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Indoor microbiome and allergic diseases:From theoretical advances to prevention strategies

Eco-Environment & Health 2022年第3期1卷 133-146页

作者： Xi Fu zheyuan ou Yu Sun School of Public Health Guangdong Pharmaceutical UniversityGuangzhou 510006China Guangdong Provincial Engineering Research Center of Public Health Detection and Assessment Guangdong Pharmaceutical UniversityGuangzhou 510006China Guangdong Provincial Key Laboratory of Protein Function and Regulation in Agricultural Organisms College of Life SciencesSouth China Agricultural UniversityGuangzhou 510642China Guangdong Laboratory for Lingnan Modern Agriculture Guangzhou 510642China

The prevalence of allergic diseases,such as asthma,rhinitis,eczema,and sick building syndrome(SBS),has increased drastically in the past few decades.Current medications can only relieve the symptoms but not cure these diseases whose development is suggested to be greatly impacted by the indoor microbiome.However,no study comprehensively summarizes the progress and general rules in the field,impeding subsequent translational application.To close knowledge gaps between theoretical research and practical application,we conducted a comprehensive literature review to summarize the epidemiological,environmental,and molecular evidence of indoor microbiome studies.Epidemiological evidence shows that the potential protective indoor microorganisms for asthma are mainly from the phyla Actinobacteria and Proteobacteria,and the risk microorganisms are mainly from Bacilli,Clostridia,and Bacteroidia.Due to extremely high microbial diversity and geographic variation,different health-associated species/genera are detected in different regions.Compared with indoor microbial composition,indoor metabolites show more consistent associations with health,including microbial volatile organic compounds(MVOCs),lipopolysaccharides(LPS),indole derivatives,and flavonoids.Therefore,indoor metabolites could be a better indicator than indoor microbial taxa for environmental assessments and health outcome prediction.The interaction between the indoor microbiome and environmental characteristics(surrounding greenness,relative humidity,building confinement,and CO_(2) concentration)and immunology effects of indoor microorganisms(inflammatory cytokines and pattern recognition receptors)are briefly reviewed to provide new insights for disease prevention and treatment.Widely used tools in indoor microbiome studies are introduced to facilitate standard practice and the precise identification of health-related targets.

关键词： Indoor microbial metabolite Asthma Rhinitis Eczema Sick building syndrome Environmental characteristic

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Distinct gut microbiota and health outcomes in asymptomatic infection,viral nucleic acid test re-positive,and convalescent COVID-19 cases

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mLife 2022年第2期1卷 183-197页

作者： Ruqin Lin Mingzhong Xiao Shanshan Cao Yu Sun Linhua Zhao Xiaoxiao Mao Peng Chen Xiaolin Tong zheyuan ou Hui Zhu Dong Men Xiaodong Li Yiqun Deng Xian-En Zhang Jikai Wen Guangdong Provincial Key Laboratory of Protein Function and Regulation in Agricultural Organisms College of Life SciencesSouth China Agricultural UniversityGuangzhouChina Hepatic Disease Institute Hubei Key Laboratory of Theoretical and Applied Research of Liver and Kidney in Traditional Chinese MedicineHubei Provincial Hospital of Traditional Chinese MedicineWuhanChina State Key Laboratory of Virology Wuhan Institute of VirologyCenter for Biosafety Mega-ScienceChinese Academy of SciencesWuhanChina National Laboratory of Biomacromolecules Institute of BiophysicsChinese Academy of SciencesBeijingChina Department of Endocrinology Guang'anmen HospitalChina Academy of Chinese Medical SciencesBeijingChina Guangdong Laboratory for Lingnan Modern Agriculture South China Agricultural UniversityGuangzhouChina Hubei Province Academy of Traditional Chinese Medicine WuhanChina Faculty of Synthetic Biology Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenChina University of Chinese Academy of Sciences BeijingChina

Gut microbiota composition is suggested to associate with coronavirus disease 2019(COVID-19)severity,but the impact of gut microbiota on health outcomes is largely unclear.We recruited 81 individuals from Wuhan,China,including 13 asymptomatic infection cases(Group A),24 COVID-19 convalescents with adverse outcomes(Group C),31 severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)re-positive cases(Group D),and 13 non-COVID-19 healthy controls(Group H).The microbial features of Groups A and D were similar and exhibited higher gut microbial diversity and more abundant short-chain fatty acid(SCFA)-producing species than Group C.Group C was enriched with opportunistic pathogens and virulence factors related to adhesion and toxin production.The abundance of SCFA-producing species was negatively correlated,while Escherichia coli was positively correlated with adverse outcomes.All three groups(A,C,and D)were enriched with the mucusdegrading species Akkermansia muciniphila,but decreased with Bacteroides-encoded carbohydrate-active enzymes.The pathways of vitamin B6 metabolic and folate biosynthesis were decreased,while selenocompound metabolism was increased in the three groups.Specifically,the secondary bile acid(BA)metabolic pathway was enriched in Group A.Antibiotic resistance genes were common among the three groups.Conclusively,the gut microbiota was related to the health outcomes of COVID-19.Dietary supplementations(SCFAs,BA,selenium,folate,vitamin B6)may be beneficial to COVID-19 patients.

