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Predictors of pathologic complete response in patients with residual flat mucosal lesions after neoadjuvant chemoradiotherapy for locally advanced rectal cancer

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Chinese Journal of Cancer Research 2022年第4期34卷 383-394页

作者： Changlong li Zhen Guan Yi Zhao Tingting Sun Zhongwu li Weihu Wang zhexuan li lin Wang Aiwen Wu Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Gastrointestinal Cancer CenterPeking University Cancer Hospital&InstituteBeijing 100142China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of RadiologyPeking University Cancer Hospital&InstituteBeijing 100142China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of PathologyPeking University Cancer Hospital&InstituteBeijing 100142China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of Radiation OncologyPeking University Cancer Hospital&InstituteBeijing 100142China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of Cancer EpidemiologyPeking University Cancer Hospital&InstituteBeijing 100142China

Objective:The accurate prediction of tumor response to neoadjuvant chemoradiotherapy(nCRT)remains challenging.Few studies have investigated pathologic complete response(ypCR)prediction in patients with residual flat mucosal lesions after treatment.This study aimed to identify variables for predicting ypCR in patients with residual flat mucosal lesions after nCRT for locally advanced rectal cancer(LARC).Methods:Data of patients with residual flat mucosal lesions after nCRT who underwent radical resection between 2009 and 2015 were retrospectively collected from the LARC database at Peking University Cancer Hospital.Univariate and multivariate analyses of the association between clinicopathological factors and ypCR were performed,and a nomogram was constructed by incorporating the significant predictors.Results:Of the 246 patients with residual flat mucosal lesions included in the final analysis,56(22.8%)had ypCR.Univariate and multivariate analyses showed that pretreatment cT stage(pre-cT)≤T2(P=0.016),magnetic resonance tumor regression grade(MR-TRG)1-3(P=0.001)and residual mucosal lesion depth=0 mm(Plibration curve showed that the nomogram model had good predictive consistency.The follow-up time ranged from 3.0 to 113.3 months,with a median follow-up time of 63.77 months.The multivariate Cox regression model showed that the four variables in the nomogram model were not risk factors for disease-free survival(DFS)or overall survival(OS).Conclusions:Completely flat mucosa,early cT stage and good MR-TRG were predictive factors for ypCR instead of DFS or OS in patients with LARC with residual flat mucosal lesions after nCRT.Endoscopic mucosal re-evaluation before surgery is important,as it may contribute to decision-making and facilitate nonoperative management or organ preservation.

关键词： Rectal cancer preoperative chemoradiotherapy tumor regression grade flat mucosal lesions pathologic complete response

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Effects of Helicobacter pylori eradication on the profiles of blood metabolites and their associations with the progression of gastric lesions: a prospective follow-up study

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Cancer Biology & Medicine 2022年第8期19卷 1259-1273页

作者： Wenhui Wu Zongchao liu zhexuan li Weidong liu Lanfu Zhang Yang Zhang Tong Zhou Weicheng You Kaifeng Pan Wenqing li Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of Cancer EpidemiologyPeking University Cancer Hospital and InstituteHaidian DistrictBeijing 100142China linqu County Public Health Bureau Linqu 262600China linqu County People’s Hospital Linqu 262600China

Objective:This study aimed at examining the alterations in metabolomic profiles caused by treatment of H.pylori infection,and the associations between key plasma metabolites and the risk of gastric lesion progression during follow-up after treatment.Methods:An intervention trial was performed in 183 participants,117 of whom were H.pylori positive participants receiving treatment for H.pylori infection.H.pylori positive participants were prospectively followed for 182 to 1,289 days.Untargeted metabolomics assays were conducted on plasma samples collected at baseline,6 months after treatment,and during continued follow-up.Results:We identified 59 metabolites with differential posttreatment changes between participants with successful and failed H.pylori eradication,17 metabolites significantly distinguished participants with successful vs.failed eradication.Two metabolites[PC(18:1(11Z)/14:1(9Z))and(2S)-6-amino-2-formamidohexanamide]showed posttreatment changes positively associated with successful H.pylori eradication,and were inversely associated with the risk of gastric lesion progression among participants with successful eradication.In contrast,9-decenoic acid showed posttreatment changes inversely associated with successful eradication:its level was positively associated with the risk of gastric lesion progression among participants with successful eradication.Although the identified metabolites showed a temporary but significant decline after treatment,the trend generally reversed during continued follow-up,and pretreatment levels were restored.Conclusions:Treatment of H.pylori infection significantly altered plasma metabolic profiles in the short term,and key metabolites were capable of distinguishing participants with successful vs.failed eradication,but might not substantially affect metabolic regulation in the long term.Several plasma metabolites were differentially associated with the risk of gastric lesion progression among participants with successful or failed eradication.

