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Tailoring nanoprecipitates for ultra-strong high-entropy alloys via machine learning and prestrain aging

Journal of Materials Science & Technology 2021年第10期69卷 156-167页

作者： Tao Zheng Xiaobing Hu Feng He Qjngfeng wu Bin Han Chen Da Junjie Li Zhijun Wang Jincheng Wang Ji-jung Kai zhenhai Xia C.T.Liu State Key Laboratory of Solidification Processing Northwestern Polytechnical UniversityXi'an 710072China Center for Advanced Nuclear Safety and Sustainable Development City University of Hong KongHong KongChina Institute of Atomic and Molecular Science.Shaanxi University of Science and Technology Xi'an710021China Department of Material Science and Engineering College of Science and EngineeringCity University of Hong KongHong KongChina Department of Materials Science and Engineering University of North TexasDentonTXUSA Center for Advanced Structural Materials Department of Mechanical EngineeringCollege of Science and EngineeringCity University of Hong KongHong KongChina

The multi-principal-component concept of high-entropy alloys(HEAs) generates numerous new *** them,nanoscale precipitated HEAs have achieved superior mechanical properties and shown the potentials for structural ***,it is still a great challe nge to find the optimal alloy within the numerous *** to now,the reported nanoprecipitated HEAs are mainly designed by a trialand-error approach with the aid of phase diagram calculations,limiting the development of structural *** the current work,a novel method is proposed to accelerate the development of ultra-strong nanoprecipitated *** the guidance of physical metallurgy,the volume fraction of the required nanoprecipitates is designed from a machine learning of big data with thermodynamic foundation while the morphology of precipitates is kinetically tailored by prestrain *** a proof-of-principle study,an HEA with superior strength and ductility has been designed and systematically *** newly developed γ’-strengthened HEA exhibits 1.31 GPa yield strength,1.65 GPa ultimate tensile strength,and 15% tensile *** probe tomography and transmission electron microscope characterizations reveal the well-controlled high γ’ volume fraction(52%) and refined precipitate size(19 nm).The refinement of nanoprecipitates originates from the accelerated nucleation of the γ’ phase by prestrain aging.A deeper understanding of the excellent mechanical properties is illustrated from the aspect of strengthening mecha ***,the versatility of the current design strategy to other precipitation-hardened alloys is discussed.

关键词： High-entropy alloys Machine learning Prestrain aging Mechanical properties Strengthening mechanisms

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Is there a survival benefit from adjuvant chemotherapy for patients with liver oligometastases from colorectal cancer after curative resection?

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Cancer Communications 2018年第1期38卷 319-328页

作者： Zhizhong Pan Jianhong Peng Junzhong Lin Gong Chen Xiaojun wu zhenhai Lu Yuxiang Deng Yujie Zhao Qiaoqi Sui Desen Wan Department of Colorectal Surgery Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer Medicine651 Dongfeng Road EastGuangzhou 510060GuangdongP.R.China

Background:Although colorectal oligometastases to the liver can potentially be cured with aggressive local abla-tion,the efficacy of adjuvant chemotherapy(ACT)for such metastasis remains *** present study explored the effects of ACT on patients with colorectal liver oligometastases(CLO)after curative resections and aimed to iden-tify patients who could benefit from ***:We retrospectively analyzed 264 eligible patients with CLO who underwent curative resection between September 1999 and June ***-free survival(RFS)and overall survival(OS)were analyzed using the Kaplan-Meier method and log-rank test;prognostic factors were a by Cox regression ***:Among 264 patients,200(75.8%)patients received ACT and 64(24.2%)did not receive *** two groups did not significantly differ in clinicopathologic characteristics,and had comparable 3-year OS and RFS rates(RFS:42.1%vs.45.7%,P=0.588;OS:69.7%vs.62.7%,P=0.446)over a median follow-up duration of 35.5 months,irrespective of preoperative *** markedly improved 3-year OS in high-risk patients with Memorial Sloan-Kettering Cancer Center clinical risk scores(MSKCC-CRS)of 3-5(68.2%vs.33.8%,P=0.015),but presented no additional benefit in patients with MSKCC-CRS of 0-2(72.2%vs.78.6%,P=0.834).In multivariate analysis,ACT was independently associated with improved OS in patients with MSKCC-CRS of ***:ACT might offer a prognostic benefit in high-risk patients with CLOs after curative liver resection,but not in low-risk ***,patients’risk status should be determined before ACT administration to optimize postoperative therapeutic strategies.