关键词： COVID-19 gut microbiota health outcomes re-positive SARS-CoV-2

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Indoor metabolites and chemicals outperform microbiome in classifying childhood asthma and allergic rhinitis

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Eco-Environment & Health 2023年第4期2卷 208-218页

作者： Yu Sun Hao Tang Shuang Du Yang Chen zheyuan ou Mei Zhang Zhuoru Chen Zhiwei Tang Dongjun Zhang Tianyi Chen Yanyi Xu Jiufeng Li Dan Norback Jamal Hisham Hashim Zailina Hashim Jie Shao Xi Fu Zhuohui Zhao Guangdong Provincial Key Laboratory of Protein Function and Regulation in Agricultural Organisms College of Life SciencesSouth China Agricultural UniversityGuangzhou 510642China Department of Environmental Health School of Public HealthFudan UniversityNHC Key Laboratory of Health Technology Assessment(Fudan University)Shanghai 200032China Department of Pediatrics Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200025China Department of Medical Sciences Uppsala UniversityUppsala SE-751Sweden Department of Environmental Health Faculty of Health SciencesUniversiti SelangorShah Alam 40000Malaysia Department of Environmental and Occupational Health Faculty of Medicine and Health SciencesUniversiti Putra MalaysiaUPMSerdang 43400Malaysia Guangdong Provincial Engineering Research Center of Public Health Detection and Assessment School of Public HealthGuangdong Pharmaceutical UniversityGuangzhou 510006China Key Laboratory of Public Health Safety of the Ministry of Education Shanghai Typhoon Institute/CMAShanghai Key Laboratory of Meteorology and HealthShanghai 200030China IRDR International Center of Excellence on Risk Interconnectivity and Governance on Weather/Climate Extremes Impact and Public Health Fudan UniversityShanghai 200438China WMO/IGAC MAP-AQ Asian Office Shanghai Fudan UniversityShanghai 200438China

Indoor microorganisms impact asthma and allergic rhinitis(AR),but the associated microbial taxa often vary extensively due to climate and geographical variations.To provide more consistent environmental assessments,new perspectives on microbial exposure for asthma and AR are needed.Home dust from 97 cases(32 asthma alone,37 AR alone,28 comorbidity)and 52 age-and gender-matched controls in Shanghai,China,were analyzed using high-throughput shotgun metagenomic sequencing and liquid chromatography-mass spectrometry.Homes of healthy children were enriched with environmental microbes,including Paracoccus,Pseudomonas,and Psychrobacter,and metabolites like keto acids,indoles,pyridines,and flavonoids(astragalin,hesperidin)(False Discovery Rate<0.05).A neural network co-occurrence probability analysis revealed that environmental microorganisms were involved in producing these keto acids,indoles,and pyridines.Conversely,homes of diseased children were enriched with mycotoxins and synthetic chemicals,including herbicides,insecticides,and food/cosmetic additives.Using a random forest model,characteristic metabolites and microorganisms in Shanghai homes were used to classify high and low prevalence of asthma/AR in an independent dataset in Malaysian schools(N=1290).Indoor metabolites achieved an average accuracy of 74.9%and 77.1%in differentiating schools with high and low prevalence of asthma and AR,respectively,whereas indoor microorganisms only achieved 51.0%and 59.5%,respectively.These results suggest that indoor metabolites and chemicals rather than indoor microbiome are potentially superior environmental indicators for childhood asthma and AR.This study extends the traditional risk assessment focusing on allergens or air pollutants in childhood asthma and AR,thereby revealing potential novel intervention strategies for these diseases.

关键词： Dust Environmental classifier Home Indoor Allergy

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基础医学阶段PBL线上教学模式效果初探

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中国组织化学与细胞化学杂志 2022年第3期31卷 321-326页

作者：许哲源胡毅雪熊娟余佯洋王霞赵书平沙鸥深圳大学医学部深圳518060 深圳大学医学部口腔医学院深圳518060

目的新冠疫情推动了线上教学工作的展开和应用,本文旨在探讨深圳大学医学部基础医学教育阶段线上、线下以问题为基础的学习(problem-based learning,PBL)教学模式的应用和学生的反馈分析。方法本研究以本校2018级临床医学专业和口腔医... 详细信息

目的新冠疫情推动了线上教学工作的展开和应用,本文旨在探讨深圳大学医学部基础医学教育阶段线上、线下以问题为基础的学习(problem-based learning,PBL)教学模式的应用和学生的反馈分析。方法本研究以本校2018级临床医学专业和口腔医学专业本科生为研究对象,采用问卷的方式进行线上、线下PBL教学效果的反馈和评估。结果共计129位临床和口腔本科生参与调查。53.49%的学生认为线下PBL学习方式更有助于师生及同学间的互动交流,40.31%的学生认为线下的学习效率及授课形式更好。另外,课程成果展示与汇报方式方面,学生认为幻灯片是较好的选择。结论在疫情期间,线上PBL课程发挥了重要作用,但是在鼓励和提升学生的存在感和参与度等方面不如线下PBL教学模式。

关键词：教改 PBL 线上教学线下教学

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数字西安地理信息公共服务平台的建设与应用

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城市勘测 2010年第5期 22-27页

作者：张周平欧长红马哲元西安市勘察测绘院陕西西安710054 北京超图软件股份有限公司北京100192 西安市工业与信息化委员会陕西西安710007

城市地理信息公共服务平台的建设对于整合城市地理空间数据资源、促进行业部门间数据交换与共享、推动城市信息化和数字城市的建设与发展具有十分重要的意义。本文介绍了基于Service GIS服务共享体系的数字西安地理信息公共服务平台的... 详细信息

城市地理信息公共服务平台的建设对于整合城市地理空间数据资源、促进行业部门间数据交换与共享、推动城市信息化和数字城市的建设与发展具有十分重要的意义。本文介绍了基于Service GIS服务共享体系的数字西安地理信息公共服务平台的设计、实现、应用及建设与共享模式。

关键词：地理信息公共服务平台共享交换服务模式一体化服务体系 Service GIS

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