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Space Charge Effects of Bunched Beam with Nonuniform Distribution in Both Longitudinal and Transverse Directions

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Chinese journal of nuclear physics 1995年第1期17卷 81-88页

作者： Chen, Yinbao Fu, Shinian Huang, Zhibin zhang, zhenhai China Inst of Atomic Energy Beijing China

The nonlinear space charge effect of bunched beam with nonuniform densitydistribution in both longitudinal and transverse directions is *** usefulformulae are derived for calculating the potential induced by a cylinder model of spacecharge in the waveguide of a linac with longitudinal density distributions of waterbag(WB) or parabolic (PA) type combining with transverse density distributions ofKapchinskij-Vladimirskij (K-V).waterbag,parabolic and Gaussian (GA) types,resepectively.

关键词： Space charge effect Nonuniform distribution Longitudinal density Transverse density

Space Charge Effect of Bunched Beam With Gaussian Distribution

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Chinese journal of nuclear physics 1995年第2期17卷 174-178页

作者： Chen, Yinbao Fu, Shinian Huang, Zhibin zhang, zhenhai China Inst of Atomic Energy Beijing China

The nonlinear space charge effect of a bunched beam with Gaussian distribu-tion in the longitudinal direction is *** useful formulae are derived for cal-culating the potential induced by a cylinder model of space charge in the waveguide of alinac with different combinations of density distribution:Gaussian distribution in thelongitudinal direction versus Kapchinskij Vladimirskij,waterbag,parabolic andGaussian distribution in the transverse direction,rcspectively.

关键词： Gaussian distribution in the longitudinal direction Space charge effect Bunched beam

Chlorella sp.-ameliorated undesirable microenvironment promotes diabetic wound healing

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Acta Pharmaceutica Sinica B 2023年第1期13卷 410-424页

作者： Hangyi Wu Pei Yang Aiqin Li Xin Jin zhenhai zhang HuiXia Lv Department of Pharmaceutics China Pharmaceutical UniversityNanjing 211198China The Affiliated Suqian First People's Hospital of Nanjing Medical University Suqian 223800China Jiangsu Province Academy of Traditional Chinese Medicine Nanjing 210023China Affiliated Hospital of Integrated Traditional Chinese and Western Medicine Nanjing University of Chinese MedicineNanjing 210028China

Chronic diabetic wound remains a critical challenge suffering from the complicated negative microenvironments,such as high-glucose,excessive reactive oxygen species(ROS),hypoxia and ***,few strategies have been developed to ameliorate the multiple microenvironments *** this study,Chlorella sp.(Chlorella)hydrogels were prepared against diabetic *** vitro experiments demonstrated that living Chlorella could produce dissolved oxygen by photosynthesis,actively consume glucose and deplete ROS with the inherent antioxidants,during the *** night,Chlorella was inactivated in situ by chlorine dioxide with human-body harmless concentration to utilize its abundant *** was verified in vitro that the inactivated-Chlorella could supply nutrition,relieve inflammation and terminate the oxygen-consumption of *** advantages of living Chlorella and its contents were integrated *** abovementioned functions were proven to accelerate cell proliferation,migration and angiogenesis in ***,streptozotocininduced diabetic mice were employed for further *** in vivo outcomes confirmed that Chlorella could ameliorate the undesirable microenvironments,including hypoxia,high-glucose,excessiveROS and chronic inflammation,thereby synergistically promoting tissue *** the results above,Chlorella is considered as a tailor-made therapeutic strategy for diabetic wound healing.

关键词： Chlorella sp. Diabetic wound healing Oxygen production Glucose consumption ROS depletion Nutrition supplement Anti-inflammation

The Biological Significance of Multi-copy Regions and Their Impact on Variant Discovery

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Genomics, Proteomics & Bioinformatics 2020年第5期18卷 516-524页

