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Necroptosis-elicited host immunity:GOx-loaded MoS_(2) nanocatalysts for self-amplified chemodynamic immunotherapy

Nano Research 2022年第3期15卷 2244-2253页

作者： Wensheng Xie Jingsong Lu zhenhu guo Xiaoxiao guo Yongjiu Chi Jieling Ye Junxin Zhang Wanling Xu Lingyun Zhao Yen Wei The Key Laboratory of Bioorganic Phosphorus Chemistry&Chemical Biology(Ministry of Education) Department of ChemistryTsinghua UniversityBeijing 100084China State Key Laboratory of New Ceramics and Fine Processing School of Materials Science and EngineeringTsinghua UniversityBeijing 100084China Research Center of Magnetic and Electronic Materials College of Materials Science and EngineeringZhejiang University of TechnologyHangzhou 310014China State Key Laboratory of Powder Metallurgy Powder Metallurgy Research InstituteCentral South UniversityChangsha 410083China Department of Chemistry Tsinghua UniversityBeijing 100084China.

Nanoparticles induced potent antitumor immunotherapy plays a significant role for enhancing conventional therapeutic ***,revealing the pathway of how nanoagents themselves trigger the host immunity or how to maximize the immunotherapy efficacy still needs further ***,rose-like MoS2 nanoflowers modified with 2-deoxy-D-glucose(2-DG)and glucose oxidase(GOx)(MPGGFs)have been successfully fabricated via a one-pot hydrothermal reaction and following one-by-one surface modification as a multifunctional nanocatalyst for photothermal therapy enhanced self-amplified chemodynamic immunotherapy(PTT-co-CDT).By introducing GOx,the obtained MPGGFs exhibited self-amplified chemodynamic therapeutic efficacy under hypoxia tumor microenvironment(TME)because of the raised intracellular H2O2 level via enzyme-catalysis of ***,combined with the intrinsic excellent photothermal conversion efficiency of MoS2 nanoflowers,PTT-co-CDT performances by MPGGFs could effectively induce the necroptosis of tumor cells both in vitro and in *** the induced necroptosis via PTT-co-CDT by MPGGFs could directly trigger host immunity by activating the antigen-specific T-cells(CD4^(+) and CD8^(+)).Finally,the excellent in vivo safety of MPGGFs makes us believe that the successful construction of rose-like multifunctional nanocatalyst not only has great potentials for self-amplified chemodynamic immunotherapy,but also provides a paradigm for exploring necroptosis triggered host immunity for cancer treatment.

关键词： chemodynamic immunotherapy necroptosis nanocatalyst photothermal therapy self-amplified

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Recent advances for liquid metals:Synthesis,modification and bio-applications

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Journal of Materials Science & Technology 2023年第12期143卷 153-168页

作者： zhenhu guo Xiaohan Gao Jingsong Lu Wanling Xu Jielin Ye Ying Li Wensheng Xie Lingyun Zhao Key Laboratory of Advanced Materials Ministry of Education of ChinaSchool of Materials Science and EngineeringTsinghua UniversityBeijing 100084China State Key Laboratory of New Ceramics and Fine Processing School of Materials Science and EngineeringTsinghua UniversityBeijing 100084China School of Medicine Tsinghua UniversityBeijing 100084China Department of Neurosurgery Yuquan HospitalSchool of Clinical MedicineTsinghua UniversityBeijing 100084China The Key Laboratory of Bioorganic Phosphorus Chemistry&Chemical Biology(Ministry of Education) Department of ChemistryTsinghua UniversityBeijing 100084China

Considering the application requirements for modern biomedicine,research into novel biomaterials with unusual functions is highly *** an alternative,liquid metals(LMs),a nontraditional family of metal materials,have piqued the interest of biomedical researchers and made significant advances in biomed-ical areas,owing to their shape transformability,self-healing capability,excellent electrical,and thermal *** particular,many functionalized strategies for the preparation and modification of LMs or LMs-based composites to achieve extended biomedical applications have been investigated in recent *** findings provided inspiring while constructive reference for the fabrication and engineering of novel LMs-based ***,in this topic review,we elaborate on the recent advances of LMs-based functional materials,with particular focuses on the synthesis,modification,and bio-applications,especially in antitumor therapy,antibacterial,contrast agent for imaging,bone repair,electronic skin sen-sor,and nerve connection *** on,the current challenges and future prospects of LMs-based composites are carefully discussed.

