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Distribution and influencing factors of acoustic characteristics of seafloor sediment in the Sunda Shelf

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Journal of Oceanology and Limnology 2024年第5期42卷 1486-1492页

作者： zhengyu HOU Danling TANG Jianguo LIU Zhenglin LI Peng XIAO School of Ocean Engineering and Technology Sun Yat-sen University&Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai)Zhuhai 519000China Key Laboratory of Comprehensive Observation of Polar Environment(Sun Yat-sen University) Ministry of EducationZhuhai 519082China Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou)&South China Sea Institute of Oceanology Chinese Academy of SciencesGuangzhou 511458China

To understand the acoustic and physical properties of piston core samples collected from the Sunda continental shelf and analyze their distribution patterns,the samples were analyzed in laboratory,from which three provinces were divided in sound speed,sound speed ratio,porosity,wet bulk density,and maximum shear ***Ⅰhad lower sound speed and sound speed ratio(1.04),low porosity,and high wet bulk ***Ⅲhad the lowest sound speed and sound speed ratio(0.99),highest porosity(81%),and lowest wet bulk density(1.34 g/cm^(3)).The distribution pattern indicates that sediment movement,sediment source,topography,and hydrodynamic conditions influenced the distribution of acoustic and physical ***,we investigated the relationship of the maximum shear strength to the porosity and wet bulk density,and found that the maximum shear strength was proportional to both the porosity and wet bulk *** finding has significant implications for ocean engineering applications.

关键词： seafloor sediment acoustic property Sunda Shelf

图像中的国家与地方社会——从一套十三世纪的匝嘎利看图像与文字的双向锚固

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西藏大学学报（社会科学版） 2023年第2期38卷 104-111页

作者：王正宇西藏大学中华民族共同体研究院藏拉萨850000

综合利用符号学、历史学、人类学等相关理论、方法与材料,可以发现十三世纪的匝嘎利作品中不仅包含了宗教与艺术,还包含了政治权力等社会性因素。因应多民族国家重新恢复统一的历史进程,僧人发展了特殊的匝嘎利艺术形式,在符号层面实现... 详细信息

综合利用符号学、历史学、人类学等相关理论、方法与材料,可以发现十三世纪的匝嘎利作品中不仅包含了宗教与艺术,还包含了政治权力等社会性因素。因应多民族国家重新恢复统一的历史进程,僧人发展了特殊的匝嘎利艺术形式,在符号层面实现了国家与地方社会的双向锚固。一定程度上,这套匝嘎利反映了当时统一的多民族国家中国家与西藏地方社会的双向互动与建构过程已经深入人心,而不仅仅是国家对西藏地方的政治或文化征服。

关键词：图像国家地方社会双向锚固匝嘎利

Fc receptor-like 5(FCRL5)-directed CAR-T cells exhibit antitumor activity against multiple myeloma

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Signal Transduction and Targeted Therapy 2024年第2期9卷 724-737页

作者： zhengyu Yu Hexian Li Qizhong Lu Zongliang Zhang Aiping Tong Ting Niu Department of Hematology State Key Laboratory of Biotherapy and Cancer CenterWest China HospitalSichuan UniversityChengdu 610041China

Multiple myeloma(MM)remains a challenging hematologic malignancy despite advancements in chimeric antigen receptor T-cell(CAR-T)*** targets of CAR-T cells used in MM immunotherapy have limitations,with a subset of patients experiencing antigen loss resulting in ***,novel targets for enhancing CAR-T cell therapy in MM remain *** receptor-like 5(FCRL5)is a protein marker with considerably upregulated expression in MM and has emerged as a promising target for CAR-T cell therapeutic interventions,offering an alternative treatment for *** further explore this option,we designed FCRL5-directed CAR-T cells and assessed their cytotoxicity in vitro using a co-culture system and in vivo using MM cell-derived xenograft models,specifically focusing on MM with gain of chromosome *** the challenges in CAR-T therapies arising from limited T cell persistence,our approach incorporates interleukin-15(IL-15),which enhances the functionality of central memory T(TCM)cells,into the design of FCRL5-directed CAR-T cells,to improve cytotoxicity and reduce T-cell dysfunction,thereby promoting greater CAR-T cell survival and *** in vitro and xenograft models displayed that FCRL5 CAR-T cells incorporating IL-15 exhibited potent antitumor efficacy,effectively inhibiting the proliferation of MM cells and leading to remarkable tumor *** results highlight the capacity of FCRL5-specific CAR-T cells with the integration of IL-15 to improve the therapeutic potency,suggesting a potential novel immunotherapeutic strategy for MM treatment.

