检索结果-南通市图书馆

DeepRetention:A Deep Learning Approach for Intron Retention Detection

在线全文

学校读者我要写书评

暂无评论

Big Data Mining and Analytics 2023年第2期6卷 115-126页

作者： zhenpeng wu Jiantao Zheng Jiashu Liu Cuixiang Lin Hong-Dong Li Hunan Provincial Key Lab on Bioinformatics School of Computer Science and EngineeringCentral South UniversityChangsha 410083China

As the least understood mode of alternative splicing,Intron Retention(IR)is emerging as an interesting area and has attracted more and more attention in the field of gene regulation and disease *** methods detect IR exclusively based on one or a few predefined metrics describing local or summarized characteristics of retained *** metrics are not able to describe the pattern of sequencing depth of intronic reads,which is an intuitive and informative characteristic of retained *** hypothesize that incorporating the distribution pattern of intronic reads will improve the accuracy of IR *** we present DeepRetention,a novel approach for IR detection by modeling the pattern of sequencing depth of *** to the lack of a gold standard dataset of IR,we first compare DeepRetention with two state-of-the-art methods,*** and IRFinder,on simulated RNA-seq datasets with retained *** results show that DeepRetention outperforms these two ***,DeepRetention performs well when it is applied to third-generation long-read RNA-seq data,while IRFinder and iREAD are not applicable to detecting IR from the third-generation sequencing ***,we show that IRs predicted by DeepRetention are biologically meaningful on an RNA-seq dataset from Alzheimer’s Disease(AD)*** differential IRs are found to be significantly associated with AD based on statistical evaluation of an AD-specific functional gene *** parent genes of differential IRs are enriched in AD-related *** summary,DeepRetention detects IR from a new angle of view,providing a valuable tool for IR analysis.

关键词： Alternative Splicing(AS) Intron Retention(IR) intronic reads distribution pattern RNA-seq

An Improved Solov2 Based on Attention Mechanism and Weighted Loss Function for Electrical Equipment Instance Segmentation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Computers, Materials & Continua 2024年第1期78卷 677-694页

作者： Junpeng wu zhenpeng Liu Xingfan Jiang Xinguang Tao Ye Zhang Key Laboratory of Modern Power System Simulation and Control&Renewable Energy Technology Ministry of EducationNortheast Electric Power UniversityJilin132012China School of Electrical Engineering Northeast Electric Power UniversityJilin132012China Baishan Power Supply Company State Grid Jilin Electric Power CoLtd.Jilin134300China

The current existing problem of deep learning framework for the detection and segmentation of electrical equipment is dominantly related to low *** of the reliable,safe and easy-to-operate technology provided by deep learning-based video surveillance for unmanned inspection of electrical equipment,this paper uses the bottleneck attention module(BAM)attention mechanism to improve the Solov2 model and proposes a new electrical equipment segmentation ***,the BAM attention mechanism is integrated into the feature extraction network to adaptively learn the correlation between feature channels,thereby improving the expression ability of the feature map;secondly,the weighted sum of CrossEntropy Loss and Dice loss is designed as the mask loss to improve the segmentation accuracy and robustness of the model;finally,the non-maximal suppression(NMS)algorithm to better handle the overlap problem in instance *** results show that the proposed method achieves an average segmentation accuracy of mAP of 80.4% on three types of electrical equipment datasets,including transformers,insulators and voltage transformers,which improve the detection accuracy by more than 5.7% compared with the original Solov2 *** segmentation model proposed can provide a focusing technical means for the intelligent management of power systems.

