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宁绍平原中全新世火历史与影响因素研究

第四纪研究 2024年第1期44卷 84-99页

作者：周锦清马春梅刘泽雨王冰翎李珍黄振辉胡竹君周斌杨青王永磊孙国平郑洪波南京大学地理与海洋科学学院江苏南京210023 南京师范大学地理科学学院江苏南京210023 南京大学地球科学与工程学院表生地球化学教育部重点实验室江苏南京210023 云南大学地球系统科学研究中心云南昆明650504 浙江省考古研究所浙江杭州310014

宁绍平原是研究全新世火事件、气候环境以及人类活动之间复杂关系的理想场所。本研究选取宁绍平原田螺山遗址(30°01′20″N,121°22′38″E)和井头山遗址(30°01′28.45″N,121°21′40.69″E)两钻孔(长度分别为18.17 m和19.8 m)进行... 详细信息

宁绍平原是研究全新世火事件、气候环境以及人类活动之间复杂关系的理想场所。本研究选取宁绍平原田螺山遗址(30°01′20″N,121°22′38″E)和井头山遗址(30°01′28.45″N,121°21′40.69″E)两钻孔(长度分别为18.17 m和19.8 m)进行炭屑分析,并结合孢粉记录,旨在研究宁绍平原中全新世(9000~5700 cal.a B.P.)火历史、气候环境变化与人类活动的变化规律。结果表明:1)2个钻孔炭屑浓度在早中全新世都很低,田螺山钻孔100μm(粗粒)这3种粒径的炭屑浓度均为钻孔最低值,反映当时火事件发生频率低;此时正值全新世大暖期,亚洲夏季风强劲,降水丰沛,孢粉记录也显示此时的植被类型为亚热带阔叶林,温暖湿润的气候不利于火事件发生。2)随着研究区水文环境的稳定,人类被丰富的资源吸引前来定居,人类活动的加强可能导致火事件频发,炭屑浓度升高。7900 cal.a B.P.左右,随着海平面上升速度减缓,人类先民选择井头山区域定居,并开始了早期稻作农业的尝试,炭屑浓度随着人类在此定居出现了高值。在7000 cal.a B.P.之后,研究区淡水湿地广泛分布,河姆渡文化兴起,炭屑浓度再次上升。田螺山钻孔炭屑浓度在6300 cal.a B.P.左右出现最大值,但此时研究区环境尚未稳定,仍会受到海水影响,7000~6000 cal.a B.P.期间田螺山钻孔炭屑浓度多次出现低值都与海水入侵有关;5900 cal.a B.P.之后研究区完全成陆,稻作农业也开始了蓬勃发展,炭屑浓度也出现了明显上升。本研究探讨了中全新世宁绍平原火事件、气候环境以及人类活动之间的相互关系,揭示了气候与人类活动对该区域火事件的影响,为该区域的相关研究提供了一个新的视角。

关键词：炭屑火历史宁绍平原人类活动环境变化中全新世

Construction of ZnO@CDs@Co_(3)O_(4) sandwich heterostructure with multi-interfacial electron-transfer toward enhanced photocatalytic CO_(2) reduction

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Chinese Chemical Letters 2024年第4期35卷 147-152页

作者： Xiuzheng Deng Yi Ke Jiawen Ding Yingtang Zhou Hui huang Qian Liang zhenhui Kang Advanced Catalysis and Green Manufacturing Collaborative Innovation Center CNPC-CZU Innovation AllianceSchool of Petrochemical EngineeringChangzhou UniversityChangzhou 213164China Institute of Functional Nano&Soft Materials(FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials&DevicesSoochow UniversitySuzhou 215123China Zhejiang Key Laboratory of Petrochemical Environmental Pollution Control National Engineering Research Center for Marine AquacultureMarine Science and Technology CollegeZhejiang Ocean UniversityZhoushan 316004China

