检索结果-南通市图书馆

Cellular senescence-driven transcriptional reprogramming of the MAFB/NOTCH3 axis activates the PI3K/AKT pathway and promotes osteosarcoma progression

引用

Genes & Diseases 2024年第2期11卷 952-963页

作者： zhenhao zhang Doudou Jing Baijun Xuan Zhicai zhang Wei Wu Zengwu Shao Department of Orthopedics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430022China Department of Orthopedics The Second Hospital of Shanxi Medical UniversityTaiyuanShanxi 030001China Department of Cardiology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430022China

Osteosarcoma is the most common primary malignancy of bones and primarily occurs in adolescents and young adults.However,a second smaller peak of osteosarcoma incidence was reported in the elderly aged more than 60.Elderly patients with osteosarcoma exhibit different characteristics compared to young patients,which usually results in a poor prognosis.The mechanism underlying osteosarcoma development in elderly patients is intriguing and of significant value in clinical applications.Senescent cells can accelerate tumor progression by metabolic reprogramming.Recent research has shown that methylmalonic acid(MMA)was significantly up-regulated in the serum of older individuals and played a central role in the development of aggressive characteristics.We found that the significant accumulation of MMA in elderly patients imparted proliferative potential to osteosarcoma cells.The expression of MAFB was excessively up-regulated in osteosarcoma specimens and was further enhanced in response to MMA accumulation as the patient aged.Specifically,we first confirmed a novel molecular mechanism between cellular senescence and cancer,in which the MMA-driven transcriptional reprogramming of the MAFB-NOTCH3 axis accelerated osteosarcoma progression via the activation of PI3K-AKT pathways.Moreover,the down-regulation of the MAFB-NOTCH3 axis increased the sensitivity and effect of AKT inhibitors in osteosarcoma through significant inhibition of AKT phosphorylation.In conclusion,we confirmed that MAFB is a novel age-dependent biomarker for osteosarcoma,and targeting the MAFB-NOTCH3 axis in combination with AKT inhibition can serve as a novel therapeutic strategy for elderly patients with osteosarcoma in experimental and clinical trials.

关键词： Cellular senescence Elderly patients MAFB-NOTCH3axis Methylmalonic acid Osteosarcoma PI3K-AKTpathway

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Corrigendum to"Cellular senescence-driven transcriptional reprogramming of the MAFB/NOTCH3 axis activates the PI3K/AKT pathway and promotes osteosarcoma progression"[Genes&Diseases 11(2024)952-963]

引用

Genes & Diseases 2024年第3期11卷 491-492页

The authors regret that some data errors were made in"Cellular senescence-driven transcriptional reprogramming of the MAFB/NOTCH3 axis activates the PI3K/AKT pathway and promotes osteosarcoma progression"at Figure 5F for the colony formation of MNNG/HOS cells with si-NOTCH3 and 5G for the tranwell assay of U2OS cells with si-NOCTH3.Correction and supplementation to Figure 5.The author used confusing experimental data and did not notice these errors when submitting the original manuscript.Here,the authors made the latest corrections to the data of the batch of U2OS cells and MNNG/HOS cells transfected with si-NoTCH3.The authors confirm that this correction will not alter the conclusions in the original manuscript.

关键词： PI3K/AKT osteosarcoma submit

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Flotation separation of scheelite from calcite using luteolin as a novel depressant

引用

International Journal of Minerals,Metallurgy and Materials 2024年第3期31卷 462-472页

作者： Xiaokang Li Ying zhang Haiyang He Yu Wu Danyu Wu zhenhao Guan Faculty of Land and Resources Engineering Kunming University of Science and TechnologyKunming 650093China State Key Laboratory of Clean Utilization of Complex Non-Ferrous Metal Resources Kunming University of Science and TechnologyKunming 650093China

This paper proposes luteolin(LUT)as a novel depressant for the flotation-based separation of scheelite and calcite in a sodium oleate(NaOL)system.The suitability of LUT as a calcite depressant is confirmed through micro-flotation testing.At pH=9,with LUT concentration of 50 mg·L^(-1) and NaOL concentration of 50 mg·L^(-1),scheelite recovery reaches 80.3%.Calcite,on the other hand,exhibits a recovery rate of 17.6%,indicating a significant difference in floatability between the two minerals.Subsequently,the surface modifica-tions of scheelite and calcite following LUT treatment are characterized using adsorption capacity testing,Zeta potential analysis,Fourier transform infrared spectroscopy(FT-IR),X-ray photoelectron spectroscopy(XPS),and atomic force microscopy(AFM).The study in-vestigates the selective depressant mechanism of LUT on calcite.Adsorption capacity testing and Zeta potential analysis demonstrate sub-stantial absorption of LUT on the surface of calcite,impeding the further adsorption of sodium oleate,while its impact on scheelite is min-imal.FT-IR and XPS analyses reveal the selective adsorption of LUT onto the surface of calcite,forming strong chemisorption bonds between the hydroxyl group and calcium ions present.AFM directly illustrates the distinct adsorption densities of LUT on the two miner-al types.Consequently,LUT can effectively serve as a depressant for calcite,enabling the successful separation of scheelite and calcite.