关键词： directed thereby offering

Visible-light-induced organocatalyzed C（sp2）–H bond functionalization of 1,3-azoles with trifluoroacetylsilanes

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Science China Chemistry 2024年第11期67卷 3662-3668页

作者： zhengyu Li Zeguo Zhang Zhihan Zhang Gang Zhou Yizhi Zhang Shanshan Liu Xiao Shen The Institute for Advanced Studies Engineering Research Center of Organosilicon Compounds & Materials Ministry of EducationWuhan University College of Chemistry Central China Normal University

Previous carbene insertion to C–H bonds of 1,3-azoles relied on metal carbene species. Herein, we report a metal-free C（sp2）–H bond functionalization of 1,3-azoles with trifluoroacetylsilanes. The reaction features mild conditions, broad substrate scope and wide functional group tolerance. The mechanistic study supports that the success of the reaction is probably attributed to the dual roles of trifluoroacetylsilanes under the photocatalyzed conditions: generating carbenes which undergo cyclopropanation and generating biradicals which promote ring-opening aromatization of the in situ generated fused cyclopropanes.

关键词： C(sp2)–H bond functionalization carbenes biradicals cyclopropanation brook rearrangement

A mechanically tuned Kerr comb in a dispersion-engineered silica microbubble resonator

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Science China(Physics,Mechanics & Astronomy) 2020年第5期63卷 92-97页

作者： FangJie Shu PeiJi Zhang YanJun Qian zhengyu wang Shuai Wan Chang Ling Zou GuangCan Guo ChunHua Dong Department of Physics Shangqiu Normal Universiy Shangqius 476000.China FCAS Key Laboratory of Quantum Information University of Science and Technology of ChinaHefei 230026China CAS Center for Excellence in Quantum Information and Quantum Physics University of Science and Technology of ChinaHefei 230026China

This paper discusses the developement and investigation of a silica microbubble resonator(MBR) that is optimized to cancel mode dispersion with material dispersion, at a wavelength of approximately 1550 nm and maintain a quality factor of an optical mode as large as 5.4 × 10~7. Benefitting from the near-zero dispersion and high quality factor, a primary optical comb is generated in the MBR using cascaded four-wave mixing processes, which span over 300 nm with several tens of teeth. Furthermore, the frequency comb could be gradually tuned by mechanically stretching the MBR. This tunable Kerr comb has multiple potential applications in precision measurements and sensing applications, such as molecular spectroscopy and ranging.

关键词： microresonator nonlinear optics frequency comb

MMAE-loaded PLGA nanomedicine with improved biosafety to achieve efficient antitumor treatment

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Journal of Innovative Optical Health Sciences 2024年第2期17卷 79-93页

作者： Changqiang Xie Yan wang Zhenzhen Cai Jianghai Du zhengyu Chen Junjie wang Xingzhou Peng State Key Laboratory of Digital Medical Engineering School of Biomedical Engineering Hainan University Haikou 570228P.R.China Key Laboratory of Biomedical Engineering of Hainan Province One Health Institute Hainan University Haikou 570228P.R.China Key Laboratory of Hainan Trauma and Disaster Rescue The First Affiliated Hospital of Hainan Medical University Hainan Medical University Haikou 571199P.R.China Engineering Research Center for Hainan Bio.Smart Materials and Bio-Medical Devices Key Laboratory of Emergency and Trauma Ministry of EducationKey Laboratory of Hainan Functional Materials and Molecular ImagingCollege of Emergency and Trauma Hainan Medical UniversityHaikou 571199P.R.China

Monomethyl auristatin E(MMAE)is a derivative of the marine peptide Dolastatin 10,which has therapeutic effects against various cancers according to its antimitotic activity in multiple clinical *** antibody drug conjugate(ADC)of MMAE is currently used in clinical ***,the safety issues of MMAE-based ADC,such as high drug toxicity and poor bioavailability,still exist when using it for anticancer therapy.A sustained release of drug delivery approach should be used to reduce toxicity and achieve sufficient anticancer ***,PLGA-b-PEG 2000 with excellent biocompatibility and slow degradation ability was adopted to construct MMAE-loaded nanoparticles for safe and effective *** sustained release effect and the immunogenic cell death(ICD)effect of PLGA-MMAE nanoparticles were assessed by in vitro *** PLGA-MMAE nanoparticles effectively accumulated in the tumor through the enhanced permeability and retention(EPR)effect,inducing cell apoptosis and causing a certain degree of immune *** sustained drug release of PLGA-MMAE improved the bioavailability and effectively reduced the toxicity and development of the tumor compared to the effect of free MMAE or ***,this study provides a safe and effective chemotherapeutic approach,as well as a simple and effective synthetic process for MMAE-based nanoparticles,improving their therapeutic efficacy and safety.

关键词： Monomethyl auristatin E poly(lactic-co-glycolic acid)nanoparticles sustained release chemotherapy immunogenic cell death

Building stabilized Cu_(0.17)Mn_(0.03)V_(2)O_(5−□)·2.16H_(2)O cathode enables an outstanding room‐/low‐temperature aqueous Zn‐ion batteries

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Carbon Energy 2024年第8期6卷 25-35页

作者： Ao wang Dai‐Huo Liu Lin Yang Fang Xu Dan Luo Haozhen Dou Mengqin Song Chunyan Xu Beinuo Zhang Jialin Zheng Zhongwei Chen zhengyu Bai Key Laboratory of Green Chemical Media and Reactions Ministry of EducationCollaborative Innovation Center of Henan Province for Green Manufacturing of Fine ChemicalsSchool of Chemistry and Chemical EngineeringHenan Normal UniversityXinxiangHenanChina The State Key Laboratory of Catalysis(SKLC) Power Battery and System Research CenterDalian Institute of Chemical PhysicsChinese Academy of SciencesDalianChina

