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Nano Research 2024年第3期17卷 1251-1258页

作者： Zhe Li Tobias K.Misicko Fan Yang Xiaopeng Liu Zhenwei Wu Xiaoyang Gao Tao Ma Jeffrey T.Miller Daniela S.Mainardi Collin D.Wick zhenhua zeng Yang Xiao Yue Wu Department of Chemical and Biological Engineering Iowa State University618 Bissell RoadAmesIA 50011USA Institute for Micromanufacturing Louisiana Tech University505 Tech DriveRustonLA 71272USA Davidson School of Chemical Engineering Purdue University480 Stadium Mall DriveWest LafayetteIN 47907USA Michigan Center for Materials Characterization University of Michigan2800 Plymouth RdAnn Arbor MI 48109USA College of Engineering and Science Louisiana Tech UniversityRustonLA 71272USA

Atomically thin Pt nanolayers were synthesized on the surface of Mo2TiC2 MXenes and used for the catalytic dehydrogenation of ethane and propane into ethylene and propylene,two important chemicals for the petrochemical *** compared with Pt nanoparticles,the atomically thin Pt nanolayer catalyst showed superior coke-resistance(no deactivation for 24 h),high activity(turnover frequencies(TOFs)of 0.4–1.2 s^(-1)),and selectivity(>95%)toward ethylene and *** unique Pt nanolayer has a similar geometric surface to Pt nanoparticles,enabling the investigations of the electronic effect on the catalytic performance,where the geometric effect is *** is found that the electronic effect plays a critical role in dehydrogenative product selectivity and catalyst *** metal–support interaction is found dependent on the substrate and metal components,providing wide opportunities to explore high-performance MXene-supported metallic catalysts.

关键词： MXene catalysis alkane dehydrogenation nanolayers

Gut commensal metabolite rhamnose promotes macrophages phagocytosis by activating SLC12A4 and protects against sepsis in mice

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Acta Pharmaceutica Sinica B 2024年第7期14卷 3068-3085页

作者： Dongping Li Rongjuan Wei Xianglong Zhang Shenhai Gong Meijuan Wan Fangzhao Wang Jiaxin Li Meiling Chen Ruofan Liu Yantong Wan Yinghao Hong zhenhua zeng Peng Gu Zhang Wang Kutty Selva Nandakumar Yong Jiang Hongwei Zhou Peng Chen Department of Pathophysiology Guangdong Provincial Key Laboratory of ProteomicsSchool of Basic Medical SciencesSouthern Medical UniversityGuangzhou 510000China Department of Critical Care Medicine Nanfang HospitalSouthern Medical UniversityGuangzhou 510000China Department of Gastroenterology Shenzhen HospitalSouthern Medical UniversityShenzhen 518000China dInstitute of Ecological Sciences School of Life SciencesSouth China Normal UniversityGuangzhou 510000China Department of Environmental and Biosciences School of BusinessInnovation and SustainabilityKristian IV’s vag 3Halmstad UniversityHalmstad 30004Sweden Microbiome Medicine Center Zhujiang HospitalSouthern Medical UniversityGuangzhou 510000China

Sepsis progression is significantly associated with the disruption of gut ***,the modulatory mechanisms of gut microbiota operating during sepsis are still ***,we investigated how gut commensals impact sepsis development in a pre-clinical *** ligation and puncture(CLP)surgery was used to establish polymicrobial sepsis in *** depleted of gut microbiota by an antibiotic cocktail(ABX)exhibited a significantly higher level of mortality than *** determined by metabolomics analysis,ABX treatment has depleted many metabolites,and subsequent supplementation with L-rhamnose(rhamnose,Rha),a bacterial carbohydrate metabolite,exerted profound immunomodulatory properties with a significant enhancement in macrophage phagocytosis,which in turn improved organ damage and ***,rhamnose binds directly to and activates the solute carrier family 12(potassium-chloride symporter),member 4(SLC12A4)in macrophages and promotes phagocytosis by activating the small G-proteins,Ras-related C3 botulinum toxin substrate1(Rac1)and cell division control protein 42 homolog(Cdc42).Interestingly,rhamnose has enhanced the phagocytosis capacity of macrophages from sepsis *** conclusion,by identifying SLC12A4 as the host interacting protein,we disclosed that the gut commensal metabolite rhamnose is a functional molecular that could promote the phagocytosis capacity of macrophages and protect the host against sepsis.

