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Sex-dependent obesogenic effect of tetracycline on Drosophila melanogaster deteriorated by dysrhythmia

Journal of Environmental Sciences 2023年第2期124卷 472-480页

作者： Xueping Guo zhenyang yu Daqiang Yin State Key Laboratory of Pollution Control and Resource Reuse Key Laboratory of Yangtze River Water EnvironmentMinistry of EducationCollege of Environmental Science and EngineeringTongji UniversityShanghai 200092China Jiaxing Tongji Institute for Environment Jiaxing 3014051China Shanghai Institute of Pollution Control and Ecological Security Shanghai 200092China

Antibiotics have been identified as obesogens contributing to the prevalence of obesity.Moreover,their environmental toxicity shows sex dependence,which might also explain the sex-dependent obesity observed.Yet,the direct evidence for such a connection and the underlying mechanisms remain to be explored.In this study,the effects of tetracycline,which is a representative antibiotic found in both environmental and food samples,on Drosophila melanogaster were studied with consideration of both sex and circadian rhythms(represented by the eclosion rhythm).Results showed that in morning-eclosed adults,tetracycline significantly stimulated the body weight of females(AM females)at 0.1,1.0,10.0 and 100.0μg/L,while tetracycline only stimulated the body weight of males(AM males)at 1.0μg/L.In the afternoon-eclosed adults,tetracycline significantly stimulated the body weight of females(PM females)at 0.1,1.0 and 100.0μg/L,while it showed more significant stimulation in males(PM males)at all concentrations.Notably,the stimulation levels were the greatest in PMmales among all the adults.The results showed the clear sex dependence of the obesogenic effects,which was diminished by dysrhythmia.Further biochemical assays and clustering analysis suggested that the sex-and rhythm-dependent obesogenic effects resulted from the bias toward lipogenesis against lipolysis.Moreover,theywere closely related to the preference for the energy storage forms of lactate and glucose and also to the presence of excessive insulin,with the involvement of glucolipid metabolism.Such relationships indicated potential bridges between the obesogenic effects of pollutants and other diseases,e.g.,cancer and diabetes.

关键词： Obesogenic effect Tetracycline Sex Circadian rhythm Glucolipid metabolism

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Behavior toxicity to Caenorhabditis elegans transferred to the progeny after exposure to sulfamethoxazole at environmentally relevant concentrations

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Journal of Environmental Sciences 2011年第2期23卷 294-300页

作者： zhenyang yu Key Laboratory of Yangtze River Water Environment Ministry of Education Shanghai 200092 China College of Environmental Science and Engineering Tongji University Shanghai 200092 China

Sulfamethoxazole （SMX） is one of the most common detected antibiotics in the environment. In order to study whether SMX can affect behavior and growth and whether these effects could be transferred to the progeny, Caenorhabditis elegans was exposed at environmentally relevant concentrations for 24, 48, 72 and 96 hr, respectively. After exposure, the exposed parent generation （P0） was measured for behavior and growth indicators, which were presented as percentage of controls （POC）. Then their corresponding unexposed progeny （F1） was separated and measured for the same indicators. The lowest POC for P0 after 96 hr-exposure at 100 mg/L were 37.8%, 12.7%, 45.8% and 70.l% for body bending frequency （BBF）, reversal movement （RM）, Omega turns （OT） and body length （BL）, respectively. And F1 suffered defects with the lowest POC as 55.8%, 24.1%, 48.5% and 60.7% for BBF, RM, OT and BL, respectively. Defects in both P0 and F1 showed a time- and concentration-dependent fashion and behavior indicators showed better sensitivity than growth indicator. The observed effects on F1 demonstrated the transferable properties of SMX. Defects of SMX at environmental concentrations suggested that it is necessary to perform further systematical studies on its ecological risk in actual conditions.

