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GLUL stabilizes N-Cadherin by antagonizing β-Catenin to inhibit the progresses of gastric cancer

Acta Pharmaceutica Sinica B 2024年第2期14卷 698-711页

作者： Qiwei Jiang Yong Li Songwang Cai Xingyuan Shi Yang Yang Zihao Xing zhenjie he Shengte Wang Yubin Su Meiwan Chen Zhesheng Chen Zhi Shi Department of Cell Biology&Institute of Biomedicine National Engineering Research Center of Genetic MedicineState Key Laboratory of Bioactive Molecules and Druggability AssessmentMOE Key Laboratory of Tumor Molecular BiologyGuangdong Provincial Key Laboratory of Bioengineering MedicineCollege of Life Science and TechnologyJinan UniversityGuangzhou 510632China Department of Gastrointestinal Surgery&General Surgery the Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou 510080China Department of Thoracic Surgery The First Affiliated Hospital of Jinan UniversityGuangzhou 510632China Department of Radiation Oncology The Fifth Hospital of Guangzhou Medical UniversityGuangzhou 510150China State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacao 519000China Department of Pharmaceutical Sciences College of Pharmacy and Health SciencesSt.John’s UniversityQueensNY 11439USA

Glutamate-ammonia ligase(GLUL, also known as glutamine synthetase) is a crucial enzyme that catalyzes ammonium and glutamate into glutamine in the ATP-dependent condensation. Although GLUL plays a critical role in multiple cancers, the expression and function of GLUL in gastric cancer remain unclear. In the present study, we have found that the expression level of GLUL was significantly lower in gastric cancer tissues compared with adjacent normal tissues, and correlated with N stage and TNM stage, and low GLUL expression predicted poor survival for gastric cancer patients. Knockdown of GLUL promoted the growth, migration, invasion and metastasis of gastric cancer cells in vitro and in vivo, and vice versa, which was independent of its enzyme activity. Mechanistically, GLUL competed with β-Catenin to bind to N-Cadherin, increased the stability of N-Cadherin and decreased the stability of β-Catenin by alerting their ubiquitination. Furthermore, there were lower N-Cadherin and higher β-Catenin expression levels in gastric cancer tissues compared with adjacent normal tissues. GLUL protein expression was correlated with that of N-Cadherin, and could be the independent prognostic factor in gastric cancer. Our findings reveal that GLUL stabilizes N-Cadherin by antagonizing β-Catenin to inhibit the progress of gastric cancer.

关键词： Gastric cancer GLUL N-Cadherin β-Catenin Enzyme

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基于宏基因组学分析安徽地区畜禽粪便微生物耐药性特征

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中国微生态学杂志 2024年第1期36卷 29-40页

作者：桑金慧何振杰余相宇余波宋祥军邵颖祁钊安徽省动物性食品质量与生物安全工程实验室安徽合肥230036 安徽农业大学信息与人工智能学院

目的为深入了解在食用动物生产过程中滥用抗生素,迫使肠道共生细菌成为微生物耐药性(antimicrobial resistance,AMR)重要宿主之一的现象,本研究利用宏基因组学针对食用动物的肠道细菌AMR进行分析。方法利用宏基因组学技术对安徽地区猪... 详细信息

目的为深入了解在食用动物生产过程中滥用抗生素,迫使肠道共生细菌成为微生物耐药性(antimicrobial resistance,AMR)重要宿主之一的现象,本研究利用宏基因组学针对食用动物的肠道细菌AMR进行分析。方法利用宏基因组学技术对安徽地区猪和鸡粪便中的AMR及可移动遗传元件进行定量和表征,并且在核心抗性基因亚型水平上研究猪和鸡共生细菌群落的耐药性特征。结果从抗性基因(antimicrobial resistance gene,ARG)的丰度和多样性来看,鸡肠道共生菌中ARG的多样性和检出率高于猪,而猪肠道共生菌中ARG总丰度高于鸡。大环内酯―林可酰胺―链菌素类抗性基因和四环素抗性基因是所有样本中含量最高的2种ARG,研究也检测到了世界范围内流行的ARG,包括optrA、qnrS、lsaE和tem等,同时,一些可移动遗传元件,包括噬菌体、质粒和插入序列也显示出与ARG存在一定相关性,这揭示了ARG的水平转移潜力。此外,食物链动物的抗性组和微生物组之间在统计学上也被证明存在正相关性。宿主溯源分析表明,在鸡样本中的拟杆菌和大肠埃希菌被检测出含有大量ARG,而在猪的样本中被检测出含有丰富ARG的为瘤胃球菌和罗氏菌。结论本研究通过对猪和鸡共生细菌群落中AMR的调查统计,证实肠道微生物群是ARG的重要宿主及传播途径之一,为评价食用动物安全性及后续泛耐药基因数据库的构建提供科学依据,对公共健康具有重要意义。