Photocatalytic conversion of CO_(2) into small-molecule chemical feedstocks can meet the growing demand for energy and alleviate the global warming. Herein, a p-n ZnO@CDs@Co_(3)O_(4) heterojunction with sandwich structure was constructed by calcination method of self-assembled ZIF-8@CDs@ZIF-67. The ZnO@CDs@Co_(3)O_(4) with well-defined interfacial structure exhibited the significantly enhanced photocatalytic CO_(2) reduction activity, and the optimal catalyst indicated the(CO + CH_(4)) evolution rate of 214.53μmol g^(-1)h^(-1) under simulated solar light, which was superior to ZnO, Co_(3)O_(4) and binary ZnO@Co_(3)O_(4).The internal cavity, exposed active sites, multiple interfaces and constructed p-n heterojunction can facilitate the light harvesting and photoexcited electron transfer. Besides, after introduction of CDs placed in the middle layer between ZnO and Co_(3)O_(4), CDs with excellent photoelectric property further promoted charge separation and migration. This work represents an appealing strategy to construct well-defined photocatalysts for boosting CO_(2) photoreduction.

关键词： Metal-organic framework Photocatalytic CO_(2) reduction Carbon dots p-n heterojunction Sandwich heterostructure

Recent advances in photodynamic therapy based on emerging two-dimensional layered nanomaterials

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Nano Research 2020年第6期13卷 1485-1508页

作者： Xinqiang Wu Xiaofeng Jiang Taojian Fan Zhiwei Zheng Zhaoyuan Liu Yubin Chen Liangqi Cao Zhongjian Xie Dawei Zhang Jiaqi Zhao Qiwen Wang zhenhui huang Zhijian Chen Ping Xue Han Zhang Department of Hepatobiliary Surgery the Second Affiliated Hospital of Guangzhou Medical UniversityGuangzhou510260China Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province Collaborative Innovation Centre for Optoelectronic Science&TechnologyInstitute of Microscale OptoelectronicsShenzhen UniversityShenzhen518060China College of Physics and Optoelectronic Engineering Shenzhen UniversityShenzhen518060China Shenzhen Key Laboratory of Micro-Nano Photonic Information Technology Guangdong Laboratory of Artificial Intelligence and Digital Economy(SZ)Shenzhen UniversityShenzhen518060China

Photodynamic therapy(PDT)is a promising non-invasive therapy approach for various diseases including malignant *** process of PDT involves three interrelated aspects,namely photosensitizer(PS),light source,and oxygen,among which PS is the decisive factor that determines its anticancer *** exist some defects in currently applied PDT,such as inadequate production of reactive oxygen species(ROS),poor penetration of exciting light,insufficient oxygen supply,and nonselective distribution of *** unique physicochemical and optical properties,two-dimensional nanomaterials(2DNMs)have aroused great interest in biomedical fields.2DNMs-based PDT is promising to significantly improve antitumor efficacy compared to conventional *** this review,we will firstly introduce the underlying mechanism of PDT and how 2DNMs are absorbed and distribute inside tumor *** that,we will not only illustrate how 2DNMs-based PDT can enhance tumor-killing efficacy and minimize side-effects through conquering the above-mentioned defects of conventional PDT and the preparation process of 2DNMs,but also elaborate recent advances about 2DNMs-based ***,we will summarize the challenges and future prospects of 2DNMs-based PDT.

关键词： two-dimensional nanomaterials photodynamic therapy photosensitizer reactive oxygen species

The Magnaporthe oryzae effector Avr-PikD suppresses rice immunity by inhibiting an LSD1-like transcriptional activator

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The Crop Journal 2024年第2期12卷 482-492页

作者： Jiayuan Guo Yiling Wu Jianqiang huang Kaihui Yu Meilian Chen Yijuan Han zhenhui Zhong Guodong Lu Yonghe Hong Zonghua Wang Xiaofeng Chen Fujian Universities Engineering Research Center of Marine Biology and Drugs Fuzhou Institute of OceanographyCollege of Geography and OceanographyMinjiang UniversityFuzhou 350108FujianChina Rice Research Institute Fujian Academy of Agricultural SciencesFuzhou 350018FujianChina Ministerial and Provincial Joint Innovation Center for Safety Production of Cross-Strait Crops Minjiang UniversityFuzhou 350108FujianChina State Key Laboratory of Ecological Pest Control for Fujian and Taiwan Crops College of Plant ProtectionFujian Agriculture and Forestry UniversityFuzhou 350002FujianChina