关键词： sulfamethoxazole transferable property Caenorhabditis elegans environmental concentration

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Phase separation-hydrogen etching-derived Cu-decorated Cu-Mn bimetallic oxides with oxygen vacancies boosting superior sodium-ion storage kinetics

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Journal of Energy Chemistry 2023年第5期80卷 163-173,I0005页

作者： Lin Yan Lingshuo Zong Qi Sun Junpeng Guo zhenyang yu Zhijun Qiao Jiuhui Han Zhenyu Cui Jianli Kang School of Material Science and Engineering Tiangong UniversityTianjin 300387China School of Mechanical Engineering Tiangong UniversityTianjin 300387China Institute for New Energy Materials and Low-Carbon Technologies Tianjin University of TechnologyTianjin 300384China School of Materials Science and Engineering Tianjin UniversityTianjin 300072China

Understanding the crystal phase evolution of bimetallic oxide anodes is the main concern to profoundly reveal the conversion reaction kinetics and sodium-ion storage mechanisms.Herein,an integrated selfsupporting anode of the Cu-decorated Cu-Mn bimetallic oxides with oxygen vacancies(Ov-BMO-Cu)are in-situ generated by phase separation and hydrogen etching using nanoporous Cu-Mn alloy as selfsacrificial templates.On this basis,we have elucidated the relationship between the phase evolution,oxygen vacancies and sodium-ion storage mechanisms,further demonstrating the evolution of oxygen vacancies and the inhibition effect of manganese oxides as an“anchor”on grain aggregation of copper oxides.The kinetic analyses confirm that the expanded lattice space and increased oxygen vacancies of cycled Ov-BMO-Cu synergistically guarantee effective sodium-ion diffusion and storage mechanisms.Therefore,the Ov-BMO-Cu electrode exhibits higher reversible capacities of 4.04 mA h cm^(-2)at 0.2 mA cm^(-2)after 100 cycles and 2.20 m A h cm^(-2)at 1.0 mA cm^(-2)after 500 cycles.Besides,the presodiated Ov-BMO-Cu anode delivers a considerable reversible capacity of 0.79 m A h cm^(-2)at 1.0 mA cm^(-2)after 60 cycles in full cells with Na_(3)V_(2)(PO_(4))_(3)cathode,confirming its outstanding practicality.Thus,this work is expected to provide enlightenment for designing high-capacity bimetallic oxide anodes.

关键词： Sodium-ion storage mechanism Bimetallic oxide anode material Crystal phase evolution Oxygen vacancies Kinetic analyses

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中世纪晚期英格兰的走私贸易及关税监管

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经济社会史评论 2024年第2期 60-72,128页

作者：于振洋安徽师范大学历史学院安徽芜湖241011

中世纪晚期英格兰对外贸易较为活跃,贸易额呈增长态势,关税成为王室政府财政收入的重要来源。但国内外商人以各种方式走私羊毛、呢绒等大宗出口货物,逃避关税,使王室政府的财政收入锐减。为了打击走私活动,王室政府不仅采取没收货物、... 详细信息

中世纪晚期英格兰对外贸易较为活跃,贸易额呈增长态势,关税成为王室政府财政收入的重要来源。但国内外商人以各种方式走私羊毛、呢绒等大宗出口货物,逃避关税,使王室政府的财政收入锐减。为了打击走私活动,王室政府不仅采取没收货物、监禁走私者等常规举措,还针对性地实施寄宿、货物抵押、运输证明等监管方式,甚至不惜以重罪惩处。这些监管举措一定程度上遏制了走私贸易,但由于这一时期关税政策的特权并未惠及所有商人群体,导致走私贸易屡禁不止,再因税率上涨简单粗暴,致使治理效果低下。直至近代以后,随着自由贸易政策的推行,关税逐步放开,走私贸易才渐趋消弭。

关键词：英格兰走私贸易关税商栈

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SARS-CoV-2 N protein enhances the anti-apoptotic activity of MCL-1 to promote viral replication

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Signal Transduction and Targeted Therapy 2023年第6期8卷 3055-3069页