关键词： Colorectal cancer Oligometastases Adjuvant chemotherapy Liver resection Benefit

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低氮燃气燃烧器在电站快启炉改造上的试验分析

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工业锅炉 2024年第1期 38-43页

作者：吴建林张寅浙江浙能镇海燃气热电有限责任公司浙江宁波315200

介绍了低氮燃气燃烧器在电站快启炉改造上的CFD仿真优化、试验分析及降低NO_(x)排放浓度的方法和稳定燃烧的机理。试验证明采用烟气再循环的大型低氮燃气燃烧器,通过合理结构和喷嘴布置,能够降低NO_(x)排放质量浓度到50 mg/m^(3)以下,... 详细信息

介绍了低氮燃气燃烧器在电站快启炉改造上的CFD仿真优化、试验分析及降低NO_(x)排放浓度的方法和稳定燃烧的机理。试验证明采用烟气再循环的大型低氮燃气燃烧器,通过合理结构和喷嘴布置,能够降低NO_(x)排放质量浓度到50 mg/m^(3)以下,同时保证正常的烟气含氧量和燃烧效率,满足锅炉各项技术参数的要求。

关键词：快启炉 NO_(x)排放低氮燃气燃烧器热效率

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Material patterning on substrates by manipulation of fluidic behavior

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National Science Review 2019年第4期6卷 758-766页

作者： Yitan Li Hao Wang Henglu Xu Shiting wu Xuemei Li Jiapeng Yu Chaoyu Huang Zeyao Zhang Hao Sun Lu Han Meihui Li Anyuan Cao zhenhai Pan Yan Li Key Laboratory for the Physics and Chemistry of Nanodevices Beijing National Laboratory of Molecular SciencesState Key Laboratory of Rare Earth Materials Chemistry and Applications College of Chemistry and Molecular Engineering Peking University Academy for Advanced Interdisciplinary Studies Peking University College of Engineering Peking University Electron Microscopy Laboratory Peking University Bruker (Beijing) Scientific Technology Co. Ltd. 6. Institute of Engineering ThermophysicsShanghai Jiao Tong University

Patterned materials on substrates are of great importance for a wide variety of applications. In solution-based approaches to material patterning, fluidic flow is inevitable. Here we demonstrate not only the importance of fluidic behavior but also the methodology of engineering the flow pattern to guide the material crystallization and assembly. We show by both experiment and simulation that substrate heating,which is generally used to accelerate evaporation, produces irregular complex vortexes. Instead, a top-heating–bottom-cooling(THBC) set-up offers an inverse temperature gradient and results in a single Marangoni vortex, which is desired for ordered nanomaterial patterning near the contact line. We then realize the fabrication of large-scale patterns of iodide perovskite crystals on different substrates under THBC conditions. We further demonstrate that harnessing the flow behavior is a general strategy with great feasibility to pattern various functional materials ranging from inorganic, organic, hybrid to biological categories on different substrates, presenting great potential for practical applications.

关键词： Marangoni flow temperature gradient large-scale material patterning flexible device contact line

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Research progress in electrospinning engineering for all-solid-state electrolytes of lithium metal batteries

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Journal of Energy Chemistry 2021年第10期30卷 253-268,I0008页

作者： Manxi Wang Yaling wu Min Qiu Xuan Li Chuanping Li Ruiling Li Jiabo He Ganggang Lin Qingrong Qian zhenhai Wen Xiaoyan Li Ziqiang Wang Qi Chen Qinghua Chen Jinhyuk Lee Yiu-Wing Mai Yuming Chen College of Environmental Science and Engineering Fujian Normal UniversityFuzhou 350000FujianChina Fujian Key Laboratory of Innate Immune Biology Biomedical Research Center of South Chinaand College of Life ScienceFujian Normal UniversityFuzhou 350000FujianChina College of Chemistry and Materials Science Fujian Normal UniversityFuzhou 350000FujianChina State Grid Fujian Maintenance Company Fuzhou 350000FujianChina CAS Key Laboratory of Design and Assembly of Functional Nanostructures and Fujian Provincial Key Laboratory of NanomaterialsFujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350000FujianChina Department of Nuclear Science and Engineering and Department of Materials Science and Engineering Massachusetts Institute of TechnologyCambridgeMA 02139United States Department of Mining and Materials Engineering McGill UniversityMontréalQC H3A 0C5Canada Centre for Advanced Materials Technology(CAMT) School of AerospaceMechanical and Mechatronics Engineering J07The University of SydneyNSW 2006Australia State Key Laboratory of Structural Chemistry Fuzhou 350000FujianChina

