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Frontiers of Chemical Science and Engineering 2022年第1期16卷 103-111页

作者： Mingyue Zhu zhenhao Tian Lingling Jin xiaokui Huo Chao Wang Jingnan Cui Yan Tian xiangge Tian Lei Feng College of Pharmacy School of MedicineKey Laboratory of Elemene Class Anti-Cancer Chinese MedicinesEngineering Laboratory of Development and Application of Traditional Chinese MedicinesHangzhou Normal UniversityHangzhou 311121China Dalian Key Laboratory of Metabolic Target Characterization and Traditional Chinese Medicine Intervention College of PharmacyCollege of Integrative MedicineDalian Medical UniversityDalian 116044China School of Life Sciences Northwestern Polytechnical UniversityXi’an 710072China State Key Laboratory of Fine Chemicals Dalian University of TechnologyDalian 116024China

Uridine diphosphate(UDP)-glucuronosyltransferases(UGTs)are enzymes involved in the biotransformation of important endogenous compounds such as steroids,bile acids,and hormones as well as exogenous substances including drugs,environmental toxicants,and ***,a novel fluorescent probe BDMP was developed based on boron-dipyrromethene(BODIPY)with high sensitivity for the detection of *** glucuronidation of BDMP not only exhibited a redemission wavelength(lex/lem=500/580 nm),but also displayed an excellent UGT1A8-dependent fluorescence signal with a good linear relationship with UGT1A8 *** on this perfect biocompatibility and cell permeability,BDMP was successfully used to image endogenous UGT1A8 in human cancer cell lines(LoVo and HCT15)in real *** addition,BDMP could also be used to visualize UGT1A8 in tumor *** results suggested that BDMP is a promising molecular tool for the investigation of UGT1A8-mediated physiological function in humans.

关键词： UDP-glucuronosyltransferase 1A8 fluorescent probe subtype selectivity fluorescence imaging

The influence of temperature,pressure,salinity and capillary force on the formation of methane hydrate

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Geoscience Frontiers 2011年第2期2卷 125-135页

作者： zhenhao Duan Ding Li Yali Chen Rui Sun Key Laboratory of the Earth ＇s Deep Interior Institute of Geology and Geophysics Chinese Academy of Sciences Beijing 100029 China School of Earth Sciences and Resources China University of Geoseiences Beijing 100083 China Northwest University Xi＇an 710069 China

We present here a thermodynamic model for predicting multi-phase equilibrium of methane hydrate liquid and vapor phases under conditions of different temperature, pressure, salinity and pore sizes. The model is based on the 1959 van der Waals--Platteeuw model, angle-dependent ab initio intermolecular potentials, the DMW-92 equation of state and Pitzer theory. Comparison with all available experimental data shows that this model can accurately predict the effects of temperature, pressure, salinity and capillary radius on the formation and dissociation of methane hydrate. Online calculations of the p-T conditions for the formation of methane hydrate at given salinities and pore sizes of sediments are available on： ***/***.

关键词： Methane hydrate ab initio potential Salinity Porous sediment Forming conditions Phase equilibria

Real-time identification of gut microbiota with aminopeptidase N using an activable NIR fluorescent probe

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Chinese Chemical Letters 2021年第10期32卷 3053-3056页

作者： Lei Feng zhenhao Tian Ming Zhang xin He xiangge Tian Zhenlong Yu xiaochi Ma Chao Wang Dalian Key Laboratory of Metabolic Target Characterization and Traditional Chinese Medicine Intervention College of PharmacyAcademy of Integrative MedicineThe National&Local Joint Engineering Research Center for Drug Development of Neurodegenerative DiseaseDalian Medical UniversityDalian 116044China School of Life Sciences Northwestern Polytechnical UniversityXuzhou 221004China Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy Xuzhou Medical UniversityXi’an 710072China

A NIR fluorescent probe(DDAA) derived from fluorophore DDAO with alanine as the recognition group was developed for sensing aminopeptidase N(APN) in gut *** DDAA as the real-time guidance tool for the fluorescence imaging of intestinal microorganism,target bacteria and saccharomycete possessing active APN were identified successfully from human feces.