作者： Pan Pan Weiwei Ge Zhiwei Lei Wei luo yuqing Liu Zhanwen Guan Lumiao Chen zhenyang yu Miaomiao Shen Dingwen Hu Qi Xiang Wenbiao Wang Pin Wan Mingfu Tian Yang yu Zhen Luo Xulin Chen Heng Xiao Qiwei Zhang Xujing Liang Xin Chen Yongkui Li Jianguo Wu The First Affiliated Hospital of Jinan University 510632GuangzhouChina Foshan Institute of Medical Microbiology 528315FoshanChina Guangdong Provincial Key Laboratory of Virology Institute of Medical MicrobiologyJinan University510632GuangzhouChina State Key Laboratory of Virology College of Life SciencesWuhan University430072WuhanChina The First People’s Hospital of Foshan 528315FoshanChina

Viral infection in respiratory tract usually leads to cell death,impairing respiratory function to cause severe disease.However,the diversity of clinical manifestations of SARS-CoV-2 infection increases the complexity and difficulty of viral infection prevention,and especially the high-frequency asymptomatic infection increases the risk of virus transmission.Studying how SARS-CoV-2 affects apoptotic pathway may help to understand the pathological process of its infection.Here,we uncovered SARS-CoV-2 imployed a distinct anti-apoptotic mechanism via its N protein.We found SARS-CoV-2 virus-like particles(trVLP)suppressed cell apoptosis,but the trVLP lacking N protein didn’t.Further study verified that N protein repressed cell apoptosis in cultured cells,human lung organoids and mice.Mechanistically,N protein specifically interacted with anti-apoptotic protein MCL-1,and recruited a deubiquitinating enzyme USP15 to remove the K63-linked ubiquitination of MCL-1,which stabilized this protein and promoted it to hijack Bak in mitochondria.Importantly,N protein promoted the replications of IAV,DENV and ZIKV,and exacerbated death of IAV-infected mice,all of which could be blocked by a MCL-1 specific inhibitor,S63845.Altogether,we identifed a distinct anti-apoptotic function of the N protein,through which it promoted viral replication.These may explain how SARS-CoV-2 effectively replicates in asymptomatic individuals without cuasing respiratory dysfunction,and indicate a risk of enhanced coinfection with other viruses.We anticipate that abrogating the N/MCL-1-dominated apoptosis repression is conducive to the treatments of SARS-CoV-2 infection as well as coinfections with other viruses.

关键词： apo prevention promoted

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NiCuCoMn电极材料的制备及其储锂性能研究

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功能材料 2024年第2期55卷 2001-2008页

作者：于镇洋马金虎孙琦张志佳天津工业大学机械工程学院天津300387 天津工业大学材料科学与工程学院天津300387

采用熔炼甩带和化学脱合金相结合的方法制备纳米多孔NiCuCoMn过渡金属氧化物(NiCuCoMn@TMOs),并通过热处理进一步制备R-NiCuCoMn@TMOs。通过X射线衍射(XRD)、扫描电子显微镜(SEM)、X射线光电子能谱(XPS)等测试对材料进行结构表征并对其... 详细信息

采用熔炼甩带和化学脱合金相结合的方法制备纳米多孔NiCuCoMn过渡金属氧化物(NiCuCoMn@TMOs),并通过热处理进一步制备R-NiCuCoMn@TMOs。通过X射线衍射(XRD)、扫描电子显微镜(SEM)、X射线光电子能谱(XPS)等测试对材料进行结构表征并对其进行电化学性能测试。作为锂离子电池负极材料,R-NiCuCoMn@TMOs在0.1 A/g的电流密度下,经过200次循环后具有394.9 mAh/g的高比容量,并且表现出97.53%的优异容量保持率。与热处理前相比,热处理后的材料具有更丰富的氧空位、更低的电荷转移电阻(38Ω)和更优异的倍率性能(在2 A/g的电流密度下,比容量为141.1 mAh/g)。其独特的纳米多孔结构提供了丰富的反应活性位点;不同半径、价态和反应电位的多种金属阳离子的协同效应使得该材料有很好的体积容忍度以适应脱嵌锂过程中的体积变化,表现出优异的电化学性能。此外,该电极材料原料储量丰富,价格低廉,易于实现批量化制备。该工作为设计多组元过渡金属氧化物负极材料提供了新的思路。

