检索结果-南通市图书馆

维普期刊数据库博看期刊

Fibroblast growth factor 21(FGF21) attenuates tacrolimus-induced hepatic lipid accumulation through transcription factor EB(TFEB)-regulated lipophagy

在线全文

学校读者我要写书评

暂无评论

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2023年第6期24卷 485-495页

作者： zhensheng zhang Li XU Xun QIU Xinyu YANG Zhengxing LIAN Xuyong WEI Di LU Xiao XU Zhejiang University School of Medicine Hangzhou 310058China Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province Hangzhou 310006China Department of Hepatobiliary and Pancreatic Surgery the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Institute of Organ Transplantation Zhejiang UniversityHangzhou 310003China NHC Key Laboratory of Combined Multi-organ Transplantation Hangzhou 310003China Westlake Laboratory of Life Sciences and Biomedicine Hangzhou 310024China

Tacrolimus(TAC),also called FK506,is one of the classical immunosuppressants to prevent allograft rejection after liver transplantation.However,it has been proved to be associated with post-transplant hyperlipemia.The mechanism behind this is unknown,and it is urgent to explore preventive strategies for hyperlipemia after transplantation.Therefore,we established a hyperlipemia mouse model to investigate the mechanism,by injecting TAC intraperitoneally for eight weeks.After TAC treatment,the mice developed hyperlipemia(manifested as elevated triglyceride(TG)and low-density lipoprotein cholesterol(LDL-c),as well as decreased high-density lipoprotein cholesterol(HDL-c)).Accumulation of lipid droplets was observed in the liver.In addition to lipid accumulation,TAC induced inhibition of the autophagy-lysosome pathway(microtubule-associated protein 1light chain 3β(LC3B)II/I and LC3B II/actin ratios,transcription factor EB(TFEB),protein 62(P62),and lysosomal-associated membrane protein 1(LAMP1))and downregulation of fibroblast growth factor 21(FGF21)in vivo.Overexpression of FGF21may reverse TAC-induced TG accumulation.In this mouse model,the recombinant FGF21 protein ameliorated hepatic lipid accumulation and hyperlipemia through repair of the autophagy-lysosome pathway.We conclude that TAC downregulates FGF21and thus exacerbates lipid accumulation by impairing the autophagy-lysosome pathway.Recombinant FGF21 protein treatment could therefore reverse TAC-caused lipid accumulation and hypertriglyceridemia by enhancing autophagy.

关键词： Autophagy Fibroblast growth factor 21(FGF21) Lipid Lipophagy Lysosome Tacrolimus Transcription factor EB(TFEB)

Aspirin in hepatocellular carcinoma:Is it an out-of-date or promising treatment?

在线全文

学校读者我要写书评

暂无评论

iLIVER 2022年第1期1卷 55-64页

作者： Xun Qiu Fengqiang Gao Kai Wang zhensheng zhang Chuxiao Shao Xiao Xu Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province Department of Hepatobiliary and Pancreatic SurgeryAffiliated Hangzhou First People's HospitalZhejiang University School of MedicineHangzhou310006China Westlake Laboratory of Life Sciences and Biomedicine Hangzhou310024China NHC Key Laboratory of Combined Multi-organ Transplantation Hangzhou310003China Institute of Organ Transplantation Zhejiang UniversityHangzhou310003China Department of Hepatobiliary and Pancreatic Surgery Affiliated Lishui HospitalZhejiang University School of MedicineLishui323000China

Hepatocellular carcinoma(HCC)is one of the most aggressive human malignancies with a dismal survival rate.Few strategies can effectively prevent the occurrence of HCC.Although immunotherapy has significantly improved HCC-related survival in recent years,this systemic therapy is very expensive and lays a heavy burden on most HCC patients.Aspirin,which is currently one of the most widely used medications in analgesic and cardiovascular diseases,is reported to have anti-tumor effects on HCC.Most importantly,long-term administration of low-dose aspirin does not significantly increase the risk of gastrointestinal bleeding.Owing to its costeffectiveness and wide use,aspirin can be easily applied as an HCC treatment and is affordable for a wide range of patients.Therefore,deeper understanding and more attention are needed to extend the frontline of aspirin's preventive and therapeutic potential into cancer research and management.In this review,we discuss the preventive effect of aspirin on HCC in the context of different etiological factors,including hepatitis B or hepatitis C virus infection,non-alcoholic fatty liver disease,and alcohol-associated liver disease.The therapeutic role of aspirin in resectable or unresectable HCC management is also discussed.Furthermore,the mechanisms underlying the anti-cancer effects of aspirin on HCC are fully reviewed and discussed in the following two aspects:the effect of aspirin on multi-oncogenic signaling pathways in HCC(e.g.,AMPK,Wnt/β-catenin,NF-κB)and aspirinmediated immunometabolic responses in liver diseases.These findings indicate aspirin is a promising agent for populations at risk and HCC patients to prevent or treat HCC.