关键词： Deep learning electrical equipment attention mechanism weighted loss function

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

缩短断路器传动试验时间

农村电气化 2024年第9期 70-74页

作者：项锦晔吴俊飞于兴羽周利庆叶瀚冰吴振鹏国网浙江省电力有限公司衢州供电公司浙江衢州324002

在变电站检修、投产、技术改造等电力工程中需要对继电保护装置进行调试,并带上断路器进行传动试验。断路器传动试验必须结合停电进行,而试验时间的长短直接影响了设备复电时间。为了确保设备准时复役,提高供电可靠性,文章研制了一种多... 详细信息

在变电站检修、投产、技术改造等电力工程中需要对继电保护装置进行调试,并带上断路器进行传动试验。断路器传动试验必须结合停电进行,而试验时间的长短直接影响了设备复电时间。为了确保设备准时复役,提高供电可靠性,文章研制了一种多断路器联合控制装置,通过优化试验接线,实现了同时控制多台断路器就地化操作功能,应用后有效降低断路器传动试验时间,缩小作业范围,提升作业安全性,拥有广泛的实际应用前景。

关键词：电力系统联合控制传动试验

Ca and Sr co-doping induced oxygen vacancies in 3DOM La_(2-x)Sr_(x)Ce_(2-y)CayO_(7-δ)catalysts for boosting low-temperature oxidative coupling of methane

在线全文

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2024年第4期91卷 331-344页

作者： Tongtong wu Yuechang Wei Jing Xiong Yitao Yang zhenpeng Wang Dawei Han Zhen Zhao Jian Liu State Key Laboratory of Heavy Oil Processing China University of PetroleumBeijing 102249China Key Laboratory of Optical Detection Technology for Oil and Gas China University of PetroleumBeijing 102249China

It is urgent to develop catalysts with application potential for oxidative coupling of methane(OCM)at relatively lower ***,three-dimensional ordered macro porous(3 DOM)La_(2-x)Sr_(x)Ce_(2-y)CayO_(7-δ)(A_(2)B_(2)O_(7)-type)catalysts with disordered defective cubic fluorite phased structure were successfully prepared by a colloidal crystal template method.3DOM structure promotes the accessibility of the gaseous reactants(O2and CH4)to the active *** co-doping of Ca and Sr ions in La_(2-x)Sr_(x)Ce_(2-y)CayO_(7-δ)catalysts improved the formation of oxygen vacancies,thereby leading to increased density of surface-active oxygen species(O_(2)^(-))for the activation of CH4and the formation of C2products(C2H6and C2H4).3DOM La_(2-x)Sr_(x)Ce_(2-y)CayO_(7-δ)catalysts exhibit high catalytic activity for OCM at low temperature.3DOM La1.7Sr0.3Ce1.7Ca0.3O7-δcatalyst with the highest density of O_(2)^(-)species exhibited the highest catalytic activity for low-temperature OCM,i.e.,its CH4conversion,selectivity and yield of C2products at 650℃are 32.2%,66.1%and 21.3%,*** mechanism was proposed that the increase in surface oxygen vacancies induced by the co-doping of Ca and Sr ions boosts the key step of C-H bond breaking and C-C bond coupling in catalyzing low-temperature *** is meaningful for the development of the low-temperature and high-efficient catalysts for OCM reaction in practical application.

关键词： 3DOM catalysts Ca ions Sr ions Low-temperature oxidative couplingof methane Oxygen vacancies O_(2)^(-) species

Subsurface deformation mechanism and the interplay relationship between strength–ductility and fretting wear resistance during fretting of a high-strength titanium alloy

在线全文

学校读者我要写书评

暂无评论

Friction 2024年第10期12卷 2259-2280页

作者： Yanlin TONG Ke HUA Haoyang XIE Yue CAO Zhuobin HUANG zhenpeng LIANG Xiaolin LI Hongxing wu Haifeng WANG State Key Laboratory of Solidification Processing Center of Advanced Lubrication and Seal MaterialsNorthwestern Polytechnical UniversityXi’an 710072China

