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Biomedical and Environmental Sciences 2024年第7期37卷 739-753页

作者： Keyuan Xu Xiaoting Tang Yun Xiang Yiding Shen zhennan deng Pingping Ma Xinkun Shen Department of Orthopaedics The Third Affiliated Hospital of Wenzhou Medical University(Ruian People’s Hospital)Wenzhou 325016ZhejiangChina School and Hospital of Stomatology Wenzhou Medical UniversityWenzhou 325027ZhejiangChina

Objective A high sodium(HS)diet is believed to affect bone metabolism *** its impact on osseointegration of titanium(Ti)implants holds significant implications for postoperative dietary management of implanted *** This investigation probed the impact of sodium ions(Na^(+))on neovascularization and osteogenesis around Ti implants in vivo,utilizing micro-computed tomography,hematoxylin and eosin staining,and immunohistochemical ***,in vitro experiments assessed the effects of varied Na^(+)concentrations and exposure durations on human umbilical vein endothelial cells(HUVECs)and MC3T3-E1 *** In vivo,increased dietary sodium(0.8%-6.0%)led to a substantial decline in CD34 positive HUVECs and new bone formation around Ti implants,alongside an increase in inflammatory *** vitro,an increase in Na^(+)concentration(140-150 mmol/L)adversely affected the proliferation,angiogenesis,and migration of HUVECs,especially with prolonged *** MC3T3-E1 cells initially exhibited less susceptibility to high Na^(+)concentrations compared to HUVECs during short-term exposure,prolonged exposure to a HS environment progressively diminished their proliferation,differentiation,and osteogenic *** These findings suggest that HS diet had a negative effect on the early osseointegration of Ti implants by interfering with the process of postoperative vascularized bone regeneration.

关键词： High-sodium Implants Vascularization Osseointegration

Microstructure and Tribological Behavior of Self-lubricating(Si:N)-DLC/MAO Coatings on AZ80 Magnesium Substrate

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Acta Metallurgica Sinica(English Letters) 2013年第6期26卷 693-698页

作者： Wei YANG zhennan deng Dong ZHANG Peiling KE Aiying WANG School of Materials Science and Chemical Engineering Xi an Technological University Ningbo key laboratory of Marine Protection Materials Ningbo Institute of Materials Technology and EngineeringChinese Academy of Sciences Department of Prosthodontics School & Hospital of StomatologyWenzhou Medical College

The combined micro arc oxidation （MAO） and a hybrid beam deposition process was used to deposit duplex （Si：N）-DLC/MAO coatings on AZ80 magnesium alloy. The microstructure and composition of the duplex coatings were analyzed by Raman spectroscopy, X-ray photoelectron spectroscope （XPS）, scanning electron microscope （SEM） and atomic force microscopy （AFM）. Tribological behaviors of the coatings were studied by ball-on-disk friction test. It was found that the ID/IG ratio of the （Si：N）-DLC （diamond-like carbon） top films increases with decreasing C2H2/N2 ratio. The （Si：N）-DLC top film with SigN4 was formed on the MAO coated sample as the C2H2/N2 ratio was 10sccm：5sccm, which showed an increasing critical load compared with the pure DLC directly deposited on the Mg alloy substrate. As a result, the （Si：N）-DLC/MAO coating exhibited an advanced wear protection for the substrate.

关键词： Mg alloy Micro arc oxidation DLC Coating Microstructure Tribologicalbehavior

Characterization and Properties of Duplex a-C:H/MAO Coatings on Magnesium Alloy using Combined Microarc Oxidation and Hybrid Magnetron Sputtering

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Journal of Wuhan University of Technology(Materials Science) 2015年第4期30卷 822-826页

作者：杨巍 deng zhennan YANG Zhong LI Jianping 汪爱英 School of Materials Science and Chemical Engineering Xi'an Technological University Ningbo key laboratory of Marine Protection Materials Ningbo Institute of Materials Technology and Engineering Chinese Academy of Sciences Department of Prosthodontics School & Hospital of Stomatology Wenzhou Medical College