关键词： Gut microbiota Sepsis Rhamnose SLC12A4 GTP-Rac1 GTP-Cdc42 Macrophage Phagocytosis

Engineering the high-entropy phase of Pt-Au-Cu nanowire for electrocatalytic hydrogen evolution

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Nano Research 2023年第8期16卷 10742-10747页

作者： Yanan Yu Guangdong Liu Shuaihu Jiang Ruya Zhang Huiqiu Deng Eric AStach Shujuan Bao zhenhua zeng Yijin Kang Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of ChinaChengdu 610054China School of Physics and Electronics Hunan UniversityChangsha 410082China Department of Materials Science and Engineering University of PennsylvaniaPhiladelphiaPA 19104USA Institute for Clean Energy&Advanced Materials School of Materials and EnergySouthwest UniversityChongqing 400715China Davidson School of Chemical Engineering Purdue UniversityWest LafayetteIN 47907USA

Hydrogen economy,as the most promising alternative energy system,relies on the hydrogen production through sustainable water splitting which in turn relies on the high efficiency *** A1-phase alloy has been predicted to be a promising electrocatalyst for the hydrogen *** such preferred phase of Pt-Au-Cu is not thermodynamically favored,herein,we stabilize PtAuCu alloy by engineering the high-entropy phase in the form of *** functional theory(DFT)calculations indicate that,in comparison with the ordered phase and segregated phases with discrete hydrogen binding energy,the high-entropy phase provides a diverse combination of site composition to continuously tune the hydrogen binding energy,and thus generate a series of highly active sites for the hydrogen *** the theoretical prediction,electrochemical tests show that the A1-phase PtAuCu nanowire significantly outperforms its nanoparticle counterpart with phase segregation,toward the electrocatalysis of hydrogen evolution,offering one of the best hydrogen evolution electrocatalysts.

关键词： hydrogen evolution reaction phase engineering high entropy alloys

Synthesis and Application of Carbon Nanotubes

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Journal of Natural Gas Chemistry 2006年第3期15卷 235-246页

作者： Qun zeng zhenhua Li Yuhong Zhou Key Laboratory for Green Chemical Technology School of Chemical Engineering and Technology Tianjin University Tianjin 300072 China

Owing to the unique structure, the superior physical and chemical properties, the super strong mechanical performances, and so on, carbon nanotubes have attracted the attention of researchers all over the world. In this article, the basic properties and the main production processes of carbon nanotubes are introduced in brief, and the progress of applied research for carbon nanotubes is reviewed.

关键词： carbon nanotube arc discharge chemical vapor deposition laser ablation application

First-principles calculation of core-level binding energy shift in surface chemical processes

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Science China Chemistry 2010年第2期53卷 402-410页

作者： zeng zhenhua MA XiuFang DING WuChen LI WeiXue State Key Laboratory of Catalysis and Center for Theoretical and Computational Chemistry Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China

Combined with third generation synchrotron radiation light sources, X-ray photoelectron spectroscopy (XPS) with higher energy resolution, brilliance, enhanced surface sensitivity and photoemission cross section in real time found extensive applications in solid-gas interface chemistry. This paper reports the calculation of the core-level binding energy shifts (CLS) using the first-principles density functional theory. The interplay between the CLS calculations and XPS measurements to uncover the structures, adsorption sites and chemical reactions in complex surface chemical processes are highlight. Its application on clean low index (111) and vicinal transition metal surfaces, molecular adsorption in terms of sites and configuration, and reaction kinetics are domonstrated.

关键词： first principles core-level binding energy shift surface chemical processes

A novel chromogenic and fluorogenic scaffold for detection of oxidative radicals

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Chinese Chemical Letters 2017年第10期28卷 2001-2004页

作者： Zuhai Lei zhenhua zeng Xuhong Qian Youjun Yang State Key Laboratory of Bioreactor Engineering East China University of Science and Technology Shanghai 200237 China Shanghai Key Laboratory of Chemical Biology School of Pharmacy East China University of Science and Technology Shanghai 200237 China

Radical detection has attracted significant attention recently. Here we have developed a scaffold through covalent assembly principle（OR570）, which could facile applications in detection of oxidative *** primary advantage of the assembly type probe lies at the turn-on fluorescence signal from a zero background and hence high fluorescence turn-on ratio for sensitive detection of weak signal.