Avirulence effectors(Avrs),encoded by plant pathogens,can be recognized by plants harboring the corresponding resistance proteins,thereby initiating effector-triggered immunity(ETI).In susceptible plants,however,Avrs can function as effectors,facilitating infection via effector-triggered susceptibility(ETS).Mechanisms of Avr-mediated ETS remain largely *** we report that the Magnaporthe oryzae effector Avr-PikD enters rice cells via the canonical cytoplasmic secretion pathway and suppresses rice basal ***-PikD interacts with an LSD1-like transcriptional activator AKIP30 of rice,and AKIP30 is also a positive regulator of rice immunity,whereas Avr-PikD impedes its nuclear localization and suppresses its transcriptional *** summary,*** delivers Avr-PikD into rice cells to facilitate ETS by inhibiting AKIP30-mediated transcriptional regulation of immune response against ***.

关键词： Magnaporthe oryzae Avirulence effector Avr-PikD Effector-triggered susceptibility Rice immunity Transcriptional activator

Artificial intelligence-based analysis of tumor-infiltrating lymphocyte spatial distribution for colorectal cancer prognosis

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Chinese Medical Journal 2024年第4期137卷 421-430页

作者： Ming Cai Ke Zhao Lin Wu Yanqi huang Minning Zhao Qingru Hu Qicong Chen Su Yao zhenhui Li Xinjuan Fan Zaiyi Liu Department of Radiology Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouGuangdong 510080China Guangdong Provincial Key Laboratory of Artificial Intelligence in Medical Image Analysis and Application GuangzhouGuangdong 510080China Guangdong Cardiovascular Institute Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouGuangdong 510080China Medical Research Institute Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouGuangdong 510080China Department of Pathology The Third Affiliated Hospital of Kunming Medical UniversityYunnan Cancer HospitalYunnan Cancer CenterKunmingYunnan 650118China The Second School of Clinical Medicine Southern Medical UniversityGuangzhouGuangdong 510515China Institute of Computing Science and Technology Guangzhou UniversityGuangzhouGuangdong 510006China Department of Pathology Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouGuangdong 510080China Department of Pathology The Sixth Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong 510655China

Background:Artificial intelligence(AI)technology represented by deep learning has made remarkable achievements in digital pathology,enhancing the accuracy and reliability of diagnosis and prognosis *** spatial distribution of CD3^(+)and CD8^(+)T cells within the tumor microenvironment has been demonstrated to have a significant impact on the prognosis of colorectal cancer(CRC).This study aimed to investigate CD3_(CT)(CD3^(+)T cells density in the core of the tumor[CT])prognostic ability in patients with CRC by using AI ***:The study involved the enrollment of 492 patients from two distinct medical centers,with 358 patients assigned to the training cohort and an additional 134 patients allocated to the validation *** facilitate tissue segmentation and T-cells quantification in whole-slide images(WSIs),a fully automated workflow based on deep learning was *** the completion of tissue segmentation and subsequent cell segmentation,a comprehensive analysis was ***:The evaluation of various positive T cell densities revealed comparable discriminatory ability between CD3_(CT) and CD3-CD8(the combination of CD3^(+)and CD8^(+)T cells density within the CT and invasive margin)in predicting mortality(C-index in training cohort:0.65 vs.0.64;validation cohort:0.69 vs.0.69).The CD3_(CT) was confirmed as an independent prognostic factor,with high CD3_(CT) density associated with increased overall survival(OS)in the training cohort(hazard ratio[HR]=0.22,95%confidence interval[CI]:0.12–0.38,P<0.001)and validation cohort(HR=0.21,95%CI:0.05–0.92,P=0.037).Conclusions:We quantify the spatial distribution of CD3^(+)and CD8^(+)T cells within tissue regions in WSIs using AI *** CD3_(CT) confirmed as a stage-independent predictor for OS in CRC ***,CD3_(CT) shows promise in simplifying the CD3-CD8 system and facilitating its practical application in clinical settings.