Owing to safety issue and low energy density of liquid lithium-ion batteries(LIBs),all-solid-state lithium metal batteries(ASLMBs)with unique all-solid-state electrolytes(SEs)have attracted wide *** arises mainly from the advantages of the SEs in the suppression of lithium dendrite growth,long cycle life,and broad working temperature range,showing huge potential applications in electronic devices,electric vehicles,smart grids,and biomedical ***,SEs suffer from low lithiumion conductivity and low mechanical integrity,slowing down the development of practical *** engineering is of great efficiency in tuning the structure and composition of the SEs with improved lithium-ion conductivity and mechanical *** various available technologies for nanostructure engineering,electrospinning is a promising technique because of its simple operation,cost-effectiveness,and efficient integration with different *** this review,we will first give a simple description of the electrospinning ***,the use of electrospinning technique in the synthesis of various SEs is summarized,for example,organic nanofibrous matrix,organic/inorganic nanofibrous matrix,and inorganic nanofibrous matrix combined with other *** current development of the advanced architectures of SEs through electrospinning technology is also presented to provide references and ideas for designing high-performance ***,an outlook and further challenges in the preparation of advanced SEs for ASLMBs through electrospinning engineering are given.

关键词： Solid-state composite electrolyte Lithium metal batteries Electrospinning engineering Organic/inorganic matrices

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Potentiating CD8^(+) T cell antitumor activity by inhibiting PCSK9 to promote LDLR-mediated TCR recycling and signaling

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Protein & Cell 2021年第4期12卷 240-260页

作者： Juanjuan Yuan Ting Cai Xiaojun Zheng Yangzi Ren Jingwen Qi Xiaofei Lu Huihui Chen Huizhen Lin Zijie Chen Mengnan Liu Shangwen He Qijun Chen Siyang Feng Yingjun wu zhenhai Zhang Yanqing Ding Wei Yang Shunde Hospital Southern Medical University(The First People's Hospital of Shunde)Foshan 528308China Guangdong Provincial Key Laboratory of Molecular Oncologic Pathology Department of PathologySchool of Basic Medical SciencesSouthern Medical UniversityGuangzhou 510515China Department of Pathology Nanfang HospitalSouthern Medical UniversityGuangzhou 510515China Guangdong Provincial Key Laboratory of Molecular Oncologic Pathology Southern Medical UniversityGuangzhou 510515China Center for Precision Medicine Guangdong Provincial People's HospitalSchool of MedicineSouth China University of TechnologyGuangzhou 510030China

Metabolic regulation has been proven to play a critical role in T cell antitumor ***,cholesterol metabolism as a key component of this regulation remains largely ***,we found that the low-density lipoprotein receptor(LDLR),which has been previously identified as a transporter for cholesterol,plays a pivotal role in regulating CD8+T cell antitumor *** the involvement of cholesterol uptake which is mediated by LDLR in T cell priming and clonal expansion,we also found a non-canonical function of LDLR in CD8+T cells:LDLR interacts with the T-cell receptor(TCR)complex and regulates TCR recycling and signaling,thus facilitating the effector function of cytotoxic T-lymphocytes(CTLs).Furthermore,we found that the tumor microenvironment(TME)downregulates CD8+T cell LDLR level and TCR signaling via tumor cell-derived proprotein convertase subtilisin/kexin type 9(PCSK9)which binds to LDLR and prevents the recycling of LDLR and TCR to the plasma membrane thus inhibits the effector function of ***,genetic deletion or pharmacological inhibition of PCSK9 in tumor cells can enhance the antitumor activity of CD8+T cells by alleviating the suppressive effect on CD8+T cells and consequently inhibit tumor *** previously established as a hypercholesterolemia target,this study highlights PCSK9/LDLR as a potential target for cancer immunotherapy as well.