关键词： Liquid metals Synthesis Composites Antitumor therapy Bio-application

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Regenerative Biomaterials 2023年第1期10卷 377-385页

作者： Jianping Gao zhenhu guo Yang Zhang Yuying Liu Fangyu Xing Junjie Wang Xi Luo Yingjun Kong Guifeng Zhang National Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China School of Chemical and Engineering University of Chinese Academy of SciencesBeijing 100049China

The content of type I collagen(COL-I)and type III collagen(COL-III)and the ratio between them not only affect the skin elasticity and mechanical strength,but also determine the fibril *** this research,we investigated the age-related changes in COL-I/COL-III ratio with their formed fibril *** experimental result was obtained from high performance liquid chromatography-mass spectrometer,hydroxyproline determination,picrosirius red staining and transmission electron microscopes(TEM),*** result indicated that the COL-I/COL-III ratio in mouse skin increased with *** the 0th to 9th week,the COL-I/COLIII ratio increased from 1.3:1 to 4.5:*** the 9th to the 18th week,it remained between 4.5:1 and 4.9:*** total content of COL-I and COL-III firstly increased and then decreased with *** TEM result showed that the fibril diameter increased with *** the 0th to 9th week,the average fibril diameter increased from 40 to 112 nm;From the 9th to 18th weeks,it increased from 112 to 140 *** the 9th *** fibril diameter showed obvious uneven ***,the COL-I/COLIII ratio was proportional to the fibril diameter,but inversely proportional to the uniformity of fibril diameter.

关键词： collagen skin ratio fibril diameter

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Enhanced corrosion resistance,antibacterial properties and osteogenesis by Cu ion optimized MgAl-layered double hydroxide on Mg alloy

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Journal of Magnesium and Alloys 2024年第10期12卷 4174-4190页

作者： Qingge Wang Chuting Liao Bo Liu Shaohui Jing zhenhu guo Luxin Liang Jingbo Liu Ning Li Runhua Zhou Ian Baker Hong Wu State Key Laboratory of Powder Metallurgy Central South UniversityChangsha 410083China Department of General Surgery The Second Xiangya HospitalCentral South UniversityChangsha 410011China National Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China Department of Orthopedics The Second Xiangya HospitalCentral South UniversityChangsha 410011China Department of Oral and Maxillofacial Surgery Center of StomatologyXiangya HospitalCentral South UniversityChangsha 410008China School of Mechanical and Aerospace Engineering Nanyang Technological University639798Singapore Thayer School of Engineering Dartmouth CollegeHanoverNH 03755-8000USA

Magnesium(Mg)and its alloys have similar densities and elastic moduli to natural bone,making them an excellent choice for orthopedic ***,Mg alloys are prone to electrochemical corrosion,which often leads to implant failure and hinders the further development of Mg alloys due to bacterial infection around the *** work aims to enhance the corrosion resistance of Mg alloys,and provide theoretical guidance for solving the problem that Mg-based orthopedic implants are susceptible to bacterial infection and,thus,implant *** order to solve the corrosion problem,the Mg alloy AZ91D was used as the substrate,and a compact and uniform MgAlCu-layered double hydroxide(Mg(Cu)-LDH)was prepared on its surface using a hydrothermal *** Mg(Cu)-LDH provides a barrier between the AZ91D and corrosive liquid,which effectively protects the Mg substrate from being *** Mg(Cu)-LDH shows great cell viability for MC3T3-E1 *** Cu^(2+)and Mg^(2+) in the coating also endow the Mg(Cu)-LDH/AZ91D with antibacterial properties,showing strong antibacterial effects on both *** and *** with antibacterial rates over 85%.Finally,in vivo results indicated that a LDH-coated implant had no systemic effects on the hearts,livers,spleens,lungs or *** was shown that 4 weeks after surgery the ratio of bone volume to tissue volume(BV/TV)of the LDH implant was 24%,which was 1.7 times that observed for AZ91D.