关键词： Aminopeptidase N Fluorescent probe Gut microbiota Bacteria Fungi

A NIR fluorescent probe for Vanin-1 and its applications in imaging, kidney injury diagnosis,and the development of inhibitor

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Acta Pharmaceutica Sinica B 2022年第1期12卷 316-325页

作者： zhenhao Tian Fei Yan xiangge Tian Lei Feng Jingnan Cui Sa Deng Baojing Zhang Tian xie Shanshan Huang xiaochi Ma Dalian Key Laboratory of Metabolic Target Characterization and Traditional Chinese Medicine Intervention The Second Affiliated HospitalCollege of Integrative MedicineCollege of PharmacyDalian Medical UniversityDalian 116044China Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy Xuzhou Medical UniversityXuzhou 221004China School of Life Sciences Northwestern Polytechnical UniversityXi'an 710072China School of Chemistry and Chemical Engineering Henan Normal UniversityXinxiang 453007China State Key Laboratory of Fine Chemicals Dalian University of TechnologyDalian 116024China College of Pharmacy Key Laboratory of Elemene Class Anti-Cancer Chinese MedicinesHangzhou Normal UniversityHangzhou 311121China

Vanin-1 is an amidohydrolase that catalyses the conversion of pantetheine into the aminothiol cysteamine and pantothenic acid(coenzyme A precursor), which plays a vital role in multiple physiological and pathological processes. In this study, an enzyme-activated near-infrared(NIR) fluorescent probe(DDAV) has been constructed for sensitively detecting Vanin-1 activity in complicated biosamples on the basis of its catalytic characteristics. DDAV exhibited a high selectivity and sensitivity toward Vanin-1 and was successfully applied to the early diagnosis of kidney injury in cisplatin-induced kidney injury model. In addition, DDAV could serve as a visual tool for in situ imaging endogenous Vanin-1 in vivo. More importantly, Enterococcus faecalis 20247 which possessed high expression of Vanin-1 was screened out from intestinal bacteria using DDAV, provided useful guidance for the rational use of NSAIDs in clinic. Finally, oleuropein as a potent natural inhibitor for Vanin-1 was discovered fromherbal medicines library using a high-throughput screening method using DDAV, which held great promise for clinical therapy of inflammatory bowel disease.

关键词： Vanin-1 NIR fluorescent probe Kidney injury diagnosis Fluorescence imaging Oleuropein

Numerical Simulation of Microwaveassisted Depolymerization of Kraft Lignin

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Paper And Biomaterials 2021年第4期6卷 47-53页

作者： zhenhao Ma Wenliang Wang Jiale Huang Yujun Ma Hui Miao Yishuai Fu xiaoxiao Ren College of Bioresources Chemical and Materials Engineering Shaanxi University of Science and TechnologyXi'anShaanxi Province710021China Key Laboratory of Pulp and Paper Science&Technology of Ministry of Education Qilu University of Technology(Shandong Academy of Sciences)Ji'nanShandong Provice250353China

Kraft lignin has the potential to replace traditional fossil resources for the preparation of high-value chemicals because it is rich in aromatic rings and active functional *** effective method for the pyrolysis of kraft lignin into chemicals/fuels is microwave-assisted depolymerization.A simulation model is urgently needed to illustrate the coupling effect and mechanism of lignin conversion during the depolymerization *** this study,COMSOL Multiphysics was used to simulate the microwave-assisted depolymerization *** results showed that microwave power had a significant effect on the electric field and temperature distribution in the microwave cavity,while the reaction time had little effect on the electric *** effect of the nitrogen flow rate on the electric field and temperature was *** intensity of the electric field,heating rate of lignin,and final temperature of lignin depolymerization increased with increasing microwave power.

