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Preliminary study on the safety and efficacy of a new polymyxin B-immoblized resin column in treatment of LPS-induced sepsis beagles

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Animal Models and Experimental Medicine 2022年第2期5卷 161-171页

作者： Yonggui Li Zhenggen Yang Jialiang Hu zhennan lin Research and Development Center Guangzhou Koncen Bioscience Co.Ltd.GuangzhouPR China Guangdong Provincial Key Laboratory of Hemoadsorption Technology GuangzhouPR China

Background:This study aims to assess the safety and efficacy of direct hemoperfu-sion using a new polymyxin B-immobilized resin column(disposable endotoxin ad-sorber,KCEA)in an endotoxin/lipopolysaccharide(LPS)-induced sepsis ***:Eighteen beagles were randomized into 1 intervention group(KCEA group,n=6)and 2 control groups(sham group and model group,n=6 each).Sepsis was in-duced by continuous intravenous application of 0.5 mg/kg body weight of endotoxin for 60 *** extracorporeal hemoperfusion device made with KCEA for endotoxin adsorption was *** group beagles received standard treatment with fluids and vasoactive drugs,KCEA group beagles received standard treatment and direct hemoperfusion of KCEA for 2 h,and sham group beagles were treated with standard treatment and direct hemoperfusion of a sham column for 2 ***:Good blood compatibility of KCEA was confirmed by assessing clinical *** endotoxin peak levels in the KCEA group were significantly lower,resulting in a significant suppression of IL-6,TNF-αand procalcitonin,which improved mean arterial pressure and significantly lowered vasopressor demand,thereby pro-tecting organ function and improving survival time and *** the KCEA group,MAP was significantly higher over 6 h than those recorded both in the sham group and model *** 7-day survival rates of the KCEA,sham and model groups were 50%,0%and 0%,***:KCEA hemoadsorption was effective at detoxifying circulatory endotoxin and inflammatory mediators and contributed to the decreased mortality rate in the sepsis beagles.

关键词： endotoxin hemoadsorption polymyxin B sulfate resin sepsis

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The Genetic Association between CDKN1A and Heart Failure:Genome-Wide Exploration of m6A-SNPs and Mendelian Randomization

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Biomedical and Environmental Sciences 2024年第12期37卷 1397-1408页

作者： Ziyi Yang zhennan lin Xiaotong Ning Xingbo Mo Laiyuan Wang Xiangfeng Lu Shufeng Chen Key Laboratory of Cardiovascular Epidemiology Department of EpidemiologyFuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China Center for Genetic Epidemiology and Genomics Department of EpidemiologyJiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric DiseasesSchool of Public HealthMedical College of Soochow UniversitySuzhou 215123JiangsuChina

Objective N6-methyladenosine(m^(6)A)is a common epigenetic modification in *** this study,we explore the potential impact of m^(6)A-associated single nucleotide polymorphisms(m^(6)A-SNPs)on heart failure(HF).Methods Data from genome-wide association studies(GWAS)investigating HF in humans and from m^(6)A-SNPs datasets were used to identify HF-associated m^(6)*** functions were explored using expression quantitative trait locus(eQTL),gene expression,and gene enrichment *** protein quantitative trait locus(pQTL)-Mendelian randomization(MR)was used to investigate the potential mechanism between critical protein levels and risk factors for *** We screened 44 HF-associated m^(6)A-SNPs,including 10 m^(6)A-SNPs that showed eQTL signals and differential expressions in *** SNP rs1801270 in CDKN1A showed the strongest association with HF(P=7.75×10^(−6)).Additionally,MR verified the genetic association between the CDKN1A protein and HF,as well as the mediating effect of blood pressure(BP)in this *** circulating level of CDKN1A was associated with a lower risk of HF(odds ratio[OR]=0.82,95%confidence interval[CI]:0.69 to 0.99).The proportions of hypertension,systolic BP,and diastolic BP were 48.10%,28.94%,and 18.02%,*** of PDIA6(P=1.30×10^(−2))and SMAD3(P=4.80×10^(−2))with HF were also *** Multiple HF-related m^(6)A-SNPs were identified in this *** associations of CDKN1A and other proteins with HF and its risk factors were demonstrated,providing new ideas for further exploration of the molecular mechanisms of HF.