关键词： scheelite calcite luteolin flotation depressant separation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Ba^(2+)/Ca^(2+)co-crosslinked alginate hydrogel filtration membrane with high strength,high flux and stability for dye/salt separation

引用

Chinese Chemical Letters 2024年第5期35卷 320-324页

作者： Ningning Gao Yue zhang zhenhao Yang Lijing Xu Kongyin Zhao Qingping Xin Junkui Gao Junjun Shi Jin Zhong Huiguo Wang SINOPEC Research Institute of Petroleum Processing CO. LTD.Beijing 100083China State Key Laboratory of Separation Membranes and Membrane Processes/National Centre for International Joint Research on Separation Membranes Tiangong UniversityTianjin 300387China

Alginate is a natural polysaccharide polymer.Hydrogel filtration membranes prepared from alginate show excellent fouling resistance and controllable separation performance,but poor mechanical properties limit the use of algae hydrogels.In this study,Ba^(2+)/Ca^(2+)co-crosslinked alginate(Ba/CaAlg)hydrogel membrane was prepared by cross-linking sodium alginate with a blend aqueous solution of barium ions and calcium ions,and the membrane was applied to the separation of dyes/salts from dyeing wastewater.Compared with the CaAlg membrane,the Ba/CaAlg hydrogel membrane exhibited more stable structure,and the mechanical properties and salt tolerance of the membrane were significantly improved.The flux of Ba/CaAlg membrane for methyl blue/sodium chloride mixed solution reached 43.5 L m^(−2) h^(−1),which was significantly higher than that of CaAlg membrane.Besides,the Ba/CaAlg membrane showed higher dye rejection(>99.6%)and lower salt rejection(<8.2%).The structure of Ba/CaAlg membrane was preliminarily simulated by molecular dynamics,and the pore size and distribution of the membrane were calculated.The Ba/CaAlg membrane has a broad application prospect in dyes/salts separation.

关键词： Alginate Filtration membrane Ba^(2+)/Ca^(2+)ion crosslinking Dye/salt separation Molecular dynamic simulation Hydrogel

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Numerical analysis on phase change progress and thermal performance of different roofs integrated with phase change material(PCM)in Moroccan semi-arid and Mediterranean climates

引用

Building Simulation 2023年第1期16卷 69-85页

作者： Yanqiu Huang Shan Yang Moussa Aadmi Yi Wang Mustapha Karkri zhenhao zhang State Key Laboratory of Green Building in Western China Xi'an University of Architecture and TechnologyNo.13 Yanta RD.Xi'an 710055China School of Building Services Science and Engineering Xi'an University of Architecture and TechnologyNo.13 Yanta RD.Xi'an 710055China LMASI ElectromagnetismPhysics of Plasmas and ApplicationsPolydisciplinary Faculty of NadorMohammed First UniversityB.P 30062700SelouaneNadorMorocco CERTES Univ Paris Est Creteil61 Avenue du Général de GaulleF-94010 CreteilFrance

Phase change material(PCM)applied to roofs can weak external heat entering the room to reduce air-conditioning energy consumption.In this study,three forms of macro-encapsulated PCM roofs with different PCMs(RT27,RT31,RT35HC,PT37)are proposed.The effects of PCM thickness,the encapsulation forms,and different PCMs on the thermal performance of the roof are discussed in Moroccan semi-arid and Mediterranean climates.The results show that as the PCM thickness increases,the peak temperature attenuation of the roof inner surface decreases.In two climates,the pure PCM layer among the three encapsulation forms(i.***.pure PCM layer,PCM in aluminum tubes,PCM in triangular aluminum)is the easiest to appear the phenomenon of insufficient heat storage and release,while the reduction of the peak inner surface temperature and time lag is the most satisfying.For the PCM in the aluminum tube,phase change time is the shortest and the latent heat utilization ratio is the highest,while thermal regulation performance is the least satisfying.The PCM in triangular aluminum can improve the latent heat utilization ratio significantly,and its thermal regulation performance is in the middle.In semi-arid climate,the time lag increases with phase change temperature increasing.The time lag could reach up to 6 h with 37℃phase transition temperature.In Mediterranean climate,the longest time lag with RT31 is 5 h,while the lowest peak inner surface temperature appears with RT27.The obtained conclusions could provide guidance for the application of PCM roofs in these two climates.

