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GLUL stabilizes N-Cadherin by antagonizing β-Catenin to inhibit the progresses of gastric cancer

Acta Pharmaceutica Sinica B 2024年第2期14卷 698-711页

作者： Qiwei Jiang Yong Li Songwang Cai Xingyuan Shi Yang Yang Zihao Xing Zhenjie He Shengte Wang Yubin Su Meiwan chen zhesheng chen Zhi Shi Department of Cell Biology&Institute of Biomedicine National Engineering Research Center of Genetic MedicineState Key Laboratory of Bioactive Molecules and Druggability AssessmentMOE Key Laboratory of Tumor Molecular BiologyGuangdong Provincial Key Laboratory of Bioengineering MedicineCollege of Life Science and TechnologyJinan UniversityGuangzhou 510632China Department of Gastrointestinal Surgery&General Surgery the Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou 510080China Department of Thoracic Surgery The First Affiliated Hospital of Jinan UniversityGuangzhou 510632China Department of Radiation Oncology The Fifth Hospital of Guangzhou Medical UniversityGuangzhou 510150China State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacao 519000China Department of Pharmaceutical Sciences College of Pharmacy and Health SciencesSt.John’s UniversityQueensNY 11439USA

Glutamate-ammonia ligase(GLUL, also known as glutamine synthetase) is a crucial enzyme that catalyzes ammonium and glutamate into glutamine in the ATP-dependent condensation. Although GLUL plays a critical role in multiple cancers, the expression and function of GLUL in gastric cancer remain unclear. In the present study, we have found that the expression level of GLUL was significantly lower in gastric cancer tissues compared with adjacent normal tissues, and correlated with N stage and TNM stage, and low GLUL expression predicted poor survival for gastric cancer patients. Knockdown of GLUL promoted the growth, migration, invasion and metastasis of gastric cancer cells in vitro and in vivo, and vice versa, which was independent of its enzyme activity. Mechanistically, GLUL competed with β-Catenin to bind to N-Cadherin, increased the stability of N-Cadherin and decreased the stability of β-Catenin by alerting their ubiquitination. Furthermore, there were lower N-Cadherin and higher β-Catenin expression levels in gastric cancer tissues compared with adjacent normal tissues. GLUL protein expression was correlated with that of N-Cadherin, and could be the independent prognostic factor in gastric cancer. Our findings reveal that GLUL stabilizes N-Cadherin by antagonizing β-Catenin to inhibit the progress of gastric cancer.

关键词： Gastric cancer GLUL N-Cadherin β-Catenin Enzyme

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计及液态空气储能与综合需求响应的综合能源系统低碳经济调度

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电力自动化设备 2022年第12期42卷 1-8页

作者：朱振山盛明鼎陈哲盛福州大学电气工程与自动化学院福建福州350108 智能配电网装备福建省高校工程研究中心福建福州350108

提高供应侧风电、光伏等清洁能源的消纳,降低传统火电机组的碳排放是实现能源结构转型以及碳达峰、碳中和的重要手段。针对能源系统低碳运行的问题,提出了一种包含储液式碳捕集电厂、电转气、液化天然气气化站以及利用液化天然气冷能的... 详细信息

提高供应侧风电、光伏等清洁能源的消纳,降低传统火电机组的碳排放是实现能源结构转型以及碳达峰、碳中和的重要手段。针对能源系统低碳运行的问题,提出了一种包含储液式碳捕集电厂、电转气、液化天然气气化站以及利用液化天然气冷能的液态空气储能的综合能源系统低碳经济调度策略,并结合需求侧的响应策略,从供需两侧联合调度以实现综合能源系统的经济性和低碳性。最后,以改进的IEEE 30节点电力系统与6节点天然气系统为例,验证了所提出的低碳经济调度策略可以提高系统的风电消纳,减少系统的碳排放量,削峰填谷效果更为明显,并可有效降低系统运行的总成本。

关键词：碳捕集电厂综合需求响应液化天然气 Brayton循环液态空气储能系统

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基于柔性行动器-评判器的园区综合能源系统运行优化

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高电压技术 2022年第12期48卷 4949-4958页