The combined microarc oxidation （MAO） and magnetron sputtering deposition process was used to deposit duplex a-C：H/MAO and Ti-a-C：H/MAO coatings on AM80 magnesium alloy. The microstructure, mechanical properties and tribological behavior of the two duplex coatings were investigated. The experimental results showed that the a-C：H and Ti-a-C：H top films on Si substrates were dense and had a low G peak position and ID/IG ratio, compared with the hydrogen-free amorphous carbon films. Numerous micropores were found on the duplex a-C：H/MAO and Ti-a-C：H/MAO coatings together with low values of hardness （H） and elastic modulus （E）, which also showed good binding strength with the Mg alloy substrates. Compared to MAO treated substrate used for the protection of the Mg alloy, the duplex a-C：H/MAO and Ti-a- C：H/MAO coatings still had stable and low value of friction coefficient, even though the surface of the duplex coatings was rough and porous. Furthermore, the mechanism of friction reduction of the two duplex coatings on the Mg alloy substrates was discussed.

关键词： magnesium alloy microarc oxidation hydrogenated amorphous carbon magnetronsputtering tribological behavior

High proportion strontium-doped micro-arc oxidation coatings enhance early osseointegration of titanium in osteoporosis by anti-oxidative stress pathway

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Bioactive Materials 2022年第4期7卷 405-419页

作者： Xinkun Shen Kai Fang Kendrick Hii Ru Yie Zixin Zhou Yiding Shen Shuyi Wu Yue Zhu zhennan deng Pingping Ma Jianfeng Ma Jinsong Liu School and Hospital of Stomatology Wenzhou Medical UniversityWenzhou325027China

The excessive accumulation of reactive oxygen species(ROS)under osteoporosis precipitates a microenvironment with high levels of oxidative stress(OS).This could significantly interfere with the bioactivity of conventional titanium implants,impeding their early osseointegration with *** have prepared a series of strontium(Sr)-doped titanium implants via micro-arc oxidation(MAO)to verify their efficacy and differences in osteoinduction capabilities under normal and osteoporotic(high OS levels)*** from the chemical composition,all groups exhibited similar physicochemical properties(morphology,roughness,crystal structure,and wettability).Among the groups,the low Sr group(Sr25%)was more conducive to osteogenesis under normal *** contrast,by increasing the catalase(CAT)/superoxide dismutase(SOD)activity and decreasing ROS levels,the high Sr-doped samples(Sr75% and Sr100%)were superior to Sr25% in inducing osteogenic differentiation of MC3T3-E1 cells and the M2 phenotype polarization of RAW264.7 cells,thus enhancing early ***,the results of both in vitro cell co-culture and in vivo studies also showed that the high Sr-doped samples(especially Sr100%)had positive effects on osteoimmunomodulation under the OS ***,the collated findings indicated that the high proportion Sr-doped MAO coatings were more favorable for osteoporosis patients in implant restorations.

关键词： Osteoporosis Oxidative stress Strontium Osteoimmunomodulation Osteogenesis

Er:YAG激光照射种植体表面微形貌变化的扫描电子显微镜观察

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国际口腔医学杂志 2023年第6期50卷 669-673页

作者：孙旭邓振南文才赵颖首都医科大学宣武医院口腔科北京100053 温州医科大学附属口腔医院修复科温州325000 西南医科大学口颌面修复重建和再生实验室、西南医科大学附属口腔医院种植科泸州646000

目的探讨Er:YAG激光不同模式、不同参数照射对种植体SA、SLA、Xpeed及RBM表面微形貌的影响。方法选择波长为2940 nm的Er:YAG激光并设置为软组织模式及参数50 mJ、10 Hz,100 mJ、10 Hz,200 mJ、10 Hz;设置硬组织模式及参数100 mJ、10 Hz,... 详细信息

