检索结果-南通市图书馆

Primary hypertrophic osteoarthropathy:an update

同方期刊数据库

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Frontiers of Medicine 2013年第1期7卷 60-64页

作者： Zeng zhang Changqing zhang zhenlin zhang Metabolic Bone Disease and Genetic Research Unit Department of Osteoporosis and Bone DiseasesShanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghai 200233China Department of Orthopedic Surgery Shanghai Jiao Tong University Affliated Sixth People’s HospitalShanghai 200233China

Digital clubbing,which has been recognized as a sign of systemic disease,is one of the most ancient ***,the pathogenesis of clubbing and hypertrophic osteoarthropathy has hitherto been poorly *** study of a clinically indistinguishable idiopathic form(primary hypertrophic osteoarthropathy,PHO)provides an opportunity to understand the pathogenesis of hypertrophic *** advances in the study of PHO are *** impaired metabolism of prostaglandin E2(PGE2)plays a central role in its pathogenesis.

关键词： digital clubbing primary hypertrophic osteoarthropathy prostaglandin E2(PGE2)

Implicit numerical scheme based on SMAC method for unsteady incompressible Navier-Stokes equations

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Petroleum Science 2008年第2期5卷 172-178页

作者： Li zhenlin zhang Yongxue School of Mechanical and Electronic Engineering China University of Petroleum Beijing 102249 China

An implicit numerical scheme is developed based on the simplified marker and cell （SMAC） method to solve Reynolds-averaged equations in general curvilinear coordinates for three-dimensional （3-D） unsteady incompressible turbulent flow. The governing equations include the Reynolds-averaged momentum equations, in which contravariant velocities are unknown variables, pressure-correction Poisson equation and k- s turbulent equations. The governing equations are discretized in a 3-D MAC staggered grid system. To improve the numerical stability of the implicit SMAC scheme, the higherorder high-resolution Chakravarthy-Osher total variation diminishing （TVD） scheme is used to discretize the convective terms in momentum equations and k- e equations. The discretized algebraic momentum equations and k- s equations are solved by the time-diversion multiple access （CTDMA） method. The algebraic Poisson equations are solved by the Tschebyscheff SLOR （successive linear over relaxation） method with alternating computational directions. At the end of the paper, the unsteady flow at high Reynolds numbers through a simplified cascade made up of NACA65-410 blade are simulated with the program written according to the implicit numerical scheme. The reliability and accuracy of the implicit numerical scheme are verified through the satisfactory agreement between the numerical results of the surface pressure coefficient and experimental data. The numerical results indicate that Reynolds number and angle of attack are two primary factors affecting the characteristics of unsteady flow.

关键词： Unsteady incompressible flow SMAC method contravariant velocity TVD scheme,cascade

Recent research progress in the mechanism and suppression of fusion welding-induced liquation cracking of nickel based superalloys

在线全文

学校读者我要写书评

暂无评论

International Journal of Minerals,Metallurgy and Materials 2024年第5期31卷 1072-1088页

作者： Zongli Yi Jiguo Shan Yue Zhao zhenlin zhang Aiping Wu Department of Mechanical Engineering Tsinghua UniversityBeijing 100084China College of Engineering China Agricultural UniversityBeijing 100091China State Key Laboratory of Clean and Efficient Turbomachinery Power Equipment Department of Mechanical EngineeringTsinghua UniversityBeijing 100084China Key Laboratory for Advanced Materials Processing Technology Ministry of EducationBeijing 100084China School of Material Science and Engineering Southwest Jiaotong UniversityChengdu 610031China

Nickel-based superalloys are extensively used in the crucial hot-section components of industrial gas turbines,aeronautics,and astronautics because of their excellent mechanical properties and corrosion resistance at high *** welding serves as an effective means for joining and repairing these alloys;however,fusion welding-induced liquation cracking has been a challenging *** paper comprehensively reviewed recent liquation cracking,discussing the formation mechanisms,cracking criteria,and *** recent investigations,regulating material composition,changing the preweld heat treatment of the base metal,optimizing the welding process parameters,and applying auxiliary control methods are effective strategies for mitigating *** promote the application of nickel-based superalloys,further research on the combination impact of multiple elements on cracking prevention and specific quantitative criteria for liquation cracking is necessary.