作者：朱振山陈哲盛盛明鼎福州大学电气工程与自动化学院福州350108 智能配电网装备福建省高校工程研究中心福州350108

面向综合能源系统运行优化问题,建立了包含燃气轮机、余热回收、有机朗肯循环、空气源热泵和综合需求响应模型的电-热-气园区综合能源系统模型,并在此基础上提出一种基于柔性行动器-评判器的运行优化方法。首先,搭建综合能源系统框架和... 详细信息

面向综合能源系统运行优化问题,建立了包含燃气轮机、余热回收、有机朗肯循环、空气源热泵和综合需求响应模型的电-热-气园区综合能源系统模型,并在此基础上提出一种基于柔性行动器-评判器的运行优化方法。首先,搭建综合能源系统框架和设备模型,针对传统综合需求响应建模不精确问题,结合历史数据和门控循环单元建立了反映用户真实响应能力的神经网络模型并应用于能源定价场景。其次,以最小化系统购能成本和弃风弃光成本为目标,建立综合能源系统经济调度模型,并采用深度强化学习框架进行表述,设置了柔性行动器-评判器智能体与环境交互过程的动作空间、状态空间、奖励函数等,训练收敛后的模型可直接用于实时决策,无需再重新训练。仿真结果表明所提方法可以有效进行能量管理和能源定价优化,降低系统的综合运行成本。

关键词：综合能源系统柔性行动器-评判器门控循环单元综合需求响应运行优化新能源不确定性

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Phase engineering of Mo-V oxides molecular sieves for zinc-ion batteries

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Science China Materials 2022年第4期65卷 939-946页

作者： Gan Qu Chuntian Qiu Jun Wang Jiewen Tan Shuangfeng Jia zhesheng chen Jean-Pascal Rueff Wesley Guangyuan Zheng chenliang Su Bingbing Tian International Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology of Ministry of Education Institute of Microscale OptoelectronicsShenzhen UniversityShenzhen518060China College of Materials Science and Engineering Zhengzhou UniversityZhengzhou450001China Department of Chemical and Biomolecular Engineering National University of Singapore10 Kent Ridge CrescentSingapore119260Singapore School of Physics and Technology Center for Electron MicroscopyMOE Key Laboratory of Artificial Micro-and Nano-structuresand Institute for Advanced StudiesWuhan UniversityWuhan430072China SociétéCivile Synchrotron SOLEIL L’Ormedes MerisiersSaint-AubinBP48Gif-sur-Yvette91192France Laboratoire de Chimie Physique-Matière et Rayonnement LCPMRSorbonne UniversitéCNRSParisF-75005France

With the ever-increasing demands of grid-scale energy storage,aqueous zinc-ion batteries(ZIBs)have garnered increasing attention around the ***,limited Zn^(2+)host materials have hindered the commercialization of ***,Mo-V oxides with different phase structures(orth-,tri-,and tetra-MoVO)were precisely constructed to develop phase-dependent Mo-V oxide cathodes for Zn^(2+)storage in *** open frameworks and varied tunnel structures formed a favorable alternative for achieving suitable Zn^(2+)diffusion *** optimized phase engineering,the high specific capacity of approximately 400 mA h g^(−1) and excellent cyclic stability of 1000 cycles were achieved with orth-MoVO as the *** large amount of six-and seven-member rings in the orth-MoVO phase,which allow for alternative Zn^(2+)insertion,play a vital role in hosting Zn^(2+)ions *** proposed phase engineering strategy provides a new approach toward cathode design in ZIBs.

关键词： zinc-ion batteries phase engineering molybdenum oxides vanadium oxides

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Profile of *** chen

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Science China(Life Sciences) 2024年第10期67卷 2062-2063页

作者： chen, Songlin Yellow Sea Fisheries Res Inst Qingdao Peoples R China

For decades,*** has been engaged in fish germplasm preservation,sex control and research focusing on molecular breeding for disease *** discovered the first sex-specific molecular marker of fish(chen et al.,2007),deciphered the first fish genome(Chinese tongue sole)in China,revealed the sex determination mechanism in fish(chen et al.,2014),and created molecular sex control *** also discovered the molecular mechanism of metamorphosis in flatfish(Shao et al.,2017)and developed China's first fish disease-resistant breeding gene chip,“YUXIN No.1”.

