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Advances in ethnopharmacology,phytochemistry and pharmacology of Erigerontis Herba and its Chinese medicine prescriptions

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Traditional Medicine Research 2025年第1期10卷 44-61页

作者： Yang Zhou Yuan-Yan Huang Ding-Yue Shang Ying Chen meng Tian Cheng-Yu Jin Xin Lu Bing-Chun Yan Han-Qing Pang Institute of Translational Medicine School of MedicineYangzhou UniversityYangzhou 225009China Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases Yangzhou UniversityYangzhou 225009China School of Medicine Nanjing University of Chinese MedicineNanjing 210023China State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources Guangxi Normal UniversityGuiling 541004China.

Erigerontis Herba(EH),the dried whole plant of Erigeron breviscapus,is well-known for circulating blood,activating meridians to alleviate pain,expelling wind,and clearing away *** has been extensively utilized in southern China for the treatment of stroke hemiplegia,chest stuffiness and pains,rheumatic arthralgia,headache,and *** review focuses on the botany,ethnopharmacology,phytochemistry,pharmacology and toxicity of EH and its related prescriptions to offer new insights for prospective research of *** information about EH was retrieved from ancient records and books,PubMed,China National Knowledge Infrastructure,Chinese Pharmacopoeia,Web of Science,Doctoral and Master’s Theses,and various electronic *** is a member of Compositae family and is mainly grown in southern *** Chinese medicine records that EH has the effects of circulating blood and removing blood stasis,expelling wind,and removing cold,as well as relieving rigidity of muscle and relieving *** now,nearly 200 ingredients have been characterized from EH,including flavonoids,caffeoyls,aromatic acids,coumarins,pentacyclic terpenoids,volatile oil and other *** extracts,EH related prescriptions(Dengzhan Xixin injection,Dengzhan Shengmai capsules,etc.)or compounds(scutellarin,scutellarein,etc.)possessed obvious therapeutic effects of ischemic stroke,cerebral hemorrhage,myocardial infarction,Alzheimer’s disease,diabetes and its complications,gastric cancer,bone,and joint degenerative ***,the major active compound of EH,has been used as a quality *** no obvious toxicity of EH has been *** to its traditional applications,ethnopharmacology,phytochemistry,pharmacology,and toxicity,EH was applied as a valuable herb for clinical application in food and medicine *** several compounds have been shown to possess diverse biological activities,the underlying mechanisms of their actions remain *** fully exploi

关键词： Erigeron breviscapus traditional applications ethnopharmacology phytochemistry pharmacology

An IEEE value loop of human-technology collaboration in geospatial information science

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Geo-Spatial Information Science 2020年第1期23卷 61-67页

作者： Liqiu meng Chair of Cartography Technical University of MunichMunichGermany

Geosensing and social sensing as two digitalization mainstreams in big data era are increasingly converging toward an integrated system for the creation of semantically enriched digital *** with the rapid developments of AI technologies,this convergence has inevitably brought about a number of *** the one hand,value-adding chains from raw data to products and services are becoming value-adding loops composed of four successive stages–Informing,Enabling,Engaging and Empowering(IEEE).Each stage is a dynamic loop for *** the other hand,the“human versus technology”relationship is upgraded toward a game-changing“human and technology”*** information loop is essentially shaped by the omnipresent reciprocity between humans and technologies as equal partners,co-learners and co-creators of new *** paper gives an analytical review on the mutually changing roles and responsibilities of humans and technologies in the individual stages of the IEEE loop,with the aim to promote a holistic understanding of the state of the art of geospatial information ***,the author elicits a number of challenges facing the interwoven human-technology *** transformation to a growth mind-set may take time to realize and *** works on large-scale semantic data integration are just in the *** experiences of geovisual analytic approaches are far from being systematically ***,the ethical concerns for the handling of semantically enriched digital Earth cover not only the sensitive issues related to privacy violation,copyright infringement,abuse,*** also the questions of how to make technologies as controllable and understandable as possible for humans and how to keep the technological ethos within its constructive sphere of societal influence.

