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狼疮性肾炎患者血清补体C9、凝溶胶蛋白与肾功能及疾病转归的关系

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国际检验医学杂志 2024年第9期45卷 1106-1109,1115页

作者：张福韩碧翠刘贞妮文昌市人民医院肾内风湿科海南文昌571300

目的分析狼疮性肾炎患者血清补体C9、凝溶胶蛋白(GSN)与肾功能及疾病转归的关系。方法选择2020年7月至2022年4月该院收治的101例狼疮性肾炎患者作为研究对象,根据入院时肾小球滤过率(eGFR)分为肾功能正常组[eGFR≥90 mL/(min·1.73 m^(2... 详细信息

目的分析狼疮性肾炎患者血清补体C9、凝溶胶蛋白(GSN)与肾功能及疾病转归的关系。方法选择2020年7月至2022年4月该院收治的101例狼疮性肾炎患者作为研究对象,根据入院时肾小球滤过率(eGFR)分为肾功能正常组[eGFR≥90 mL/(min·1.73 m^(2)),n=57]和肾功能不全组[eGFR<90 mL/(min·1.73 m^(2)),n=44]。所有患者入院后24 h内检测血清补体C9、GSN,并进行组间比较。采用Pearson相关法分析血清补体C9、GSN与狼疮性肾炎患者肾功能的关系。随访后根据疾病转归情况分为恶化组(n=35)和好转组(n=66)。采用受试者工作特征(ROC)曲线评估血清补体C9、GSN对狼疮性肾炎患者疾病转归的预测价值,多因素Logistic回归分析探讨狼疮性肾炎患者疾病转归的相关因素。结果肾功能正常组患者血清补体C9低于肾功能不全组,血清GSN水平高于肾功能不全组,差异有统计学意义(P<0.05)。Pearson相关性分析发现,血清补体C9与狼疮性肾炎患者的肾功能呈显著负相关(r=-0.554,P<0.001),血清GSN与狼疮性肾炎患者的肾功能呈显著正相关(r=0.448,P<0.001)。恶化组血清补体C9水平高于好转组,GSN水平低于好转组,差异有统计学意义(P<0.05)。ROC曲线分析显示,血清补体C9预测狼疮性肾炎疾病转归的曲线下面积(AUC)为0.826(95%CI:0.776~0.876);血清GSN预测狼疮性肾炎疾病转归的AUC为0.830(95%CI:0.780~0.880);二者联合检测预测狼疮性肾炎疾病转归的AUC为0.905(95%CI:0.855~0.955)。多因素Logistic回归分析发现,血清补体C9(OR=3.480,95%CI:1.983~6.108)、GSN(OR=4.225,95%CI:2.050~8.708)及eGFR(OR=3.762,95%CI:2.069~6.840)、24 h尿蛋白(OR=1.939,95%CI:1.442~2.642)均为影响狼疮性肾炎疾病转归的危险因素(P<0.05)。结论血清补体C9、GSN水平变化与狼疮性肾炎肾功能、疾病转归密切相关,且均可作为评估狼疮性肾炎患者疾病转归的有效指标,二者联合检测具有更好的预测价值。

关键词：狼疮性肾炎补体C9 凝溶胶蛋白肾功能疾病转归

Label-noise robust classification with multi-view learning

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Science China(Technological Sciences) 2023年第6期66卷 1841-1854页

作者： LIANG NaiYao YANG ZuYuan LI LingJiang LI zhenni XIE ShengLi Guangdong Key Laboratory of IoT Information Technology School of AutomationGuangdong University of TechnologyGuangzhou 510006China Key Laboratory of iDetection and Manufacturing-IoT Ministry of EducationGuangzhou 510006China Guangdong-HongKong-Macao Joint Laboratory for Smart Discrete Manufacturing Guangzhou 510006China

Label noise is often contained in the training data due to various human factors or measurement errors,which significantly causes a negative effect on *** many previous methods that have been proposed to learn robust classifiers,they are mainly based on the single-view *** the other hand,although existing multi-view classification methods benefit from the more comprehensive information,they rarely consider label *** this paper,we propose a novel label-noise robust classification model with multi-view learning to overcome these *** the proposed model,not only the classifier learning but also the label-noise removal can benefit from the multi-view ***,we relax the label matrix of the basic multi-view least squares regression model,and develop a nonlinear transformation with a natural probabilistic approximation in the process of labels,which is conveniently optimized and beneficial to improve the discriminative ability of ***,we preserve the intrinsic manifold structure of multi-view data on the relaxed label matrix,facilitating the process of label *** optimizing the proposed model with the nonlinear transformation,we derive a lemma about the partial derivation of the softmax related function,and develop an efficient alternating *** evaluations on six real-world datasets confirm the advantages of the proposed method,compared to the related state-of-the-art methods.