关键词： microwave depolymerization numerical simulation kraft lignin COMSOL Multiphysics

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基于生成对抗网络的磁共振图像重建

计算机工程与应用 2022年第15期58卷 238-245页

作者：胥祯浩沈茜李霞中国计量大学信息工程学院杭州310018

磁共振成像因具有无辐射、无创伤性,成为临床中最常用的辅助诊断技术之一,但过长的扫描时间和封闭的环境,不仅导致病人产生幽闭恐惧心理,也造成医疗成本的升高。针对此问题,提出了一种以生成对抗网络为核心的磁共振图像重建算法,将U-ne... 详细信息

磁共振成像因具有无辐射、无创伤性,成为临床中最常用的辅助诊断技术之一,但过长的扫描时间和封闭的环境,不仅导致病人产生幽闭恐惧心理,也造成医疗成本的升高。针对此问题,提出了一种以生成对抗网络为核心的磁共振图像重建算法,将U-net网络作为生成器,编码部分使用残差结构以缓解网络退化,并提出空洞金字塔结构,利用空洞卷积的不同扩张率融合不同尺度的上下文信息并添加于解码层之前。判别器中通过一系列卷积实现特征下采样,并利用sigmoid函数完成特征分类,将集成学习的思想融入其中,使重建效果进一步提升。对比已有研究成果和主流重建网络,该模型在10%、20%、30%、50%采样率的测试集中,各项重建指标均排名第一。结果表明,该模型不仅能有效提升磁共振图像重建质量,同时也具有良好的泛化性。

关键词：磁共振成像图像重建生成对抗网络空洞金字塔集成学习

热处理对连续点式锻压激光快速成形GH4169合金组织与拉伸性能的影响

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金属学报 2017年第2期53卷 239-247页

作者：席明哲周玮尚俊英吕超吴贞号高士友燕山大学先进锻压成形技术与科学教育部重点实验室秦皇岛066004

研究了热处理对连续点式锻压激光快速成形GH4169合金显微组织和拉伸性能的影响。结果表明,980STA热处理未能使连续点式锻压激光快速成形GH4169合金发生再结晶,合金的拉伸性能达不到锻件标准。经1020STA热处理后,合金发生完全再结晶,等... 详细信息

研究了热处理对连续点式锻压激光快速成形GH4169合金显微组织和拉伸性能的影响。结果表明,980STA热处理未能使连续点式锻压激光快速成形GH4169合金发生再结晶,合金的拉伸性能达不到锻件标准。经1020STA热处理后,合金发生完全再结晶,等轴晶晶粒尺寸分布均匀,平均晶粒尺寸约为12.8μm,Laves相未被完全固溶,合金的强度和塑性超过锻件标准。1050STA热处理合金的再结晶平均晶粒尺寸约为25.3μm,Laves相完全固溶消失,与1020STA热处理合金相比,合金的强度下降而塑性上升,强度和塑性超过锻件标准。经1080STA热处理后,合金再结晶晶粒尺寸分布不均匀程度明显增大,平均晶粒尺寸约为123.6μm,与1020STA和1050STA热处理合金相比,合金的强度和塑性都大幅度下降,仅与锻件标准相当。

关键词：连续点式锻压激光快速成形 GH4169 显微组织拉伸性能

连续点式锻压激光快速成形TC11钛合金的组织和力学性能

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金属学报 2017年第9期53卷 1065-1074页

作者：席明哲吕超吴贞号尚俊英周玮董荣梅高士友燕山大学先进锻压成形技术与科学教育部重点实验室秦皇岛066004

采用连续点式锻压激光快速成形技术进行了TC11钛合金厚壁零件成形实验,利用OM、SEM等手段研究了连续点式锻压激光快速成形TC11钛合金的组织和力学性能。结果表明,TC11钛合金试样内部的等轴晶晶粒尺寸均匀,平均晶粒尺寸48.7 mm。等轴晶... 详细信息

