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加味参芪四物汤对老年不稳定性股骨粗隆间骨折患者(气血亏虚型)IL-6、TNF-α、骨代谢及免疫功能的影响

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全科医学临床与教育 2024年第4期22卷 321-324页

作者：王玲星李正文吕伟胜浙江省永康市中医院骨伤科浙江金华321300

目的探讨加味参芪四物汤在老年不稳定性股骨粗隆间骨折患者(气血亏虚型)血清白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、骨代谢及免疫功能的影响。方法选取老年不稳定性股骨粗隆间骨折(气血亏虚型)患者89例,采用随机数字表法分为两组。... 详细信息

目的探讨加味参芪四物汤在老年不稳定性股骨粗隆间骨折患者(气血亏虚型)血清白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、骨代谢及免疫功能的影响。方法选取老年不稳定性股骨粗隆间骨折(气血亏虚型)患者89例,采用随机数字表法分为两组。对照组45例采用股骨近端防旋髓内钉(PFNA)内固定术治疗,观察组44例在对照组的基础上联合加味参芪四物汤治疗,治疗2周后比较临床疗效。结果治疗后观察组血清IL-6、TNF-α、D-二聚体(D-D)水平低于对照组,β-内啡肽(β-EP)、血清骨特异性碱性磷酸酶(BALP)、骨钙素(BGP)水平、CD3+、CD4+、CD4+/CD8+高于对照组(t分别=9.19、12.18、12.94、-8.29、7.92、9.35、7.61、9.27、7.90,P均<0.05)。观察组总有效率明显高于对照组(χ^(2)=8.21,P<0.05);并发症总发生率明显低于对照组(χ^(2)=7.35,P<0.05)。结论对于PFNA内固定术联合加味参芪四物汤治疗老年不稳定性股骨粗隆间骨折(气血亏虚型)可有效降低炎症反应和并发症的发生,对骨代谢具有一定的调节作用,还能促进患者术后康复效果,改善预后。

关键词：参芪四物汤不稳定性股骨粗隆间骨折气血亏虚型炎症因子老年人骨代谢免疫功能

A DNA tetrahedron-based ferroptosis-suppressing nanoparticle: superior delivery of curcumin and alleviation of diabetic osteoporosis

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Bone Research 2024年第1期12卷 227-239页

作者： Yong li zhengwen Cai Wenjuan Ma Long Bai En Luo Yunfeng lin State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases West China Hospital of StomatologySichuan UniversityChengduSichuan 610041PR China Department of Oral and Maxillofacial Surgery Affiliated Stomatological HospitalSouthwest Medical UniversityLuzhouSichuan 646000PR China Sichuan Provincial Engineering Research Center of Oral Biomaterials ChengduSichuan 610041China

Diabetic osteoporosis(DOP)is a significant complication that poses continuous threat to the bone health of patients with diabetes;however,currently,there are no effective treatment *** patients with diabetes,the increased levels of ferroptosis affect the osteogenic commitment and differentiation of bone mesenchymal stem cells(BMSCs),leading to significant skeletal *** address this issue,we aimed to target ferroptosis and propose a novel therapeutic approach for the treatment of *** synthesized ferroptosis-suppressing nanoparticles,which could deliver curcumin,a natural compound,to the bone marrow using tetrahedral framework nucleic acid(tFNA).This delivery system demonstrated excellent curcumin bioavailability and stability,as well as synergistic properties with *** in vitro and in vivo experiments revealed that nanoparticles could enhance mitochondrial function by activating the nuclear factor E2-related factor 2(NRF2)/glutathione peroxidase 4(GPX4)pathway,inhibiting ferroptosis,promoting the osteogenic differentiation of BMSCs in the diabetic microenvironment,reducing trabecular loss,and increasing bone *** findings suggest that curcumin-containing DNA tetrahedron-based ferroptosissuppressing nanoparticles have a promising potential for the treatment of DOP and other ferroptosis-related diseases.

关键词： curcumin osteoporosis diabetic

Alternating nitrogen feeding strategy induced aerobic granulation:Influencing conditions and mechanism

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Journal of Environmental Sciences 2021年第11期33卷 135-147页

作者： Chunli Wan zhengwen li Yanggui Shen Xiang liu Department of Environmental Science and Engineering Fudan UniversityShanghai 200438China College of Materials Science and Chemical Engineering Harbin Engineering UniversityHarbin 150001China

Effective cultivation of stable aerobic granular sludge(AGS)is a crucial step in the successful application of this technology,and the formation of AGS could be facilitated by some environmental stress *** identical sequencing batch reactors(SBRs)were established to investigate the aerobic granulation process under the same alternating ammonia nitrogen feeding strategy superimposed with different environmental conditions(inorganic carbon source,temperature,N/COD).Although various superimposed conditions induced a significant difference in the size,settling velocity,mechanic strength of AGS,mature aerobic granules could be successfully obtained in all four reactors after 70 days’operation,indicating the alternating ammonia nitrogen feeding strategy was the most critical factor for AGS *** on the results of redundancy analysis,the presence of an inorganic carbon source could facilitate the cultivation of AGS with nitrification function,while the moderate temperature and fluctuant N/COD might benefit the cultivation of more stable *** addition,superimposed stress conditions could result in the difference in the microbial population between four reactors,but the population diversity and abundance of microorganisms were not the determinants of AGS *** study provided an effective method for the cultivation of AGS by using alternating ammonia nitrogen feeding strategy.