关键词：禽畜粪便肠道微生物耐药性宏基因组学二代测序

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基于虚、痰、瘀、毒理论浅析射血分数保留的心力衰竭炎症状态与中医药干预策略

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天津中医药大学学报 2024年第7期43卷 637-649页

作者：和振杰时晓迟赵英强天津中医药大学天津301617 天津中医药大学第二附属医院天津300250

射血分数保留的心力衰竭(HFpEF)是常见的心力衰竭类型之一,约占全部心力衰竭的50%,具有较高的发病率、再住院率及病死率。HFpEF的发病机制较其他类型的心力衰竭更为复杂,具有高度异质性特点。近年来,关于其细胞分子学发病机制的相关研... 详细信息

射血分数保留的心力衰竭(HFpEF)是常见的心力衰竭类型之一,约占全部心力衰竭的50%,具有较高的发病率、再住院率及病死率。HFpEF的发病机制较其他类型的心力衰竭更为复杂,具有高度异质性特点。近年来,关于其细胞分子学发病机制的相关研究越来越受到重视,大量研究显示HFpEF的发病及疾病进展与炎症密切相关,微血管炎症和内皮细胞炎症是HFpEF的关键分子机制,涉及一氧化氮(NO)-环磷酸鸟苷(cGMP)-蛋白激酶G(PKG)、转化生长因子-β1(TGF-β1)/Smads、血管紧张素Ⅱ(AngⅡ)/TGF-β1/Smad2/3、白细胞介素-33(IL-33)/跨膜型ST2(ST2L)等信号通路。HFpEF合并症通过全身炎症和氧化应激,进而导致冠状动脉微血管内皮炎症驱动心肌功能障碍及重塑。现代研究表明炎症与中医“虚、痰、瘀、毒”理论高度相似,结合HFpEF的致病因素、病理机制及病程不同阶段的临床表现采用中医药干预策略,注重补虚、化痰、祛瘀、解毒等治法的运用,结果显示中医药可以通过改善线粒体功能,调节能量代谢,从而抑制炎症反应,减轻心肌纤维化,逆转心肌肥厚,进而保护心肌细胞,抑制心室重构,延缓HFpEF病理进程,能够减轻患者临床症状,提高生活质量。文章试从虚、痰、瘀、毒理论浅析HFpEF病理变化,以期为临床防治HFpEF提供科学依据。

关键词：射血分数保留的心力衰竭炎症状态中医药

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When to start renal replacement therapy in acute kidney injury: What are we waiting for?

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Journal of Intensive Medicine 2024年第3期4卷 341-346页

作者： Lixia Liu zhenjie Hu Department of Critical Care Medicine The Fourth Hospital of Hebei Medical UniversityShijiazhuangHebeiChina

Acute kidney injury remains a serious condition with a high mortality risk. In the absence of any new drugs, renal replacement therapy (RRT) is the most important treatment option. Randomized controlled trials have concluded that in critically ill patients without an emergency indication for RRT, a watchful waiting strategy is safe;however, further delays in RRT did not seem to confer any benefit, rather was associated with potential harm. During this process, balancing the risks of complications due to an unnecessary intervention with the risk of not correcting a potentially life-threatening complication remains a challenge. Dynamic renal function assessment, especially dynamic assessment of renal demand-capacity matching, combined with renal biomarkers such as neutrophil gelatinase-associated lipocalin and furosemide stress test, is helpful to identify which patients and when the patients may benefit from RRT.

关键词： Acute kidney injury Renal replacement therapy Initiation timing Dynamic assessment Biomarkers

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Sequence design in terpolymerization ofε-caprolactone,CO_(2) and cyclohexane oxide:Random ester-carbonate distributions lead to large-span tunability

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Chinese Chemical Letters 2024年第5期35卷 259-264页

作者： zhenjie Yang Chenyang Hu Xuan Pang Xuesi Chen Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China

It is of great interest to make a degradable material widely tailorable to replace petroleum-derived products among diverse ***,we report the construction of a new multi-purpose degradable material for the first time via a simple ternary copolymerization system comprisingε-caprolactone(ε-CL),cyclohexane oxide(CHO)and CO_(2).Under low pressure of 1 bar∼5 bar,the ring-opening polymerization(ROP)ofε-CL and ring-opening copolymerization(ROCOP)of CO_(2) and CHO can simultaneously *** carbonate units are randomly distributed on the polymer *** random terpolymers have controllable molar mass(10-106 kDa)and compositions(4-33 mol%CO_(2)).And the obtained materials show large-span tunability from tough plastic to elastomer and even adhesive.

