检索结果-南通市图书馆

Ecological niches and blood sources of sand fly in an endemic focus of visceral leishmaniasis in Jiuzhaigou,Sichuan,China

在线全文

学校读者我要写书评

暂无评论

Infectious Diseases of Poverty 2016年第1期5卷 288-293页

作者： Huiying Chen Kaili Li Hua Shi Yong Zhang Yu Ha Yan Wang Jinjin Jiang Yubin Wang zhenzhou yang Jiannong Xu Yajun Ma Department of Tropical Infectious Diseases Faculty of Tropical Medicine and Public HealthSecond Military Medical UniversityShanghai 200433China Biology Department Molecular Biology ProgramNew Mexico State UniversityLas CrucesNM 88003USA Center for Disease Control and Prevention of PLA Beijing 100071China Jiuzhaigou Center of Disease Control and Prevention JiuzhaigouSichuan 623400China Center of Disease Control and Prevention General Equipment Department of PLABeijing 100101China

Background:Sand fly Phlebotomus chinensis is a principle vector for the visceral leishmaniasis(VL)in China with a wide geographic ***,Sichuan is a mountain type endemic area of VL in *** term effective control efforts in the region have successfully reduced VL *** assess the current status of the sand flies and their ecological aspects in the region,a survey was conducted in the summer of 2014 and ***:Sand fly specimens were collected by light traps in a village and blood sources were identified by PCR and sequencing of the mitochondrial cytochrome b ***:In a rock cave,65.2%–79.8%of collected sand flies were *** a rabbit farm,92.9%–98.8%of specimens were *** pig pens,61.1%of specimens were *** females had visible blood *** feeding rate was 49.4%from the pig pens,12.3%from the cave,and only 1.7%from the rabbit ***,rabbit,chicken,dog,and human blood were detected in the fed *** blood,present in all tested samples,was a preferred blood source,while chicken and dog blood were present in a third of the ***:In Jiuzhaigou County,Sichuan Province of China,the considerable sandfly density and the peridomestic feeding behavior all increases the risk of VL transmission,and insecticide spraying in animal sheds could be exploited to reduce sand fly populations in human surroundings.

关键词： Sand fly Phlebotomus chinensis Ecological niche Blood sources China

Field Method Research for Leak-off Coefficient Analysis Using Instantaneous Shut-in Pressure

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Energy and Power Engineering 2014年第1期8卷 103-106页

作者： Cai Bo Ding Yunhong Lu Yongjun Shen Hua yang zhenzhou Petroleum Exploration & Development PetroChina Research Institute Beijing 100083 China Petroleum Exploration & Development-Lang fang Branch PetroChina Research Institute Langfang 065007 China Huabei Oilfield Company PetroChina Renqiu 062250 China

The accurate monitor and prediction of fracturing pressure for formation is very important to hydraulic fracturing treatment operation, but whether hydraulic fracturing is successful or not, the fracturing fluid plays a very important role, leak-off coefficient is the most leading parameters of fracturing fluids. Mini-frac test was the most commonly used tools for leak-off coefficient analysis, but it has the shortcoming of time-consuming and costly that can not meet the requirement of the production. The main purpose of this paper is to introduce a simple and convenient leak off coefficient analysis method with more inexpensive and time-saving than former methods. Based on ISIP （instantaneous shut-in pressure） method, a new field method of leak off coefficient field analysis model was presented. According to twice ISIP of the fracturing treatment in field operation, therefore, fluid leak off coefficient and formation characteristic can be studied quickly and reliably. More than 40 wells were fractured using this field method. The results show that average liquid rates of post-fracturing was 20 m3/d which double improvement compared with the past treatment wells. It had an important role for fracturing treatments in low permeability used in field application. reservoirs, the new model for real time analysis and adjust is successful

关键词： Hydraulic fracturing fracturing fluid leak off coefficient instantaneous shut-in pressure field method post-fracturingperformance.

An Online Calibration 2-DoF Attitude and Height State Estimator

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

An Online Calibration 2-DoF Attitude and Height State Estima...

