microbial community in the waste ore was studied with 16S rRNA gene clone library and denaturing gradient gel electrophoresis （DGGE）. Eighteen different clones were identified and affiliated withActinobacteria, low G ＋ C Gram-positives, Thermomicrobia, Acidobacteria, Proteobacteria, candidate division TM7, and Planctomycetes. Phylogenetic analysis of 16S rRNA gene sequences revealed a diversity of acidophiles in the samples that were mostly novel. It is unexpected that the moderately thermophilic acidophiles were abundant in the acidic ecosystem and may play a great role in the generation of AMD. The result of DGGE was consistent with that of clone library analysis. These findings help in the better understanding of the generation mechanism of AMD and in developing a more efficient method to control AMD.

关键词： acid mine drainage acidophile 16S rRNA DGGE waste ore

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Existence of Solutions for p-Laplace Equations Subjected to Neumann Boundary Value Problem

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Journal of China University of Mining and Technology 2006年第3期16卷 381-384页

作者： hu zhi-gang RUI Wen-juan LIU Wen-bing School of Sciences China University of Mining ＆ Technology Xuzhou Jiangsu 221008 China

The existence of solutions for one dimensional p-Laplace equation （φp（u′））′=f（t,u,u′） with t∈（0,1） and Фp（s）=｜s｜^p-2 s, s≠0 subjected to Neumann boundary value problem at u′（0） = 0, u′（1） = 0. By using the degree theory, the sufficient conditions of the existence of solutions for p-Laplace equation subjected to Neumann boundary value condition are established.

关键词： p-Laplace equation neumann boundary value problem degree theory

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