关键词： Polyesters CO_(2)-derived copolymers Random copolymerization Elastomers Adhesives

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Quasi-2D weak lensing cosmological constraints using the PDF-SYM method

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Science China(Physics,Mechanics & Astronomy) 2024年第7期67卷 44-58页

作者： zhenjie Liu Jun Zhang hekun Li Zhi Shen Cong Liu Department of Astronomy Shanghai Jiao Tong UniversityShanghai 200240China Shanghai Key Laboratory for Particle Physics and Cosmology Shanghai 200240China Shanghai Astronomical Observatory Chinese Academy of SciencesShanghai 200030China

Cosmic shear statistics,such as the two-point correlation function(2PCF),can be evaluated with the PDF-SYM method instead of the traditional weighted-sum *** makes use of the full PDF information of the shear estimators,and does not require weightings on the shear estimators,which can in principle introduce additional systematic *** work presents our constraints on S8and?mfrom the shear-shear correlations using the PDF-SYM *** data we use is from the z-band images of the Dark Energy Camera Legacy Survey(DECa LS),which covers about 10000 deg2with more than 100 million *** shear catalog is produced by the Fourier Quad method,and well tested on the real data itself with the field-distortion *** main approach is called quasi-2D as we do use the photo-z information of each individual galaxy,but without dividing the galaxies into redshift *** mainly use galaxy pairs within the redshift interval between 0.2 and 1.3,and the angular range from 4.7 to 180 *** analysis yields S8=0.762±0.026 and?m=0.234±0.075,with the baryon effects and the intrinsic alignments *** results are robust against redshift *** check the consistency of our results by deriving the cosmological constraints from auto-correlations ofγ1andγ2separately,and find that they are consistent with each other,but the constraints from theγ1component are much weaker than that fromγ*** implies a much worse data quality ofγ1,which is likely due to additional shear uncertainties caused by CCD electronics(according to the survey strategy of DECa LS).We also perform a pure 2D analysis,which gives S8=0.81_(-0.04)^(+0.03)and?m=0.25_(-0.05)^(+0.06).Our findings demonstrate the potential of the PDF-SYM method for precision cosmology.

关键词： weak lensing shear-shear correlations cosmological parameters observations analysis

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Resource Allocation for Cognitive Network Slicing in PD-SCMA System Based on Two-Way Deep Reinforcement Learning

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China Communications 2024年第6期21卷 53-68页

作者： Zhang Zhenyu Zhang Yong Yuan Siyu Cheng zhenjie School of Electronic Engineering Beijing University of Posts and TelecommunicationsBeijing 100876China Beijing Key Laboratory of Work Safety Intelligent Monitoring(Beijing University of Posts and Telecommunications) Beijing 100876China

In this paper,we propose the Two-way Deep Reinforcement Learning(DRL)-Based resource allocation algorithm,which solves the problem of resource allocation in the cognitive downlink network based on the underlay *** users(SUs)in the cognitive network are multiplexed by a new Power Domain Sparse Code Multiple Access(PD-SCMA)scheme,and the physical resources of the cognitive base station are virtualized into two types of slices:enhanced mobile broadband(eMBB)slice and ultrareliable low latency communication(URLLC)*** design the Double Deep Q Network(DDQN)network output the optimal codebook assignment scheme and simultaneously use the Deep Deterministic Policy Gradient(DDPG)network output the optimal power allocation *** objective is to jointly optimize the spectral efficiency of the system and the Quality of Service(QoS)of *** results show that the proposed algorithm outperforms the CNDDQN algorithm and modified JEERA algorithm in terms of spectral efficiency and QoS ***,compared with the Power Domain Non-orthogonal Multiple Access(PD-NOMA)slices and the Sparse Code Multiple Access(SCMA)slices,the PD-SCMA slices can dramatically enhance spectral efficiency and increase the number of accessible users.