关键词： label noise multi-view learning classification robust least squares regression label relaxation

大同方言詈辞“□[x?u423]”缀本字考

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忻州师范学院学报 2024年第3期40卷 33-37页

作者：张珍妮黄思贤海南师范大学文学院

在大同方言中，有多种形式的詈辞，其中有一种以“[x?u423]”为类词缀的詈词，“[x?u423]”位于词末，形成“X+[x?u423]”的结构。在以往文献中，这一类词缀一般用“猴”字表示，故此类词常描写为“X猴”。虽然该类词缀有了记录字，但... 详细信息

在大同方言中，有多种形式的詈辞，其中有一种以“[x?u423]”为类词缀的詈词，“[x?u423]”位于词末，形成“X+[x?u423]”的结构。在以往文献中，这一类词缀一般用“猴”字表示，故此类词常描写为“X猴”。虽然该类词缀有了记录字，但是目前学界尚未对这一本字进行深入考证，缺乏说服力。文章从语音和语义两方面出发，通过田野调查和综合比较，认为这一类词缀的本字确为“猴”字。

关键词：大同方言本字詈辞猴

基于在地化教育培养高中生地理批判性思维的教学设计——以“农业区位因素及其变化”为例

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地理教学 2024年第4期 8-12页

作者：沈素琴安珍妮吴涛张建珍葛佳浩浙江师范大学地理与环境科学学院浙江金华321004 浙江师范大学教育学院浙江金华321004

地理批判性思维是学生应对复杂地理问题的关键能力。在地化教育通过联结学校、地方和社区,将地方资源与课程内容相结合,鼓励学生以批判性眼光看待真实问题,与地理批判性思维的培养有着紧密联系。本研究以“农业区位因素及其变化”为例,... 详细信息

地理批判性思维是学生应对复杂地理问题的关键能力。在地化教育通过联结学校、地方和社区,将地方资源与课程内容相结合,鼓励学生以批判性眼光看待真实问题,与地理批判性思维的培养有着紧密联系。本研究以“农业区位因素及其变化”为例,在把握地理批判性思维概念框架的基础上,依托图尔敏论证教学模型,构建在地化教育新模式,为中学地理教学开展在地化教育、培养学生地理批判性思维提供借鉴。

关键词：在地化教育地理批判性思维农业区位因素图尔敏论证模型

4-取代-1-(2-甲基-6-(吡啶-3-基)-烟酰)氨基脲类衍生物合成与生物活性研究（英文）

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有机化学 2019年第9期39卷 2507-2514页

作者：胡鸿雨吴俊袁建锋王珍妮李晨帆严晓阳方美娟赵胜贤浙江师范大学行知学院金华321004 厦门大学药学院厦门361102 宁波大学科学技术学院慈溪315302

经分子杂交技术[A1]合成了一系列4-取代-1-(2-甲基-6-(吡啶-3-基)-烟酰)氨基脲类衍生物.采用噻唑蓝(MTT)比色法研究了目标化合物对人肝癌细胞(QGY-7703)、人肺癌细胞(NCl-H460)和乳腺癌细胞(MCF-7)的体外抗肿瘤活性.1-(2-甲基-6-(吡啶-3... 详细信息

经分子杂交技术[A1]合成了一系列4-取代-1-(2-甲基-6-(吡啶-3-基)-烟酰)氨基脲类衍生物.采用噻唑蓝(MTT)比色法研究了目标化合物对人肝癌细胞(QGY-7703)、人肺癌细胞(NCl-H460)和乳腺癌细胞(MCF-7)的体外抗肿瘤活性.1-(2-甲基-6-(吡啶-3-基)烟酰基)-4-(2,4,6-三氯苯基)氨基脲(4n)显示了最优的活性,其半数抑制浓度(IC50)为8.89~11.45 μmol/L.细胞体内的生物研究显示,4n药物[A2]处理能明显增加细胞体内PARP切割水平以及诱导QGY-7703肿瘤细胞的凋亡.

