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Clinical applications and pharmacological research progress of Lianhua Qingwen capsules/granules

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Journal of Traditional Chinese Medical Sciences 2021年第2期8卷 101-109页

作者： zhenhua jia Yiling Wu Hebei Yiling Hospital Shijiazhuang050091China State Key Laboratory of Collateral Disease Research and Innovative Chinese Medicine Medicines Key Laboratory of National Administration of Traditional Chinese MedicineShijiazhuang050035China Key Laboratory of National Administration of Traditional Chinese Medicine(Cardiovascular&Cerebrovascular Collateral Disease) Shijiazhuang050035China Hebei Academy of Integrated Traditional Chinese and Western Medicine Shijiazhuang050035China

Lianhua Qingwen capsule/granule is an innovative Chinese medicine developed under the guidance of the traditional Chinese medicine(TCM)collateral disease *** has the effect of“clearing heat and removing toxin,ventilating the lungs and discharging heat”.In 2003,it was approved as a new drug by the China National Medical Products Administration,through expedited approval during severe acute respiratory syndrome,and now,it has become a representative proprietary Chinese medicine for the treatment of infectious diseases of the respiratory *** studies have revealed that Lianhua Qingwen has broad-spectrum antiviral,antibacterial and anti-inflammatory,antipyretic,coughrelieving,and immunoregulation *** it has been used in the treatment of communicable and infectious respiratory diseases such as Coronavirus Disease 2019,influenza,colds,pulmonary infections,*** has achieved remarkable curative effects,showing the important clinical guidance of the TCM collateral disease theory.

关键词： Collateral disease theory Lianhua Qingwen COVID-19 Influenza Pneumonia Traditional Chinese medicine

Photo-promoted transition metal-free organic transformations in the absence of conventional photo-sensitizers

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Chinese Chemical Letters 2019年第8期30卷 1488-1494页

作者： zhenhua jia Yalin Yuan Xinlong Zong Bingquan Wu Jingyu Ma Institute of Advanced Synthesis School of Chemistry and Molecular Engineering Jiangsu National Synergetic Innovation Center for Advanced MaterialsNanjing Tech University

During the last decade,photo-catalysis is emerging as a powerful tool in synthetic organic *** mini-review summarizes the recent advances of photo-promoted organic transformations under transition metal-free condition... 详细信息

关键词： Photo-promoted Transition metal-free Organic transformations Photo-sensitizer

An eco-friendly and highly sensitive loofah@CF/CNT 3D piezoresistive sensor for human activity monitoring and mechanical cotrol

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Science China(Technological Sciences) 2022年第11期65卷 2667-2674页

作者： ZHU Jie SONG YongTao XUE XiaoFei LIU ZhiLong MAO QingYuan jia zhenhua School of Computer Science and Engineering North China Institute of Aerospace EngineeringLangfang 065000China

Three-dimensional(3D)porous piezoresistive sensors are widely used because of their simple fabrication and convenient signal ***,because of the dependence on organic skeleton materials and the complexity of conductive coating preparation,the electrical and mechanical properties of 3D wearable piezoresistive sensors have gradually failed to accommodate many emerging ***,a new flexible 3D piezoresistive sensor(NF3PS)with high sensitivity and a wide measurement range is proposed,which comprises a natural porous loofah as a flexible framework and carbon fiber/carbon nanotube(CF/CNT)multiscale composite as a conductive *** of cellulose and lignin,the irregular,porous loofah has excellent mechanical strength,elasticity,and toughness,ensuring a repeated compression/recovery behavior of the *** addition,compared with the single-size carbon coating,the coupling of multiscale CF/CNT composite coating improves sensitivities over a range of *** NF3PS demonstrates a sensitivity of 6.94 kPa^(-1) with good linearity in the pressure range of 0–11.2 kPa and maintains a sensitivity of 0.28 kPa^(-1) in an ultrawide measurement range of 11.2–84.6 *** flexibility,robustness,and wide-ranging linear resistance variation,the feasibility of the NF3PS in human activity monitoring,mechanical control,and smart homes is *** work provides a novel strategy for a new generation of 3D flexible pressure sensors for improving sensitivity and measurement range and demonstrates attractive applications in wearable sensors.