Fretting wear damage of high-strength titanium fasteners has caused a large number of disastrous ***,it is believed that both high strength and excellent ductility can reduce fretting wear ***,whether strength and ductility are contradictory or not and their appropriate matching strategy under the external applied normal stress(Fw)are still confusing ***,by analyzing the subsurface-microstructure deformation mechanism of several samples containing variousαprecipitate features,for the first time,we design strategies to improve fretting damage resistance under different matching relation between Fw and the tensile strength of materials(Rm).It is found that when Fw is greater than Rm or Fw is nearly equivalent to Rm,the deformation mechanism mainly manifests as serious grain fragmentation ofβandαGB *** deformation in large areas only reduces damage to a limited *** is crucial to improve the strength to resist cracking and wear,but it is of little significance to improve the ***,when Fw is far less than Rm,coordinated deformation ability reflected by ductility plays a more important *** deformation mechanism mainly manifests as localized deformation ofβandαGB constituents(kinking induced by twinning and spheroidizing).A unique composite structure of nano-grained/lamellar layer and localized deformation transition layer reduces fretting damage by five times compared with a single nanograined *** when the strength is great enough,improving the plasticity can reduce *** study can provide a principle for designing fretting damage resistant alloys.

关键词： fretting wear high-strength titanium alloy microstructures subsurface deformation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

混沌神经网络与CPG的作用机制

西安电子科技大学学报 2016年第5期43卷 173-177页

作者：马振鹏吴宗法同济大学经济与管理学院上海201804

大脑皮层是一个具有混沌特性的非线性系统,中枢模式发生器可产生节律性运动.依据生物学经验,中枢模式发生器受大脑皮层控制,但两者作用机制的研究对于生物运动控制仍是一个开放性问题.文中建立了混沌神经网络与中枢模式发生器相互作用... 详细信息

大脑皮层是一个具有混沌特性的非线性系统,中枢模式发生器可产生节律性运动.依据生物学经验,中枢模式发生器受大脑皮层控制,但两者作用机制的研究对于生物运动控制仍是一个开放性问题.文中建立了混沌神经网络与中枢模式发生器相互作用的模型和状态方程,通过分岔变化对模型的动态特性进行分析,说明混沌神经网络与中枢模式发生器间的相互工作机制,以及中枢模式发生器参数对模型的影响.同时,提出了大脑皮层有许多稳定点模式与步态模式相对应,大脑皮层模式的改变可控制步态模式的改变.研究结果表明,可通过调整大脑皮层自身外部输入和中枢模式发生器反馈回大脑皮层的值,来改变大脑皮层模式.

关键词：中枢模式发生器混沌神经网络大脑皮层分岔仿真

Performance analysis of semi-active cab’s hydraulic system of the vibratory roller using optimal fuzzy-PID control

在线全文

学校读者我要写书评

暂无评论

Journal of Southeast University(English Edition) 2019年第4期35卷 399-407页

作者： Nguyen Van Liem Zhang Jianrun wu zhenpeng Yang Xiuzhi School of Mechanical Engineering Southeast UniversityNanjing 211189China School of Mechanical and Electrical Engineering Hubei Polytechnic UniversityHuangshi 435003China

In order to evaluate the performance of semi-active cab’s hydraulic mounts(SHM)of the off-road vibratory roller with the optimal fuzzy-PID(proportional integral derivative)control,a nonlinear dynamic model of the vehicle interacting with off-road terrains is established based on Matlab/Simulink *** weighted root-mean-square(RMS)acceleration responses of the driver’s seat heave and the cab’s pitch angle are chosen as objective *** SHM is then optimized and analyzed via the optimal fuzzy-PID control under different operation *** simulations results show that the driver’s ride comfort and the cab shaking are greatly affected by the off-road terrains under various operating conditions of the vehicle,especially at the speed from 8 to 12 km/h on a very poor terrain surface of Grenville soil ground under the vehicle *** SHM using the optimal fuzzy-PID control,the driver’s ride comfort and the cab shaking are clearly improved under various operation conditions of the vehicle,particularly at the speed from 6 to 7 km/h of the vehicle traveling.