作者： Jing Sun Yanfang zhang Minhui Wang Qian Guan Xiujia Yang Jin Xia Ou Mingchen Yan Chengrui Wang Yan zhang Zhi-Hao Li Chunhong Lan Chen Mao Hong-Wei Zhou Bingtao Hao zhenhai zhang State Key Laboratory of Organ Failure Research National Clinical Research Center for Kidney DiseaseDivision of NephrologyNanfang HospitalSouthern Medical UniversityGuangzhou 510515China Department of Bioinformatics School of Basic Medical SciencesSouthern Medical UniversityGuangzhou 510515China Key Laboratory of Mental Health of the Ministry of Education Guangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired IntelligenceSouthern Medical UniversityGuangzhou 510515China Center for Precision Medicine Shunde Hospital of Southern Medical UniversityFoshan 528399China Microbiome Medicine Center Division of Laboratory MedicineZhujiang HospitalSouthern Medical UniversityGuangzhou 510282China Division of Epidemiology School of Public HealthSouthern Medical UniversityGuangzhou 510515China

Identification of genetic variants via high-throughput sequencing(HTS)technologies has been essential for both fundamental and clinical ***,to what extent the genome sequence composition affects variant calling remains *** this study,we identified 63,897 multi-copy sequences(MCSs)with a minimum length of 300 bp,each of which occurs at least twice in the human *** 151,749 genomic loci(multi-copy regions,or MCRs)harboring these MCSs account for 1.98% of the genome and are distributed unevenly across *** containing the same MCS tend to be located on the same *** Ontology(GO)analyses revealed that 3800 genes whose UTRs or exons overlap with MCRs are enriched for Golgirelated cellular component terms and various enzymatic activities in the GO biological function *** are also enriched for loci that are sensitive to neocarzinostatin-induced double-strand ***,genetic variants discovered by genome-wide association studies and recorded in dbSNP are significantly underrepresented in *** simulated HTS datasets,we show that false variant discovery rates are significantly higher in MCRs than in other genomic *** results suggest that extra caution must be taken when identifying genetic variants in the MCRs via HTS technologies.

关键词： Multi-copy sequence Multi-copy region Genetic study Variant discovery High-throughput sequencing

基于关联规则的高速铁路信息服务组合方法研究

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铁道学报 2021年第4期43卷 85-94页

作者：张振海张湘婷兰州交通大学自动化与电气工程学院甘肃兰州730070

随着高速铁路信息化与智能化的发展,移动应用不断涌现,基于服务组合的移动应用开发技术已成为高铁信息服务研究的热点之一。目前,服务组合主要采用静态的服务功能分类组合方法,这种方式未利用大数据挖掘的优势,难以解决服务功能过载的... 详细信息

随着高速铁路信息化与智能化的发展,移动应用不断涌现,基于服务组合的移动应用开发技术已成为高铁信息服务研究的热点之一。目前,服务组合主要采用静态的服务功能分类组合方法,这种方式未利用大数据挖掘的优势,难以解决服务功能过载的问题。针对此问题,提出一种基于关联规则的探索式服务组合方法,在服务组合中加入上下文信息,利用FP-growth优化算法实现对二维上下文项的挖掘,根据关联规则向用户推荐符合当前应用场景下的服务集合。在高速铁路信息服务组合试验中进行测试和验证,结果表明此方法可有效提高准确率和命中率,对未来的高速铁路移动服务组合技术发展提供了新的解决思路。

关键词：探索式服务组合关联规则高速铁路服务 FP-growth 上下文感知

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旧重整反应器的修复

石油炼制与化工 2000年第5期31卷 15-20页

作者：张振海抚顺石油化工公司石油二厂抚顺113004

对抚顺石油二厂重整反应器进行解剖分析、技术鉴定、剩余寿命评估 ,找到了恢复其机械性能的热处理方法 ,使已停用的旧重整反应器在使用 2 6年后 ,经修复处理重新投入使用 ,为石化企业的重整反应器找到了延长寿命的方法。

关键词：重整反应器寿命试验热处理炼油维修

The Application of Intelligent Transportation Technology in Beijing Metro

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The Application of Intelligent Transportation Technology in ...

Potentiating CD8^(+) T cell antitumor activity by inhibiting PCSK9 to promote LDLR-mediated TCR recycling and signaling

第五届全国智慧城市与轨道交通科技创新学术年会

作者： zhenhai zhang Yongnan Weng Yi Lu Subway Operation Technology Center Mass Transit Railway Operation Corporation LTD

In this paper we first reviewed the application of information technology system in Urban Rail Transit secondly we overviewed the efforts had been done and discussed the key points will be done in the future on information technology field of Beijing subway Then described the being built systems that multi-disciplinary and cross-platform such *** Management Information Platform in Beijing metro and National key research and development *** guarantee technology of urban rail system program. Finally this paper summarized the basic framework of urban rail transit information construction we hope it will help the research on intelligent transport of city rail transit.