关键词： 3D piezoresistive sensor loofah framework CF/CNT multiscale composite high sensitivity human activity monitoring mechanical control

Enhanced methanation stability of nano-sized MoS2 catalysts by adding Al2O3

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Frontiers of Chemical Science and Engineering 2015年第1期9卷 33-39页

作者： zhenhua LI jia HE Haiyang WANG Baowei WANG Xinbin MA Key Lab for Green Chemical Technology of Ministry of Education School of Chemical Engineering and Technology Tianjin University Tianjin 300072 China

A series of unsupported MoS2 catalysts with or without Al2O3 modification was prepared using a modified thermal decomposition approach. The catalysts were tested for the methanation of carbon monoxide and the optimum one has 25.6wt-% Al2O3 content. The catalysts were characterized by nitrogen adsorption measurement, X-ray diffraction and transmission electron microscopy. The results show that adding appropriate amount of Al2O3 increases the dispersion of MoS2, and the increased interaction force between MoS2 and Al2O3 can inhibit the sintering of active MoS2 to some extent.

关键词： unsupported catalyst molybdenum sulfide,stability alumina methanation

Strategies for constructing seven-membered rings:Applications in natural product synthesis

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Chinese Chemical Letters 2024年第6期35卷 53-70页

作者： Peng Chen Lijuan Liang Yufei Zhu Zhimin Xing zhenhua jia Teck-Peng Loh College of Advanced Interdisciplinary Science and Technology Henan University of TechnologyZhengzhou 450001China Division of Chemistry and Biological Chemistry School of Chemistry Chemical Engineeringand BiotechnologyNanyang Technological UniversitySingapore 637371Singapore Institute of Advanced Synthesis School of Chemistry and Molecular Engineering Nanjing Tech UniversityNanjing 211816China State Key Laboratory of Applied Organic Chemistry Department of ChemistryLanzhou UniversityLanzhou 730000China

The seven-membered ring motifs are found in bioactive pharmaceuticals and a wide range of natural products,including alkaloids and terpenoids,which hold significant importance in synthetic chemistry and has garnered considerable attention from both academia and *** the challenges faced in the past decade,the total synthesis of natural products incorporating the non-aromatic cycloheptane skeletons remains a compelling ***,numerous elegant strategies for constructing the sevenmembered ring system have been successfully *** review focuses on the recent advancements in this field from 2017 to April 2023,highlighting key transformations utilized to construct the non-aromatic cycloheptane core structures and serves as a valuable guide for synthetic chemists engaged in the total synthesis of natural products containing seven-membered ring motifs.

关键词： Seven-membered rings Total synthesis Natural products Synthetic strategy Cycloheptane

TMSCF_(2)Br as both a C1 synthon and a F1 reagent

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Green Synthesis and Catalysis 2022年第4期3卷 303-305页

作者： Danhua Ge zhenhua jia Xuegiang Chu Institute of Advanced Synthesis School of Chemistry and Molecular EngineeringNanjing Tech UniversityNanjing 211816China

This highlight summarizes a recent development of KF-promoted three-component fluorinationaminocarbonylation reaction of aldehydes,tertiary amines,and TMSCF_(2)Br for the synthesis of structurally importantα-fluoroamide *** key to the success of this method could be attributed to the multiple functions of difluorocarbene precursor(TMSCF_(2)Br)as both a C1 synthon and a F1 reagent through the process of C-F bond cleavage and C-F bond re-formation.