关键词： nickel-based superalloy fusion welding liquation cracking cracking mechanism cracking suppression

Numerical Simulation of Flow in Flowrate Measurement Section of Natural Gas Pipelines

在线全文

学校读者我要写书评

暂无评论

Petroleum Science 2006年第3期3卷 79-85页

作者： Li zhenlin zhang Yongxue Faculty of Mechanical and Electronic Engineering China University of Petroleum Beijing 102249 China

The orifice-plate flowmeter and ultrasonic flowmeter are used widely for natural gas flowrate measurement, and the measurement accuracy is affected greatly by flow state. Numerical simulation was used to study the flow of natural gas in the diffusion pipe, and the length of the irregular flow induced by the diffuser or rectifier was computed. Simulation results indicated that the flow in the diffusion pipe was three-dimensional turbulent flow and the steady state flow was restored at 17 pipe-diameters downstream of the diffuser. The rectifiers equipped in the diffusion pipe showed good rectification effect, notwithstanding the induced irregular flow. Downstream the rectifier, the flow became symmetrical and uniform in a shorter length than the case without a rectifier. For the diffusion pipe equipped with plate rectifier, tube rectifier and tube-plate rectifier, the lengths at which uniformly distributed flow was restored were 12, 6 and 5 pipe-diameters downstream the rectifier respectively. On the basis of simulation results, the minimum installation length for flowmeters equipped in the diffusion pipe was determined. This provides a new method for improving natural gas measurement accuracy.

关键词： Natural gas measurement computational fluid dynamics (CFD) rectifier numerical simulation diffusion pipe

Kinetic-boosted CO_(2) electroreduction to formate via synergistic electric-thermal field on hierarchical bismuth with amorphous layer

在线全文

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2024年第3期90卷 233-243,I0007页

作者： Bing Yang Junyi Zeng zhenlin zhang Lin Meng Donglin Shi Liang Chen Youju Huang College of Material Chemistry and Chemical EngineeringKey Laboratory of Organosilicon Chemistry and Material TechnologyMinistry of EducationHangzhou Normal UniversityHangzhou 311121ZhejiangChina State Key Laboratory of Metastable Materials Science and Technology College of Materials Science and EngineeringYanshan UniversityQinhuangdao 066004HebeiChina

Electrocatalytic converting CO_(2) into chemical products has emerged as a promising approach to achieving carbon ***,we report a bismuth-based catalyst with high curvature terminal and amorphous layer which fabricated via two-step electrodeposition achieves stable formate output in a wide voltage window of 600 *** Faraday efficiency(FE) of formate reached up to 99.4% at-0.8 V *** and it remained constant for more than 92 h at-15 mA cm^(-2).More intriguingly,FE formate of95.4% can be realized at a current density of industrial grade(-667.7 mA cm^(-2)) in flow *** special structure promoted CO_(2) adsorption and reduced its activation energy and enhanced the electric-thermal field and K^(+) enrichment which accelerated the reaction *** situ spectroscopy and theoretical calculation further confirmed that the introduction of amorphous structure is beneficial to adsorpting CO_(2)and stabling*OCHO *** work provides special insights to fabricate efficient electrocatalysts by means of structural and crystal engineering and makes efforts to realize the industrialization of bismuth-based catalysts.

关键词： CO_(2) electroreduction Hierarchical bismuth Amorphous layer Electric-thermal field Kinetic-boosting

在线全文

学校读者我要写书评

暂无评论

模具局部激光熔覆耐磨涂层研究及应用

金属加工(热加工) 2025年第1期 74-80页

作者：刘宗义张振林孙军浩张义海冯珂焦伟四川省宜宾普什模具有限公司四川宜宾644007 高端装备先进材料与制造技术实验室四川成都610031 宜宾上交大新材料研究中心四川宜宾644005

注塑模具流道出口工况苛刻,极易发生磨损,导致其形状和尺寸发生变化,对产品的质量和生产效率造成较大影响。基于此,本研究采用激光熔覆技术对注塑模具流道出口进行局部强化,针对强化涂层材料成分的设计、熔覆成形和缺陷控制、组织性能... 详细信息

注塑模具流道出口工况苛刻,极易发生磨损,导致其形状和尺寸发生变化,对产品的质量和生产效率造成较大影响。基于此,本研究采用激光熔覆技术对注塑模具流道出口进行局部强化,针对强化涂层材料成分的设计、熔覆成形和缺陷控制、组织性能分析、实际工件加工工艺调控等开展研究。结果表明:相比商用耐磨涂层材料,所开发的涂层材料具备优异的熔覆成形和无裂纹缺陷,硬度由强化前基体硬度400HV提升至900HV以上,涂层耐磨性能相对基体提升43倍,摩擦系数由基体的0.635降至0.412,极大改善了模具的耐磨性能;强化涂层内部晶粒细小,主要由马氏体和原位陶瓷碳化物保障其耐磨性,并残留少量奥氏体保障其韧性;通过特殊的路径规划和工艺控制,在注塑模具局部强化中得到成功应用,强化后模具的服役寿命提升3倍以上。