关键词： Colorectal cancer Artificial intelligence Deep learning Digital pathology Prognosis Immune cells CD3 CD8 TME

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激励合约视角中的服务型政府

社会主义研究 2006年第2期 83-85页

作者：黄振辉华南师范大学政治与行政学院

服务型政府以消费者主权为基本的指导理念,按照公民的需求生产出符合公民要求的行政产品。“国家———社会”的外部合约和“政府———公职人员”的内部合约体系是服务型政府的制度要素。在激励合约的分析中,中国服务型政府的建构欠缺... 详细信息

服务型政府以消费者主权为基本的指导理念,按照公民的需求生产出符合公民要求的行政产品。“国家———社会”的外部合约和“政府———公职人员”的内部合约体系是服务型政府的制度要素。在激励合约的分析中,中国服务型政府的建构欠缺某些必要因素。由此所导出中国建设服务型政府的可能性战略是:短期内进行思想意识动员,中期目标是建设服务型政府的内部合约体系,长期的目标是推进中国的民主化进程。

关键词：服务型政府合约合法性消费者主权

In-situ study of the hydrogen peroxide photoproduction in seawater on carbon dot-based metal-free catalyst under operation condition

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Nano Research 2024年第7期17卷 5956-5964页

作者： Jiaxuan Wang Jiacheng Li Zenan Li Jie Wu Honglin Si Yangbo Wu Zhiyong Guo Xuepeng Wang Fan Liao Hui huang Mingwang Shao Yang Liu zhenhui Kang Institute of Functional Nano and Soft Materials(FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials&DevicesSoochow UniversitySuzhou 215123China Faculty of Electrical Engineering and Computer Science Ningbo UniversityNingbo 315211China State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products School of Material Science and Chemical EngineeringNingbo UniversityNingbo 315211China Macao Institute of Materials Science and Engineering(MIMSE) MUST-SUDA Joint Research Center for Advanced Functional MaterialsMacao University of Science and TechnologyTaipa 999078MacaoChina

Hydrogen peroxide(H_(2)O_(2))photoproduction in seawater with metal-free photocatalysts derived from biomass materials is a green,sustainable,and ultra environmentally friendly ***,most photocatalysts are always corroded or poisoned in seawater,resulting in a significantly reduced catalytic ***,we report the metal-free photocatalysts(RUT-1 to RUT-5)with in-situ generated carbon dots(CDs)from biomass materials(Rutin)by a simple microwave-assisted pyrolysis *** visible light(λ≥420 nm,81.6 mW/cm^(2)),the optimized catalyst of RUT-4 is stable and can achieve a high H_(2)O_(2)yield of 330.36μmol/L in seawater,1.78 times higher than that in normal *** transient potential scanning(TPS)tests are developed and operated to in-situ study the H_(2)O_(2)photoproduction of RUT-4 under operation ***-4 has strong oxygen(O_(2))absorption capacity,and the O_(2)reduction rate in seawater is higher than that in *** cations in seawater further promote the photo-charge separation and facilitate the photo-reduction *** RUT-4,the conduction band level under operating conditions only satisfies the requirement of O_(2)reduction but not for hydrogen(H2)*** work provides new insights for the in-situ study of photocatalyst under operation condition,and gives a green and sustainable path for the H_(2)O_(2)photoproduction with metal-free catalysts in seawater.