关键词： Radicals Fluorescent probe Covalent assembly Nitrogen dioxide Fluorogenic

A metabolite from commensal Candida albicans enhances the bactericidal activity of macrophages and protects against sepsis

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Cellular & Molecular Immunology 2023年第10期20卷 1156-1170页

作者： Peng Gu Ruofan Liu Qin Yang Li Xie Rongjuan Wei Jiaxin Li Fengyi Mei Tao Chen zhenhua zeng Yan He Hongwei Zhou Hongjuan Peng Kutty Selva Nandakumar Huikuan Chu Yong Jiang Wei Gong Ye Chen Bernd Schnabl Peng Chen Department of Gastroenterology Shenzhen HospitalSouthern Medical UniversityShenzhenChina Department of Pathophysiology Guangdong Provincial Key Laboratory of ProteomicsSchool of Basic Medical SciencesSouthern Medical UniversityGuangzhouChina Department of Gastroenterology The Seventh Affiliated Hospital of Southern Medical UniversityFoshanChina Department of Critical Care Medicine Nanfang HospitalSouthern Medical UniversityGuangzhouChina Microbiome Medicine Center Zhujiang HospitalSouthern Medical UniversityGuangzhouChina Department of Pathogen Biology Guangdong Provincial Key Laboratory of Tropical Disease ResearchSchool of Public HealthSouthern Medical UniversityGuangzhouChina Department of Environment and Biosciences School of BusinessInnovation and SustainabilityHalmstad UniversityHalmstadSweden Division of Gastroenterology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Department of Medicine University of California San DiegoLa JollaCAUSA

The gut microbiome is recognized as a key modulator of sepsis ***,the contribution of the gut mycobiome to sepsis development is still not fully ***,we demonstrated that the level of Candida albicans was markedly decreased in patients with bacterial sepsis,and the supernatant of Candida albicans culture significantly decreased the bacterial load and improved sepsis symptoms in both cecum ligation and puncture(CLP)-challenged mice and Escherichia coli-challenged *** metabolomics and the genetic engineering of fungi revealed that Candida albicans-derived phenylpyruvate(PPA)enhanced the bactericidal activity of macrophages and reduced organ damage during ***,PPA directly binds to sirtuin 2(SIRT2)and increases reactive oxygen species(ROS)production for eventual bacterial ***,PPA enhanced the bacterial clearance capacity of macrophages in sepsis patients and was inversely correlated with the severity of sepsis in *** findings highlight the crucial contribution of commensal fungi to bacterial disease modulation and expand our understanding of the host-mycobiome interaction during sepsis development.

关键词： Candida albicans Phenylpyruvate Sepsis Macrophage Bacterial clearance

VA-ECMO患者院内死亡风险预测模型的构建及验证:一项多中心、回顾性、病例对照研究

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南方医科大学学报 2024年第3期44卷 491-498页

作者：戈悦李建伟梁宏开侯六生左六二陈珍卢剑海赵新梁静漪彭岚包静娜段佳欣刘俐毛可晴曾振华胡鸿彬陈仲清南方医科大学南方医院重症医学科广东广州510515 南方医科大学护理学院广东广州510515 中山市人民医院重症医学科广东中山528403 南方医科大学顺德医院//顺德第一人民医院重症医学科广东佛山528308

目的分析静脉-动脉体外膜肺氧合技术(VA-ECMO)患者死亡危险因素,构建并验证VA-ECMO患者院内死亡风险预测模型。方法采用便利抽样,选取2015年1月~2022年1月广东省3家三甲综合医院ICU的302例VA-ECMO患者作为研究对象,随机分为建模组201... 详细信息

目的分析静脉-动脉体外膜肺氧合技术(VA-ECMO)患者死亡危险因素,构建并验证VA-ECMO患者院内死亡风险预测模型。方法采用便利抽样,选取2015年1月~2022年1月广东省3家三甲综合医院ICU的302例VA-ECMO患者作为研究对象,随机分为建模组201例,验证组101例。运用单因素及多因素Logistic回归分析VA-ECMO患者死亡危险因素,构建VAECMO患者死亡风险预测模型并以列线图形式呈现。使用受试者工作特征曲线(ROC曲线)、校准曲线和临床决策曲线评价模型区分度、一致性及临床有效性。结果预测VA-ECMO患者院内死亡风险的最终模型包括了高血压(OR=3.694,95%CI 1.582-8.621)、连续性肾脏替代治疗(OR=9.661,95%CI 4.103-22.745)、钠离子(OR=1.048,95%CI 1.003-1.095)、血红蛋白(OR=0.987,95%CI 0.977-0.998)。建模组预测模型的受试者工作特征曲线下面积AUC=0.829(95%CI 0.770-0.889),高于4个单独危险因素(AUC0.05。结论构建的VA-ECMO患者院内死亡风险预测模型区分度、校准度及临床有效性均较好,优于常用疾病严重程度评分系统,对评估重症患者疾病的严重程度及预后的风险水平有重要意义。