关键词：纳米多孔过渡金属氧化物热处理电化学性能锂离子电池

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基于电流多特征融合的窄间隙P-GMAW摆动电弧传感焊缝跟踪方法

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传感技术学报 2024年第4期37卷 612-619页

作者：刘文吉朱鹏飞于镇洋杨嘉昇肖宇天津工业大学机械工程学院天津300387

电弧传感是实现窄间隙焊接焊缝跟踪的主要方式之一。针对电弧传感稳定性差、可靠性低的问题,提出融合摆动周期内电流信息的多个统计学特征进行偏差提取的方法,克服单一数据特征容易受到电弧稳定性影响、导致传感精度下降的问题。首先,... 详细信息

电弧传感是实现窄间隙焊接焊缝跟踪的主要方式之一。针对电弧传感稳定性差、可靠性低的问题,提出融合摆动周期内电流信息的多个统计学特征进行偏差提取的方法,克服单一数据特征容易受到电弧稳定性影响、导致传感精度下降的问题。首先,提取电流信号的多个时域特征,计算特征矩阵与偏差矢量相关性;然后,取相关性高的特征用主成分分析的方法进行融合,取前两个主成分作为观测数据;最后,基于多分类的支持向量机模型对其进行分类试验。试验结果表明最大误差为0.2 mm,0.1 mm以内的误差占93.75%。该方法对比传统方法精度有所提升,对比神经网络方法,所用训练样本少,训练过程更加简单。

关键词：数据处理焊缝跟踪特征融合电弧传感

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基于秀丽线虫构建生态环境健康课程链式实验教学体系

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生态毒理学报 2024年第3期19卷 124-130页

作者：于振洋 Rafeeq Karam Mustafa Mustafa 尹大强同济大学环境科学与工程学院上海200092 上海污染控制与生态安全研究院上海200092 嘉兴同济环境研究院嘉兴314051

我国生态环境健康领域不断发展,生态环境健康教学逐渐形成完善的教育体系与课程链,但目前尚缺乏与课堂理论教学相匹配的实验教学体系,对培养创新思维与实践能力兼备的专业人才提出了新的挑战。秀丽线虫,生物学背景雄厚,是生命科学、生... 详细信息

我国生态环境健康领域不断发展,生态环境健康教学逐渐形成完善的教育体系与课程链,但目前尚缺乏与课堂理论教学相匹配的实验教学体系,对培养创新思维与实践能力兼备的专业人才提出了新的挑战。秀丽线虫,生物学背景雄厚,是生命科学、生态环境健康中广泛使用的模式生物。本文以秀丽线虫为模式动物,构建较为完整的实验内容和案例教学体系,涵盖培养基配制、微生物显微观测、个体生长发育、生殖能力、总蛋白含量、催化酶活性、基因表达水平等方面内容与检测方法,与微生物学、分子生物学、生物化学、环境毒理学、生态毒理学等相关理论体系匹配,锻炼学生实践动手与实验设计技能,为学生后续围绕科学问题开拓创造性思维、提升科研能力奠定基础。

关键词：生态环境健康秀丽线虫实验教学体系课程链

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N-乙基吡啶溴对秀丽隐杆线虫生殖与脂代谢的多世代与跨世代效应

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生态毒理学报 2024年第3期19卷 387-395页

作者：于振洋 Addis Fentaw Sisay 刘红张晶同济大学环境科学与工程学院上海200092 上海污染控制与生态安全研究院上海200092 上海应用技术大学上海201418 嘉兴同济环境研究院嘉兴314051

离子液体(ILs)的毒物兴奋效应(hormesis)使其低浓度、长期暴露的生态危害备受关注。本文以N-乙基吡啶溴([epyr]Br)作为ILs代表,以秀丽隐杆线虫为受试生物,开展连续多世代与跨世代生殖毒性效应研究,并从脂代谢酶、代谢中间产物探索其潜... 详细信息