关键词： vibratory roller off-road terrains semi-active cab’s hydraulic system optimal fuzzy-PID(proportional integral derivative)control

Pectin Oligosaccharides Glycosylation Modification Reduced the Sensitization of Shrimp Tropomyosin by Regulating Cytokines Expression and Th1/Th2 Immune Balance

在线全文

学校读者我要写书评

暂无评论

Food Science and Human Wellness 2024年

作者： Mengya Zhao Chunyu wu Jing Liu Xinian Li zhenpeng Gao Xin Yang Di Liu Fangyu Long College of Food Science and Engineering， Northwest A&F University Institute of Animal Husbandry and Veterinary Medicine， Guizhou Academy of Agricultural Sciences College of Animal Science and Technology， Northwest A&F University

Tropomyosin (TM) is the predominant allergenic protein in shrimp， which has induced IgE-mediated food allergy reactions. In this study， Lit v 1 was purified from Penaeus vannamei muscles， which were glycosylated by pectic oligosaccharides. The results showed that Di-Galacturonic acid (DGA) and galacturonic acid (GA) induced the unfolding of the primary protein structure of TM， and changed alpha-helical structure， and IgE binding capacity. In addition， compared with TM-sensitized BALB/c mice， galacturonic acid-modified TM (GA-TM) and Di-Galacturonic acid-modified TM (DGA-TM) were insufficient to stimulate sensitization， and significantly reduced the hypersecretion of IgE， IgG1， HIS， and IL-4， up-regulated IgG2a and IFN-γ levels to improve imbalanced Th1/Th2， Treg/Th17 immunity， and promoted mRNA expression of tight junction proteins. Together， this study confirmed that glycosylation modification alleviated sensitization by altering TM structure， reducing IgE binding allergic inflammatory response， and regulating cytokine immune balance. Overall， these results indicated that glycosylation modification was a promising method for decreasing the allergenic reactivity of allergic proteins.

关键词：

In vivo evaluation of guide-free Cas9-induced safety risks in a pig model

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2024年第8期9卷 3493-3506页

作者： Weikai Ge Shixue Gou Xiaozhu Zhao Qin Jin zhenpeng Zhuang Yu Zhao Yanhui Liang Zhen Ouyang Xiaoyi Liul Fangbing Chen Hui Shi Haizhao Yan Han wu Liangxue Lai Kepin Wang China-New Zealand Joint Laboratory on Biomedicine and Health CAS Key Laboratory of Regenerative BiologyGuangdong Provincial Key Laboratory of Stem Cell and Regenerative MedicineJoint School of Life SciencesGuangzhou Institutes of Biomedicine and HealthChinese Academy of SciencesGuangzhou Medical UniversityGuangzhou 510530China Sanya institute of Swine resource Hainan Provincial Research Center of Laboratory AnimalsSanya 572000China Guangdong Provincial Key Laboratory of Large Animal models for Biomedicine Wuyi UniversityJiangmen 529020China Guangzhou National Laboratory Guangzhou 510005China SUniversity of Chinese Academy of Sciences 100049 BeijingChina Research Unit of Generation of Large Animal Disease Models Chinese Academy of Medical Sciences(2019RU015)Guangzhou 510530China

The CRISPR/Cas9 system has shown great potential for treating human genetic diseases through gene ***,there are concerns about the safety of this system,specifically related to the use of guide-free *** studies have shown that guidefree Cas9 can induce genomic instability in ***,the in vivo safety risks associated with guide-free Cas9 have not been evaluated,which is necessary for the development of gene therapy in clinical *** this study,we used doxycycline-inducible Cas9-expressing pigs to evaluate the safety risks of guide-free Cas9 in *** findings demonstrated that expression of guide-free Cas9 could induce genomic damages and transcriptome changes in *** severity of the genomic damages and transcriptome changes were correlate with the expression levels of Cas9 ***,prolonged expression of Cas9 in pigs led to abnormal phenotypes,including a significant decrease in body weight,which may be attributable to genomic damage-induced nutritional absorption and metabolic ***,we observed an increase in whole-genome and tumor driver gene mutations in pigs with long-term Cas9 expression,raising the risk of tumor *** in vivo evaluation of guide-free Cas9 in pigs highlights the necessity of considering and monitoring the detrimental effects of Cas9 alone as genome editing via the CRISPR/Cas9 system is implemented in clinical gene *** research emphasizes the importance of further study and implementation of safety measures to ensure the successful and safe application of the CRiSPR/Cas9 system in clinical practice.

关键词： CRISPR/Cas9 vivo alone