关键词： LDLR PCSK9 TCR CD8^(+) T cells tumor microenvironment cancer immunotherapy

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农业院校生物类创新型人才培养模式的研究

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吉林蔬菜 2023年第2期 108-109页

作者：吴铭于振海吉林农业大学吉林东北亚国际工程技术集团有限公司

大多数地方农业高等学校,通过组织全校大学生队伍参加生物类学科竞赛,激发大学生创新实践兴趣,加强培养大学生创新实践能力和创新精神.我们课程组提出,以"团队引领,平台支持,以赛促学,以赛促研,以赛促创"的主旨,实践生物类"赛—学—研—... 详细信息

大多数地方农业高等学校,通过组织全校大学生队伍参加生物类学科竞赛,激发大学生创新实践兴趣,加强培养大学生创新实践能力和创新精神.我们课程组提出,以"团队引领,平台支持,以赛促学,以赛促研,以赛促创"的主旨,实践生物类"赛—学—研—创"创新型人才培养模式,为进一步推进大学生创新创业实践教育的改革与创新,创新人才培养模式,完善卓越人才培养体系,优化人才培养结构,提升我校实践育人质量做出努力.

关键词：学科竞赛生物类人才培养模式

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GIS技术在新时代找矿中的应用探究

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四川有色金属 2022年第3期 1-3,49页

作者：吴晓荣陈镇海甘肃省有色金属地质勘查局张掖矿产勘查院甘肃张掖734000

国家在进入改革开放的新时代以后越来越重视地质矿产工作,但是一些地区的金属地表露头矿和易识别矿不断减少,专家们逐渐开始关注寻找隐伏矿、难识别矿与盲矿。随着地球科学领域多源数据空间信息处理技术在新时代高速发展,GIS凭借强大的... 详细信息

国家在进入改革开放的新时代以后越来越重视地质矿产工作,但是一些地区的金属地表露头矿和易识别矿不断减少,专家们逐渐开始关注寻找隐伏矿、难识别矿与盲矿。随着地球科学领域多源数据空间信息处理技术在新时代高速发展,GIS凭借强大的信息处理与分析功能成为专家综合分析多源信息和找矿的理想技术。鉴于此,在新时代找矿中需要充分认识GIS技术的应用,以此明确其要点和有效途径,提高找矿效能。

关键词：地质勘查地质找矿 GIS技术应用

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大掺量废玻璃混凝土受压基本力学性能研究

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中原工学院学报 2024年第2期35卷 55-63页

作者：赵毅吴帅鲍一捷林庆利孟宾中原工学院建筑工程学院郑州450007

废玻璃掺入混凝土中有助于解决直接填埋废玻璃造成的环境污染问题,且具有改善混凝土性能的作用。选取粒径为1072μm的废玻璃颗粒和粒径为13μm的废玻璃粉分别大掺量替代混凝土中的砂和水泥,制备废玻璃细骨料混凝土和废玻璃掺合料混凝土... 详细信息

废玻璃掺入混凝土中有助于解决直接填埋废玻璃造成的环境污染问题,且具有改善混凝土性能的作用。选取粒径为1072μm的废玻璃颗粒和粒径为13μm的废玻璃粉分别大掺量替代混凝土中的砂和水泥,制备废玻璃细骨料混凝土和废玻璃掺合料混凝土,对两种混凝土进行流动性和抗压强度试验,研究废玻璃混凝土单轴受压应力-应变关系变化规律和破坏形态,并利用ABAQUS有限元软件模拟两种废玻璃混凝土棱柱体受压破坏过程。研究结果表明:废玻璃细骨料混凝土和废玻璃掺合料混凝土流动性均随废玻璃取代率的增加而增强;废玻璃细骨料混凝土的力学性能在废玻璃取代率为15%时达到最佳;随着废玻璃取代率的增加,废玻璃掺合料混凝土抗压性能大幅减弱;利用过镇海模型计算得到的两种混凝土单轴受压应力-应变关系曲线与试验曲线吻合较好;有限元模型能够较好地模拟两种废玻璃混凝土棱柱体单轴受压破坏过程。

关键词：大掺量废玻璃混凝土受压性能应力-应变曲线破坏形态数值模拟

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炼厂干气制氢用于加氢装置

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石油炼制与化工 2004年第2期35卷 40-43页

作者：陈雷吴弘中国石化镇海炼化股份有限公司宁波315207

通过对制氢装置进行扩能改造 ,将焦化干气等炼厂气引入作制氢原料 ,实现制氢原料气体化 ,这不仅降低了制氢装置的生产成本 ,为加氢裂化、加氢精制等用氢装置的挖潜增效奠定了基础 ,而且提高了炼厂干气利用率 ,减少火炬排放 ,实现清洁生产。

关键词：制氢原料制氢装置焦化干气火炬排放挖潜增效扩能改造炼厂干气加氢装置加氢裂化炼厂气

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