目的探讨Er:YAG激光不同模式、不同参数照射对种植体SA、SLA、Xpeed及RBM表面微形貌的影响。方法选择波长为2940 nm的Er:YAG激光并设置为软组织模式及参数50 mJ、10 Hz,100 mJ、10 Hz,200 mJ、10 Hz;设置硬组织模式及参数100 mJ、10 Hz,200 mJ、10 Hz。均在水冷却环境下,采取非接触模式,工作尖距离种植体表面1 mm,对SA、SLA、Xpeed及RBM 4种种植体表面固定一点照射5 s。用扫描电子显微镜(SEM)观察照射前后表面微形貌的变化。结果SEM观察可见,SA表面在软组织模式50 mJ、10 Hz及100 mJ、10 Hz照射下无变化,能量提高到200 mJ、10 Hz可见表面微形貌部分熔化;SLA表面在软组织模式50 mJ、10 Hz照射下无变化,能量提高到100 mJ、10Hz及200 mJ、10 Hz可见表面部分熔化及完全熔化;SA及SLA表面在硬组织模式100 mJ、10 Hz或200 mJ、10 Hz照射下,表面无变化。Xpeed和RBM表面在软组织模式50 mJ、10 Hz照射下分别表现为高峰塌陷和片状熔化;在能量提高到100 mJ、10 Hz及200 mJ、10 Hz均可见部分熔化及完全熔化;Xpeed及RBM表面在硬组织模式100 mJ、10 Hz照射下无变化,能量提高到200 mJ、10 Hz可见部分熔化;Xpeed表面未见涂层剥脱。结论本研究显示,在用Er:YAG激光处理种植体表面时,为避免对种植体表面造成损伤,SA和SLA表面用软组织模式时能量参数需设置在50 mJ、10 Hz以下,硬组织模式时参数设置200 mJ、10 Hz以下。Xpeed及RBM表面不适合用软组织模式处理,可在硬组织模式100 mJ、10 Hz以下处理。

关键词： Er:YAG激光种植体微形貌表面处理

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口内反光镜专用清洗篮筐的制作及应用

中华护理杂志 2020年第6期55卷 956-958页

作者：范小兰王慧敏张和平邓振南温州医科大学附属口腔医院消毒供应中心温州市325027 温州医科大学附属口腔医院护理部温州市325027 温州医科大学附属口腔医院院感科温州市325027 温州医科大学附属口腔医院修复科温州市325027

目的针对口内反光镜清洗消毒存在的不足,自行研发口内反光镜专用清洗篮筐,探讨其应用后的清洗消毒效果。方法选取全新大号口内反光镜480件,随机分成2组,每组各240件,临床上依次使用后统一送消毒供应中心进行机械热力清洗消毒,实验组采... 详细信息

目的针对口内反光镜清洗消毒存在的不足,自行研发口内反光镜专用清洗篮筐,探讨其应用后的清洗消毒效果。方法选取全新大号口内反光镜480件,随机分成2组,每组各240件,临床上依次使用后统一送消毒供应中心进行机械热力清洗消毒,实验组采用自制的口内反光镜专用清洗篮筐装载清洗消毒,对照组采用普通清洗篮筐装载清洗消毒,比较两组目测清洗合格率、三磷酸腺苷生物荧光阳性率、划痕率、装载量等指标。结果实验组目测清洗合格率为97.91%,对照组为80.41%,两组比较,差异有统计学意义(χ^2=38.045,P<0.001)。实验组三磷酸腺苷生物荧光测试阳性率为0.84%,对照组为18.75%,两组比较,差异有统计学意义(χ^2=43.611,P<0.001)。第1次清洗消毒后,实验组划痕率为0.42%,对照组为15.00%,两组比较,差异有统计学意义(χ^2=35.813,P<0.001)。第2次清洗消毒后,实验组划痕率仍为0.42%,对照组为26.67%,两组比较,差异有统计学意义(χ^2=70.625,P<0.001)。实验组一次最多可装载120件口内反光镜,对照组一次只能装载9件口内反光镜。结论在机械热力清洗消毒口内反光镜时采用口内反光镜专用清洗装载篮筐,可以明显提高清洗消毒质量及装载量,同时有效减少划痕。

关键词：口腔外科手术口内反光镜灭菌消毒中心供应室,医院

PDCA循环在住院医师规范化培训出科理论考核中的应用及思考

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科教导刊 2023年第35期 59-61页

作者：廖仕贤周日照熊琨邓振南温州医科大学附属口腔医院浙江温州325000

住院医师规范化培训出科考核是住院医师培训过程的关键环节,也是保障培养质量的重要举措。文章通过PDCA循环管理方法,分析住院医师规范化培训出科理论考核中存在的问题并持续改进,以提升学员考核成绩。结果显示,PDCA循环管理方法对提升... 详细信息

住院医师规范化培训出科考核是住院医师培训过程的关键环节,也是保障培养质量的重要举措。文章通过PDCA循环管理方法,分析住院医师规范化培训出科理论考核中存在的问题并持续改进,以提升学员考核成绩。结果显示,PDCA循环管理方法对提升学员出科理论考核成绩具有明显效果,值得在住院医师规范化培训过程管理中应用和推广。