离子液体(ILs)的毒物兴奋效应(hormesis)使其低浓度、长期暴露的生态危害备受关注。本文以N-乙基吡啶溴([epyr]Br)作为ILs代表,以秀丽隐杆线虫为受试生物,开展连续多世代与跨世代生殖毒性效应研究,并从脂代谢酶、代谢中间产物探索其潜在机理。研究结果表明,在连续暴露的11代中,[epyr]Br在0.53 mg·L^(-1)水平对F1、F2、F3、F7、F8、F9和F10代线虫生殖产生刺激效应,在F6和F11中产生抑制效应;在53 mg·L^(-1)水平,在更多世代中表现出抑制效应,并且抑制水平比低浓度更强。跨世代效应中,[epyr]Br对F1脱离暴露的后代T3的生殖效应在高、低浓度均表现为抑制效应;同时,[epyr]Br在低浓度连续11代暴露后,对其脱离暴露的后代T3’的生殖依然表现出刺激效应;但[epyr]Br在高浓度多世代暴露后,对T3’无显著残留效应。在F1~F11代中,[epyr]Br对三酰基甘油(TG)、乙酰辅酶A(ACA)、磷酸甘油酰基转移酶(GPAT)、肉碱棕榈酰转移酶(CPT)等脂代谢物、代谢酶活性的多世代效应也表现为刺激、抑制效应的波动变化,各生化指标效应之间以及与生殖效应之间均存在密切关联,并存在高低浓度效应差异。在T3、T3’中,[epyr]Br对脂代谢物、脂代谢酶表现出显著的跨世代残留效应。综上,[epyr]Br连续多世代暴露的生殖毒性及其在脱离暴露后代中的残留效应,均与脂代谢密切相关,并受到暴露浓度的显著影响。

关键词：离子液体秀丽隐杆线虫生殖毒性多世代跨世代脂代谢

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Reproductive Influences of Erythromycin and Sulfamethoxazole on Caenorhabditis elegans over Generations Mediated by Lipid Metabolism

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Chemical Research in Chinese Universities 2023年第3期39卷 434-440页

作者： yu zhenyang WANG Lei LI Gaotian ZHANG Jing Ecological Technique and Engineering College Shanghai Institute of TechnologyShanghai201418P.R.China Jiaxing Tongji Institute for Environment Jiaxing314051P.R.China State Key Laboratory of Pollution Control and Resource Reuse Key Laboratory of Yangtze River Water EnvironmentMinistry of EducationCollege of Environmental Science and EngineeringTongji UniversityShanghai200092P.R.China

Antibiotics are emerging pollutants with pseudo-persistence.However,their reproductive toxicities over generations and underlying mechanisms were seldom explored.In the present study,reproductive effects of erythromycin(ERY)and sulfamethoxazole(SMZ)were studied on Caenorhabditis elegans(C.elegans)with multi-generational exposure from F1 to F4,and their effects in the non-direct exposed offspring of F1 and F4(T4 and T4’)were explored to investigate trans-generational outcomes.At high concentrations,ERY and SMZ inhibited the reproduction and the inhibition decreased with more generations’exposure.At low concentrations,SMZ stimulated reproduction in T4,opposite to its inhibition in F1.Further analysis on ten enzymes and proteins in lipid and glucolipid metabolism showed that ERY commonly inhibited fatty acid synthetase(FAS)in F1 to F4,while ERY and SMZ showed stimulation and inhibition on other biochemicals.Integrated biomarker response(IBR)index values showed that ERY and SMZ stimulated the overall metabolism in F1,and the stimulation decreased and even altered to inhibition in later generations.When comparing multi-and trans-generational effects,ERY and SMZ at high concentration caused inhibition on reproduction in T4 and stimulation in T4’,which were opposite to those in F1 and F4.

关键词： Multi-generational effect Antibiotic Reproduction Lipid metabolism

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