关键词： Helicobacter pylori infection gastric cancer gastric lesion metabolomics eradication

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A systematic review of metabolomic profiling of gastric cancer and esophageal cancer

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Cancer Biology & Medicine 2020年第1期17卷 181-198页

作者： Sha Huang Yang Guo zhexuan li Yang Zhang Tong Zhou Weicheng You Kaifeng Pan Wenqing li Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of Cancer EpidemiologyPeking University Cancer Hospital&InstituteBeijing 100142China Joint International Research Center of Translational and Clinical Research Beijing 100142China

Objective:Upper gastrointestinal(UGI)cancers,predominantly gastric cancer(GC)and esophageal cancer(EC),are malignant tumor types with high morbidity and mortality rates.Accumulating studies have focused on metabolomic profiling of UGI cancers in recent years.In this systematic review,we have provided a collective summary of previous findings on metabolites and metabolomic profiling associated with GC and EC.Methods:A systematic search of three databases(Embase,PubMed,and Web of Science)for molecular epidemiologic studies on the metabolomic profiles of GC and EC was conducted.The Newcastle–Ottawa Scale(NOS)was used to assess the quality of the included articles.Results:A total of 52 original studies were included for review.A number of metabolites were differentially distributed between GC and EC cases and non-cases,including those involved in glycolysis,anaerobic respiration,tricarboxylic acid cycle,and protein and lipid metabolism.Lactic acid,glucose,citrate,and fumaric acid were among the most frequently reported metabolites of cellular respiration while glutamine,glutamate,and valine were among the most commonly reported amino acids.The lipid metabolites identified previously included saturated and unsaturated free fatty acids,aldehydes,and ketones.However,the key findings across studies to date have been inconsistent,potentially due to limited sample sizes and the majority being hospital-based case-control analyses lacking an independent replication group.Conclusions:Studies on metabolomics have thus far provided insights into etiological factors and biomarkers for UGI cancers,supporting the potential of applying metabolomic profiling in cancer prevention and management efforts.

关键词： Gastric cancer esophageal cancer metabolomics Warburg effect biomarkers

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Screening for gastric cancer in China:Advances,challenges and visions

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Chinese Journal of Cancer Research 2021年第2期33卷 168-180页

作者： Xiaohan Fan Xiangxiang Qin Yang Zhang zhexuan li Tong Zhou Jingying Zhang Weicheng You Wenqing li Kaifeng Pan Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of Cancer EpidemiologyPeking University Cancer Hospital&InstituteBeijing 100142China

Gastric cancer(GC)is one of the major cancers in China and all over the world.Most GCs are diagnosed at an advanced stage with unfavorable prognosis.Along with some other countries,China has developed the government-funded national screening programs for GC and other major cancers.GC screening has been shown to effectively decrease the incidence of and mortality from GC in countries adopting nationwide screening programs(Japan and Korea)and in studies based on selected Chinese populations.The screening of GC relies mostly on gastroendoscopy,the accuracy,reliability and safety of which have been indicated by previous studies.However,considering its invasive screening approach,requirements on skilled endoscopists and pathologists,and a high cost,developing noninvasive methods to amend endoscopic screening would be highly needed.Numerous studies have examined biomarkers for GC screening and the combination of biomarkers involving pepsinogen,gastrin,and Helicobacter pylori antibodies has been proposed for risk stratification,seeking to narrow down the high-risk populations for further endoscopy.Despite all the achievements of endoscopic screening,evidence on appropriate screening age,intervals for repeated screening,novel biomarkers promoting precision prevention,and health economics need to be accumulated to inform policymakers on endoscopic screening in China.With the guide of Health China 2030 Planning Outline,we have golden opportunities to promote prevention and control of GC.In this review,we summarize the characteristics of screening programs in China and other East Asian countries and introduce the past and current approaches and strategies for GC screening,aiming for featuring the latest advances and key challenges,and illustrating future visions of GC screening.