关键词： TMSCF_(2)Br C1 synthon F1 reagent C-F functionalization Organofluoride

Development of catalyst-free carbon-sulfur bond formation reactions under aqueous media and their applications

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Green Synthesis and Catalysis 2022年第4期3卷 309-316页

作者： Min Sun Kang Joycelyn Yi Xin Khoo zhenhua jia Teck-Peng Loh Division of Chemistry and Biological Chemistry School of ChemistryChemical Engineering and Biotechnology(CCEB)Nanyang Technological UniversitySingapore 637371Singapore Henan University of Technology 100 Lianhua StZhongyuan DistrictZhengzhou 450001China

Methods for the carbon-sulfur bond formation under catalyst-free,aqueous conditions are extremely useful in organic synthesis and chemical *** laboratory has developed methodologies to construct carbon-thiol bonds,carbon-sulfinic acid bonds,and carbon-disulfide bonds and such methodologies have been widely adopted by other research groups over multidisciplinary *** this article,our work on C-S bond formation in an aqueous solvent and its corresponding applications is summarized.

关键词： Green synthesis Biocompatible Water-based reaction Biologics C-S bond

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Hopx报告基因小鼠谱系示踪乳腺干细胞

中国组织工程研究 2025年第13期29卷 2720-2727页

作者：石建云李文静彭映贾振华张书锦谭露露原一桐杜若琛山西医科大学细胞生理学教育部重点实验室内分泌代谢病山西省重点实验室山西医科大学生理学系山西省太原市030001 山西医科大学细胞生理学教育部重点实验室山西医科大学动物中心山西省太原市030001

背景:乳腺干细胞对于乳腺组织的发育和稳态维持十分重要。乳腺癌的发生与乳腺干细胞有着紧密联系。最新研究表明,Hopx作为形态发生和细胞分化的重要转录调节因子已被证实在神经、肠道、毛囊等多种成体干细胞中表达,然而其在乳腺中的作... 详细信息

背景:乳腺干细胞对于乳腺组织的发育和稳态维持十分重要。乳腺癌的发生与乳腺干细胞有着紧密联系。最新研究表明,Hopx作为形态发生和细胞分化的重要转录调节因子已被证实在神经、肠道、毛囊等多种成体干细胞中表达,然而其在乳腺中的作用至今尚未见报道。目的:探究Hopx是否可以作为乳腺干细胞的特异性标志物。方法:①选取8周龄雌性Hopx-LacZ转基因小鼠,利用β-半乳糖苷酶染色检测Hopx在乳腺组织中的本底表达情况。②选取4周龄、6周龄、8周龄及妊娠14.5 d的雌性野生型小鼠,分别进行乳腺全组织洋红染色及K14、K8免疫荧光染色。③选取8周龄与妊娠17.5 d的雌性Hopx-CreERT2;Rosa26LacZ转基因小鼠,进行乳腺β-半乳糖苷酶染色。④选取4周龄雌性Hopx-CreERT2;Rosa26LacZ转基因小鼠,通过腹腔注射他莫昔芬(隔天注射1次,注射3次)来激活Cre/loxp系统,注射后4周进行乳腺β-半乳糖苷酶染色;选取8周龄雌性Hopx-CreERT2;Rosa26LacZ转基因小鼠,通过腹腔注射他莫昔芬(隔天注射1次,注射3次)来激活Cre/loxp系统,末次注射后4,10周进行乳腺β-半乳糖苷酶染色。⑤选取8周龄雌性Hopx-CreERT2;Rosa26LacZ转基因小鼠,通过腹腔注射他莫昔芬(隔天注射1次,注射3次)来激活Cre/loxp系统,注射后2周使Hopx-CreERT2;Rosa26LacZ转基因小鼠怀孕,对第1次妊娠17.5 d、第3次妊娠17.5 d的小鼠乳腺组织进行β-半乳糖苷酶染色。结果与结论:①β-半乳糖苷酶染色结果显示,8周龄Hopx-LacZ转基因小鼠的乳腺导管内确实含有Hopx阳性细胞且位于基底上皮,数量较少。②乳腺全组织染色及免疫荧光染色结果显示,野生型小鼠的乳腺在青春期、成熟期及妊娠期等不同发育阶段具有各自相应时期依赖性的特征,并且经历了一系列复杂的上皮重塑过程。③β-半乳糖苷酶染色结果显示,与8周龄雌性Hopx-CreERT2;Rosa26LacZ转基因小鼠相比,妊娠17.5 d的Hopx-CreERT2;Rosa26LacZ转基因小鼠乳腺导管内Hopx标记阳性细胞增多。④β-半乳糖苷酶染色结果显示,4,8周龄雌性Hopx-CreERT2;Rosa26LacZ转基因小鼠他莫昔芬注射后的乳腺Hopx标记阳性细胞位于基底上皮,数量较少。⑤β-半乳糖苷酶染色结果显示,第1次妊娠17.5 d、第3次妊娠17.5 d的小鼠乳腺内的Hopx标记阳性细胞位于腺泡周围的基底上皮,数量较多,并且第3次妊娠17.5 d的Hopx标记阳性细胞数量更多。⑥结果表明,Hopx报告基因标记的细胞为休眠乳腺干细胞,负责妊娠期间乳腺的生长,对腺泡形成有贡献。