关键词： Mg alloy Surface modification Layered double hydroxide Corrosion resistance Antibacterial mechanisms Osteogenesis

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Doxorubicin-Ioaded Fe3O4@MoS2-PEG-2DG nanocubes as a theranostic platform for magnetic resonance imaging- guided chemo-photothermal therapy of breast cancer

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Nano Research 2018年第5期11卷 2470-2487页

作者： Wensheng Xie Qin Gao Dan Wang zhenhu guo Fei Gao Xiumei Wang Qiang Cai Si-shen Feng Haiming Fan Xiaodan Sun Lingyun Zhao State Key Laboratory of New Ceramics and Fine Processing School of Materials Science & Engineering Tsinghua University Beijing 100084 China Key Laboratory of Advanced Materials Ministry of Education of China School of Materials Science & Engineering Tsinghua University Beijing 100084 China School of Chemical and Biomolecular Engineering Notional University of Singapore 119077 Singapore College of Chemistry and Materials Science Northwest University Xi'an 710069 China

Molybdenum disulfide （MoS2）, a typical transition-metal dichalcogenide, has attracted increasing attention in the field of nanomedicine because of its preeminent properties. In this study, magnetic resonance imaging （MRI）-guided chemo-photothermal therapy of human breast cancer xenograft in nude mice was demonstrated using a novel core/shell structure of Fe3O4@MoS2 nanocubes （IOMS NCs） via the integration of MoS2 （MS） film onto iron oxide （IO） nanocubes through a facile hydrothermal method. After the necessary PEGylation modification of the NCs for long-circulation purposes, such PEGylated NCs were further capped by 2-deoxy-D-glucose （2-DG）, a non-metabolizable glucose analogue to increase the accumulation of the as-prepared NCs at the tumor site, as 2-DG molecules could be particularly attractive to resource-hungry cancer cells. Such 2-DG- modified PEGylated NCs （IOMS-PEG-2DG NCs） acted as drug-carriers for doxorubicin （DOX）, which could be easily loaded within the NCs. The obtained IOMS-PEG（DOX）-2DG NCs exhibited a 3？2 relaxivity coefficient of 48.86 （mM）^-1·s^-1 and excellent photothermal performance. 24 h after intravenous injection of IOMS-PEG（DOX）-2DG NCs, the tumor site was clearly detected by enhanced T2-weighted MRI signal. Upon exposure to an NIR 808-nm laser for 5 rain at a low power density of 0.5 W·cm^-2 a marked temperature increase was noticed within the tumor site, and the tumor growth was efficiently inhibited by the chemo-photothermal effect. Therefore, our study highlights an excellent theranostic platform with great potential for targeted MRI-guided precise chemo-photothermal therapy of breast cancer.

关键词： iron oxide nanocubes molybdenum disulfide multimodality therapy photothermal therapy nanotheranostics

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Galvanic replacement reaction for in situ fabrication of litchi-shaped heterogeneous liquid metal-Au nano-composite for radio-photothermal cancer therapy

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Bioactive Materials 2021年第3期6卷 602-612页

作者： zhenhu guo Jingsong Lu Dan Wang Wensheng Xie Yongjie Chi Jianzhong Xu Nonaka Takuya Junxin Zhang Wanling Xu Fei Gao Hong Wu Lingyun Zhao State Key Laboratory of Powder Metallurgy Powder Metallurgy Research InstituteCentral South UniversityChangshaHunan410083China Key Laboratory of Advanced Materials Ministry of Education of ChinaSchool of Materials Science and EngineeringTsinghua UniversityBeijing100084China State Key Laboratory of New Ceramics and Fine Processing School of Materials Science and EngineeringTsinghua UniversityBeijing100084China Research Center of Magnetic and Electronic Materials College of Materials Science and EngineeringZhejiang University of TechnologyHangzhouZhejiang310014China Department of Nanoengineering Chemical Engineering Programand Moores Cancer CenterUniversity of California San DiegoLa JollaCA92093United States The Key Laboratory of Bioorganic Phosphorus Chemistry&Chemical Biology(Ministry of Education) Department of ChemistryTsinghua UniversityBeijing100084China School of Earth Sciences and Resources China University of Geosciences(Beijing)Beijing100083China Shaanxi University of Chinese Medicine Xi'anShanxi712046China

With tremendous research advances in biomedical application,liquid metals(LM)also offer fantastic chemistry for synthesis of novel ***,as a pioneering trial,litchi-shaped heterogeneous eutectic gallium indium-Au nanoparticles(EGaIn-Au NPs),served as effective radiosensitizer and photothermal agent for radio-photothermal cancer therapy,have been successfully prepared using in situ interfacial galvanic replacement *** enhanced photothermal conversion efficiency and boosted radio-sensitization effect could be achieved with the reduction of Au nanodots onto the eutectic gallium indium(EGaIn)NPs *** importantly,the growth of tumor could be effectively inhibited under the combined radio-photothermal therapy mediated by EGaIn-Au *** by this approach,in situ interfacial galvanic replacement reaction may open a novel strategy to fabricate LM-based nano-composite with advanced multi-functionalities.