关键词： Heart failure N6-methyladenosine modification Genome-wide association study Expression quantitative trait locus Mendelian randomization

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Metabolomics signature of blood pressure salt sensitivity and its link to cardiovascular disease:A dietary salt-intervention trial

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Science China(Life Sciences) 2024年第8期67卷 1666-1675页

作者： zhennan lin Jianxin Li Fangchao Liu Jie Cao Shufeng Chen Jichun Chen Keyong Huang Yaqin Wang Hongfan Li Yan Wang Jianfeng Huang Dongfeng Gu Xiangfeng Lu Key Laboratory of Cardiovascular Epidemiology Department of EpidemiologyFuwai HospitalChinese Academy of Medical Sciences and Peking Union Medical College/National Center for Cardiovascular DiseasesBeijing 100037China Medical School Southern University of Science and TechnologyShenzhen 518055China

Individuals with a high degree of salt sensitivity(SS)have a greater risk of cardiovascular disease(CVD),but whether SS fosters CVD by influencing metabolomics homeostasis remains *** study aimed to reveal the role of the SS-related metabolomics signature in the development of CVDs,based on the MetaSalt study,which was a dietary salt-intervention trial conducted at four centers in China in 2019.A total of 528 participants were recruited and underwent 3 days of baseline observations,a 10-day low-salt intervention,and a 10-day highsalt *** untargeted metabolomics,lipidomics,and BP measurements were scheduled at each *** were grouped into extreme SS,moderate SS,and salt-resistant(SR)individuals according to their BP responses to *** mixed models were used to identify SS-related metabolites and determine the relationship between the SS-related metabolomics signature and arterial *** randomization(MR)analyses were applied to establish the causal pathways among the SS-related metabolites,BP,and *** the 713 metabolites,467 were significantly changed after the high-salt *** them,the changes in 30 metabolites from the low-salt to the high-salt intervention differed among the SS *** the remaining nonsalt-related metabolites,the baseline levels of 11 metabolites were related to *** 41 metabolites explained 23%of the variance in ***,SS and its metabolomics signature were positively correlated with arterial *** analyses demonstrated that the SS-related metabolites may affect CVD risk by altering BP,indicating that the increase in BP was the consequence of the changes in SS-related metabolites rather than the *** study revealed that the metabolomics signature of SS individuals differs from that of SR individuals and that the changes in SS-related metabolites may increase arterial stiffness and foster *** study provides insight into understanding the biolog

关键词： salt sensitivity dietary salt intake metabolomics Mendelian randomization cardiovascular disease

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Impacts of PM_(2.5) on Ambulatory Blood Pressure Monitoring Indicators Attenuated by Blood Pressure Control Status and Treatment-Two Cities and Two Municipalities,China,2017−2019

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China CDC weekly 2021年第45期3卷 948-953页

作者： Fangchao Liu zhennan lin Xinyan Wang Xueli Yang Qiong Liu Xiaolong Xing Jie Cao Jianxin Li Keyong Huang Weli Yan Tingting Liu Wei Li Shufeng Chen Xiangfeng Lu Dongfeng Gu Jianfeng Huang Department of Epidemiology Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Key Laboratory of Cardiovascular Epidemiology Chinese Academy of Medical SciencesBeijingChina Center for Reproductive Medicine Tianjin Central Hospital of Gynecology ObstetricsTianjinChina Tianjin Key Laboratory of Environment Nutrition and Public HealthDepartment of Occupational and Environmental HealthSchool of Public HealthTianjin Medical UniversityTianjinChina Department of Clinical Epidemiology&Clinical Trial Unit Children’s Hospital of Fudan UniversityNational Children’s Medical CenterShanghaiChina Department of Cardiology Renmin Hospital of Wuhan UniversityWuhanHubeiChina Function Test Center Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina School of Medicine Southern University of Science and TechnologyShenzhenGuangdongChina