关键词：静脉-动脉体外膜肺氧合死亡率危险因素风险预测模型

密度泛函理论研究无水环境下铂基催化剂上氧还原反应活性位点和反应机制

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Chinese Journal of Catalysis 2022年第12期43卷 3126-3133页

作者：刘广东邓辉球 Greeley Jeffrey 曾振华湖南大学物理与微电子科学学院中国湖南长沙410082 普渡大学化学工程学院美国

2050-2060年实现碳净零排放已经成为世界上很多国家的战略使命.为实现该目标,氢燃料电池将在汽车燃料方面发挥重要作用.虽然客运燃料电池电动汽车已经成功推出,但其广泛应用仍是一个挑战,主要是因为质子交换膜燃料电池的铂阴极氧还原反... 详细信息

2050-2060年实现碳净零排放已经成为世界上很多国家的战略使命.为实现该目标,氢燃料电池将在汽车燃料方面发挥重要作用.虽然客运燃料电池电动汽车已经成功推出,但其广泛应用仍是一个挑战,主要是因为质子交换膜燃料电池的铂阴极氧还原反应动力学过于缓慢.理论上,提高氢燃料电池的运行温度有助于改善氧还原反应动力学,例如低温质子交换膜燃料电池的工作温度在80℃,如果反应活性位点和反应机制不变,将操作温度提升到120℃就可以使反应速率提高一个数量级.但是在实际应用过程中,目前最先进的高温质子交换膜燃料电池的性能仍然低于低温质子交换膜燃料电池的性能.为了进一步提高高温质子交换膜燃料电池的性能,研究人员在优化质子交换膜、电解质、催化剂结构、纳米颗粒的稳定性等方面开展了大量的研究工作并取得了显著进展,但对活性位点和反应机制仍缺乏了解.虽然已知高温质子交换膜燃料电池中的铂催化剂在温度高于100℃的无水条件下的活性位点和氧还原机制可能与低温质子交换膜燃料电池的不同,但以往研究并没有从原子尺度上获得相关的认识.本文结合平整的Pt(111)表面上以及含有(110)和(100)型台阶的Pt(332)和Pt(322)台阶表面上的氧还原反应,采用密度泛函理论计算研究了无水条件下铂基催化剂的氧还原反应的活性位点和催化机理.结合反应自由能和表面相图,发现在典型的氧还原反应电位下,Pt(111),Pt(332)和Pt(322)表面上分别集聚0.25,0.2和0.4 ML的氧原子.与有水环境下Pt(111)平台面的氧还原反应不同,由于无水条件下平台面上O*的聚集,使得氧还原中间体的吸附减弱,过电势远大于实验值.此外氧的聚集会增加O_(2)的解离势垒,这些都表明平台面在无水环境下不是氧还原反应的活性位.虽然台阶边缘位置在有水环境下不是氧还原反应的活性位,但是理论计算表明,它们是无水环境下的活性位点.这是因为台阶边缘的存在能稳定O_(2)的吸附,促进O_(2)的解离势垒.独特O聚集构型的(110)型台阶边缘尤其如此:与0.25 ML O集聚的Pt(111)表面相比,O_(2)的吸附能增强了0.36 eV,O_(2)的解离势垒降低了0.32 eV,反应过电势为0.38 V.综上,本文研究为设计具有更高性能的高温质子交换膜燃料电池的氧还原催化剂提供了理论指导.

关键词：氧还原反应活性位无水环境高温质子交换膜燃料电池密度泛函理论

金融科技赋能乡村振兴的现状及建议——以湖南省岳阳市为例

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金融科技时代 2023年第11期31卷 13-16页

作者：曾振华中国人民银行岳阳市分行

文章以湖南省岳阳市为例,通过对岳阳市金融机构金融科技赋能乡村振兴的诸多举措和产生的效果进行调研走访,分析了当前金融科技赋能乡村振兴存在的困难和问题,并就如何提高金融科技赋能质效、更好地助力乡村振兴战略目标的实现提出了相... 详细信息

文章以湖南省岳阳市为例,通过对岳阳市金融机构金融科技赋能乡村振兴的诸多举措和产生的效果进行调研走访,分析了当前金融科技赋能乡村振兴存在的困难和问题,并就如何提高金融科技赋能质效、更好地助力乡村振兴战略目标的实现提出了相应建议。

关键词：金融科技乡村振兴数字化转型