关键词：氨基脲联吡啶分子杂交生物活性

Structured Sparse Coding With the Group Log-regularizer for Key Frame Extraction

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IEEE/CAA Journal of Automatica Sinica 2022年第10期9卷 1818-1830页

作者： zhenni Li Yujie Li Benying Tan Shuxue Ding Shengli Xie the School of Automation Guangdong University of TechnologyGuangzhou 510006 the Guangdong-Hong Kong-Macao Joint Laboratory for Smart Discrete Manufacturing Guangdong University of Technology(GDUT)Guangzhou 510006China the School of Artificial Intelligence Guilin University of Electronic TechnologyGuilin 541004China the National Institute of Advanced Industrial Science and Technology TsukubaIbaraki 305-8560Japan IEEE the Key Laboratory of Intelligent Information Processing and System Integration of Io T(GDUT) Ministry of Education Guangdong Key Laboratory of IoT Information Technology(GDUT) Guangzhou 510006China

Key frame extraction based on sparse coding can reduce the redundancy of continuous frames and concisely express the entire ***,how to develop a key frame extraction algorithm that can automatically extract a few frames with a low reconstruction error remains a *** this paper,we propose a novel model of structured sparse-codingbased key frame extraction,wherein a nonconvex group log-regularizer is used with strong sparsity and a low reconstruction *** automatically extract key frames,a decomposition scheme is designed to separate the sparse coefficient matrix by *** rows enforced by the nonconvex group log-regularizer become zero or nonzero,leading to the learning of the structured sparse coefficient *** solve the nonconvex problems due to the log-regularizer,the difference of convex algorithm(DCA)is employed to decompose the log-regularizer into the difference of two convex functions related to the l1 norm,which can be directly obtained through the proximal ***,an efficient structured sparse coding algorithm with the group log-regularizer for key frame extraction is developed,which can automatically extract a few frames directly from the video to represent the entire video with a low reconstruction *** results demonstrate that the proposed algorithm can extract more accurate key frames from most Sum Me videos compared to the stateof-the-art ***,the proposed algorithm can obtain a higher compression with a nearly 18% increase compared to sparse modeling representation selection(SMRS)and an 8% increase compared to SC-det on the VSUMM dataset.

关键词： Difference of convex algorithm(DCA) group logregularizer key frame extraction structured sparse coding

丹曲林对心房颤动大鼠心肌纤维化及TGF-β_(1)/Smad2信号通路的影响

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中西医结合心脑血管病杂志 2024年第4期22卷 632-639页

作者：谭珍妮吕春美邹海林邵阳学院附属第一医院湖南邵阳422000

目的:探讨丹曲林对心房颤动大鼠心肌纤维化及转化生长因子-β_(1)(TGF-β_(1))/Smad2信号通路的影响。方法:72只SD大鼠采用随机数字表法分为空白对照组、模型组、丹曲林低剂量组、丹曲林高剂量组、阳性对照组、丹曲林高剂量+SRI-011381(... 详细信息

目的:探讨丹曲林对心房颤动大鼠心肌纤维化及转化生长因子-β_(1)(TGF-β_(1))/Smad2信号通路的影响。方法:72只SD大鼠采用随机数字表法分为空白对照组、模型组、丹曲林低剂量组、丹曲林高剂量组、阳性对照组、丹曲林高剂量+SRI-011381(TGF-β激动剂)组,每组12只。丹曲林低剂量组、丹曲林高剂量组大鼠分别腹腔注射5、10 mg/kg丹曲林;阳性对照组大鼠灌胃20 mg/kg维拉帕米;丹曲林高剂量+SRI-011381组大鼠腹腔注射10 mg/kg丹曲林和30 mg/kg SRI-011381;空白对照组、模型组大鼠腹腔注射等体积生理盐水,每日1次,持续4周。4周后,除空白对照组外,其余各组大鼠均按1 mL/kg尾静脉注射乙酰胆碱-氯化钙混合液(乙酰胆碱66μg/mL+氯化钙10 mg/mL)构建心房颤动模型,空白对照组大鼠尾静脉注射等体积生理盐水,每日1次,持续1周,1周后采集心电图数据并记录心房颤动诱发时间;彩色多普勒超声仪检测左室舒张末期内径(LVEDD)、左室缩短分数(LVFS)、左室射血分数(LVEF)、左室收缩末期内径(LVESD)的变化;苏木精-伊红(HE)染色检测大鼠心肌组织病理损伤;Masson染色检测大鼠心肌纤维化;免疫组化法检测心肌组织中Ⅰ型胶原蛋白(COL-Ⅰ)、Ⅲ型胶原蛋白(COL-Ⅲ)表达;酶联免疫吸附测定法(ELISA)法检测心肌组织中肿瘤坏死因子-α(TNF-α)、白细胞介素-1β(IL-1β)水平;蛋白质免疫印迹法(Western Blot)检测TGF-β_(1)、p-Smad2、α平滑肌肌动蛋白(α-SMA)蛋白表达。结果:与空白对照组比较,模型组大鼠心律不齐,心肌组织病理损伤及纤维化严重,LVEDD、LVESD、COL-Ⅰ、COL-Ⅲ阳性表达及IL-1β、TNF-α水平以及TGF-β_(1)、p-Smad2、α-SMA蛋白表达升高,LVFS、LVEF降低(P<0.05);与模型组比较,丹曲林低剂量组、丹曲林高剂量组、阳性对照组对应指标变化趋势与上述相反,且丹曲林浓度越高,对应的变化趋势越明显(P<0.05);SRI-011381减弱了高剂量丹曲林对心房颤动大鼠心肌纤维化及炎症反应的抑制作用。结论:丹曲林可能通过抑制TGF-β_(1)/Smad2信号通路减轻心房颤动大鼠心肌纤维化及炎症反应。