关键词： Gastric cancer screening gastroendoscopy pepsinogen gastrin 17 Helicobacter pylori

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Helicobacter pylori antibody responses in association with eradication outcome and recurrence： a population-based intervention trial with 7.3-year follow-up in China

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Chinese Journal of Cancer Research 2017年第2期29卷 127-136页

作者： Tianyi Wang Yang Zhang Huijuan Su zhexuan li lian Zhang Junling Ma Weidong liu Tong Zhou Weicheng You Kaifeng Pan Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing) Department of Cancer Epidemiology Peking University Cancer Hospital & Institute Beijing 100142 China linqu Public Health Bureau Linqu 262600 China

Objective： To identify serum biomarkers that may predict the short or long term outcomes of anti-Helicobacter gylori （H. pylori） treatment, a follow-up study was performed based on an intervention trial in linqu County, China. Methods： A total of 529 subjects were selected randomly from 1,803 participants to evaluate total anti-H, pylori immunoglobulin G （IgG） and 10 specific antibody levels before and after treatment at 1-, 2- and 7.3-year. The outcomes of anti-H, pylori treatment were also parallelly assessed by 13C-urea breath test at 45-d after treatment and 7.3-year at the end of follow-up. Results： We found the medians of anti-H, pylori IgG titers were consistently below cut-off value through 7.3 years in eradicated group, however, the medians declined in recurrence group to 1.2 at 1-year after treatment and slightly increased to 2.0 at 7.3-year. While the medians were significantly higher （〉3.0 at 2- and 7.3-year） among subjects who failed the eradication or received placebo. For specific antibody responses, baseline seropositivities of FliD and HpaA were reversely associated with eradication failure [for FIiD, odds ratio （OR）=0.44, 95% confidence interval （95% CI）： 0.27-0.73; for HpaA, OR=0.32, 95% Ch 0.I7-0.60]. The subjects with multiple positive specific antibodies at baseline were more likely to be successfully eradicated in a linear fashion （Ptrend=0.006）. Conclusions： Our study suggested that total anti-H, pylori IgG level may serve as a potential monitor of long- term impact on anti-H, pylori treatment, and priority for H. pylori treatment may be endowed to the subjects with multiple seropositive antibodies at baseline, especially for FliD and HapA.

关键词： Helicobacterpylori biomarker serology treatment outcome recurrence

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Cr-C类石墨复合涂层制备表征及其在硬质合金铣刀上的应用

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南京工业大学学报（自然科学版） 2024年第1期46卷 55-64页

作者：张哲轩杨忠仪夏荣华李新陈彭浩南京工业大学机械与动力工程学院江苏南京211800 南京工业大学材料科学与工程学院江苏南京211800

为了提高硬质合金铣刀的使用寿命,降低摩擦加工时的摩擦因数,本文结合Cr元素对涂层生长的促进作用与类石墨(GLC)涂层的优异性能,采用磁控溅射离子镀的方法,在硬质合金(YG8)上制备Cr-C类石墨复合涂层。通过拉曼光谱对复合涂层成分类石墨... 详细信息