关键词： Au nanodots Gallium Galvanic replacement reaction Indium Radio-photothermal therapy

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高速逆流色谱法分离纯化大风艾中的黄酮类成分

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遵义医科大学学报 2021年第4期44卷 535-539页

作者：谭道鹏郭振虎何莉秦琳何芋岐遵义医科大学药学院贵州遵义563009 贵州医科大学省部共建药用植物功效与利用国家重点实验室贵州贵阳550014 贵州黄果树立爽药业有限公司贵州贵阳550014 贵州苗药生物技术有限公司贵州铜仁554300

目的建立分离纯化大风艾中黄酮苷类成分的方法。方法目标成分可以通过高速逆流色谱,以水-甲醇-乙酸乙酯-正己烷(5∶1∶5∶1,v/v/v/v)两相溶剂系统进行分离。结果经一次分离纯化可获得9.3 mg金丝桃苷(纯度97.1%)、5.7 mg紫云英苷(纯度82.... 详细信息

目的建立分离纯化大风艾中黄酮苷类成分的方法。方法目标成分可以通过高速逆流色谱,以水-甲醇-乙酸乙酯-正己烷(5∶1∶5∶1,v/v/v/v)两相溶剂系统进行分离。结果经一次分离纯化可获得9.3 mg金丝桃苷(纯度97.1%)、5.7 mg紫云英苷(纯度82.8%)和7.6 mg槲皮苷(纯度98.8%),以上3个化合物经ESI-MS,1H NMR鉴定。结论本研究建立的方法可用于大风艾中黄酮苷类成分的分离和纯化。

关键词：高速逆流色谱分离纯化大风艾黄酮

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功能型复合生物材料用于肿瘤局部热疗的研究进展

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现代肿瘤医学 2018年第3期26卷 474-477页

作者：谢文升高琴郭振虎王伟王丹赵凌云清华大学材料学院新型陶瓷与精细工艺国家重点实验室北京100084 中国地质大学北京100083

肿瘤热疗不但具有杀伤广谱恶性肿瘤的能力,还可与化疗、放疗在临床治疗上相结合产生协同增敏的效果。同时又能减轻放、化疗治疗的毒副作用,因而被国际医学界称为"绿色疗法"。当前新型的热疗手段与传统的热疗手段相比较而言,能够提高治... 详细信息

肿瘤热疗不但具有杀伤广谱恶性肿瘤的能力,还可与化疗、放疗在临床治疗上相结合产生协同增敏的效果。同时又能减轻放、化疗治疗的毒副作用,因而被国际医学界称为"绿色疗法"。当前新型的热疗手段与传统的热疗手段相比较而言,能够提高治疗的适形性、有效性和靶向性,并且能够极大的减小热疗的毒副作用。但是新型的热疗手段需要借助于外界的能量源和热疗介质,即由安全、高效的热疗介质将外源的能量转化为热量并在肿瘤区域实现能量的"聚焦",从而达到对肿瘤组织精确、高效的杀伤。所以,对基于功能型生物材料的热疗介质的开发和选择就成为了决定新型热疗治疗效果的关键因素。目前,针对肿瘤局部热疗的功能型复合生物材料的综述鲜有报道,因此,本文就目前肿瘤热疗领域中光热治疗、磁感应热疗和微波热疗的相关复合介质材料进行总结阐述,为功能型复合生物材料在未来肿瘤热疗领域提供借鉴。

关键词：肿瘤治疗热疗光热治疗磁感应热疗微波热疗

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良附滴丸抗大鼠乙醇型胃溃疡预防作用及机制

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贵州医科大学学报 2020年第7期45卷 767-772页