考虑支撑剂及其嵌入程度对支撑裂缝导流能力影响的数值模拟

第三十九届中国控制会议

作者： zhenzhou yang Qun Zong Hongming Chen Bailing Tian School of Electrical and Information Engineering Tianjin University

The Visual-inertial based simultaneous localization and mapping（SLAM） method has been a hot topic in recent *** Unmanned Aerial Vehicle（UAV） detects in the unknown environment, stable control and mapping is need. It is intolerable for the error of roll and pitch estimation of the attitude, and the altitude needs to maintain continuous and effective observations to prevent drift. In this paper, based on nonlinear optimization methods with a sliding window, we propose an visual-inertial odometry that solves more precise pitch and roll by IMU using EKF algorithm and integrates it into the tightly-coupled state estimation to keep 2-DoF attitude estimation precision, while simultaneous calculating the 6-DoF state by IMU pre-integration and vision. Meanwhile, the height radar is used to eliminate the cumulative drift of the drone height. A terrain estimator is set to prevent terrain abrupt changes.

关键词： Visual-inertial Odometry State Estimator Attitude Correction

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

天然气工业 2013年第5期33卷 65-68页

作者：吴国涛胥云杨振周杨立峰张静中国石油勘探开发研究院中国石油勘探开发研究院廊坊分院中国石油天然气集团公司油气藏改造重点实验室新疆油田新港作业分公司

目前支撑剂粒径、铺置浓度、嵌入程度对裂缝导流能力的影响主要为实验研究,缺乏相应的理论计算模型研究,而理论计算模型会促使压裂方案设计更加合理、可靠,增加施工的成功率,达到预期的改造效果。为此,根据Carman-Kozeny公式,建立了一... 详细信息

目前支撑剂粒径、铺置浓度、嵌入程度对裂缝导流能力的影响主要为实验研究,缺乏相应的理论计算模型研究,而理论计算模型会促使压裂方案设计更加合理、可靠,增加施工的成功率,达到预期的改造效果。为此,根据Carman-Kozeny公式,建立了一种考虑支撑剂在岩石表面嵌入的支撑裂缝导流能力数值计算模型,利用实验数据对理论模型进行拟合校正,并通过校正后的理论模型计算了20～40目、30～50目和40～70目支撑剂在不同铺置层数、不同嵌入程度条件下的裂缝导流能力,分析了铺置层数、嵌入程度对导流能力的影响。结果表明:支撑剂粒径越大、铺置层数越多,裂缝导流能力越大;在单层铺置情况下,嵌入程度对导流能力的影响较大,嵌入程度从0增加到33%,导流能力降低85%。所建立的模型为致密油、页岩气等不同类型储层的粒径优选、砂比优化提供了参考和依据,也为后续考虑支撑剂嵌入的相关软件研究提供了理论模型。

关键词：支撑剂嵌入支撑裂缝导流能力嵌入程度数值模拟计算

TSA可能通过抑制APE1BER功能增强顺铂的肺腺癌细胞毒性

在线全文

学校读者我要写书评

暂无评论

第三军医大学学报 2017年第5期39卷 413-416页

作者：张志敏杨镇洲第三军医大学大坪医院野战外科研究所肿瘤中心重庆400042

目的探讨曲古抑菌素A(trichostatin A,TSA)对顺铂诱导的细胞毒性的影响。方法给予0、250、500 nmol/L TSA预处理A549细胞24 h后,分别联合0、5、10、15μmol/L顺铂处理A549细胞24 h后,通过0、0.5、1、2μmol/L APE1 InhibitorⅢ调控APE1 BER功能,应用CCK-8方法检测细胞增殖率,AP内切酶活性实验检测APE1 BER功能,通过流式细胞仪检测细胞凋亡水平,immunoblot检测γ-H2AX表达水平。结果 TSA联合顺铂处理A549细胞明显增强顺铂的细胞增殖抑制,并促进顺铂诱导的细胞凋亡;随着TSA浓度的升高APE1内切酶活性逐渐减弱,TSA联合顺铂促进顺铂诱导的γ-H2AX表达;利用inhibitorⅢ抑制APE1内切酶活性,促进顺铂诱导细胞增殖抑制和凋亡水平。结论TSA可能通过抑制APE1BER功能增强顺铂诱导的细胞毒性反应。

关键词： TSA 顺铂 AP核酸内切酶活性 DNA损伤

在线全文

学校读者我要写书评

暂无评论

脑转移瘤动物模型的构建及应用研究进展

现代医药卫生 2024年第20期40卷 3421-3425,3431页

作者：杨镇洲重庆医科大学附属第二医院肿瘤中心重庆400072

脑转移瘤是恶性肿瘤晚期常见的并发症之一。研究其发生、发展及治疗机制对于提高患者生存率至关重要。动物模型的发展为深入探讨脑转移机制提供了重要工具,并促进了新型治疗策略的开发与评估。该文综述了脑转移动物模型的建立与应用的... 详细信息