为了提高硬质合金铣刀的使用寿命,降低摩擦加工时的摩擦因数,本文结合Cr元素对涂层生长的促进作用与类石墨(GLC)涂层的优异性能,采用磁控溅射离子镀的方法,在硬质合金(YG8)上制备Cr-C类石墨复合涂层。通过拉曼光谱对复合涂层成分类石墨进行表征。利用扫描电镜观察涂层截面形貌,结合线扫描与面扫描结果对涂层元素成分分布进行表征。对复合涂层试样进行摩擦磨损试验,测定摩擦因数并计算磨损率,采用硬度测量仪测定复合涂层的硬度,使用自动划痕仪来评定复合涂层结合力。结果表明:Cr-C类石墨复合涂层具有典型的类石墨非晶碳结构特征,复合涂层整体厚度约为0.68μm;Cr元素主要分布在底层与过渡层,少量掺杂在工作层;C元素主要分布在工作层中,各层涂层内部没有裂纹、孔洞等缺陷,涂层的致密性较好。Cr-C类石墨复合涂层摩擦因数约为0.2,由磨痕形貌测得磨损体积为65.6651 mm^(3),磨损率为2.28×10^(-4) mm^(3)/(N·mm),复合涂层摩擦因数低,耐磨性好。复合涂层硬度可达824~986 HRV,与传统类石墨涂层相比,硬度提升28.22%~51.69%,复合涂层与基体之间的结合力为24 N,与同样应用于硬质合金铣刀的涂层相比,具有良好的结合性能。本文研究可为Cr-C类石墨复合涂层在硬质合金铣刀中的应用提供依据。

关键词：复合涂层磁控溅射类石墨硬质合金铣刀铝合金摩擦因数涂层致密性

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Reconstructing interfacial manganese deposition for durable aqueous zinc-manganese batteries

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National Science Review 2023年第10期10卷 139-150页

作者： Yida Hu zhexuan liu Lanyan li Shan Guo Xuefang Xie Zhigao Luo Guozhao Fang Shuquan liang School of Materials Science and Engineering Key Laboratory of Electronic Packaging and Advanced Functional Materials of Hunan ProvinceCentral South University School of Science Hunan University of Technology and Business College of Physical Science and Technology Xinjiang University College of Chemistry Xiangtan University

Low-cost,high-satety,and broad-prospect aqueous zinc-manganese batteries(ZMBs) are limited by complex interracial reactions.The solid-liquid interfacial state of the cathode dominates the Mn dissolution/deposition process of aqueous ZMBs,especially the important influence on the mass and charge transfer behavior of Zn2+and Mn2+.We proposed a quasi-eutectic electrolyte(QEE) that would stabilize the reversible behavior of interracial deposition and favorable interracial reaction kinetic of manganese-based cathodes in a long cycle process by optimizing mass and charge transfer.We emphasize that the initial interfacial reaction energy barrier is not the main factor affecting cycling performance,and the good reaction kinetics induced by interfacial deposition during the cycling process is more conducive to the stable cycling of the battery,which has been confirmed by theoretical analysis,quartz crystal microbalance with dissipation monitoring,depth etching X-ray photon-electron spectroscopy,etc.As a result,the QEE electrolyte maintained a stable specific capacity of 250 mAh g-1at 0.5 A g-1after 350 cycles in zinc-manganese batteries.The energy density retention rate of the ZMB with QEE increased by 174%compared to that of conventional aqueous electrolyte.Furthermore,the multi-stacked soft-pack battery with a cathodic mass load of 54.4 mg maintained a stable specific capacity of 200 mAh g-1for 100 cycles,demonstrating its commercial potential.This work proves the feasibility of adapting lean-water QEE to the stable aqueous ZMBs.

关键词： quasi-eutectic electrolyte aqueous zinc −manganese batteries solid −liquid interfacial state mass transfer charge transfer

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Hetero Nucleus Growth Stabilizing Zinc Anode for High‑Biosecurity Zinc‑Ion Batteries

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Nano-Micro Letters 2023年第12期15卷 349-360页

作者： Jingjing li zhexuan liu Shaohua Han Peng Zhou Bingan Lu Jianda Zhou Zhiyuan Zeng Zhizhao Chen Jiang Zhou Department of Plastic Surgery and National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangsha 410008People’s Republic of China School of Materials Science and Engineering Hunan Provincial Key Laboratory of Electronic Packaging and Advanced Functional MaterialsCentral South UniversityChangsha 410083People’s Republic of China Hunan Provincial Key Defense Laboratory of High Temperature Wear‑Resisting Materials and Preparation Technology Hunan University of Science and TechnologyXiangtan 411201People’s Republic of China School of Physics and Electronics Hunan UniversityChangsha 410082People’s Republic of China Department of Plastic Surgery The Third Xiangya HospitalCentral South UniversityChangsha 410013People’s Republic of China Department of Materials Science and Engineering City University of Hong Kong83 Tat Chee AvenueKowloon 999077Hong KongPeople’s Republic of China