关键词：注塑模具激光熔覆微观组织耐磨性能

Drug discovery of sclerostin inhibitors

在线全文

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2022年第5期12卷 2150-2170页

作者： Sifan Yu Dijie Li Ning zhang Shuaijian Ni Meiheng Sun Luyao Wang Huan Xiao Dingdong Liu Jin Liu Yuanyuan Yu Zongkang zhang Samuel Tin Yui Yeung Shu zhang Aiping Lu zhenlin zhang Baoting zhang Ge zhang Law Sau Fai Institute for Advancing Translational Medicine in Bone and Joint Diseases School of Chinese MedicineHong Kong Baptist UniversityKowloon TsaiHong Kong 999077China Institute of Integrated Bioinfomedicine and Translational Science School of Chinese MedicineHong Kong Baptist UniversityKowloon TsaiHong Kong 999077China Institute of Precision Medicine and Innovative Drug Discovery HKBU Institute for Research and Continuing EducationShenzhen 518000China School of Chinese Medicine Faculty of Medicinethe Chinese University of Hong KongHong Kong 999077China The Key Laboratory of Aerospace Medicine Ministry of EducationAir Force Medical UniversityXi’an 710000China Shanghai Clinical Research Center of Bone Disease Department of Osteoporosis and Bone DiseasesShanghai Jiao Tong University Afﬁliated Sixth People’s HospitalShanghai 200000China

Sclerostin, a protein secreted from osteocytes, negatively regulates the WNT signaling pathway by binding to the LRP5/6 co-receptors and further inhibits bone formation and promotes bone resorption. Sclerostin contributes to musculoskeletal system-related diseases, making it a promising therapeutic target for the treatment of WNT-related bone diseases. Additionally, emerging evidence indicates that sclerostin contributes to the development of cancers, obesity, and diabetes, suggesting that it may be a promising therapeutic target for these diseases. Notably, cardiovascular diseases are related to the protective role of sclerostin. In this review, we summarize three distinct types of inhibitors targeting sclerostin, monoclonal antibodies, aptamers, and small-molecule inhibitors, from which monoclonal antibodies have been developed. As the first-in-class sclerostin inhibitor approved by the U.S. FDA,the monoclonal antibody romosozumab has demonstrated excellent effectiveness in the treatment of postmenopausal osteoporosis;however, it conferred high cardiovascular risk in clinical trials. Furthermore,romosozumab could only be administered by injection, which may cause compliance issues for patients who prefer oral therapy. Considering these above safety and compliance concerns, we therefore present relevant discussion and offer perspectives on the development of next-generation sclerostin inhibitors by following several ways, such as concomitant medication, artificial intelligence-based strategy, druggable modification, and bispecific inhibitors strategy.

关键词： Sclerostin WNT signalling pathway Sclerostin inhibitors Antibody Bone diseases Aptamer Small molecule inhibitors Artificial intelligence

象山县成人25羟维生素D水平及其与骨转换标志物和骨密度的相关性分析

在线全文

学校读者我要写书评

暂无评论

中华全科医学 2025年第1期23卷 36-39页

作者：鲍红丹周雅芬史琼瑶郭婧怡章振林高超宁波市第四医院内分泌科浙江宁波315700 上海交通大学医学院附属第六人民医院临床研究中心上海200233 上海交通大学医学院附属第六人民医院骨质疏松和骨病专科上海市骨疾病临床研究中心上海200233

目的了解宁波市象山县成人25羟维生素D[25(OH)D]水平和缺乏情况,分析25(OH)D水平与骨转换标志物(BTMs)、骨密度(BMD)的关系。方法2020年8—11月招募来自宁波市象山县的志愿者3117例,其中男性1122例,女性1995例,年龄为22~95岁。采集研究... 详细信息