关键词：住院医师规范化培训出科考核 PDCA循环考核成绩

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C型美观卡环可摘局部义齿和传统卡环可摘局部义齿的满意度对比

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现代口腔医学杂志 2019年第4期33卷 211-214页

作者：孙旭李媛媛张大风王思钱麻健丰邓振南首都医科大学宣武医院口腔科北京100053 温州医科大学附属口腔医院修复科

目的调查患者对C型美观卡环可摘局部义齿和传统卡环可摘局部义齿的满意度,为美观卡环临床应用提供参考。方法选取2016年1月至2018年6月于温州医科大学附属口腔医院修复科就诊,诊断为肯氏Ⅰ类或Ⅱ类的上颌牙列缺损,牙弓末端天然牙为第一... 详细信息

目的调查患者对C型美观卡环可摘局部义齿和传统卡环可摘局部义齿的满意度,为美观卡环临床应用提供参考。方法选取2016年1月至2018年6月于温州医科大学附属口腔医院修复科就诊,诊断为肯氏Ⅰ类或Ⅱ类的上颌牙列缺损,牙弓末端天然牙为第一前磨牙或第二前磨牙,拟行可摘局部义齿修复的患者42例,随机分为试验组和对照组,分别选择C型美观卡环可摘局部义齿和传统RPI卡环可摘局部义齿修复。修复后3个月使用《口腔健康影响程度量表(OHIP-14中文版)》对患者进行问卷调查,收集数据并进行统计分析。结果试验组计分低于对照组,且差异有统计学意义(P<0.05),说明患者对C型美观卡环可摘局部义齿的总体满意度比传统RPI可摘局部义齿高。从分类计分看,在"机能不适"和"疼痛"方面,试验组和对照组无明显区别,说明C型美学卡环可满足可摘局部义齿固位稳定的要求;在"心理不适"和"独立能力减弱"方面,试验组计分比对照组低,且差异具有统计学意义(P<0.05),说明C型美学卡环对患者心理产生积极影响,增强了患者的自信心及独立能力。结论 C型美观卡环可摘局部义齿的美观性明显优于传统RPI卡环可摘局部义齿,患者满意度较高。

关键词：美观卡环可摘局部义齿 OHIP-14 满意度

Application of sialic acid/polysialic acid in the drug delivery systems

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Asian Journal of Pharmaceutical Sciences 2014年第2期9卷 75-81页

作者： Ting Zhang zhennan She Zhenjun Huang Jing Li Xiang Luo Yihui deng School of Pharmacy Shenyang Pharmaceutical UniversityShenyang 110016China

The properties of modified biomaterial are gaining more and more importance in drug delivery *** acid(SA)and polysialic acid(PSA)serve as endogenous substances,which are non-immunogenic and *** the same time,SA modification of the drugs/carriers can enhance the uptake of tumor cell and retention in brain;PSA modifi-cation can reduce the immunogenicity of the proteins or polypeptides and increase circulation time of the modified drugs/carriers in the blood,thus achieving active targeting *** properties offer a variety of opportunities for applications in drug delivery *** article summarizes the biological functions of SA and PSA and presents the technologies of SA/PSA modified small molecule drugs,proteins and carriers in drug delivery systems.

关键词： Sialic acid Polysialic acid Drug delivery system Active targeting Circulation time

Progress involving new techniques for liposome preparation

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Asian Journal of Pharmaceutical Sciences 2014年第4期9卷 176-182页

作者： Zhenjun Huang Xuan Li Ting Zhang Yanzhi Song zhennan She Jing Li Yihui deng School of Pharmacy Shenyang Pharmaceutical UniversityNo.103Wenhua RoadShenyang 110016China

The article presents a review of new techniques being used for the preparation of liposomes.A total of 28 publications were *** addition to the theories,characteristics and problems associated with traditional methods,the advantages and drawbacks of the latest techniques were *** the light of developments in many relevant areas,a variety of new techniques are being used for liposome preparation and each of these new technique has particular advantages over conventional preparation ***,there are still some problems associated with these new techniques that could hinder their applications and further improvements are *** speaking,due to the introduction of these latest techniques,liposome preparation is now an improved *** applications promote not only advances in liposome research but also the methods for their production on an industrial scale.

关键词： Liposome Supercritical fluid Dual asymmetric centrifugation Membrane contactor Cross-flow filtration Freeze drying