检索结果-南通市图书馆

Brain-derived neurotrophic factor signaling in the neuromuscular junction during developmental axonal competition and synapse elimination

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第2期20卷 394-401页

作者： Josep Tomàs Víctor Cilleros-Mañé Laia Just-Borràs Marta Balanyà-segura Aleksandra Polishchuk Laura Nadal Marta Tomàs Carolina silvera-simón Manel M.santafé Maria A.Lanuza Unitat d’Histologia i Neurobiologia(UHNeurob) Facultat de Medicina i Ciències de la SalutUniversitat Rovira i VirgiliReusSpain

During the development of the nervous system,there is an overproduction of neurons and *** competition between neighboring nerve endings and synapses performing different activity levels leads to their elimination or *** have extensively studied the involvement of the brain-derived neurotrophic factor-Tropomyosin-related kinase B receptor neurotrophic retrograde pathway,at the neuromuscular junction,in the axonal development and synapse elimination process versus the synapse *** purpose of this review is to describe the neurotrophic influence on developmental synapse elimination,in relation to other molecular pathways that we and others have found to regulate this *** particular,we summarize our published results based on transmitter release analysis and axonal counts to show the different involvement of the presynaptic acetylcholine muscarinic autoreceptors,coupled to downstream serine-threonine protein kinases A and C(PKA and PKC)and voltage-gated calcium channels,at different nerve endings in developmental *** dynamic changes that occur simultaneously in several nerve terminals and synapses converge across a postsynaptic site,influence each other,and require careful studies to individualize the mechanisms of specific *** describe an activity-dependent balance(related to the extent of transmitter release)between the presynaptic muscarinic subtypes and the neurotrophin-mediated TrkB/p75NTR pathways that can influence the timing and fate of the competitive interactions between the different axon *** downstream displacement of the PKA/PKC activity ratio to lower values,both in competing nerve terminals and at postsynaptic sites,plays a relevant role in controlling the elimination of supernumerary ***,calcium entry through L-and P/Q-subtypes of voltage-gated calcium channels(both channels are present,together with the N-type channel in developing nerve terminals)contributes to red

关键词： acetylcholine release adenosine receptors axonal competition brain-derived neurotrophic factor calcium channels motor end-plate muscarinic acetylcholine receptors postnatal synapse elimination serine kinases tropomyosin-related kinase receptorB

Women in visual neural regeneration research

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第2期20卷 489-490页

作者： Tonia s.Rex David J.Calkins Vanderbilt Eye Institute Vanderbilt University Medical CenterNashvilleTNUSA

The year 2024 marks the 60^(th)anniversary of Title IX and 25 years since the New York Times revealed bias against female faculty members at the Massachusetts Institute of *** take an opportunity here to examine the state of gender bias in a relatively new yet already prominent field,neural regeneration in the visual system,for which there is a well-defined context useful for this *** National Eye Institute(NEI)provided the first round of research funding for its Audacious Goals Initiative(AGI)on visual neural regeneration in 2013 and the last round in ***,we focus on this *** sources included PubMed,the National science Foundation(NsF),the NEI,the Blue Ridge Institute for Medical Research and data from the major professional organization for eye and vision research,the Association for Research in Vision and Ophthalmology(ARVO).

关键词： neural visual Times

Arsenic redox transformation by Pseudomonas ***-2 isolated from arsenic-contaminated soil in Hunan,China

在线全文

学校读者我要写书评

暂无评论

Journal of environmental sciences 2016年第9期28卷 165-173页

作者： Zhennan Zhang Naiyi Yin Xiaolin Cai zhenzhou Wang Yanshan Cui College of Resources and environment University of Chinese Academy of Sciences Beijing 101408 China Research Center for Eco-environmental sciences Chinese Academy of Sciences Beijing 100085 China