Summary What is already known about this topic?Short-term PM_(2.5) exposure has been associated with hourly,24-hour,daytime,and nighttime blood pressure(BP)levels,and further studies focusing whether and how the assoc... 详细信息

关键词： Blood monitoring indicators

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YTaO_4:Gd,Eu体系光致发光中的能量传递

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物理化学学报 1999年第9期15卷 784-798页

作者：李博顾镇南林建华苏勉曾北京大学化学系北京100871 北京大学化学系稀土材料化学与应用国家重点实验室北京100871

用高温固相反应法合成了钆、铕离子双掺杂的正钽酸盐化合物YTaO4 :Gd ,Eu ,研究了该体系在紫外光激发下的发光性能 .对该体系激发、发射及漫反射光谱的研究表明 ,Gd3+ 离子在发光过程中可以作为能量传递的中介 ,该体系在发光过程中存在... 详细信息

用高温固相反应法合成了钆、铕离子双掺杂的正钽酸盐化合物YTaO4 :Gd ,Eu ,研究了该体系在紫外光激发下的发光性能 .对该体系激发、发射及漫反射光谱的研究表明 ,Gd3+ 离子在发光过程中可以作为能量传递的中介 ,该体系在发光过程中存在钽酸根到Eu3+ 离子 ,或者钽酸根到Gd3+ 离子、再到Eu3+

关键词：钽酸盐稀土光致发光 X射线发光材料钆铕

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Prevalence of familial hypercholesterolemia and its association with coronary artery disease:A Chinese cohort study

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Chronic Diseases and Translational Medicine 2023年第2期9卷 134-142页

作者： Xiapikatijiang Aihaiti Shufeng Chen Jianxin Li zhennan lin Qingmei Cui Xue Xia Fangchao Liu Chong Shen Dongsheng Hu Keyong Huang Yingxin Zhao Fanghong Lu Xiaoqing Liu Jie Cao ling Yu Ying Li Huan Zhang Zhenyan Fu Liancheng Zhao Jianfeng Huang Dongfeng Gu Xiangfeng Lu Department of Epidemiology Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Key Laboratory of Cardiovascular Epidemiology Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijingChina China National Clinical Research Center for Neurological Diseases Beijing Tiantan Hospital Capital Medical UniversityBejingChina Department of Epidemiology and Biostatistics Center for Global HealthSchool of Public HealthNanjing Medical UniversityNanjingJiangsuChina School of Public Health Zhengzhou UniversityZhengzhouHenanChina School of Public Health Shenzhen UniversityShenzhenGuangdongChina Cardio-Cerebrovascular Control and Research Center Institute of Basic MedicineShandong Academy of Medical SciencesJinanShandongChina Division of Epidemiology Guangdong Provincial People's Hospital Guangdong Cardiovascular InstituteGuangzhouGuangdongChina Department of Cardiology Fujian Provincial People's HospitalFuzhouFujianChina Center for Genetic Epidemiology and Genomics School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric DiseasesSoochow University Medical CollegeSuzhouJiangsuChina Department of Cardiology First Affiliated Hospital of Xinjiang Medical UniversityUrumqiXinjiangChina School of Medicine Southern University of Science and TechnologyShenzhenGuangdongChina