Vanadium oxide cathode materials with stable crystal structure and fast Zn^(2+)storage capabilities are extremely important to achieving outstanding electrochemical performance in aqueous zinc‐ion *** this work,a one‐step hydrothermal method was used to manipulate the bimetallic ion intercalation into the interlayer of vanadium *** pre‐intercalated Cu ions act as pillars to pin the vanadium oxide(V‐O)layers,establishing stabilized two‐dimensional channels for fast Zn^(2+)*** occupation of Mn ions between V‐O interlayer further expands the layer spacing and increases the concentration of oxygen defects(Od),which boosts the Zn^(2+)diffusion *** a result,as‐prepared Cu_(0.17)Mn_(0.03)V_(2)O_(5−□)·2.16H_(2)O cathode shows outstanding Zn‐storage capabilities under room‐and lowtemperature environments(e.g.,440.3 mAh g^(−1)at room temperature and 294.3 mAh g^(−1)at−60°C).Importantly,it shows a long cycling life and high capacity retention of 93.4%over 2500 cycles at 2 A g^(−1)at−60°***,the reversible intercalation chemistry mechanisms during discharging/charging processes were revealed via operando X‐ray powder diffraction and ex situ Raman *** strategy of a couple of 3d transition metal doping provides a solution for the development of superior room‐/lowtemperature vanadium‐based cathode materials.

关键词： aqueous zinc‐ion batteries Cu_(0.17)Mn_(0.03)V_(2)O_(5−□)·2.16H_(2)O oxygen defects room‐/lowtemperature performance stabilized nanostructure

Palladium-Catalyzed[4+2]and[6+2]Dipolar Cycloadditions for the Construction of Benzo[d]isothiazole 1,1-Dioxide Fused 1,3-Oxazinanes and 1,3-Oxazocanes

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Chinese Journal of Chemistry 2024年第8期42卷 829-834页

作者： Lei Chen Hongling Xie Yu Xue zhengyu Han Jianwei Sun Hai Huang Jiangsu Key Laboratory of Advanced Catalytic Materials&Technology School of Petrochemical EngineeringChangzhou UniversityChangzhouJiangsu213164 China Department of Chemistry The Hong Kong University of Science and TechnologyClear Water BayKowloonHong Kong SARChina

Comprehensive Summary,The Pd-catalyzed dipolar cycloaddition represents a significant synthetic strategy for the construction of useful heterocyclic *** study developed the dipolar[4+2]and[6+2]cycloaddition reactions of benzo[d]isothiazole 1,1-dioxides(BDs)leading to the synthesis of BD-fused 1,3-oxazinane and 1,3-oxazocane derivatives,*** particular,the synthesis of BD-fused 1,3-oxazinanes demonstrated regio-and enantioselective characteristics,resulting in products with good yields,enantioselectivity and regioselectivity(if applicable).Furthermore,the[6+2]cycloaddition reaction developed in this work represented the first strategy for the synthesis of medium-sized ring compounds based on BDs.

关键词： Cycloaddition 1,3-Oxazinanes 1,3-Oxazocanes Medium-ring compounds Stereochemistry N-Heterocycles Sulfonamides Enantioselectivity Asymmetricsynthesis

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蛇管与夹套冷却CSTR温度双重控制

计算机与应用化学 2012年第7期29卷 829-833页

作者：王再英王正宇西安科技大学电气与控制工程学院陕西西安710054 西安交通大学电气工程学院陕西西安710049

连续搅拌釜式化学反应器(CSTR)是重要的化工设备。对蛇管与夹套双冷却CSTR单回路温度控制方案只利用一种操纵变量,无法兼顾动态性能与静态性能的不足进行了深入分析后,提出了CSTR温度双重控制系统方案。通过双重系统的协调控制,在温度... 详细信息

连续搅拌釜式化学反应器(CSTR)是重要的化工设备。对蛇管与夹套双冷却CSTR单回路温度控制方案只利用一种操纵变量,无法兼顾动态性能与静态性能的不足进行了深入分析后,提出了CSTR温度双重控制系统方案。通过双重系统的协调控制,在温度出现偏差时由蛇管冷却器快速消除温度偏差,使温度迅速返回设定值;然后由冷却效率高的夹套冷却器逐步取代蛇管冷却器所承担的冷却负荷变化——即在动态过程,由动态性能好的操作变量(蛇管冷却器)进行控制,过渡过程短,动态偏差小;在平稳生产过程,CSTR冷却负荷主要由静态性能好的操作变量(夹套冷却器)承担,冷却效率高,冷却水用量少。CSTR温度双重控制充分发挥了CSTR蛇管与夹套冷却器各自的优势,使CSTR温度控制的动态性能与静态性能都达到较为理想水平。最后,通过半实物仿真实验验证了CSTR温度双重控制在动态性能和节能降耗二方面的优越性。该双重控制方案可应用于具有类似结构特征的其他生产系统。

关键词：蛇管与夹套双冷却CSTR 温度双重控制动态响应节能降耗