A mesophilic,Gram-negative,arsenite[As（Ⅲ）]-oxidizing and arsenate[As（V）]-reducing bacterial strain,Pseudomonas ***-2,was isolated from an As-contaminated *** analysis based on 16 s r RNA gene sequencing indicated that the strain was closely related to Pseudomonas *** aerobic conditions,this strain oxidized 92.0%（61.4 μmol/L） of arsenite to arsenate within 3 hr of *** of As（V） to As（Ⅲ） occurred in anoxic *** ***-2 is among the first soil bacteria shown to be capable of both aerobic As（Ⅲ） oxidation and anoxic As（V） *** strain,as an efficient As（Ⅲ） oxidizer and As（V） reducer in Pseudomonas,has the potential to impact arsenic mobility in both anoxic and aerobic environments,and has potential application in As remediation processes.

关键词： Arsenic Arsenite oxidation Arsenate reduction Detoxification Pseudomonas

Unlocking hypoglycemia–associated brain microvascular dysfunction:critical insights from proteomic analysis

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第6期20卷 1707-1708页

作者： siva s.V.P.sakamuri Anil sakamuri Department of Chemistry Auburn University at MontgomeryMontgomeryALUSA Vascular Biology Center and Department of Medicine Medical College of Georgia at Augusta UniversityAugustaGAUSA

Hypoglycemia-a critical complication linked to worsened brain function in diabetic subjects:Hypoglycemia is characterized by a decline in circulatory glucose levels below sta nda rd physiological *** hypoglycemia,classified as level 1 hypoglycemia,is defined by blood glucose levels below 70 mg/dL and can be effectively addressed through carbohydrate *** hypoglycemia,denoted by blood glucose levels less than 54 mg/dL,poses a life-threatening risk if left *** with type 1 and type 2 diabetes undergoing insulin treatment are particularly susceptible to hypoglycemia due to impaired counterregulatory mechanisms.

关键词： impaired intake critical

Pre-judgment and Incomplete Allocation Approach for Query Result Cache

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Electronics 2016年第6期25卷 1101-1108页

作者： QIAN Libing JI zhenzhou FU Zhongchuan WU Qianqian sONG Guangjia school of Computer science and Technology Harbin Institute of Technology

Query result caching is a crucial technique employed in search engines, reducing the response time and load of the search engines. As search engines continuously update their indexes, the query results in long-lived cache entries may become stale. It is important to provide the refresh mechanism to enhance the degree of freshness of cached results. We present a pre-judgment approach to improve the freshness of the result cache and design an incomplete allocation algorithm. We introduce the queryTime-to-live(TTL) and term-TTL structure to pre-judge the result cache. The query-TTL is used to pre-check the likelihood of a cache hit and term-TTL is applied to maintain all terms of the latest posting list. For the cache structure, we design a Queue-Hash structure and develop the corresponding incomplete allocation algorithm. The preliminary results demonstrate that our approaches can improve the freshness of cached results and decrease processing overhead compared with no pre-judgment approaches.

关键词： Time-to-live(TTL) Caching freshness Pre-judgment Result cache Cache structure

Nataf transformation based point estimate method

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Chinese science Bulletin 2008年第17期53卷 2586-2592页

作者： LI Hongshuang LU zhenzhou YUAN XiuKai school of Aeronautics Northwestern Polytechnical University Xi'an 710072 China

structural probabilistic analysis quantifies the effect of input random variables, such as material proper- ties, geometrical parameters and loading conditions, on the structural responses. The point estimate method (PEM) is a direct and easy-used way to perform the structural probabilistic analysis in practice. In this paper, a novel and efficient point estimate method is proposed for computing the first four statistical moments of structural response which is a function of input random variables. The method adopts Nataf transformation to replace Rosenblatt transformation in conventional point estimate method. Because of the nature of engineering problems and limited statistical data, the joint probability density function (PDF) of all input random variables is hard to acquire, but it must be known in Rosenblatt transformation. A more common case is that the marginal PDF of each random variable and the correlation matrix are available, which just satisfy the service condition of Nataf transformation. Hence the Nataf transformation based point estimate method is particularly suitable for engineering applications. The comparison between the proposed method and the conventional point estimate method shows that (1) they are equivalent when all random variables are mutually independent; (2) if the marginal PDFs and the correlation matrix are known, the conventional PEM cannot be applicable, but the proposed method can give a rational approximation. Finally, the procedure is demonstrated in detail through a simple illustration.