Background:Familial hypercholesterolemia(FH)is underrecognized,and its association with coronary artery disease(CAD)remains limited,especially in *** aimed to investigate the prevalence of FH and its relationship with CAD in a large Chinese ***:FH was defined using the Make Early Diagnosis to Prevent Early Death(MEDPED)*** crude and age-sex standardized prevalence of FH were calculated based on surveys of the Prediction for Atherosclerotic Cardiovascular Disease Risk in China(China-PAR)project during 2007−*** associations of FH with incident CAD and its major subtypes were estimated with the cohort-stratified multivariate Cox proportional hazard models based on the data from the baseline to the last follow-up(2018−2020).Results:Among 98,885 included participants,190 participants were defined as *** and age−sex standardized prevalence and 95%confidence interval(CI)of FH were 0.19%(0.17%-0.22%)and 0.13%(0.10%-0.16%),*** prevalence varied across age groups and peaked in the group of 60-<70 years(0.28%),and the peak prevalence(0.18%)in males was earlier,yet lower than the peak crude prevalence in females(0.41%).During a mean follow-up of 10.7 years,2493 cases of incident CAD were *** multivariate adjustment,FH patients had a 2.03-fold greater risk of developing CAD compared to non-FH ***:The prevalence of FH was estimated to be 0.19%in the participants,and it was associated with an elevated risk of incident *** study suggests that early screening of FH has certain public health significance for the prevention of CAD.

关键词： cohort study coronary artery disease familial hypercholesterolemia prevalence

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脂蛋白(a)基因多态性与冠心病相关性的Meta分析

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中国动脉硬化杂志 2022年第2期30卷 152-160页

作者：林振南贾砚慧陈恕凤北京协和医学院国家心血管病中心中国医学科学院阜外医院流行病研究部中国医学科学院心血管流行病学重点实验室北京市100037

目的评估脂蛋白(a)基因(LPA)多态性与冠心病风险之间的相关性。方法检索PubMed、Embase、Web of Science、Cochran、中国知网和万方数据库中LPA基因rs10455872和/或rs3798220多态性与冠心病的关联研究,检索时限均为建库至2021年6月10日... 详细信息

目的评估脂蛋白(a)基因(LPA)多态性与冠心病风险之间的相关性。方法检索PubMed、Embase、Web of Science、Cochran、中国知网和万方数据库中LPA基因rs10455872和/或rs3798220多态性与冠心病的关联研究,检索时限均为建库至2021年6月10日。由两名研究者独立筛选文献、提取信息和评价偏倚风险。使用纽卡斯尔-渥太华评分(NOS)对各研究质量进行评分。研究间的异质性根据I^(2)和Cochran Q检验评估,若异质性明显(I^(2)≥50%且P<0.05)则使用随机效应模型估计比值比(OR)和95%可信区间(95%CI)。采用网状Meta分析比较不同多态性对冠心病的影响程度。采用漏斗图和Egger检验评价发表偏倚。所有分析应用RevMan 5.3和R4.0.5软件进行。P<0.05认为有统计学意义。结果最终纳入分析的研究中,rs10455872相关研究9项,rs3798220相关研究15项。Meta分析结果表明,rs10455872_G与rs3798220_C等位基因均与冠心病显著关联(rs10455872_G:OR 1.19,95%CI 1.10~1.30;rs3798220_C:OR 1.59,95%CI 1.27~2.00)。显性模型结果表明,rs10455872_G等位基因携带者患冠心病风险较AA纯合子增加21%(OR 1.21,95%CI 1.11~1.32),而rs3798220_C等位基因携带者患冠心病风险较TT纯合子增加59%(OR 1.59,95%CI 1.26~2.02)。网状Meta分析提示rs3798220_C携带者患冠心病风险更高。结论LPA基因多态性与冠心病风险显著相关,携带危险等位基因的人群更需要积极预防心血管疾病。

关键词：脂蛋白(a) 单核苷酸多态性关联研究冠心病

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Influence of travel speed on microstructure and mechanical properties of wire + arc additively manufactured 2219 aluminum alloy

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Journal of Materials Science & Technology 2020年第2期37卷 143-153页