关键词： Hepatocellular carcinoma Aspirin Chemoprevention Cancer therapy Oncogenic signaling Immunometabolic response

Hierarchical Dynamic Capabilities and Strategic Entrepreneurship in Changing Industrial Environments

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Frontiers of Business Research in China 2014年第3期8卷 388-410页

作者： zhensheng zhang Department of Information Systems National University of Singapore 119077 Singapore

The research fields of dynamic capabilities and strategic entrepreneurship have developed concurrently but separately. This study aims to bridge the gap in research on the underlying linkage between the two independent areas, both of which are critical for firms to sustain competitiveness in changing industrial environments. Drawing upon insights from the integrated perspective of hierarchical dynamic capabilities, strategic entrepreneurship, and environmental dynamics, an explicit theoretical framework is put forward to achieve a better understanding of the ways through which hierarchical dynamic capabilities promote strategic entrepreneurship. Moreover, through the proposed theoretical lens, this study further explores the detailed mechanisms of how first-order and second-order dynamic capabilities improve strategic entrepreneurship with regard to uncertainty of market conditions.

关键词： dynamic capabilities hierarchical dynamic capabilities strategicentrepreneurship environmental dynamics

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

建设工程安全文明管理智慧化场景设计研究

项目管理技术 2024年第3期22卷 113-116页

作者：张振生上海建科工程咨询有限公司上海200032

随着绿色低碳、高品质、智慧化成为建筑业发展的内生需求,融合建筑信息模型(BIM)、大数据、深度学习、机器视觉、物联网、人工智能等先进信息技术的智慧化场景解决方案为建筑业安全管理带来发展机遇,助力实现建筑业的“智慧化+”转型。... 详细信息

随着绿色低碳、高品质、智慧化成为建筑业发展的内生需求,融合建筑信息模型(BIM)、大数据、深度学习、机器视觉、物联网、人工智能等先进信息技术的智慧化场景解决方案为建筑业安全管理带来发展机遇,助力实现建筑业的“智慧化+”转型。围绕建设工程安全文明管理智慧化转型,设计环境智慧化监测及塔机安全智慧化监管两大典型的智慧化场景,包括场景工作流、场景布置及应用,提高智慧化程度,提升施工机械性能和效率。通过智能化分析和数据处理,实现工程施工精细化控制,避免人为失误导致的信息损失和其他问题,旨在提升建设工程安全文明管理水平与质量。

关键词：智慧化场景环境监测塔机监测安全文明管理

区域开发建设统筹管理平台系统研究——以上海国际创新协同区为例

在线全文

学校读者我要写书评

暂无评论

建设监理 2024年第2期 25-28页

作者：张振生上海建科工程咨询有限公司上海200032

区域开发建设统筹模式打通了跨部门“信息孤岛”。为支撑建设统筹数字化管理,研究开发了区域开发建设统筹管理平台系统。系统由用户层、访问层、应用层、支撑层、传输层和基础层等组成,并且从区域层面和项目层面详细分析了十三种典型应... 详细信息

区域开发建设统筹模式打通了跨部门“信息孤岛”。为支撑建设统筹数字化管理,研究开发了区域开发建设统筹管理平台系统。系统由用户层、访问层、应用层、支撑层、传输层和基础层等组成,并且从区域层面和项目层面详细分析了十三种典型应用场景。平台系统应用于上海国际创新协同区,提升了区域开发建设统筹管理的精细化水平,提高了跨区域、跨部门和跨行业的信息交换效率。

关键词：区域开发建设统筹应用场景平台系统

在线全文

学校读者我要写书评

暂无评论

旋转流体多边形自由表面形成机制研究

实验流体力学 2024年第2期38卷 78-87页

作者：李唯一王涛张先念李雪琴孙振生火箭军工程大学西安710025

针对流体在约束旋转中产生多边形涡流的现象,设计了旋转圆筒实验装置,对不同旋转频率、液面高度及圆筒半径下的旋转流体行为进行了研究。基于实验现象,提出了全局复合波理论模型,该模型的计算结果与实验现象一致。根据流动相似理论,利... 详细信息

针对流体在约束旋转中产生多边形涡流的现象,设计了旋转圆筒实验装置,对不同旋转频率、液面高度及圆筒半径下的旋转流体行为进行了研究。基于实验现象,提出了全局复合波理论模型,该模型的计算结果与实验现象一致。根据流动相似理论,利用量纲分析法对实验数据进行分析处理;借助黑体辐射模型给出了流体参数在一定范围下的经验公式,该公式在径长比小于4的情况下与实验数据符合程度较好。本文建立的全局复合波理论模型及相关研究结论可为多边形涡流形成机制与变化规律研究提供理论参考。