作者：潘洁李莉娜李勇军曹闯郭振虎陆苑贵州医科大学民族药与中药开发应用教育部工程研究中心贵州贵阳550004 贵州医科大学贵州省药物制剂重点实验室&省部共建药用植物功效与利用国家重点实验室贵州贵阳550004 贵州医科大学药学院贵州贵阳550004 贵州黄果树立爽药业有限公司贵州贵阳550008

目的:研究良附滴丸对乙醇型胃溃疡大鼠模型的预防作用及机制。方法:48只SD大鼠均分为良附滴丸(低、中、高)剂量组、奥美拉唑组、模型组以及空白对照组,低、中、高剂量组分别灌胃良附滴丸[良附滴丸剂量0.27 g/(kg·d)、0.54 g/(kg·d)、1... 详细信息

目的:研究良附滴丸对乙醇型胃溃疡大鼠模型的预防作用及机制。方法:48只SD大鼠均分为良附滴丸(低、中、高)剂量组、奥美拉唑组、模型组以及空白对照组,低、中、高剂量组分别灌胃良附滴丸[良附滴丸剂量0.27 g/(kg·d)、0.54 g/(kg·d)、1.08 g/(kg·d)],奥美拉唑组灌胃奥美拉唑[18 mg/(kg·d)],模型组和空白组给予等体积生理盐水,连续给药5 d,每天给药1次,第5天给药后禁食不禁水24 h,再给药1次,末次给药1 h后,除空白对照组外,其余各组大鼠灌胃无水乙醇(5 mL/kg)诱导胃溃疡,于1 h后处死大鼠并收集胃组织,观察各组大鼠胃组织表观形态和HE染色下组织形态特征,比较胃组织溃疡指数、计算溃疡抑制百分率,检测胃组织匀浆中一氧化氮(NO)、丙二醛(MDA)、超氧化物歧化酶(SOD)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、前列腺素(PGE 2)等指标的含量。结果:与模型组比较,良附滴丸中、高剂量组可改善胃溃疡组织水肿、黏膜糜烂、血管扩张出血及炎症细胞浸润等病理改变;良附滴丸低、中、高剂量组的溃疡抑制百分率依次升高;与模型组比较,良附滴丸低剂量组能够升高NO、SOD的含量(P0.05);良附滴丸中、高剂量组能降低胃黏膜损伤大鼠胃溃疡指数(P<0.01),胃组织中NO、SOD、PGE 2含量明显升高(P<0.01),TNF-α、IL-6、MDA水平明显降低(P<0.05或P<0.01)。结论:良附滴丸可减轻大鼠无水乙醇诱导的胃溃疡病理改变,其机制可能与增加NO、SOD、PGE 2水平或降低TNF-α、IL-6、MDA水平有关。

关键词：胃溃疡乙醇大鼠一氧化氮丙二醛超氧化物歧化酶良附滴丸胃溃疡

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旋转填充床脱除裂解气中酸性气体的冷模实验

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石油化工 2006年第5期35卷 452-457页

作者：金沙杨李振虎戴伟郭锴北京化工大学教育部超重力工程研究中心北京100029 中国石油化工股份有限公司北京化工研究院北京100013

用空气和CO2的混合气体模拟裂解气，在旋转填充床中进行酸性气体吸收实验。考察了吸收液流量、吸收液浓度、空气流是、空气中CO2含量、旋转填充床转速和吸收液温度对气相传质系数（KGa）的影响。实验结果表明，KGa为0．2-3．0s^-1，时，... 详细信息

用空气和CO2的混合气体模拟裂解气，在旋转填充床中进行酸性气体吸收实验。考察了吸收液流量、吸收液浓度、空气流是、空气中CO2含量、旋转填充床转速和吸收液温度对气相传质系数（KGa）的影响。实验结果表明，KGa为0．2-3．0s^-1，时，KGa随吸收液流量、吸收液浓度、空气流量、旋转填充床转速和吸收液温度的升高而增大，随空气中CO2含量的增加而减小。用冷模数据推算工业操作条件（约1.5MPa，50℃）下旋转填充床的吸收效果，预计可将裂解气中酸性气体的体积分数由1.00％降至1×10^-6以下。旋转填充床脱除裂解气中酸性气体的效果优于传统的脱除工艺。

关键词：裂解气吸收旋转填充床酸性气体二氧化碳冷模实验超重力技术

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