关键词： Aerobic granule sludge Granulation Alternating nitrogen feeding Cultivation

High resolution 3D nonlinear integrated inversion

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Applied Geophysics 2009年第2期6卷 159-165页

作者： li Yong Wang Xuben li Zhirong li Qiong li zhengwen Key Lab of Earth Exploration ＆ Information Technology Chengdu University of Technology Chengdu 610059 China CNPC Chuanqing Drilling Engineering Company Limited Sichuan Geophysical Company Chengdu 610213 China

高分辨率 3D 非线性的综合倒置方法基于非线性的理论。在层控制下面，从几口井的日志数据(或所有井) 在学习区域和地震踪迹，邻近井的数据是到有多重输入和产量的一个网络的输入并且综合地被训练获得全部学习区域的一个适应重量函数。... 详细信息

高分辨率 3D 非线性的综合倒置方法基于非线性的理论。在层控制下面，从几口井的日志数据(或所有井) 在学习区域和地震踪迹，邻近井的数据是到有多重输入和产量的一个网络的输入并且综合地被训练获得全部学习区域的一个适应重量函数。综合非线性的印射关系被水库的侧面、垂直的地质的变化造并且更新。因此，倒置过程和它的倒置结果能被抑制并且控制并且有有速度倒置，阻抗倒置，和密度倒置节的高分辨率的稳定的地震倒置节，能被获得。好地质的效果在模型计算测试并且真实数据处理被获得了，它证实这个方法让高精确，好实物，和罐头被用于量的水库分析。

关键词：三维非线性综合反演高分辨率非线性映射关系测试数据处理非线性理论波阻抗反演反演方法

The nature of electron density enhancement over a wide altitude range during ionosphere heating experiments at EISCAT

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Earth and Planetary Physics 2024年第2期8卷 408-414页

作者： Jun Wu Jian Wu Jie Feng Qingliang li ShuJi Hao zhengwen Xu HaiSheng Zhao YaBin Zhang National Key Laboratory of Electromagnetic Environment China Research Institute of Radio Wave PropagationBeijing 102206China School of Physics Xidian UniversityXi’an 710071China

During the course of ionospheric heating experiments, researchers at the European Incoherent Scatter Scientific Association (EISCAT) observed an apparent electron density enhancement. The enhancement extended over a wide range of altitudes, above the reflection altitude of the high-frequency pump wave. However, whether this enhancement actually corresponds to a true enhancement in electron density remains an open question. When the dispersion relation of ion acoustic waves is followed, the frequency ratio of the enhanced ion line to the background ion line suggests that the profile of the effective ion mass may have remained unchanged. Furthermore, the solar radio flux and ion drift velocity indicate no significant changes in the ion species and their densities. In conclusion, the electron density enhancement observed at EISCAT should not, in fact, be considered a true enhancement.

关键词： incoherent scatter radar(ISR) ionospheric heating electron density ion acoustic wave

Biomimetic Fabrication of Polymer Film with High Adhesive Superhydrophobicity by Duplicating Locust Wing Surface

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Chemical Research in Chinese Universities 2015年第5期31卷 895-898页

作者： SUN Gang FANG Yan ZHI Heng li zhengwen School of life Science Changchun Normal University Changchun 130032 P. R. China School of life Science Northeast Normal University Changchun 130024 P. R. China

Locust is a common flying insect. Locust wings were used as biomimetic templates to fabricate multi-functional polymer（polydimethylsiloxane, PDMS） films by soft lithography. The microstructure and wettability of the natural and artificial locust wing surfaces were investigated by means of a scanning electron microscope（SEM） and a video-based contact angle meter. The natural locust wing surface exhibits complicated hierarchical structures and high adhesive superhydrophobicity（contact angle 152°）. The prepared polymer film faithfully reproduces the surface microstructures of the bio-template, and displays a good hydrophobicity and high adhesion（contact angle 144°）. The complex wettability of the natural and artificial locust wing surfaces ascribes to the cooperative effect of hydrophobic composition and multi-dimensional rough microstructures. This work not only promotes our understanding of the wetting mechanism on bio-surfaces, but offers an inexpensive and effective approach for biomimetic fabrication of multi-functional interfacial materials.