Biocompatible devices are widely employed in modernized lives and medical fields in the forms of wearable and implantable devices,raising higher requirements on the battery biocompatibility,high safety,low cost,and excellent electrochemical performance,which become the evaluation criteria toward developing feasible biocompatible batteries.Herein,through conducting the battery implantation tests and leakage scene simulations on New Zealand rabbits,zinc sulfate electrolyte is proved to exhibit higher biosecurity and turns out to be one of the ideal zinc salts for biocompatible zinc-ion batteries(ZIBs).Furthermore,in order to mitigate the notorious dendrite growth and hydrogen evolution in mildly acidic electrolyte as well as improve their operating stability,Sn hetero nucleus is introduced to stabilize the zinc anode,which not only facilitates the planar zinc deposition,but also contributes to higher hydrogen evolution overpotential.Finally,a long lifetime of 1500 h for the symmetrical cell,the specific capacity of 150 mAh g^(-1)under 0.5 A g^(-1)for the Zn-MnO_(2)battery and 212 mAh g^(-1)under 5 A g^(-1)for the Zn—NH4V4O10 battery are obtained.This work may provide unique perspectives on biocompatible ZIBs toward the biosecurity of their cell components.

关键词： Aqueous zinc-ion batteries Biocompatible devices Operating stability Zinc anode Zinc salts electrolyte

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中国深度参与全球海洋生物多样性保护的研究与展望

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科学通报 2024年第12期69卷 1598-1612页

作者：林昕李艺王磊吴思扬王宏伟石哲萱陈治学张欣宜章紫曦柳欣戴民汉厦门大学近海海洋环境科学国家重点实验室厦门361102 厦门大学海洋与地球学院厦门361102 厦门大学环境与生态学院厦门361102 自然资源部第三海洋研究所自然资源部海洋生态保护与修复重点实验室厦门361005

海洋是全球生物多样性的宝库,目前全球海洋的保护面积不足10%.世界各国如何携手实现“30×30”目标,将面临诸多争议与挑战,全球海洋治理体系正在发生变革.海洋生物多样性保护已成为未来全球海洋治理的重要议题,中国应抓住契机,规划路径... 详细信息

海洋是全球生物多样性的宝库,目前全球海洋的保护面积不足10%.世界各国如何携手实现“30×30”目标,将面临诸多争议与挑战,全球海洋治理体系正在发生变革.海洋生物多样性保护已成为未来全球海洋治理的重要议题,中国应抓住契机,规划路径,以实现深度参与.本文通过对全球海洋生物多样性议题发展过程中的关键事件开展溯源分析,系统梳理了全球海洋生物多样性保护的现行治理机制与发展趋势,并基于该领域代表性的国际调查评估,重点剖析全球海洋生物多样性的现状以及未来实现“30×30”目标将要面临的挑战.综合以上,对中国未来深度参与全球海洋生物多样性保护的实施路径进行思考与展望.面对国际形势与国家需求,中国应首先夯实科技支撑,加快构建自主化、智能化和国际化的海洋生物多样性观测网络与基础数据库.以科技引领海洋强国建设,支撑中国积极参与重塑全球海洋治理秩序,为海洋资源的可持续开发与利用提供中国方案.

关键词：海洋生物多样性全球海洋治理 “30×30”目标 BBNJ协定可持续发展命运共同体

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Single event transients induced by pulse laser in Ge pMOSFETs and its supply voltage dependence

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Science China(Information Sciences) 2022年第8期65卷 295-296页

作者： Jingyi liU Xia AN Gensong li zhexuan REN Ming li Xing ZHANG Ru HUANG Institute of Microelectronics Peking University

Dear editor,Germanium(Ge) has been considered as a promising candidate of channel material for sub-7 nm owing to its high carrier mobility and good compatibility with conventional Si CMOS process [1]. Although Ge-based technology is still under development and not in massive production, it is quite meaningful to explore its single event effect(SEE) before potential space applications.

关键词： CHARGE COLLECTION BULK

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