关键词： technology breeding

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小儿咳喘灵口服液联合西药治疗小儿支气管炎临床研究

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新中医 2021年第14期53卷 97-99页

作者：陈哲晟陈峰丽水市妇幼保健院浙江丽水323000

目的:观察小儿咳喘灵口服液联合西药治疗小儿支气管炎的临床疗效。方法:选取80例支气管炎患儿,随机分为观察组和对照组,每组40例。对照组给予常规西药治疗,观察组在对照组基础上联合小儿咳喘灵口服液治疗,2组均治疗6~8 d。比较2组气促... 详细信息

目的:观察小儿咳喘灵口服液联合西药治疗小儿支气管炎的临床疗效。方法:选取80例支气管炎患儿,随机分为观察组和对照组,每组40例。对照组给予常规西药治疗,观察组在对照组基础上联合小儿咳喘灵口服液治疗,2组均治疗6~8 d。比较2组气促改善、咳喘消失、体温恢复正常、肺部啰音消失、胸片恢复正常时间,评价2组临床疗效。结果:观察组气促改善、咳喘消失、体温恢复正常、肺部啰音消失、胸片恢复正常时间均短于对照组(P<0.05)。观察组总有效率为92.5%,对照组总有效率为75.0%,2组比较,差异有统计学意义(P<0.05)。结论:小儿咳喘灵口服液联合西药治疗小儿支气管炎较单独使用西药治疗效果更好,能够快速缓解患儿的临床症状、体征。

关键词：小儿支气管炎中西医结合疗法小儿咳喘灵口服液

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Effect of Reclamation on the Groundwater-Lake Water Interaction in chen Lake

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Journal of Earth Science 2024年第3期35卷 1083-1086页

作者： Kun Lei Teng Ma Liuzhu chen Zhenxing Li Yu chen School of Environmental Studies State Key Laboratory of Biogeology and Environmental GeologyChina University of GeosciencesWuhan 430078China

0 INTRODUCTION To relieve the short supply of suitable land for residing,cultivating,and commerce,it is accepted to reclaim land from lakes,river estuaries,and coastal regions in many countries(Mancini et al.,2020).The large-scale reclamation activities have an irreversible effect on the mico-geomorphology and hydrodynamic system of seasonally flooded areas(Zhang et al.,2019;Yu et al.,2018).For example,coastal regions reclaimed extended the groundwater flow paths,as well as created groundwater level rise,resulting in water-logging in the reclaimed area(Hu et al.,2008).Similar changes in groundwater flow systems may alter groundwater-lake water interactions,and it can ultimately affect the water cycle in the lake ***,such detailed studies are presently *** addition,natural exchanges between the lake and groundwater systems can be strongly affected by physical hydrological processes(Javadzadeh et al.,2020),chemical properties(Kamtchueng et al.,2015),and bioto behavior(Hancock et al.,2005).

关键词： groundwater coastal logging

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地噻咪松诱导乳鼠胸腺细胞凋亡的研究

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动物学杂志 1998年第3期33卷 3-5页

作者：梁福佑陈哲生李金蕾赵俊萍首都医科大学细胞生物学教研室

本文用透射电镜的方法，研究了地噻咪松诱导乳鼠胸腺细胞的凋亡，并确立了乳鼠胸腺细胞中凋亡细胞形态学特征；含溴化乙锭的琼脂多糖（１５％）电泳检测乳鼠胸腺细胞中凋亡细胞的断裂ＤＮＡ；末端标记法（ＴＵＮＥＬ法）直接、持异的... 详细信息