关键词：结构随机分析点估计法相关矩阵材料工程

Grid-based directed diffusion for wireless sensor networks

在线全文

学校读者我要写书评

暂无评论

High Technology Letters 2008年第4期14卷 342-347页

作者：毕嘉娜 Ji zhenzhou Cao Zhiyan Department of Computer science and Technology Harbin Institute of Technology Harbin 150001 P.R. China

Directed diffusion is a data dissemination protocol for wireless sensor networks. In directed diffusion, flooding is used for dissemination of interest and exploratory data, which will bring broadcast storm resulting in substantial energy consumption of networks. A grid-based directed diffusion is presented to improve the energy efficiency of directed diffusion. Virtual geographic grid clusters are constructed by self-organization of nodes using geographic location information. The flooding of interest and exploratory data of original directed diffusion is limited in cluster head nodes. The simulation results and testbed experiments show that the method effectively reduces the network energy consumption. This gain is not achieved at the cost of either delivery ratio or the delay. Importantly, the decreased load also leads to a better delivery ratio and lower delay.

关键词： wireless sensor networks directed diffusion broadcast grid cluster

New Generation Processor Architecture Research

在线全文

学校读者我要写书评

暂无评论

High Technology Letters 2003年第4期9卷 94-96页

作者：陈红松 Hu Mingzeng Ji zhenzhou Department of Computer science and Technology Harbin Institute of Technology Harbin 150001P.R.China

With the rapid development of microelectronics and hardware,the use of ever faster micro processors and new architecture must be continued to meet tomorrow′s computing needs. New processor microarchitectures are needed to push performance further and to use higher transistor counts *** the same time,aiming at different usages,the processor has been optimized in different aspects,such as high performace,low power consumption,small chip area and high security. sOC (system on chip)and sCMP (single Chip Multi Processor) constitute the main processor system architecture.

关键词： new microarchitecture development trend reusing explore parallelism

Experiment and modeling of coke formation and catalyst deactivation in n-heptane catalytic cracking over HZsM-5 zeolites

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Chemical engineering 2023年第3期55卷 165-172页

作者： zhenzhou Ma Xu Hou Bochong Chen Liu Zhao enxian Yuan Tingting Cui school of Chemical engineering Changchun University of TechnologyChangchun 130012China Advanced Institute of Materials science Changchun University of TechnologyChangchun 130012China school of Chemistry and Chemical engineering Yangzhou UniversityYangzhou 225009China Department of Chemistry Tsinghua UniversityBeijing 100084China

since paraffins catalytic cracking was of significant importance to light olefins and aromatics production,this work was intended to gain insights into the feature and model of coke formation and catalyst deactivation in n-heptane catalytic cracking over HZsM-5 zeolites. 18 tests of n-heptane catalytic cracking were designed and carried out over HZsM-5 zeolites in a wide range of operating conditions. A particular attention was paid to the measurement of the conversion, product distribution, coke content, and the porosity and acidity of the fresh and spent HZsM-5 zeolites. It was found that alkene and aromatic promoted coke formation, and it reduced the pore volume and acid site of HZsM-5 zeolites, tailoring its performance in n-heptane catalytic cracking. The specific relationship between HZsM-5 zeolites, n-heptane conversion, product distribution and coke formation was quantitively characterized by the exponential and linear function. Based on the reaction network, the coupled scheme of coke formation and catalyst deactivation were specified for n-heptane catalytic cracking. The dual-model was proposed for the process simulation of n-heptane catalytic cracking over HZsM-5 zeolites. It predicted not only the conversion and product distribution but also coke content with the acceptable errors.

关键词： n-Heptane HZsM-5 Catalytic cracking Coke Deactivation Dual-model