关键词： Geosensing social sensing geovisual analytics semantic web embodied cognition ethics uncertainty

Glyphosate exposure deteriorates oocyte meiotic maturation via induction of organelle dysfunctions in pigs

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Journal of Animal Science and Biotechnology 2022年第6期13卷 1754-1767页

作者： Chunhua Xing Shun Chen Yue Wang zhennan Pan Yuanjing Zou Shaochen Sun Zili Ren Yu Zhang College of Animal Science and Technology Nanjing Agricultural UniversityNanjing 210095China

Background:Recently,defects in mammalian oocytes maturation induced by environmental pollution results in the decreasing animal *** exposed to glyphosate is largely unavoidable because glyphosate is one of the most widely used herbicide worldwide due to its high-efficiency and broad-spectrum effects,which causes glyphosate an environmental contaminant found in soil,water and *** the last few years,the growing and wider use of glyphosate has raised great concerns about its effects of reproductive *** this study,using porcine models,we investigated effects of glyphosate on organelle functions during oocyte ***:The results showed glyphosate exposure disrupted porcine oocyte *** levels of cumulus expansion-related genes were interfered,further indicating the meiotic *** damaging effects were mediated by destruction of mitochondrial distribution and functions,which induced ROS accumulation and oxidative stress,also indicated by the decreased mRNA expression of related antioxidant enzyme *** also found an interference of endoplasmic reticulum(ER)distribution,disturbance of Ca^(2+)homeostasis,as well as fluctuation of ER stress,showing with the reduced ER stress-related mRNA or protein expression,which could indicate the dysfunction of ER for protein processing and signal transduction in glyphosate-exposed ***,glyphosate exposure induced the disruption of lysosome function for autophagy,showing with the decrease of LAMP2 expression and autophagy-related genes mRNA ***,our data showed the distribution of Golgi apparatus and the functions of ribosome were disturbed after glyphosate exposure,which might affect protein synthesis and ***:Collectively,our study showed that exposed to glyphosate could affect animal reproduction by compromising the quality of oocytes through its wide toxic effects on organelle functions.

关键词： Endoplasmic reticulum Glyphosate Lysosome Mitochondria Organelles Oocyte maturation

止血带在导航系统下行全膝关节置换的应用时机选择:一项单中心、回顾性分析

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中国组织工程研究 2025年第15期29卷 3159-3164页

作者：潘浩杨梦刘国强河北省沧州中西医结合医院河北省中西医结合骨关节病研究重点实验室河北省沧州市061000

背景:传统全膝关节置换过程中应用止血带的时机已有明确报道,随着关节相关技术不断精进,导航系统下全膝关节置换应用止血带的时机却鲜有报道。目的:评估采用全程与半程止血带对Brainlab导航系统下行全膝关节置换疗效的影响。方法:回顾... 详细信息

背景:传统全膝关节置换过程中应用止血带的时机已有明确报道,随着关节相关技术不断精进,导航系统下全膝关节置换应用止血带的时机却鲜有报道。目的:评估采用全程与半程止血带对Brainlab导航系统下行全膝关节置换疗效的影响。方法:回顾性分析2022年1-12月在河北省沧州中西医结合医院行导航系统下全膝关节置换患者的资料,选择符合条件的145例患者进行分析,按松开止血带时机分为全程组(n=71)和半程组(n=74)。收集患者一般资料、围术期情况、术后膝关节周围肿胀情况、下肢深静脉血栓发生情况、目测类比评分、美国特种外科医院膝关节评分和关节遗忘评分,评估膝关节功能并进行比较。结果与结论:①与半程组相比,全程组患者的手术时间更短、下肢深静脉血栓发生率更高、术后膝关节肿胀情况更重(P0.05);④提示采用导航系统行全膝关节置换的患者中,半程使用止血带隐匿性失血量少、术后患肢肿胀程度及下肢深静脉血栓发生率低,膝关节功能恢复更快。

关键词：导航系统全膝关节置换止血带膝关节功能关节遗忘评分

Differences in the effects and action modes of gut commensals against dextran sulfate sodium-induced intestinal inflammation

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Food Science and Human Wellness 2024年第3期13卷 1201-1211页

作者： Dingwu Qu zhennan Gu Saisai Feng Leilei Yu Fengwei Tian Hao Zhang Wei Chen Qixiao Zhai State Key Laboratory of Food Science and Technology Jiangnan UniversityWuxi 214122China School of Food Science and Technology Jiangnan UniversityWuxi 214122China National Engineering Research Center for Functional Food Jiangnan UniversityWuxi 214122China Wuxi Translational Medicine Research Center and Jiangsu Translational Medicine Research Institute Wuxi Branch Wuxi 214122China