关键词： carbon dots hydrogen peroxide photocatalysis transient potential scanning in-situ study operation condition

非小细胞肺癌脑部转移瘤适形与调强放疗的剂量研究

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基因组学与应用生物学 2019年第1期38卷 295-300页

作者：刘炜黄正辉武汉市金银潭医院武汉430023

为探讨NSCLC脑部转移瘤调强放疗与适形放疗的剂量特点,本研究选取57例非小细胞肺癌脑转移瘤患者,其中单个脑转移灶患者5例,多个脑转移灶患者52例,分别设计全脑放疗+适形放疗与调强放疗计划,用均匀指数(HI)和适形指数(CI)评价靶区剂量,... 详细信息

为探讨NSCLC脑部转移瘤调强放疗与适形放疗的剂量特点,本研究选取57例非小细胞肺癌脑转移瘤患者,其中单个脑转移灶患者5例,多个脑转移灶患者52例,分别设计全脑放疗+适形放疗与调强放疗计划,用均匀指数(HI)和适形指数(CI)评价靶区剂量,危及器官(OAR)剂量用近似最大剂量D_(2%)(串联)和中位剂量D_(50%)(并联)进行评价。研究发现,单个脑转移灶IMRT与WBRT+CRT比较中,CI为(PTV,(0.80±0.15) cGy,(0.34±0.19) cGy, p=0.00),HI为(PTV,(0.52±0.03) c Gy,(0.71±0.12) cGy, p=0.24),两者OARs剂量比较:脑干为((4 348±236) cGy,(4 593±149) cGy, p=0.01),脑垂体为((4 258±166) cGy,(4 581±123) cGy, p=0.02);在多个脑转移灶中,IMRT与WBRT+CRT比,较CI为(PTV,(0.59±0.33) cGy,(0.49±0.27) cGy, p=0.03),HI为(PTV,(0.93±0.01) cGy,(0.58±0.03) cGy, p=0.19),两者OARs剂量比较:脑干为((4 946±132) cGy,(4 843±196) cGy, p=0.51),脑垂体为((4 597±180) cGy,(4 705±149) cGy, p=0.70)。本研究的结果说明,单个脑转移灶患者,IMRT较WBRT+CRT有更好的靶区适形性、稍差的靶区异质性,脑干和垂体的IMRT剂量低于WBRT+CRT,而眼球、晶体的剂量两者差别不明显。多个脑转移灶患者,IMRT较WBRT+CRT有更好的靶区适形性、稍差的靶区异质性,而OARs剂量,IMRT较WBRT+CRT差异不明显。在临床实践过程中,应当根据患者不同的病灶情况选择合适的放疗方案,以获取更优的临床治疗效果。

关键词：非小细胞肺癌脑转移瘤调强放疗适形放疗全脑放疗

表演式抗争：景观、挑战与发生机理--基于珠江三角洲典型案例研究

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开放时代 2011年第2期 71-84页

作者：黄振辉中山市委党校公共管理教研室

底层抗争政治的研究重点应由"用什么武器"转向"武器为何有效"。"表演式抗争"或许是解开转型期底层政治的另一把密匙。从作为表演的底层抗争到作为暴力运动的底层抗争所构成的"连续统"是底层抗争的光谱:越是个体化抗争越具有表演性、仪式... 详细信息

底层抗争政治的研究重点应由"用什么武器"转向"武器为何有效"。"表演式抗争"或许是解开转型期底层政治的另一把密匙。从作为表演的底层抗争到作为暴力运动的底层抗争所构成的"连续统"是底层抗争的光谱:越是个体化抗争越具有表演性、仪式性,越是群体性的抗争则越具有暴力性、实质性;政治势能是表演式抗争实际效果决定性因素。表演式抗争具有特定的社会基础与发生机理;表演式抗争并非是标签化解释模式,它包含着焦点化、情绪触动与压力传递等三大机制。表演式抗争给底层治理带来了一系列挑战。国家制度建设、意识形态扩容以及推进民主化进程是应对挑战的战略选择。底层政治景观色彩斑斓的宏观机理是中国多维转型的非同步性;加速"功利社会—道义社会"转型,重塑社会关系的基础,才是实现底层善治乃至于解决其他棘手社会问题的根本。

关键词：表演式抗争底层政治治理机制非同步转型