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EGFR-targeted and gemcitabine-incorporated chemogene for combinatorial pancreatic cancer treatment

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Nano Research 2024年第2期17卷 848-857页

作者： Miao Xie Qiushuang Zhang Yuanyuan Guo Lijuan zhu Xinyuan zhu Chuan Zhang School of Chemistry and Chemical Engineering Frontiers Science Center for Transformative MoleculesInstitute of Molecular MedicineSixth people’s HospitalSchool of MedicineShanghai Key Laboratory for Molecular Engineering of Chiral DrugsShanghai Jiao Tong UniversityShanghai 200240China Department of Radiology Shanghai Jiao Tong University Affiliated Sixth People’s HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200233China Institute of Molecular Medicine Shanghai Jiao Tong University Affiliated Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127China

Pancreatic cancer stands out as a recognized intractable tumor due to its high malignancy and mortality rates,which are largely attributed to the insensitivity of current clinical chemotherapies or *** chemo and gene therapy that integrates different therapeutic targets,may increase the chemosensitivity of pancreatic cancer and synergistically enhance the antitumor ***,conventional co-delivery of gene and chemo drugs is intensively dependent on complex nanoparticle delivery systems,thus would be limited by unstable drug packaging,nonspecific biodistribution,and biosafety ***,we rationally designed an epidermal growth factor-receptor(EGFR)-targeted and gemcitabine-incorporated oligonucleotide(termed as chemogene)with anti-Bcl-2 sequence,which achieves simple and precise integration of gemcitabine into a gene regulative agent,as well as the EGFR-targeted delivery for pancreatic cancer *** solid-phase synthesis,gemcitabine,as the first-line chemodrug for pancreatic cancer,is introduced to the antisense oligonucleotide to replace all cytosine nucleosides to obtain the gemcitabine-integrated chemogene(Ge-ASO^(Bcl-2)).Thereafter,Ge-ASO^(Bcl-2)is covalently coupled with EGFR nanobody to construct the final targeted chemogene without any exogenous ***,this nanobody-conjugated chemogene exhibits remarkable tumor targeting capability and antitumor effects both in vitro and in vivo,which initiates a first step toward the application of combinatorial chemo and gene therapy for future pancreatic cancer treatment.

关键词： antisense oligonucleotide chemogene nanobody drug delivery system pancreatic cancer

Theoretical Modeling and Surface Roughness Prediction of Microtextured Surfaces in Ultrasonic Vibration-Assisted Milling

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Chinese Journal of Mechanical Engineering 2024年第2期37卷 163-183页

作者： Chenbing Ni Junjie zhu Youqiang Wang Dejian Liu Xuezhao Wang Lida zhu School of Mechanical and Automotive Engineering Qingdao University of TechnologyQingdao 266525China School of Mechanical Engineering and Automation Northeastern UniversityShenyang 110819China

Textured surfaces with certain micro/nano structures have been proven to possess some advanced functions,such as reducing friction,improving wear and increasing *** prediction of micro/nano surface textures is of great significance for the design,fabrication and application of functional textured *** this paper,based on the kinematic analysis of cutter teeth,the discretization of ultrasonic machining process,transformation method of coordinate systems and the cubic spline data interpolation,an integrated theoretical model was established to characterize the distribution and geometric features of micro textures on the surfaces machined by different types of ultrasonic vibration-assisted milling(UVAM).Based on the theoretical model,the effect of key process parameters(vibration directions,vibration dimensions,cutting parameters and vibration parameters)on tool trajectories and microtextured surface morphology in UVAM is ***,the effect of phase difference on the elliptical shape in 2D/3D ultrasonic elliptical vibration-assisted milling(UEVAM)was *** to conventional numerical models,the method of the cubic spline data interpolation is applied to the simulation of microtextured surface morphology in UVAM,which is more suitable for characterizing the morphological features of microtextured surfaces than traditional methods due to the presence of numerous micro *** prediction of surface roughness indicates that the magnitude of ultrasonic amplitude in z-direction should be strictly limited in 1D rotary UVAM,2D and 3D UEVAM due to the unfavorable effect of axial ultrasonic vibration on the surface *** study can provide theoretical guidance for the design and fabrication of microtextured surfaces in UVAM.

