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Protective effects of glycine pretreatment on brain-death donor liver

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Hepatobiliary & Pancreatic Diseases International 2005年第1期4卷 37-40页

作者： Shui-Jun Zhang, Ji-Hua Shi, Zhe Tang, Yang Wu and Shi Chen zhengzhou, China Department of Surgery, First Affiliated Hospital of zhengzhou University, zhengzhou 4.0052, China Institute of Organ Transplantation, Tongji Medical College , Huazhong University of Science and Technology, Wuhan 430030 , China Department of Surgery First Affiliated Hospital of Zhengzhou University Zhengzhou 450052 China. zhangshuijin@***

BACKGROUND: Morphological and functional changes commonly occur in livers of brain-death donors. Preven- tion of liver injury from brain-death will benefit the results of transplantation. This study was conducted to evaluate the protection effects of glycine on the liver of brain-death donor. METHODS: Fourty-two male Wistar rats were randomly divided into brain-death donor (BDD) group (B), glycine pretreatment group with BDD (G), and strychnine pre- treatment group with BDD(S). For these groups, brain death model was established in donor rats and liver trans- plantation was performed subsequently utilizing microsur- gical techniques. After the establishment of the model and during cold rinsing of liver donors or liver reperfusion of recipients, glycine was given at a dose of 0. 6 mmol, 25 μmol and 25 μmol in the group G, and a same dose of gly- cine and strychnine (1000 :1) was prescribed for the group S, but nothing for the group B. Before cold rinsing at 2 and 6 hours after portal vein(PV) reperfusion, blood sam- ples were taken from infrahepatic vena cava (IHVC) to de- termine the levels of alanine aminotransferase (ALT), as- partate aminotransferase (AST), tumor necrosis factor al- pha (TNF-α) and hyaluronic acid (HA). At 6 hours after PV reperfusion, graft samples were fixed for morphological observation and apoptosis of hepatocytes was detected using the TUNEL method. RESULTS: Before liver cold rinsing and at 2 and 6 hours af- ter PV reperfusion, the serum levels of ALT, AST, TNF-α, HA and apoptosis index (AI) in the groups B and S were significantly higher than those in the group G (P 0.05). Electron microscopy showed that Kupffer cells were activated and hepatic cells injured more obvious- ly in the groups B and S than in the group G. CONCLUSION: Glycine pretreatment can improve the via-bility of the liver of the brain-death donor rat.

关键词： rats liver transplantation brain death glycine Kupffer cells donor

THE CYCLIC BANDWIDTH PROBLEM

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Systems Science and Mathematical Sciences 1994年第3期7卷 282-288页

作者： LIN Yixun (Department of Mathematics, zhengzhou University, Zhezhou 4.0052, China)

ＴＨＥＣＹＣＬＩＣＢＡＮＤＷＩＤＴＨＰＲＯＢＬＥＭ￥ＬＩＮＹｉｘｕｎ（ＤｅｐａｒｔｍｅｎｔｏｆＭａｔｈｅｍａｔｉｃｓ，ＺｈｅｎｇｚｈｏｕＵｎｉｖｅｒｓｉｔｙ，Ｚｈｅｚｈｏｕ４５００５２，Ｃｈｉｎａ）Ａｂｓｔｒａｃｔ：... 详细信息

ＴＨＥＣＹＣＬＩＣＢＡＮＤＷＩＤＴＨＰＲＯＢＬＥＭ￥ＬＩＮＹｉｘｕｎ（ＤｅｐａｒｔｍｅｎｔｏｆＭａｔｈｅｍａｔｉｃｓ，ＺｈｅｎｇｚｈｏｕＵｎｉｖｅｒｓｉｔｙ，Ｚｈｅｚｈｏｕ４５００５２，Ｃｈｉｎａ）Ａｂｓｔｒａｃｔ：Ｔｈｅｃｙｃｌｉｃｂａｎｄｗｉｄｔ...

关键词： Graph labelling circuit layout cyclic bandwidth.

Creating New Germplasm by Distant Hybridization in Stone Fruits:Ⅱ-Embryo Rescue and Hybrid Identification Between Plum and Apricot

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Agricultural Sciences in China 2004年第9期3卷 656-662页

作者： YANGHong-hua CHENXue-sen FENGBao-chun LIUHuan-fang zhengzhou FruitBiologyLaboratory ShandongAgriculturalUniversityTai＇an271018P.R.China

Embryo abortion stage and rescue system of hybrids were studied in the distant hybridizationbetween plum and apricot. Identification of the hybrids was also made. The resultsshowed: (1) Embryo abortion started from three weeks after pollination. (2) The germinationand growth of embryos were different at different growth stages, which could germinateand grow with PF value>0.5, but failed with PF value<0.5. In embryo rescue system ofhybrids, the best germination and differentiation medium was MS+6-BA 2mgL-1+IAA 0.3mgL-1,the rate of germination and differentiation reached up to 80%, bud induction andmultiplication medium was MS+6-BA 1.5mgL-1+IAA 0.3mgL-1, rooting medium was 1/2 MS+IAA0.8mgL-1. Some hybrids were transplanted into the field successfully. (3) Leaf shapeinvestigation and identification by S allele-specific PCR and RAPDs showed that thehybrids were true ones.