Inflammatory bowel disease(IBD)is a complex relapsing inflammatory disease in the gut and is driven by complicated host-gut microbiome *** commensals have shown different functions in IBD prevention and *** gain a mechanistic understanding of how different commensals affect intestinal inflammation,we compared the protective effects of 6 probiotics(belonging to the genera Akkermansia,Bifidobacterium,Clostridium,and Enterococcus)on dextran sulfate sodium(DSS)-induced colitis in mice with or without gut ***-inflammatory properties(ratio of interleukin(IL)-10 and IL-12)of these strains were also evaluated in an in vitro mesenteric lymph nodes(MLN)co-culture *** showed that 4 probiotics(belonging to the species Bifidobacterium breve,Bifidobacterium bifidum,and Enterococcus faecalis)can alleviate colitis in normal *** probiotic strains differed in regulating the intestinal microbiota,cytokines(IL-10,IL-1βand interferon(IFN)-γ),and tight junction function(Zonulin-1 and Occludin).By constrast,Akkermansia muciniphila AH39 and Clostridium butyricum FHuNHHMY49T1 were not ***,*** JSNJJNM2 with high anti-inflammatory potential in the MLN model could relieve colitis symptoms in antibiotic cocktail(Abx)-treated ***,*** FJSWX25M1induced low levels of cytokines in vitro and showed no beneficial ***,we provided insight into the clinical application of probiotics in IBD treatment.

关键词： Gut commensals Dextran sulfate sodium(DSS)colitis Intestinal barrier Immunoregulation

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脂质转移蛋白SiLTP1基因参与谷子耐盐响应初探

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作物学报 2025年第1期51卷 58-67页

作者：孟凡花刘敏沈傲刘炜山东省农业科学院农作物种质资源研究所山东济南250100 上海应用技术大学生态技术与工程学院上海201418

土壤盐渍化严重制约农业生产发展,通过提高植物耐盐性进行盐碱地综合利用,对于保障粮食安全,提升农业生产效率具有重要意义。脂质转移蛋白是一类在高等植物中广泛存在的小分子蛋白质,能够参与植株生长、信号转导以及多种生物和非生物胁... 详细信息

土壤盐渍化严重制约农业生产发展,通过提高植物耐盐性进行盐碱地综合利用,对于保障粮食安全,提升农业生产效率具有重要意义。脂质转移蛋白是一类在高等植物中广泛存在的小分子蛋白质,能够参与植株生长、信号转导以及多种生物和非生物胁迫过程。前期本课题组克隆到一个谷子中编码脂质转移蛋白的基因SiLTP1,本研究通过构建其原核表达载体和植物双元过表达载体,获得了该基因的原核表达蛋白及同源转化过表达阳性植株,经进一步筛选获得4个纯合株系。体外耐盐性试验显示, SiLTP1的原核表达蛋白具有一定耐盐性;转基因植株苗期耐盐生理指标测定显示,SiLTP1过表达植株在遭受盐胁迫时,植株体内MDA积累减少,抗氧化酶含量升高,可积累更少的过氧化氢,从而降低胁迫对植株的氧化损伤,显示基因过表达植株具有更好的耐盐性。本研究结果初步揭示, SiLTP1可正向调控谷子的耐盐性,其在谷子耐盐抗逆方面具有潜在功能,为耐盐谷子品种改良及新品种培育提供了理论基础和候选基因资源。

关键词：脂质转移蛋白 SiLTP1 盐胁迫谷子耐盐响应

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Simulating Raman spectra by combining first-principles and empirical potential approaches with application to defective MoS_(2)

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npj Computational Materials 2020年第1期6卷 1182-1188页

作者： zhennan Kou Arsalan Hashemi Martti J.Puska Arkady V.Krasheninnikov Hannu-Pekka Komsa Department of Applied Physics Aalto UniversityP.O.Box 1110000076 AaltoFinland Helmholtz-Zentrum Dresden-Rossendorf Institute of Ion Beam Physics and Materials Research01328 DresdenGermany Microelectronics Research Unit University of Oulu90014 OuluFinland

Successful application of two-dimensional transition metal dichalcogenides in optoelectronic,catalytic,or sensing devices heavily relies on the materials’quality,that is,the thickness uniformity,presence of grain boundaries,and the types and concentrations of point *** spectroscopy is a powerful and nondestructive tool to probe these factors but the interpretation of the spectra,especially the separation of different contributions,is not *** to simulated spectra is beneficial,but for defective systems first-principles simulations are often computationally too expensive due to the large sizes of the systems ***,we present a combined first-principles and empirical potential method for simulating Raman spectra of defective materials and apply it to monolayer MoS_(2) with random distributions of Mo and S *** study to what extent the types of vacancies can be distinguished and provide insight into the origin of different evolutions of Raman spectra upon increasing defect *** apply to our simulated spectra the phonon confinement model used in previous experiments to assess defect concentrations,and show that the simplest form of the model is insufficient to fully capture peak shapes,but a good match is obtained when the type of phonon confinement and the full phonon dispersion relation are accounted for.