本文用透射电镜的方法，研究了地噻咪松诱导乳鼠胸腺细胞的凋亡，并确立了乳鼠胸腺细胞中凋亡细胞形态学特征；含溴化乙锭的琼脂多糖（１５％）电泳检测乳鼠胸腺细胞中凋亡细胞的断裂ＤＮＡ；末端标记法（ＴＵＮＥＬ法）直接、持异的标记乳鼠胸腺细胞中凋亡细胞断裂ＤＮＡ。获得地噻咪松诱导乳鼠胸腺细胞中凋亡细胞，以及透射电镜下可见凋亡细胞的典型形态学特征；ＤＮＡ琼脂糖电泳呈典型梯状条带；ＴＵＮＥＬ法中凋亡细胞着染，褐色颗粒沉着。提示不同浓度的地噻咪松可诱导乳鼠胸腺细胞凋亡，稍加改进ＴＵＮＥＬ法后，显示结果比较好。

关键词：地塞米松细胞凋亡胸腺细胞末端标记

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Meridional deflection of global eddy propagation derived from tandem altimetry: Mechanism and implication

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Science China Earth Sciences 2024年第3期67卷 811-825页

作者： Ge chen Xiaoyan chen Frontiers Science Center for Deep Ocean Multispheres and Earth System School of Marine TechnologyOcean University of ChinaQindao 266100China Laboratory for Regional Oceanography and Numerical Modeling Laoshan LaboratoryQindao 266237China

A common view on meridional deflection of eddy propagation is poleward for cyclones and equatorward for anticyclones. This widely accepted polarity-sensitive pattern has been increasingly undermined given that it is systematically violated on both zonal and regional scales as recently reported. Here, we approach the problem by exploring these violations in terms of eddy effects of spatiotemporal geostrophy, thermal fading, and flow dragging, yielding the following main conclusions.(1) The polarity-dependent deflection discrepancy is a pseudo feature resulting from a biased fit to the normalized eddy tracks which are spatially asymmetric(though azimuthally symmetric) between the two signs;Instead, the primary pattern of eddy deflection appears to be geographically correlated and polarity independent.(2) Geostrophic adjustment plays a critical role in defining the meridional movement of an eddy. Specifically, a consistent poleward(equatorward) trajectory bending of spatially(temporally) ageostrophic eddies is observed irrespective of their polarity.(3) The mechanism of eddy deflection is also determined by its zonal propagation direction. Westward propagating eddies are substantially affected by thermal fading, while opposite ones by flow dragging. A realistic and comprehensive understanding of eddy deflection mechanisms serves as a significant contribution to the prediction of eddy trajectory, and the protection of ocean environment.

关键词： Mesoscale eddies Eddy propagation Eddy meridional deflection Satellite observation Geostrophic adjustment

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A refined representation method of the particle size distribution curve based on grading entropy

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Particuology 2024年第5期88卷 302-311页

作者： Xing Li Qun chen Zhaozhao Liu cheng Zhou chen Wang chen chen State Key Laboratory of Hydraulics and Mountain River Engineering College of Water Resource and HydropowerSichuan UniversityChengdu610065China

The particle size distribution(PSD)curve is an important expression of the basic properties of the *** characteristic parameters such as median particle size D_(50),effective particle size D_(10),and some combinations of characteristic parameters can only represent some points of the PSD curve,failing to represent all information of the PSD *** this paper,a fraction characteristic parameter F that could reflect the fraction size variation of the PSD curve was introduced based on grading *** a new presentation method of the A-B-F three parameters was proposed for a refined representation of the PSD *** was found that the newly constructed model not only better represents the differences in the width of PSD curves but also has a higher sensitivity than the A-B two-parameter model proposed by Lő*** PSD curves with similar distributions,the new presentation method has a higher degree of discrimination than that of the D_(50)-C_(u)-C_(c) three-parameter or the four-parameter combination G_(c) proposed by ***,the application of this new method in describing the spatial nonuniformity distribution of depositions and predicting the soil hydraulic conductivity was *** research results can provide a reference for the refined representation of PSD curves.

关键词： Grading entropy Particle size distribution curve Refined representation

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