关键词： Hopx 乳腺干细胞谱系追踪妊娠期腺泡形成

Repositioning of clinically approved drug Bazi Bushen capsule for treatment of Alzheimer′s disease using network pharma⁃cology approach and in vitro experimental validation

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中国药理学与毒理学杂志 2023年第S1期37卷 22-23页

作者： WANG Tongxing CHEN Meng HOU Bin LIANG Junqing WEI Cong jia zhenhua National Key Laboratory of Collateral Disease Research and Innovative Chinese Medicine Shijia-zhuang 050035China Hebei Yiling Pharmaceu-tical Research Institute Key Laboratory of State Administration of TCM(Cardio-Cerebral Vessel Collateral Diseases)Shijiazhuang 050035China Key Disciplines of State Administration of TCM for Collateral Disease Shijiazhuang 050035China

OBJECTIVE To explore the new indications and key mechanism of Bazi Bushen capsule(BZBS)by network pharmacology and in vitro *** The potential tar⁃get profiles of the components of BZBS were pre⁃***,new indications for BZBS were predicted by disease ontology(DO)enrich⁃ment analysis and initially validated by GO and KEGG pathway enrichment ***⁃more,the therapeutic target of BZBS acting on AD signaling pathway were identified by intersec⁃tion *** Alzheimer′s disease(AD)cell models,BV-2 and SH-SY5Y,were used to pre⁃liminarily verify the anti-AD efficacy and mecha⁃nism of BZBS in *** In total,1499 non-repeated ingredients were obtained from 16 herbs in BZBS formula,and 1320 BZBS targets with high confidence were *** enrichment results strongly suggested that BZBS formula has the potential to be used in the treat⁃ment of *** vitro experiments showed that BZ⁃BS could significantly reduce the release of TNF-αand IL-6 and the expression of COX-2 and PSEN1 in Aβ25-35-induced BV-2 *** reduced the apoptosis rate of Aβ25-35 induced SH-SY5Y cells,significantly increased mitochon⁃drial membrane potential,reduced the expres⁃sion of Caspase3 active fragment and PSEN1,and increased the expression of ***⁃SIONS BZBS formula has a potential use in the treatment of AD,which is achieved through regu⁃lation of ERK1/2,NF-κB signaling pathways,and GSK-3β/β-catenin signaling ***⁃more,the network pharmacology technology is a feasible drug repurposing strategy to reposition new clinical use of approved TCM and explore the mechanism of *** study lays a foun⁃dation for the subsequent in-depth study of BZBS in the treatment of AD and provides a basis for its application in the clinical treatment of AD.

关键词： Drug repositioning Bazi Bushen capsule Network pharmacology Alzheimer′s disease Mechanism of action