关键词： numerical simulation PCM roof thermal performance inner surface temperature time lag

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

An approach of dynamic response analysis of nonlinear structures based on least square Volterra kernel function identification

引用

Transportation Safety and Environment 2023年第2期5卷 1-13页

作者： zhenhao zhang Jun Xiong Zhenpeng Zhao Fuming Wang Yi Zeng Bing Zhao Lu Ke School of Civil Engineering Changsha University of Science and TechnologyChangsha 410114HunanChina Guangxi Key Laboratory of Disaster Prevention and Engineering Safety Guangxi UniversityNanning 530004GuangxiChina College of Civil engineering and Architecture Guangxi UniversityNanning 530004GuangxiChina

Analysis of the dynamic response of a complex nonlinear system is always a difficult problem.By using Volterra functional series to describe a nonlinear system,its response analysis can be similar to using Fourier/Laplace transform and linear transfer function method to analyse a linear system’s response.In this paper,a dynamic response analysis method for nonlinear systems based on Volterra series is developed.Firstly,the recursive formula of the least square method is established to solve the Volterra kernel function vector,and the corresponding MATLAB programme is compiled.Then,the Volterra kernel vector corresponding to the nonlinear response of a structure under seismic excitation is identified,and the accuracy and applicability of using the kernel vector to predict the response of a nonlinear structure are analysed.The results show that the Volterra kernel function identified by the derived recursive formula can accurately describe the nonlinear response characteristics of a structure under an excitation.For a general nonlinear system,the first three order Volterra kernel function can relatively accurately express its nonlinear response characteristics.In addition,the obtained Volterra kernel function can be used to accurately predict the nonlinear response of a structure under the similar type of dynamic load.

关键词： nonlinear system Volterra series kernel function dynamic response least square method

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Modified room temperature solid-state synthesis of yttria-stabilized zirconia(YSZ) nano-powders for solid oxide fuel cells

引用

稀土学报:英文版 2023年第9期41卷 1385-1391,I0004页

作者： Xiaoqian Xu Yurun Feng Zhaoyu Zhong Xue Guo zhenhao zhang Jiao Li Shikai Zhao Shigang Wu Haibin Sun School of Materials Science and Engineering Shandong University of TechnologyZibo 255000China Shandong Yasai Ceramic Technology Co. Ltd.Jinan 271100China Shandong Industrial Ceramics Research&Design Institute Co. Ltd.Zibo 255000China

High-performance solid oxide fuel cell(SOFC) is in urgent need of high-quality electrolyte powders with high reactivity and chemical uniformity.Here,8 mol% Y_(2)O_(3) doped ZrO_(2)(YSZ) nano-powders were synthesized by an improved solid-state reaction method at ambient temperature,and were applied to the fabrication of SOFC electrolytes.YSZ nano-powders show average grain sizes of ^(2)0 nm and high dispersibility,which is comparable with or even better than some other chemical methods.Benefitting from their high reactivity,dense YSZ electrolytes(relative density of 97.9%) can be obtained at a relatively low sintering temperature of 1400℃.The optimized electrical conductivity reaches up to a high value of0.034 S/cm at 800 0C in air.The anode supported single cell with the construction of Ni-YSZ/YSZ/Sm_(0.2)Ce_(0.8)O_(2-δ)(SDC)/La_(0.6)Sr_(0.4)Co_(0.2)Fe_(0.8)O_(3-δ)(LSCF) exhibits the peak power density of 0.827 W/cm^(2) at800℃ while taking wet H_(2) as fuels and ambient air as oxidants.

关键词： Room temperature solid-state reaction YSZ electrolyte High sintering activity High ionic conductivity Rare earths

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

富水软弱围岩劈裂型注浆加固体力学性能与破坏模式

引用

中南大学学报（自然科学版） 2024年第2期55卷 649-664页

作者：杨磊张耀磊唐明秀李让杰徐真浩尹贺山东大学岩土与结构工程研究中心山东济南250061 云南省滇中引水工程建设管理局云南昆明650205 济南高新区管委会山东济南250101

富水软弱围岩劈裂型注浆加固体的力学性能与破坏模式对注浆整体效果具有显著影响。基于室内注浆模拟试验、劈裂型注浆加固体三轴压缩试验和相应的离散元数值模拟,研究劈裂浆脉形态与空间分布特征及注浆加固规律,分析浆脉粗糙度、厚度、... 详细信息