关键词： Prunus salicina Lindl. Armeniaca vulgaris Lam. Distant hybrid Embryo rescue RAPDs S allele-specific PCR

Human papillomavirus DNA and P16～(INK4A) expression in concurrent esophageal and gastric cardia cancers

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World Journal of Gastroenterology 2010年第46期16卷 5901-5906页

作者： Guang-Cheng Ding,Tao Guo,Department of Gastroenterology,The First Affiliated Hospital and The Fifth Affiliated Hospital,zhengzhou University,zhengzhou 4.0052,Henan Province,China Jing-Li Ren,Xin Song,Sheng-Li Zhou,Zong-Min Fan,LiDong Wang,Henan Key Laboratory for Esophageal Cancer Research,Department of Gastroenterology,The First Affiliated Hospital,College of Basic Medicine,zhengzhou University,zhengzhou 4.0052,Henan Province,China Fu-Bao Chang,Department of Thoracic Surgery,Linzhou Center Hospital,Linzhou 456500,Henan Province,China Ji-Lin Li,Department of Pathology,Yaocun Esophageal Cancer Hospital,Linzhou 456500,Henan Province,China Ling Yuan,Department of Oncoradiotherapy,Henan Province Tumor Hospital,zhengzhou 450003,Henan Province,China Yi Zeng,Institute of Virology,Chinese Academy of Preventive Medicine,Beijing 100052,China Henan Key Laboratory for Esophageal Cancer Research Department of Gastroenterology The First Affiliated Hospital College of Basic Medicine Zhengzhou University Zhengzhou 450052 Henan Province China. ldwang2007@***

AIM:To investigate the relationship between human papillomavirus (HPV) infection and concurrent esophagus and gastric cardia cancer from the same patient (CC) and examine the significance of P16 INK4A protein ***:Polymerase chain reaction was used to detect the presence of HPV type16 (HPV16).The expression of P16 INK4A protein was detected using ***:Among the CC specimens,HPV16-DNA was found in eight cases of esophageal squamous cell carcinoma (ESCC) and five cases of gastric cardia adenocarcinoma (GCA),respectively (47% vs 29%),and two of both ESCC and GCA.P16 INK4A was highly expressed in both ESCC and *** the HPV-associated positive CC,higher P16 INK4A expression was observed in the GCA than in the ESCC (75% vs 25%,P < 0.05).CONCLUSION:HPV16 as a correlated risk factor may play an important role in the development of ESCC and GCA.P16 INK4A may be a screening index in the HPVassociated carcinoma of gastric cardia.

关键词： Esophageal squamous cell carcinoma Gastric cardia adenocarcinoma Human papillomavirus Polymerase chain reaction Immunohistochemistry

One-step fabrication of cell sheet-laden hydrogel for accelerated wound healing

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Bioactive Materials 2023年第10期28卷 420-431页

作者： Huijuan Wang Deshun Sun Weiming Lin Chao Fang Kui Cheng zhengzhou Pan Daping Wang Zhangfa Song Xiaojun Long Department of Colorectal Surgery Key Laboratory of Biological Treatment of Zhejiang ProvinceSir Run Run Shaw HospitalSchool of MedicineZhejiang UniversityHangzhouZhejiang310016China Shenzhen Second People’s Hospital First Affiliated Hospital of Shenzhen University Health Science CenterShenzhen518035China Southern University of Science and Technology Hospital Intelligent Medical Innovation CenterShenzhen518035China School of Materials Science and Engineering State Key Laboratory of Silicon MaterialsCyrus Tang Center for Sensor Materials and ApplicationsZhejiang UniversityHangzhou310027China Department of Nuclear Medicine The First Affiliated Hospital of Zhejiang University School of MedicineShenzhen518035China