脑转移瘤是恶性肿瘤晚期常见的并发症之一。研究其发生、发展及治疗机制对于提高患者生存率至关重要。动物模型的发展为深入探讨脑转移机制提供了重要工具,并促进了新型治疗策略的开发与评估。该文综述了脑转移动物模型的建立与应用的最新研究进展,涵盖了不同类型的模型,包括同基因移植模型、异种移植模型及基因工程小鼠模型等。这些模型在模拟脑转移过程、解析脑转移调控机制及评价药物疗效方面发挥了重要作用。此外,该文还讨论了现有模型的优、劣势,并展望了未来脑转移动物模型在提升临床相关性和推动个体化治疗中的潜在应用前景。

关键词：脑转移动物模型模型构建综述

新型冠状病毒气溶胶医院内潜在感染风险及预防措施

在线全文

学校读者我要写书评

暂无评论

中国医药 2020年第6期15卷 812-815页

作者：杨振洲军事医学科学院疾病预防控制所有害生物监控中心北京100039

新型冠状病毒肺炎肆虐全球,此次疫情中,预防医护人员感染十分重要。2020年2月19日,国家卫生健康委员会发布的《新型冠状病毒肺炎诊疗方案(试行第六版)》中新增了:传播途径“在相对封闭的环境中长时间暴露于高浓度气溶胶情况存在气溶胶... 详细信息

新型冠状病毒肺炎肆虐全球,此次疫情中,预防医护人员感染十分重要。2020年2月19日,国家卫生健康委员会发布的《新型冠状病毒肺炎诊疗方案(试行第六版)》中新增了:传播途径“在相对封闭的环境中长时间暴露于高浓度气溶胶情况存在气溶胶传播的可能”。新型冠状病毒传播的途径尚未完全明了,为保护和提醒一线医护人员减少感染,本文特从气溶胶的定义、感染途径、防护措施几个方面阐述,以期为减少院内感染的风险提供帮助。

关键词：新型冠状病毒气溶胶传播感染风险

Radiotherapy for Lowly Malignant Cranial Inflammatory Myofibroblastic Tumor Accompanied with Intracranial Invasion:Case Report and Literature Review

在线全文

学校读者我要写书评

暂无评论

肿瘤预防与治疗 2012年第2期25卷 72-76页

作者：马俊刚 Xueqin yang Ge Wang Xian Yu Nan Hu Yanhai Liu zhenzhou yang Cancer Center Research Institute of SurgeryDaping HospitalThird Military Medical UniversityChongqing 400042P.R.China

Inflammatory myofibroblastic tumor(IMT) is rare in clinical *** its treatment mainly involves surgery,radiotherapy alone is seldom reported in *** we report a case of lowly malignant cranial IMT with intracranial invasion in a female patient. As surgery was not suitable,intensity modulated radiation therapy(IMRT) was *** radiotherapy,the cranial lesions tended to show efficacy.

关键词： Inflammatory myofibroblastic tumor cranial bone radiotherapy

生存质量评价量表在肺癌脑转移患者临床应用中的现状和研究进展

在线全文

学校读者我要写书评

暂无评论

中华内科杂志 2022年第2期61卷 234-238页

作者：张静宜张晓月彭媛杨镇洲重庆医科大学附属第二医院肿瘤中心重庆400010

脑是肺癌中最常见的远处转移部位之一,脑转移的发生率约占肺癌所有转移部位的40%~50%,且发生脑转移的肺癌患者中位生存时间仅为3~6个月。因此,选择合适的治疗策略是提高肺癌脑转移患者生存质量的重要手段。肺癌脑转移患者在整个生存阶... 详细信息

脑是肺癌中最常见的远处转移部位之一,脑转移的发生率约占肺癌所有转移部位的40%~50%,且发生脑转移的肺癌患者中位生存时间仅为3~6个月。因此,选择合适的治疗策略是提高肺癌脑转移患者生存质量的重要手段。肺癌脑转移患者在整个生存阶段受到身体疾病症状、情感、社会关系和经济状况等多种因素影响,多数患者在治疗过程中存在一定程度的认知功能障碍、神经症状和心理障碍等问题。生存质量评价量表作为评估晚期癌症患者心理、生理因素等多维结构因素的重要工具,已应用于肺癌脑转移患者的临床评估。本文总结多种生存质量评价量表在肺癌脑转移临床应用中的现状和研究进展,旨在为肺癌脑转移患者临床治疗策略的综合制定提供参考。

关键词：肺肿瘤肿瘤转移生存质量评价量表