关键词：心房颤动心肌纤维化丹曲林转化生长因子-β_(1)/Smad2信号通路

老年原发性高血压患者外周血淋巴细胞亚群及活化状态的研究

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心电与循环 2014年第3期33卷 220-222页

作者：王珍妮冯杜金邱莲女浙江省人民医院检验中心杭州市310014

目的探讨老年原发性高血压患者外周血淋巴细胞亚群活化状态变化。方法采用流式细胞术检测65岁以上老年原发性高血压患者(观察组)170例和体检健康者(对照组)50例外周血淋巴细胞亚群以及活化状态。结果观察组B淋巴细胞表达的CD3^-CD1 9^+... 详细信息

目的探讨老年原发性高血压患者外周血淋巴细胞亚群活化状态变化。方法采用流式细胞术检测65岁以上老年原发性高血压患者(观察组)170例和体检健康者(对照组)50例外周血淋巴细胞亚群以及活化状态。结果观察组B淋巴细胞表达的CD3^-CD1 9^+高于对照组,T淋巴细胞活化表达的CD3^+CD8^+CD38^+高于对照组,CD3^+HLA-DR^+,CD3^+CD8^+HLA-DR^+以及NK细胞表达的CD16^+CD56^+高于对照组(均P0.05)。结论老年原发性高血压患者B淋巴细胞、NK淋巴细胞和CD8^+T细胞的活化能力显著增加。

关键词：流式细胞术活化淋巴细胞原发性高血压

Percent body fat,but not body mass index,is associated with cardiometabolic risk factors in children and adolescents

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Chronic Diseases and Translational Medicine 2023年第2期9卷 143-153页

作者： Xin He zhenni Zhu Jiajie Zang Zhengyuan wang Ping Liao Wenjing wang Yan Shi Chen Fu Laboratory of Functional Medicine Division of Chronic Non-communicable Diseases and InjuryShanghai Municipal Center for Disease Control and PreventionShanghaiChina Department of Nutrition Hygiene Division of Health Risk Factor Monitoring and ControlShanghai Municipal Center for Disease Control and PreventionShanghaiChina

Background:The epidemic of overweight and obesity has become a worldwide public health *** diseases may originate in *** investigated the association between percent body fat(PBF)measured by the bioelectrical impedance assay and cardiometabolic risk(CMR)in ***:This cross-sectional study involved 3819 subjects(6-17 years old)in *** assessed the association between PBF and body mass index(BMI)with multiple CMR *** examined the risk for cardiometabolic abnormalities attributable to overweight and obesity based on age-and sexspecific PBF Z-scores and BMI Z-scores,***:PBF,but not BMI,was positively associated with multiple CMR factors in males and females except for total cholesterol in females(all p<0.05).Compared with the non-overweight group based on PBF,overweight and obese subjects had increasingly higher odds ratio of dyslipidemia(2.90(1.99-4.23),4.59(2.88-7.32)for males and 1.82(1.20-2.75),2.46(1.47-4.11)for females)and elevated blood pressure(BP)(3.26(2.35-4.51),4.55(2.92-7.09)for males and 1.59(1.07-2.34),3.98(2.27-6.17)for females).Obesity females showed a higher likelihood for hyperglycemia(2.19(1.24-3.84))than non-overweight *** both sexes,the predictive effect of PBF on dyslipidemia and elevated BP in adolescents was better than that in *** hyperglycemia,the predictive effect of PBF was better in male adolescents and female *** was no risk difference for cardiometabolic abnormalities attributable to BMI-based obesity ***:PBF but not BMI was associated with *** and obesity categories based on PBF had an increased risk for cardiometabolic abnormalities in children and adolescents.

关键词： adolescents cardiometabolic risk factors children obesity percent body fat