作者： Yinghui Zhou Xin lin Nan Kang Weidong Huang Jiang Wang zhennan Wang State Key Laboratory of Solidification Processing Northwestern Polytechnical UniversityXi’an 710072China Key Laboratory of Metal High Performance Additive Manufacturing and Innovative Design MIIT ChinaNorthwestern Polytechnical UniversityXi’an 710072China

Wire+arc additive manufacturing(WAAM)was preliminarily employed to fabricate the 2219 aluminum *** influence of the electric arc travel speed(TS)on the macro-morphology,microstructure,and mechanical properties were *** results indicated that as the electric arc TS increased,the size and the volume fraction of equiaxed grain *** high arc TS during WAAM also promoted the precipitation of theθ(Al2Cu)*** volume fractions ofθ’’andθ’phases reached maximum values when TS is 350 and 250 mm/min,*** thermal cycle facilitated the precipitation of theθ’*** addition,the micro-hardness and tensile strength of the alloy were analyzed,and the results indicated that samples fabricated at TS of 350 mm/min possessed finer equiaxed grain and exhibited higher ultimate tensile strength(273.5 MPa)and yield strength(182.9 MPa)compared to those fabricated at 250 mm/min.

关键词： Wire+arc additive manufacturing 2219 aluminum alloy Microstructure Mechanical properties

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先天性主动脉窦动脉瘤的X线分析

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上海第一医学院学报 1982年第1期 55-58页

作者：周康荣顾光宁陈祖望张镇南林贵上海第一医学院中山医院放射科

30例主动脉窦动脉瘤(下称主动脉窦瘤)中发生在右冠窦的29例,发生在无冠窦的1例。2例未破,28例破裂,破入右心室者23例,破入右心房者5例。单纯性18例,另12例合并室间隔缺损、主动脉瓣脱垂、动脉导管未闭等畸形。瘤破裂前,单纯性者除个别... 详细信息

30例主动脉窦动脉瘤(下称主动脉窦瘤)中发生在右冠窦的29例,发生在无冠窦的1例。2例未破,28例破裂,破入右心室者23例,破入右心房者5例。单纯性18例,另12例合并室间隔缺损、主动脉瓣脱垂、动脉导管未闭等畸形。瘤破裂前,单纯性者除个别病例外,一般无症状及阳性体征出现。瘤一旦破裂后,产生左向右分流,临床表现一般比较典型,x线片示心脏于短期内迅速增大,按26例x线片统计,心脏中度以上增大者21例。肺充血程度相对较轻,中度以下者占23例,且常伴肺郁血改变。

关键词：主动脉瓣脱垂动脉导管未闭主动脉窦瘤室间隔缺损先天性心脏病

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钢框架结构竖向撞击响应数值模拟分析

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江西建材 2022年第2期 8-10页

作者：陈银毅林振南郭金龙郭晓陈媛媛郑钰李清玥福建江夏学院工程学院福建福州350108 中建海峡建设发展有限公司福建福州350015

多层钢框架结构在工程中得到较为广泛的应用。文中通过建立有限元数值模型,对竖向撞击荷载作用下多层钢框架结构进行数值模拟,分析其在撞击荷载作用下的结构响应,并分析撞击速度和撞击物质量对结构响应的影响。结果显示,竖向撞击下,多... 详细信息

多层钢框架结构在工程中得到较为广泛的应用。文中通过建立有限元数值模型,对竖向撞击荷载作用下多层钢框架结构进行数值模拟,分析其在撞击荷载作用下的结构响应,并分析撞击速度和撞击物质量对结构响应的影响。结果显示,竖向撞击下,多层钢框架结构受到一个极大的瞬时撞击力,受撞击处发生明显的振动,并产生较大的塑性残余变形。随着撞击速度或撞击物质量的增大,撞击力峰值随之近似呈线性增大,受撞处变形也随之增大,且增长趋势逐渐增强。

关键词：钢框架结构竖向撞击荷载动力响应数值模拟

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