关键词：旋转流体多边形涡流量纲分析经验公式黑体辐射模型全局复合波理论模型

Improvement of wheat drought tolerance through editing of TaATX4 by CRISPR/Cas9

在线全文

学校读者我要写书评

暂无评论

Journal of Genetics and Genomics 2023年第11期50卷 913-916页

作者： Zhongxue Wang Yifang zhang zhensheng Kang Hude Mao State Key Laboratory of Crop Stress Biology for Arid Areas and College of Plant Protection Northwest A&F UniversityYanglingShaanxi 712100China Yangling Seed Industry Innovation Center YanglingShaanxi 712100China State Key Laboratory of Crop Stress Biology for Arid Areas and College of Agronomy Northwest A&F UniversityYanglingShaanxi 712100China

Wheat(Triticum aestivum L.)is a staple cereal crop grown in arid and semi-arid areas worldwide and provides a major source of nutrition globally.However,its production is often affected by drought or water deficit,a problem which is expected to worsen because of climate change and a rapidly expanding global population;for example,the demand for agricultural water supplies is projected to increase by an estimated 17%by 2025 to compensate for global population growth(Lesk et al.,2016;Hickey et al.,2019.

关键词： CRISPR/Cas9 Wheat drought

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

内镜逆行胰胆管造影在儿童胆胰疾病中的应用

中华肝胆外科杂志 2024年第4期30卷 281-285页

作者：潘祝彬戚士芹张涛周玉良刘振生张振强杨涌安徽省儿童医院普外科合肥230000

目的探究内镜逆行胰胆管造影(ERCP)在儿童胆胰疾病中的临床应用价值。方法回顾性分析2022年6月至2023年9月安徽省儿童医院普外科收治的21例胆胰疾病患儿的临床资料,其中男性8例,女性13例,年龄9(5,11)岁,年龄范围3~14岁。收集所有患儿的E... 详细信息

目的探究内镜逆行胰胆管造影(ERCP)在儿童胆胰疾病中的临床应用价值。方法回顾性分析2022年6月至2023年9月安徽省儿童医院普外科收治的21例胆胰疾病患儿的临床资料,其中男性8例,女性13例,年龄9(5,11)岁,年龄范围3~14岁。收集所有患儿的ERCP操作情况、操作成功率及临床表现,分析比较21例患儿首次ERCP术前与术后3 d的血液指标变化情况,记录术后并发症发生情况。结果21例患儿的临床表现为腹痛(16例次)、黄疸(3例次)、腹胀(1例次)、发热(1例次)、恶心呕吐(10例次)。21例患儿在全麻下共接受ERCP 24例次,成功23例次,失败1例次,成功率为95.8%(23/24)。治疗措施包括副乳头切开3例次,球囊扩张9例次,鼻胆管引流9例次,胆管支架置入4例次,胆管取石10例次,胰管支架置入5例次,胰管取石3例次,胆管内支架取出术2例次。与ERCP前相比,21例患儿术后总胆红素[(44.61±14.44)μmmol/L比(81.63±24.14)μmmol/L]、直接胆红素[20.32(16.34,24.27)μmmol/L比36.81(33.01,42.22)μmmol/L]、天冬氨酸氨基转移酶[128.4(125.4,132.8)U/L比250.8(248.7,261.2)U/L]、丙氨酸氨基转移酶[180.1(176.4,190.2)U/L比303.5(301.0,320.9)U/L]、γ-谷氨酰转移酶[(135.8±42.3)U/L比(206.4±78.1)U/L]均降低,差异有统计学意义(均P<0.001)。21例患儿在ERCP诊疗后共发生并发症2例,发生率为9.52%,2例均为轻度术后胰腺炎。结论ERCP在儿童胆胰系统疾病的诊疗中安全有效。

关键词：胰胆管造影术,内窥镜逆行胆胰疾病儿童治疗诊断

基于二次型升压变换器和开关电容的混合式升压方案研究

在线全文

学校读者我要写书评

暂无评论

电子器件 2024年第2期47卷 397-403页

作者：张全禹孙培刚卢振生绥化学院电气工程学院黑龙江绥化152000

提出一种混合式高升压比DC-DC变换器。该变换器由二次型升压变换器、开关电容和耦合电感单元集成。为了减少元件的数量,耦合电感一次侧与二次型升压变换器共用;二次型升压变换器的输出电容一分为二,并与开关电容共用。由于电源和负载之... 详细信息

提出一种混合式高升压比DC-DC变换器。该变换器由二次型升压变换器、开关电容和耦合电感单元集成。为了减少元件的数量,耦合电感一次侧与二次型升压变换器共用;二次型升压变换器的输出电容一分为二,并与开关电容共用。由于电源和负载之间的共地特性,则输入电流连续。对所提变换器的电压增益进行了推导,并分析其电压应力。结果表明所提逆变器具备高电压增益、低电压应力的特性。最后,搭建了80 W的实验样机,实验结果验证了所提变换器的正确性和有效性。

关键词：电压增益 DC/DC变换器开关电容耦合电感