关键词： Theoretical modeling Microtextured surface Ultrasonic vibration-assisted milling Cubic spline interpolation Surface roughness

A coupled thermo-mechanical peridynamic model for fracture behavior of granite subjected to heating and water-cooling processes

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第6期16卷 2006-2018页

作者： Luming Zhou Zhende zhu Key Laboratory of Ministry of Education for Geomechanics and Embankment Engineering Hohai UniversityNanjing210098China Jiangsu Research Center for Geotechnical Engineering Technology Hohai UniversityNanjing210098China

Thermal damage and thermal fracture of rocks are two important indicators in geothermal mining *** paper investigates the effects of heating and water-cooling on granite specimens at various *** laboratory uniaxial compression experiments were also ***,a coupled thermo-mechanical ordinary state-based peridynamic(OSB-PD)model and corresponding numerical scheme were developed to simulate the damage of rocks after the heating and cooling processes,and the change of crack evolution process was *** results demonstrate that elevated heating temperatures exacerbate the thermal damage to the specimens,resulting in a decrease in peak strength and an increase in ductility of *** escalating occurrence of thermal-induced cracks significantly affects the crack evolution process during the loading *** numerical results accurately reproduce the damage and fracture characteristics of the granite under different final heating temperatures(FHTs),which are consistent with the test results in terms of strength,crack evolution process,and failure mode.

关键词： Peridynamics(PD) Granite Heating and cooling Damage and fracture Uniaxial compression

Innovation and Firm Co-ownership Network in China’s Electric Vehicle Industry

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Chinese Geographical Science 2024年第2期34卷 195-209页

作者： JIN Zerun zhu Shengjun College of Urban and Environmental Sciences Peking UniversityBeijing 100871China Laboratory for Earth Surface Pro-cesses of the Ministry of Education Peking UniversityBeijing 100871China

Firms are embedded in complex networks,where diverse ideas combine and generate new *** of firms are of-ten seen as critical external resources that have significant influence on firm *** current literature tends to focus on the rela-tionship between firms and their shareholders,while paying less attention to the connections between firms with the same *** article identifies two types of network spillover effects,intra-city network effect and inter-city network effect,by visualizing the co-ownership networks in China’s electric vehicle(EV)*** find that firms with the same shareholders,which are defined as co-owned EV firms,are more innovative than non-co-owned ***,there are two dominant types of firm co-ownership ties formed by corporate and financial institution *** corporate shareholders help exploiting local tacit knowledge,financial institutions are more active in bridging inter-city *** conclusion is confirmed at both firm and city *** paper theor-izes the firm co-ownership network as a new form of institutional proximity and tested the result *** policy consideration,we have emphasized the importance of building formal or informal inter-firm network,and the government should further enhance the knowledge flow channel by institutional construction.

关键词： firm co-ownership intra-city network inter-city network technological innovation electric vehicle China

Low-cost portable dielectric spectrometer based on mini-vector network analyzer and open-ended coaxial probe technology

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International Journal of Agricultural and Biological Engineering 2024年第3期17卷 166-172页

作者： zhuozhuo zhu Xinhua zhu Wenchuan Guo College of Mechanical and Electronic Engineering Northwest A&F UniversityYangling 712100ShaanxiChina School of Physics and Electronic Information Yan'an UniversityYan'an 716000ShaanxiChina Shaanxi Research Center of Agricultural Equipment Engineering Technology Yangling 712100ShaanxiChina Key Laboratory of Agricultural Internet of Things Ministry of Agriculture and Rural AffairsYangling 712100ShaanxiChina Shaanxi Key Laboratory of Agricultural Information Perception and Intelligent Service Yangling 712100ShaanxiChina

As a simple,fast,and non-destructive measuring technology,dielectric spectroscopy is usually used to analyze the dielectric properties of agricultural products and food,and then to predict the main components of ***,the large and expensive vector network analyzers(VNA)with expensive analysis software applied in measuring dielectric properties make research limited to the *** acquire dielectric spectra in situ,a model for solving relative complex permittivity was derived,and its performance was ***,a low-cost portable dielectric spectrometer with a mini VNA,a Raspberry Pi,and a coaxial probe as core parts was developed over the frequency range of 100-3000 *** stability and accuracy of the developed spectrometer were tested using milk and *** results indicated that the relative errors of the model were within±5%for dielectric constant(ε′)and loss factor(ε″).The coefficients of variation of measuredε′andε″by the developed spectrometer at 100-3000 MHz were less than 1%and 2%,*** with the dielectric properties obtained by using a commercial dielectric measurement system,the relative errors of measuredε′andε″were within±3.4%and±6.0%,*** study makes fast,non-destructive,and on-site food quality detection using dielectric spectra possible.

关键词： coaxial probe mini vector network analyzer low-cost portable dielectric spectrometer

3D-shaped 3D-continuously graphene cellulose(3D^(2)GC)architecture

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Nano Research 2024年第7期17卷 6695-6699页

作者： Abdelrahman Brakat Hongwei zhu State Key Lab of New Ceramics and Fine Processing School of Materials Science and EngineeringTsinghua UniversityBeijing 100084China

In the endeavor to develop three-dimensional(3D)-architected sophisticated hierarchical structures,the synergy between inplane and out-of-plane interactions at interfaces offers new *** interplay,governed by van der Waals(vdW)interfacial nanoarchitectonics,facilitates the design of efficient thermally conductive *** work delves into the kinetics underlying a dual-templating strategy,seamlessly integrating two-dimensional(2D)-graphene sheets with one-dimensional(1D)-cellulose chains at heterointerfaces,thereby transforming into 3D-shaped and 3D-continuously anisotropic structures,termed as(3D^(2)GC)***,we designed and fabricated an anisotropic graphene cellulose scaffold(GCS)employing a nickel *** as-grown GCS replicates the 3D-shaped and configuration of the *** 3D-continuously interconnected fibrous-porous network of the GCS,combined with its anisotropic thermal properties(λ_(axial)/λ_(radial)),not only is promising for advanced thermal technologies but also offers advantages in cost-effectiveness and eco-effectiveness.