关键词： Urban Rail Transit information technology system platform

来源： cnki会议评论

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Protein & Cell 2021年第4期12卷 240-260页

作者： Juanjuan Yuan Ting Cai Xiaojun Zheng Yangzi Ren Jingwen Qi Xiaofei Lu Huihui Chen Huizhen Lin Zijie Chen Mengnan Liu Shangwen He Qijun Chen Siyang Feng Yingjun Wu zhenhai zhang Yanqing Ding Wei Yang Shunde Hospital Southern Medical University(The First People's Hospital of Shunde)Foshan 528308China Guangdong Provincial Key Laboratory of Molecular Oncologic Pathology Department of PathologySchool of Basic Medical SciencesSouthern Medical UniversityGuangzhou 510515China Department of Pathology Nanfang HospitalSouthern Medical UniversityGuangzhou 510515China Guangdong Provincial Key Laboratory of Molecular Oncologic Pathology Southern Medical UniversityGuangzhou 510515China Center for Precision Medicine Guangdong Provincial People's HospitalSchool of MedicineSouth China University of TechnologyGuangzhou 510030China

Metabolic regulation has been proven to play a critical role in T cell antitumor ***,cholesterol metabolism as a key component of this regulation remains largely ***,we found that the low-density lipoprotein receptor(LDLR),which has been previously identified as a transporter for cholesterol,plays a pivotal role in regulating CD8+T cell antitumor *** the involvement of cholesterol uptake which is mediated by LDLR in T cell priming and clonal expansion,we also found a non-canonical function of LDLR in CD8+T cells:LDLR interacts with the T-cell receptor(TCR)complex and regulates TCR recycling and signaling,thus facilitating the effector function of cytotoxic T-lymphocytes(CTLs).Furthermore,we found that the tumor microenvironment(TME)downregulates CD8+T cell LDLR level and TCR signaling via tumor cell-derived proprotein convertase subtilisin/kexin type 9(PCSK9)which binds to LDLR and prevents the recycling of LDLR and TCR to the plasma membrane thus inhibits the effector function of ***,genetic deletion or pharmacological inhibition of PCSK9 in tumor cells can enhance the antitumor activity of CD8+T cells by alleviating the suppressive effect on CD8+T cells and consequently inhibit tumor *** previously established as a hypercholesterolemia target,this study highlights PCSK9/LDLR as a potential target for cancer immunotherapy as well.

关键词： LDLR PCSK9 TCR CD8^(+) T cells tumor microenvironment cancer immunotherapy

Statistically designed enzymatic hydrolysis of an icariin/b-cyclodextrin inclusion complex optimized for production of icaritin

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Acta Pharmaceutica Sinica B 2012年第1期2卷 83-89页

作者： Xin Jin zhenhai zhang E.Suna Songlin Li Xiaobin Jia Key Laboratory of New Drug Delivery System of Chinese Meteria Medica Jiangsu Provincial Academy of Chinese MedicineNanjing 210028China College of Pharmacy Nanjing University of Chinese MedicineNanjing 210046China

This study focuses on the preparation and enzymic hydrolysis of an icariin/bcyclodextrin inclusion complex to efficiently generate *** physical characteristics of the inclusion complex were evaluated by differential scanning calorimetry(DSC).Enzymatic hydrolysis was optimized for the conversion of icariin/b-cyclodextrin complex to icaritin by Box–Behnken statistical *** inclusion complex formulation increased the solubility of icariin approximately 17-fold,from 29.2 to 513.5 mg/mL at 60℃.The optimum conditions were predicted by Box–Behnken statistical design as follows:60℃,pH 7.0,the ratio of enzyme/substrate(1:1.1)and reaction time 7 *** the optimal conditions the conversion of icariin was 97.91%and the reaction time was decreased by 68%compared with that without b-CD *** analysis by melting point,ESI-MS,UV,IR,1H NMR and 13C NMR confirmed the authenticity of icaritin with a purity of 99.3%and a yield of 473 mg of icaritin from 1.1 g icariin.

关键词： Icariin/b-CD inclusion complex Snailase Enzymatic hydrolysis Box–Behnken statistical design Icaritin