关键词： Biomimetic Superhydrophobicity Adhesion Polymer film Locust wing

In-situ/operando techniques to identify active sites for thermochemical conversion of CO_(2) over heterogeneous catalysts

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Journal of Energy Chemistry 2021年第11期30卷 153-171,I0004页

作者： Kai Feng Yaning Wang Man Guo Jingpeng Zhang zhengwen li Tianyu Deng Zhihe Zhang Binhang Yan Department of Chemical Engineering Tsinghua UniversityBeijing 100084China

The catalytic conversion of CO_(2) to fuels or chemicals is considered to be an effective pathway to mitigate the greenhouse effect. To develop new types of efficient and durable catalysts, it is critical to identify the catalytic active sites, surface intermediates, and reaction mechanisms to reveal the relationship between the active sites and catalytic performance. However, the structure of a heterogeneous catalyst usually dynamically changes during reaction, bringing a great challenge for the identification of catalytic active sites and reaction pathways. Therefore, in-situ/operando techniques have been employed to real-time monitor the dynamic evolution of the structure of active sites under actual reaction conditions to precisely build the structure–function relationship. Here, we review the recent progress in the application of various in-situ/operando techniques in identifying active sites for catalytic conversion of CO_(2) over heterogeneous catalysts. We systematically summarize the applications of various optical and X-ray spectroscopy techniques, including Raman spectroscopy, Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), and X-ray absorption spectroscopy (XAS), in identifying active sites and determining reaction mechanisms of the CO_(2) thermochemical conversion with hydrogen and light alkanes over heterogeneous catalysts. Finally, we discuss challenges and opportunities for the development of in-situ characterization in the future to further enlarge the capability of these powerful techniques.

关键词： In-situ characterization Spectroscopy techniques Active sites CO_(2)conversion Heterogeneous catalysis

大扰动下考虑电化学储能的主动频率响应优化控制策略

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电力系统自动化 2023年第17期47卷 118-127页

作者：吴限李卫东李正文郑慧聪曾辉李梓锋大连理工大学电气工程学院辽宁省大连市116024 国家电网有限公司东北分部辽宁省沈阳市110180 国网辽宁省电力有限公司辽宁省沈阳市110006 国网辽宁省电力有限公司电力科学研究院辽宁省沈阳市110006

新型电力系统在快速转型中面临严峻的频率稳定局面,隶属于安全稳定控制框架中的防失稳控制防线压力陡增。文中在构建“在线预算、实时匹配”的主动频率响应控制框架的基础上,计及紧急控制成本,提出一种安全与经济相协调的主动频率响应... 详细信息

新型电力系统在快速转型中面临严峻的频率稳定局面,隶属于安全稳定控制框架中的防失稳控制防线压力陡增。文中在构建“在线预算、实时匹配”的主动频率响应控制框架的基础上,计及紧急控制成本,提出一种安全与经济相协调的主动频率响应优化控制策略。依据不同调频资源的频率响应动态特征构建区域电网频率响应模型;从经济角度出发,以安全与经济协调为优化目标设计控制原则,构建基于模型预测控制的主动频率响应优化控制策略,通过调频资源动作深度的优化调控,实现频率安全的前提下紧急控制成本进一步降低。仿真分析表明,所提策略可优化协调不同禀赋的调频资源,实现主动频率响应控制的安全与经济协调。

关键词：安全稳定控制频率响应模型预测控制储能协调优化

计及一次调频死区与限幅的高比例风电电力系统机组组合

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电网技术 2022年第4期46卷 1326-1334页

作者：申家锴李卫东李正文曾辉郑慧聪大连理工大学电气工程学院辽宁省大连市116024 国网辽宁省电力有限公司辽宁省沈阳市110006 国网辽宁省电力有限公司电力科学研究院辽宁省沈阳市110006

高比例风电电力系统调频供需矛盾日益突出,导致运行工况变动较大,在频率安全约束中若不考虑一次调频死区与限幅影响,会导致机组组合方案难以保障系统频率稳定。对此,针对含风电电力系统频率响应模型,在模型的全响应分析的基础上,通过分... 详细信息

高比例风电电力系统调频供需矛盾日益突出,导致运行工况变动较大,在频率安全约束中若不考虑一次调频死区与限幅影响,会导致机组组合方案难以保障系统频率稳定。对此,针对含风电电力系统频率响应模型,在模型的全响应分析的基础上,通过分类聚合与分段解析推得频率时域表达式,进而构建计及一次调频死区与限幅的频率安全约束;针对所建约束的高度非线性,在机组组合中采用两阶段迭代方法将非线性规划问题转换为主子问题协同求解,并针对单方向补充优化割的不足,提出多方向并行补充优化割的方法以提升解的质量。结果表明,所建约束可更为准确地估计系统调频能力,所提算法能够向更多方向并行寻找最优解,从而使所得到的机组组合方案能有效保障高比例风电电力系统的频率稳定,且开机数量更少、成本更低。

关键词：高比例风电频率稳定大功率缺失死区与限幅机组组合