关键词： cognitive radio deep reinforcement learning network slicing power-domain non-orthogonal multiple access resource allocation

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Pushing the frontiers: Chip-based detection based on micro-and nano-structures

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Chinese Chemical Letters 2024年第4期35卷 86-98页

作者： Meihui Liu Xinyuan Zhou Xiao Li zhenjie Xue Tie Wang Tianjin Key Laboratory of Life and health Detection Life and Health Intelligent Research InstituteTianjin University of TechnologyTianjin 300384China

Changes in trace substances in human metabolites, which are related to disease processes and health status, can serve as chemical markers for disease diagnosis and symptom monitoring. Real-time online detection is an inevitable trend for the future of health monitoring, and the construction of chips for detection faces major challenges. The response of sensors often fails to meet the requirements for chipbased detection of trace substances due to the low efficiency of interfacial heterogeneous reactions, necessitating a rational design approach for micro-and nano-structures to improve sensor performance with respect to sensitivity and detection limits. This review focuses on the influence of micro-and nanostructures that used in chip on sensing. Firstly, this review categorizes sensors into chemiresistors, electrochemical sensors, fluorescence sensors, and surface enhanced Raman scattering(SERS) sensors based on their sensing principle, which have significant applications in disease diagnosis. Subsequently, commencing from the application requirements in the field of sensing, this review focuses on the different structures of nanoparticle(NP) assemblies, including wire, layered, core-shell, hollow, concave and deformable structures. These structures change in the size, shape, and morphology of conventional structures to achieve characteristics such as ordered alignment, high specific surface area, space limitation,vertical diffusion, and swaying behavior with fluid, thereby addressing issues such as poor signal transmission efficiency, inadequate adsorption and capture capacity, and slow mass transfer speed during sensing. Finally, the design direction of micro-and nano-structures, and possible obstacles and solutions to promote chip-based detection have been discussed. It is hope that this article will inspire the exploration of interface micro-and nano-structures modulated sensing methods.

关键词： Chip-based detection Micro-and nano-structures Real-time online detection Sensing health monitoring

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Role of mitochondrial dysfunction in kidney disease:Insights from the cGAS-STING signaling pathway

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Chinese Medical Journal 2024年第9期137卷 1044-1053页

作者： Lu Li Fei Liu Chunyue Feng zhenjie Chen Nan Zhang Jianhua Mao Department of Nephrology Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhouZhejiang 310052China Department of Pediatric Intensive Care Unit Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhouZhejiang 310052China

Over the past decade,mitochondrial dysfunction has been investigated as a key contributor to acute and chronic kidney ***,the precise molecular mechanisms linking mitochondrial damage to kidney disease remain *** recent insights into the cyclic guanosine monophosphate-adenosine monophosphate(GMP-AMP)synthetase(cGAS)-stimulator of interferon gene(STING)signaling pathway have revealed its involvement in many renal *** of these findings is that mitochondrial DNA(mtDNA)induces inflammatory responses via the cGAS-STING ***,we provide an overview of the mechanisms underlying mtDNA release following mitochondrial damage,focusing specifically on the association between mtDNA release-activated cGAS-STING signaling and the development of kidney ***,we summarize the latest findings of cGAS-STING signaling pathway in cell,with a particular emphasis on its downstream signaling related to kidney *** review intends to enhance our understanding of the intricate relationship among the cGAS-STING pathway,kidney diseases,and mitochondrial dysfunction.

关键词： Mitochondrial dysfunction Mitochondrial DNA cGAS-STING pathway Kidney diseases Chronic kidney disease

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heat management technology for solid-state high voltage and high repetitive pulse generators:Towards better effects and reliability

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High Voltage 2024年第1期9卷 2-21页

作者： Yanan Wang Linyuan Ren Zihao Yang Saikang Shen Zichen Deng Qi Yuan Weidong Ding zhenjie Ding School of Electrical Engineering Xi'an Jiaotong UniversityXi'anChina School of Electronic and Information Engineering Xi'an Jiaotong UniversityXi'anChina

Solid-state high voltage high repetitive pulse generators have a broad prospect in various *** high power and high-frequency operation of the pulse generator suffer from the massive heat dissipation problem,which limits the improvement of the output parameters and even affects the *** article focuses on heat management technology for high voltage high repetitive pulse ***,the typical circuit topology of the high repetitive pulse generators was *** the perspective of different application requirements,the demands of the heat management design were ***,the heat generation characteristics and difficulties of solid-state high voltage high repetitive pulse generators were ***,the different stateof-art cooling techniques were reviewed,and their applicability and limitations for the high voltage high repetitive generators were ***,a flow chart for heat management design was given.

关键词： pulse state high

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