Full-thickness skin wounds are have continued to be reconstructive challenges in dermal and skin appendage regeneration, and skin substitutes are promising tools for addressing these reconstructive procedures. Herein, the one-step fabrication of a cell sheet integrated with a biomimetic hydrogel as a tissue engineered skin for skin wound healing generated in one step is introduced. Briefly, cell sheets with rich extracellular matrix, high cell density, and good cell connections were integrated with biomimetic hydrogel to fabricate gel + human skin fibroblasts (HSFs) sheets and gel + human umbilical vein endothelial cells (HUVECs) sheets in one step for assembly as a cell sheet-laden hydrogel (CSH). The designed biomimetic hydrogel formed with UV crosslinking and ionic crosslinking exhibited unique properties due to the photo-generated aldehyde groups, which were suitable for integrating into the cell sheet, and ionic crosslinking reduced the adhesive force toward the substrate. These properties allowed the gel + cell sheet film to be easily released from the substrate. The cells in the harvested cell sheet maintained excellent viability, proliferation, and definite migration abilities inside the hydrogel. Moreover, the CSH was implanted into a full-thickness skin defects to construct a required dermal matrix and cell microenvironment. The wound closure rate reached 60.00 ± 6.26% on the 2nd day, accelerating mature granulation and dermis formation with skin appendages after 14 days. This project can provide distinct guidance and strategies for the complete repair and regeneration of full-thickness skin defects, and provides a material with great potential for tissue regeneration in clinical applications.

关键词： Cell sheets Hydrogel Full-thickness skin wound Dermal construction Cell sheet-laden hydrogel

Featureless Zone in Rapidly Solidified Aluminum Alloy Splats

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Journal of Materials Science & Technology 1993年第6期9卷 464-466页

作者： Ningfu SHEN Yali TANG Dongjie ZHANG Longqing CHEN Shaokang GUAN Research Centre for Materials,zhengzhou Institute of Technology,zhengzhou,450002,China

The microstructures of rapidly solidified (RS) Al-Fe-Ce-Ti and Al-Fe-V-Si alloys obtained by means of rotating blade quenching were studied with optical microscopy,transmission electron microscopy (TEM).The featureless zone observed in the two alloys reveals that the new technique offers a higher solidification rate than the inert-gas-atomized *** TEM observation the featureless zone presents virtually a micropartition or partitionless feature,and the solute contents in it are almost the same as the chemical composition of alloys.

关键词： rapid solidification rotating blade quenching aluminum alloy featureless zone

A Global Pinching Theorem for Compact Surfaces in S^3 with Constant Mean Curvature

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Acta Mathematica Sinica,English Series 1996年第2期12卷 126-132页

作者： Hu Zejun Li Haizhong Hu Zejun Department of Mathematics zhengzhou University zhengzhou,4.0052 ChinaLi Haizhong Department of Applied Mathematics Tsinghua University Beijing,100084 China 郑州大学数学系河南郑州清华大学应用数学系北京

Let M be a compact minimal surface in S3.*** proved that if ‖S‖2≤2(21/2π, then M is either the equatorial sphere or the Clifford torus,where 5" is the square of the length of the second fundamental form of M,‖·‖2 denotes the L2-norm on *** this paper,we generalize Hsu’s result to any compact surfaces in S3 with constant mean curvature.

关键词： Compact surface Constant mean curvature Global pinching

RAPID DETERMINATION OF GUANINE BY HIGH PERFORMANCE CAPILLARY ELECTROPHORESIS

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中国科学院大学学报 1997年第1期 35-38页

作者： Zhang Shusheng(Center of Analysis and Test ,zhengzhou University, zhengzhou 4.0052)Chen Yong Yuan Zhuobin(Graduate School, Academia Sinica, Beijing 100039)

A simple and reproduciable method for determining guanine by high performance capillary electrophoresis is presented. The method involved the use of 2-amino-5-mercapto-3,4-dithiazole as internal standard and 40mmol/L borax-H3PO4 (pH2)-5% EtOH *** background electrolyte. The result showed that the linear range for guanine is 5-300 mg/L with the recovery of 94%-98% , the detection limit of 2. 80 mg/L and the RSD of 3. 1%. The satisfactory result was obtained when it was used to detect the concentration of guanine in acyclovir product.

关键词： high performance capillary electrophoresis guanine determination

Dynamic Tensile Properties of Concrete under Different Environments

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Journal of Wuhan University of Technology(Materials Science) 2006年第4期21卷 163-168页

作者：闫东明 School of Civil and Hydraulic Engineering Dalian University of Technology Dalian 116024 ChinaSchool of Environment and Water Conservancy Engineering Zhengzhou University Zhengzhou 450002China

By using an MTS810 hydra-electro-servo universal machine, the effect of moisture content and temperature on the rate sensitivity of concrete was irwestigated, the range of strain rate was varying from 10^- 5 / s to 10^-0.03/s. It is coneluded from the tests that the water content has a significant influence on the rate sensitivity of concrete whereas the tempature has a slight one, and the effects of rate sensitivity are attributed to both the viscosity caused by free water and the transformation of fracture mode when subjected to a high strain rate. The dynamic strength, initial modulus of elasticity, critical strain, Poisson ratio and energy absorption properties were studied systematically. It is found that the strength, initial modulus of elasticity, critical strain, and energy absorption capacity of concrete all increase with the increasing strain rate, whereas Poisson ratio keeps almost unchanged.

关键词： strain rate tension moisture content fracture mechanism