关键词： two-dimensional(2D)-graphene one-dimensional(1D)-cellulose heterointerface anisotropic three-dimensional(3D)-architecture

Two Applications of the ■■-Hodge Theory

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Chinese Annals of Mathematics,Series B 2024年第1期45卷 137-150页

作者： Dingchang WEI Shengmao zhu Center of Mathematical Sciences Zhejiang UniversityHangzhou 310027China Department of Mathematics Zhejiang Normal UniversityJinhua 321004ZhejiangChina

Using Hodge theory and Banach fixed point theorem,Liu and zhu developed a global method to deal with various problems in deformation *** this note,the authors generalize Liu-zhu's method to treat two deformation problems for non-Kahler *** apply the ■■-Hodge theory to construct a deformation formula for(p,q)-forms of compact complex manifold under deformations,which can be used to study the Hodge number of complex manifold under *** the second part of this note,by using the ■■-Hodge theory,they provide a simple proof of the unobstructed deformation theorem for the non-Kahler Calabi-Yau ■■-manifolds.

关键词： Complex structures Deformations (p,q)-Forms Non-Kahler Calabi-Yaumanifolds

Wood of trees:Cellular structure,molecular formation,and genetic engineering

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Journal of Integrative Plant Biology 2024年第3期66卷 443-467页

作者： Yingying zhu Laigeng Li State Key Laboratory of Herbage Improvement and Grassland Agro-ecosystems and College of Ecology Lanzhou UniversityLanzhou 730000China National Key Laboratory of Plant Molecular Genetics CAS Center for Excellence in Molecular Plant SciencesChinese Academy of SciencesShanghai 200032China

Wood is an invaluable asset to human society due to its renewable nature,making it suitable for both sustainable energy production and material ***,wood derived from forest trees plays a crucial role in sequestering a significant portion of the carbon dioxide fixed during photosynthesis by terrestrial ***,with the expansion of the global population and ongoing industrialization,forest coverage has been substantially decreased,resulting in significant challenges for wood production and *** production practices have changed away from natural forests toward plantation ***,understanding the underlying genetic mechanisms of wood formation is the foundation for developing high-quality,fast-growing plantation *** ideal forest trees for wood production using genetic technologies has attracted the interest of *** studies have been carried out in recent years on the molecular,genetic,and cell-biological mechanisms of wood formation,and considerable progress and findings have been *** studies and findings indicate enormous possibilities and prospects for tree *** review will outline and assess the cellular and molecular mechanisms of wood formation,as well as studies on genetically improving forest trees,and address future development prospects.

关键词： cambium cell wall Populus wood formation xylem

CdS/LaFeO_(3) heterojunctions with improved optical properties for visible-light catalytic applications

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Journal of Rare Earths 2024年第5期42卷 879-888,I0003页

作者： Jiaqi Wei Wen zhu Xuelian Xu Xiao Xu Junjiang zhu Hubei Key Laboratory of Biomass Fibers and Eco-dyeing&Finishing College of Chemistry and Chemical EngineeringWuhan Textile University ChemistryWuhan430200China

Construction of heterojunctions is a normal and effective strategy to improve the photocatalytic performances of semiconductors,through which both the lifetime and the redox ability of electrons/holes can be improved,as co mpared to the respective *** this basis,we constructed Z-scheme CdS/LaFeO_(3) heterojunctions(CdS/LFO),by in-situ growing different amounts of CdS on the surface of LaFeO_(3),for photocatalytic degradation of tetracycline hydrochloride(TC)in aqueous solution at room *** crystal structure,surface morphology and optoelectronic properties of the COS/LFO heterojunctions were systemically characterized to correlate the reaction *** tests indicate that the CdS/LFO heterojunctions exhibit promising activity for TC degradation under visible light irradiation(λ≥420 nm),with 85%TC conversion obtained at reaction time of 45 min,which is 3.4 and 1.9 times higher than that of CdS and LaFeO_(3).The CdS/LFO heterojunctions are also stable in the reaction and can be reused for four cycles with no appreciable activity *** applicability of CdS/LFO to photocatalytic degradation of organic dyes,as well as the reaction mechanism,was also explored.

关键词： LaFeO_(3) CdS Photocatalytic degradation Tetracycline hydrochloride Reaction mechanism Rare earths