目的了解宁波市象山县成人25羟维生素D[25(OH)D]水平和缺乏情况,分析25(OH)D水平与骨转换标志物(BTMs)、骨密度(BMD)的关系。方法2020年8—11月招募来自宁波市象山县的志愿者3117例,其中男性1122例,女性1995例,年龄为22~95岁。采集研究对象血清样本进行25(OH)D、BTMs检测,采用双能X线吸收仪测定研究对象的腰椎、股骨颈及全髋部BMD。结果研究人群25(OH)D不足比例为39.7%(1236/3117),25(OH)D缺乏比例为9.1%(284/3117)。按年龄分组后,在小于50岁人群中,男女25(OH)D缺乏比例均最高,分别为11.1%(21/189)和31.0%(139/449)。按性别分组后,25(OH)D水平与Ⅰ型胶原羧基端肽β特殊序列(β-CTX)水平均呈负相关关系(男性:r=-0.161,P<0.001;女性:r=-0.069,P=0.002)。男性25(OH)D水平与股骨颈BMD(β=0.001,P=0.019)、全髋部BMD(β=0.001,P=0.034)呈正相关关系。结论宁波市农村地区25(OH)D缺乏和不足仍较为普遍,尤其是<50岁的女性,需引起重视,并及早调整生活方式或使用维生素D补充剂。此外,本研究发现人群中25(OH)D水平与BMD呈正相关关系,与β-CTX呈负相关关系。

关键词： 25羟维生素D 骨转换标志物骨密度

A monoallelic variant in CCN2 causes an autosomal dominant spondyloepimetaphyseal dysplasia with low bone mass

在线全文

学校读者我要写书评

暂无评论

Bone Research 2024年第4期12卷 952-965页

作者： Shanshan Li Rui Shao Shufa Li Jiao Zhao Qi Deng Ping Li Zhanying Wei Shuqin Xu Lin Chen Baojie Li Weiguo Zou zhenlin zhang Department of Osteoporosis and Bone Diseases Shanghai Clinical Research Center of Bone DiseasesShanghai Jiao Tong University of Medicine Affiliated Sixth People’s HospitalShanghaiChina Department of Orthopedic Surgery and Shanghai Institute of Microsurgery on Extremities Shanghai Jiao Tong University of Medicine Affiliated Sixth People’s HospitalShanghaiChina Department of Endocrinology and Metabolism The Affiliated Hospital of Qingdao UniversityQingdaoShandongChina Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders Bio-X InstitutesMinistry of EducationShanghai Jiao Tong UniversityShanghaiChina Department of Wound Repair and Rehabilitation State Key Laboratory of TraumaBurns and Combined InjuryTrauma CenterResearch Institute of SurgeryDaping HospitalArmy Medical UniversityChongqingChina Key Laboratory of RNA Innovation Science and EngineeringCAS Center for Excellence in Molecular Cell ScienceShanghai Institute of Biochemistry and Cell BiologyUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghaiChina Hainan Academy of Medical Sciences Hainan Medical UniversityHainanChina

Cellular communication network factor 2(CCN2)is a secreted extracellular matrix-associated protein,and its aberrantly increased expression has been implicated in a diversity of diseases involving pathological processes of fibrosis,chronic inflammation,or tissue injury,which has promoted the evaluation of CCN2 as therapeutic targets for multiple ***,human phenotypes associated with CCN2 deficiency have remained enigmatic;variants in CCN2 have not yet been associated with a human ***,we collected families diagnosed with spondyloepimetaphyseal dysplasia(SEMD),and screened candidate pathogenic genes for families without known genetic causes using next-generation *** identified a monoallelic variant in signal peptide of CCN2(NM_001901.2:c.65 G>C[***22Pro])as the cause of SEMD in 14 subjects presenting with different degree of short stature,premature osteoarthritis,and *** subjects showed decreased serum CCN2 *** lines harboring the variant displayed decreased amount of CCN2 proteins in culture medium and an increased intracellular retention,indicating impaired protein *** the variant weakened the stimulation effect of CCN2 on osteogenesis of bone marrow mesenchymal stem *** ccn2a knockout model and osteoblast lineage-specific Ccn2-deficient mice(Ccn2fl/fl;Prx1Cre)partially recapitulated the phenotypes including low bone mass observed in affected *** mechanism implicated in the skeletal abnormality in Ccn2fl/fl;Prx1Cre mice involved decreased bone formation,increased bone resorption,and abnormal growth plate ***,our study indicate that monoallelic variants in CCN2 lead to a human inherited skeletal dysplasia,and highlight the critical role of CCN2 in osteogenesis in human.

关键词： CCN2 dysplasia impaired