关键词： spectra principles phonon

Recent progress in tar removal by char and the applications:A comprehensive analysis

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Carbon Resources Conversion 2020年第1期3卷 1-18页

作者： Xi Zeng Yasuaki Ueki Ryo Yoshiie Ichiro Naruse Fang Wang zhennan Han Guangwen Xu Institute of Materials and Systems for Sustainability(IMaSS) Nagoya UniversityNagoya 464-8601Japan State Key Laboratory of Multi-Phase Complex Systems Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China Department of Mechanical Systems Engineering Nagoya UniversityNagoya 464-8601Japan Institute of Industrial Chemistry and Energy Technology Shenyang University of Chemical TechnologyShenyang 110142China

Tar catalytic removal by char is a promising technology for gasification process because of its porous structure,good catalytic activity,low cost,and easy to treatment after *** provide comprehensive information on the tar catalytic removal by char,this study focuses on the ongoing efforts and advances from fundamental researches to the industrial *** tar removal efficiency by char much depends on reaction conditions and char property,such as char origin,porous structure,the functional group on char surface,carbon structure,and AAEM *** typical reaction kinetics,reaction mechanism,and the deactivation,will be ***,for the different gasification processes,the potential or typical applications of tar removal by char are discussed and ***,a comprehensive analysis and improvement in scaling up,commercializing tar removal technologies and integrating the gasification process,are also evaluated and analyzed in this review.

关键词： Tar Catalytic removal Char Gasification Decoupling

Insights into the enhanced structure stability and electrochemical performance of Ti^(4+)/F^(-) co-doped P2-Na_(0.67)Ni_(0.33)Mn_(0.67)O_(2) cathodes for sodium ion batteries at high voltage

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Journal of Energy Chemistry 2022年第4期31卷 655-662页

作者： Pengfei Zhou Jing Zhang zhennan Che Zuhao Quan Ju Duan Xiaozhong Wu Junying Weng Jinping Zhao Jin Zhou School of Chemistry and Chemical Engineering Shandong University of TechnologyZibo 255049ShandongChina School of Materials Science and Engineering Shandong University of TechnologyZibo 255049ShandongChina Key Laboratory of Advanced Energy Materials Chemistry(Ministry of Education) College of ChemistryNankai UniversityTianjin 300071China

P2-Na_(0.67)N_(i0.33)Mn_(0.67)O_(2)is considered as a promising cathode material for sodium-ion battery (SIBs)because of its high capacity and discharge ***,its practical use is limited by Na^(+)/vacancy ordering and P2-O2 phase ***,a Ti^(4+)/F^(-) co-doping strategy is developed to address these *** optimal P2-Na_(0.67)Ni_(0.33)Mn_(0.37)Ti_(0.3)O_(1.9)F_(0.1) exhibits much enhanced sodium storage performance in the high voltage range of 2.0–4.4 V,including a cycling stability of 77.2%over 300cycles at a rate of 2 C and a high-rate capability of 87.7 m Ah g^(-1) at 6 ***,the P2-Na_(0.67)Ni_(0.33)Mn_(0.37)Ti_(0.3)O_(1.9)F_(0.1) delivers reversible capacities of 82.7 and 128.1 m Ah g^(-1) at-10 and 50℃ at a rate of 2 C,*** capacity retentions over 200 cycles at-10℃ is 94.2%,implying more opportunity for practical ***-situ X-ray diffraction analysis reveals that both P2-O2 phase transitions and Na^(+)/vacancy ordering is suppressed by Ti^(4+)/F^(-) co-doping,which resulting in fast Na^(+) diffusion and stable phase *** hard carbon//P2-Na_(0.67)Ni_(0.33)Mn_(0.37)Ti_(0.3)O_(1.9)F_(0.1) full cell exhibits a high energy density of 310.2 Wh kg^(-1) and remarkable cyclability with 82.1%retention after 300 cycles at 1 C in the voltage range of 1.5–4.2 *** results demonstrate that the co-doping Ti^(4+)/F^(-) is a promising strategy to improve the electrochemical properties of P2-Na_(0.67)Ni_(0.33)Mn_(0.67)O_(2),providing a facile tactic to develop high performance cathode materials for SIBs.

关键词： P2-Na_(0.67)N_(i0.33)Mn_(0.67)O_(2) Ti^(4+)/F^(-)co-doping Phase transition Na^(+)/vacancy ordering Sodium-ion batteries