采用连续点式锻压激光快速成形技术进行了TC11钛合金厚壁零件成形实验,利用OM、SEM等手段研究了连续点式锻压激光快速成形TC11钛合金的组织和力学性能。结果表明,TC11钛合金试样内部的等轴晶晶粒尺寸均匀,平均晶粒尺寸48.7 mm。等轴晶的晶界α相连续,晶内是初生α相板条+β转变组织组成的双态组织。在连续点式锻压激光快速成形过程中,连续点式锻压时,TC11钛合金厚壁零件的表层变形区深度约为1.5 mm,变形量为20%。在连续点式锻压冷变形TC11钛合金上表面沉积新层过程中,当激光束扫描经过时,熔池热影响区中约1 mm厚(4层)冷变形TC11钛合金被加热到钛合金β转变温度之上,并在0.86 s内完成再结晶。力学性能结果表明,与TC11钛合金锻件相比,连续点式锻压激光快速成形的TC11钛合金的强度高,而塑性低。断口形貌分析表明,晶间断裂是导致TC11钛合金塑性差的主要原因。

关键词：连续点式锻压激光快速成形 TC11钛合金显微组织拉伸性能

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通气超空化流域径向尺度影响

西北工业大学学报 2020年第3期38卷 478-484页

作者：许海雨罗凯黄闯左振浩西北工业大学航海学院陕西西安710072

为研究流域尺度对阵泄气通气超空化的影响,基于分相流模型和SST湍流模型,考虑通气可压缩性,建立了通气超空泡流动的三维数值模型,通过水洞实验对数值方法进行了验证,研究了流域径向尺度对通气超空泡尺度和压力分布特性的影响。计算结果... 详细信息

为研究流域尺度对阵泄气通气超空化的影响,基于分相流模型和SST湍流模型,考虑通气可压缩性,建立了通气超空泡流动的三维数值模型,通过水洞实验对数值方法进行了验证,研究了流域径向尺度对通气超空泡尺度和压力分布特性的影响。计算结果表明:流域径向尺度对通气超空泡流型及压力分布影响显著。流域径向尺度比小于6.5时,无法形成完全包裹航行器的超空泡,随着流域径向尺度增加,超空泡尺寸增大,空泡内压力和外流场压力均减小;当径向尺度比大于54.0时,空泡尺寸和内部压力达到稳定收敛,计算结果与经验公式吻合,研究结果为模拟阵泄气通气超空泡自由流场空泡形态提供了流域径向尺度的选择标准,可用于指导工程实践。

关键词：通气空化泡流场空泡尺寸压力分布多相流 SST湍流模型水下航行器

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基于SVDD的ADS-B异常数据检测

河北大学学报（自然科学版） 2019年第3期39卷 323-329页

作者：王振昊王布宏空军工程大学信息与导航学院陕西西安710077

自动相关监视广播(ADS-B)与空管二次监视雷达(SSR)是空中交通管制的2种重要监视手段,其中ADS-B是目前正在推出的通信协议,在下一代空管监视系统中将会发挥重要作用.然而,ADS-B协议中安全措施缺乏,容易遭受虚假数据注入的攻击.为了识别AD... 详细信息

自动相关监视广播(ADS-B)与空管二次监视雷达(SSR)是空中交通管制的2种重要监视手段,其中ADS-B是目前正在推出的通信协议,在下一代空管监视系统中将会发挥重要作用.然而,ADS-B协议中安全措施缺乏,容易遭受虚假数据注入的攻击.为了识别ADS-B中的异常数据,利用与其同步的SSR数据及通过Kalman滤波得出的的协方差矩阵,得到一组具有多维属性特征的样本数据,使用支持向量数据域描述的方法(SVDD)训练样本数据,可以得到用于检测异常的分类器.利用此分类器检测之后收到的ADS-B数据,从而识别出异常数据.通过仿真实验表明,该方法对于ADS-B异常数据具有80%以上的正确识别率,其中对于固定偏差注入的检测虚警率为5%,漏警率为0,对于随机偏差注入的检测虚警率为5%,漏警率为12.5%,验证了该方法的可行性.

关键词：自动相关监视广播空管二次监视雷达支持向量数据域描述虚假数据注入异常检测