富水软弱围岩劈裂型注浆加固体的力学性能与破坏模式对注浆整体效果具有显著影响。基于室内注浆模拟试验、劈裂型注浆加固体三轴压缩试验和相应的离散元数值模拟,研究劈裂浆脉形态与空间分布特征及注浆加固规律,分析浆脉粗糙度、厚度、数量和倾角对注浆加固体力学性能与破坏模式的影响,阐明三轴加载条件下加固体内部孔隙率和微裂纹演化规律。研究结果表明:劈裂浆脉空间分布模式主要包括半贯通型、交叉型和贯通型,注浆影响区域可分为加固区、过渡区和未扰动区;浆脉存在有效提升了加固体的整体刚度和承载力,加固体峰值偏应力与浆脉粗糙度、厚度、数量呈正相关关系,而浆脉倾角增大会导致整体强度降低;加固体破坏模式主要有局部膨胀型和剪切滑移型,受浆脉形态特征影响,二者对整体变形破坏的贡献程度不同;在加载过程中,浆-土界面处首先萌生微裂纹,进而浆脉两侧软弱介质被压缩挤密后出现大量微裂纹,裂纹数量持续增多直至试样破坏;加固体孔隙率与微裂纹萌生数量变化规律均呈现明显的阶段性特征,且受浆脉形态特征影响显著。

关键词：劈裂注浆加固体浆脉形态特征变形破坏模式峰值偏应力微裂纹萌生

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

利用全基因组光学图谱检测多发性骨髓瘤细胞遗传学异常

引用

中华血液学杂志 2024年第3期45卷 303-307页

作者：王艳芳张朕豪王化郤连永董菲景红梅北京大学第三医院血液内科北京100191

多发性骨髓瘤(MM)是一种以单克隆浆细胞在骨髓中异常增殖为特征的血液肿瘤,MM细胞具有复杂的染色体数目异常和结构异常,这些异常对于患者的危险度分层以及疗效评估具有重要的意义。全基因组光学图谱(OGM)是一项新型的细胞遗传学检测技术... 详细信息

多发性骨髓瘤(MM)是一种以单克隆浆细胞在骨髓中异常增殖为特征的血液肿瘤,MM细胞具有复杂的染色体数目异常和结构异常,这些异常对于患者的危险度分层以及疗效评估具有重要的意义。全基因组光学图谱(OGM)是一项新型的细胞遗传学检测技术,目前在肿瘤、辅助生殖、发育异常等领域已经显示出一定的应用前景,本研究首次利用OGM技术对5例新发MM患者的细胞遗传学异常进行检测,并将其与传统细胞遗传学检测技术进行了比较,从而评估该技术对染色体异常的检出能力以及在MM中的临床应用价值。

关键词：细胞遗传学异常异常增殖危险度分层染色体异常染色体数目异常血液肿瘤辅助生殖发育异常

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

高寒草甸功能群组成及营养品质对不同放牧强度的响应

引用

草业科学 2024年第1期41卷 151-162页

作者：张正义胡逸张振豪苗百岭侯扶江程云湘内蒙古大学生态与环境学院内蒙古呼和浩特010021 内蒙古自治区气象科学研究所内蒙古呼和浩特010000 兰州大学草地农业科技学院/兰州大学草地农业生态系统国家重点实验室甘肃兰州730020 蒙古高原生态学与资源利用教育部重点实验室内蒙古呼和浩特010021

为了探究高寒草甸对牦牛长期放牧活动的响应,选择青藏高原高寒草甸为对象,调查不同放牧强度对高寒草甸植物群落生物量、功能群组成变化和牧草品质的影响,探讨植被功能群组成变化及牧草品质之间的互作关系。结果表明:1)禁牧处理下的植物... 详细信息

为了探究高寒草甸对牦牛长期放牧活动的响应,选择青藏高原高寒草甸为对象,调查不同放牧强度对高寒草甸植物群落生物量、功能群组成变化和牧草品质的影响,探讨植被功能群组成变化及牧草品质之间的互作关系。结果表明:1)禁牧处理下的植物群落生物量最高,但植物群落生物量在有放牧的样地随放牧强度的增加呈下降趋势;2)物种丰富度和多样性随放牧强度的增加基本呈单峰变化,中度放牧下群落多样性指数、物种丰富度和均匀度指数均高于轻牧和重牧;3)植物粗蛋白与粗灰分含量随放牧强度增加而上升;4)放牧强度增加,豆科、毛茛科和杂类草比例无显著变化(P>0.05),禾本科占比降低,禾本科与莎草科呈此消彼长的关系;5)功能群组成变化与牧草营养之间有显著相关关系,其中粗蛋白含量随禾本科比例下降而下降,但与豆科、毛茛科及菊科占比呈负相关关系,莎草科占比与中性洗涤纤维呈显著正相关关系。综上所述,不同放牧强度下植物群落特征及营养品质发生不同程度的变化,对比禁牧,轻度放牧对地上和地下生物量有最优的促进作用,中度放牧有助于群落物种多样性的增加。适度放牧可以保持草地植物群落稳定,促进草地生态系统可持续发展。

关键词：青藏高原牦牛放牧强度植被群落特征功能群多样性指数牧草营养

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：