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Steep subduction of the Indian continental mantle lithosphere beneath the eastern Himalaya revealed by gravity anomalies

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Science China Earth Sciences 2023年第9期66卷 1994-2010页

作者： Shengxian LIANG xuben WANG zhengwei xu Yanpei DAI Yonghua WANG Jing GUO Yanjie JIAO Fu LI Key Laboratory of Earth Exploration and Information Technique Chengdu University of TechnologyChengdu 610059China Chengdu Center China Geological SurveyChengdu 610081China

The geometry and deformation of the Indian continental mantle lithosphere(ICML)beneath the India-Eurasia collision zone are critical to understanding the accommodation of continent-continent convergence.In this paper,the distribution of residual gravity anomalies in the upper mantle of southern Tibet is estimated using the gravity data and seismic velocity models,and the heterogeneous density distribution of the upper-mantle is then recovered through three-dimensional gravity inversion.The results reveal a low-density anomaly(~300 km W-E and~100 km N-S)in the upper mantle under the eastern Himalaya,while there is no obvious density anomaly under the western Himalaya.The western boundary of the low-density anomaly coincides with the Yadong-Gulu Rift(YGR)on the surface(89°–90°E),and its southern boundary is located at~28°N,approximately 130 km southward from the Indus-Yarlung suture,probably representing the mantle suture at depth.This observation indicates that,in contrast to the western ICML which is probably underthrusting at a shallow angle,the eastern ICML be likely subducting steeply,accompanying asthenosphere upwelling.Such a laterally varying geometry suggests that a major tearing of the ICML may have taken place from the intersection of the mantle suture and the YGR in the upper mantle.The tearing and the steep subduction of the ICML might be associated with the magmatic and mineralization events in the eastern Himalaya-Gangdese and the formation of the YGR.

关键词： Indian continental mantle lithosphere Steep subduction Mantle suture Major tearing point Upper mantle density Himalaya

Trojan nanobacteria hybridized with prodrug nanocapsules for efficient combined tumor therapy

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Nano Research 2023年第7期16卷 9651-9662页

作者： Mingsong Zang Yuancheng Ji Xiaoran Ding zhengwei xu Jinxing Hou Jianxin Sun Jiayun xu Shuangjiang Yu Hongcheng Sun Tingting Wang Junqiu Liu State Key Laboratory of Supramolecular Structure and Materials College of ChemistryJilin UniversityChangchun 130012China Key Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education Key Laboratory of Organosilicon Material Technology of Zhejiang ProvinceCollege of MaterialChemistry and Chemical EngineeringHangzhou Normal UniversityHangzhou 311121China Department of Biomedical Engineering College of Design and EngineeringNational University of SingaporeSingapore 117583Singapore

Live bacteria-based drug delivery systems have been raised as promising tools for enhancing drug delivery into tumors due to their active tumor targeting and easy surface modifiability.In this work,a“Trojan nanobacteria hybrid”,E.coli@highly integrated nanocapsules(HINCs)hybrid(HINE-Hybrid),was successfully constructed with HINCs of prodrug based on covalent selfassembly and the facultative anaerobic bacterium E.coli MG 1655 for combined chemotherapy,photothermal therapy(PTT),and chemodynamic therapy(CDT).HINCs were constructed by covalent cross-linking of pillar[5]arene derivatives and cisplatin prodrug linker,which can be endocytosed and lysed to release therapeutic agents.Under the near-infrared(NIR)light(at 808 nm)irradiation,the system temperature can be significantly increased by HINCs,which further leads to the highly efficient generation of reactive oxygen species(ROS).In addition,HINE-Hybrid shows significant antitumor effects in in vitro and in vivo studies and also promotes immune cell infiltration and antitumor cytokine expression in the tumor microenvironment(TME).HINEHybrid exerts its anticancer properties efficiently due to selective enrichment and multiplication of E.coli at tumor sites,which is important for the construction of bacterial-assisted antitumor platforms.

关键词： live bacteria hybrid covalent nanocapsule photothermal therapy chemodynamic therapy

Novel two-dimensional PdSe phase:A puckered material with excellent electronic and optical properties

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Frontiers of physics 2022年第5期17卷 65-73页

作者： Mingyun Huang Xingxing Jiang Yueshao Zheng zhengwei xu Xiong-Xiong xue Keqiu Chen Yexin Feng Hunan Provincial Key Laboratory of Low-Dimensional Structural Physics&Devices School of Physics and ElectronicsHunan UniversityChangsha 410082China School of Physics and Optoelectronics Xiangtan UniversityXiangtan 411105China

By combining structural search and first-principles calculations,we predict a new stable twodimensional PdSe monolayer,and systematically investigate its structural,electronic and optical properties.The calculated formation enthalpy,phonon spectra and molecular dynamic simulations confirm that PdSe monolayer possesses excellent thermodynamic and dynamic stability.PdSe monolayer is a semiconductor with an indirect band gap of∼1.10 eV.The carrier transport of PdSe monolayer is dominated by hole and exhibits remarkable anisotropy due to the intrinsic structure anisotropy.The optical properties also show obvious anisotropic characteristic with considerable absorption coefficient and broad absorption from the visible to ultraviolet regions.Benefiting from these excellent physical properties,PdSe monolayer is expected to be a promising candidate as electronic and optoelectronic devices.

关键词： first-principles calculation two-dimensional(2D) electronic structure structural search PdSe

Multi-scale boron penetration toward stabilizing nickel-rich cathode

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Fundamental Research 2023年第4期3卷 618-626页

作者： Bianzheng You Zhixing Wang Yijiao Chang Wei Yin zhengwei xu Yuexi Zeng Guochun Yan Jiexi Wang School of Metallurgy and Environment Central South UniversityChangsha 410083China Energy Storage&Distributed Resources Division Lawrence Berkeley National Laboratory1 Cyclotron RdBerkeleyCA 94720USA Engineering Research Center of the Ministry of Education for Advanced Battery Materials Central South UniversityChangsha 410083China Hunan Provincial Key Laboratory of Nonferrous Value-Added Metallurgy Central South UniversityChangsha 410083

Nickel-rich layered oxides LiNi_(x)Co_(y)Mn_(1-x-y)O_(2)(x≥0.8)have been recognized as the preferred cathode materials to develop lithium-ion batteries with high energy density(>300 Wh kg^(−1)).However,the poor cycling stability and rate capability stemming from intergranular cracks and sluggish kinetics hinder their commercialization.To address such issues,a multi-scale boron penetration strategy is designed and applied on the polycrystalline LiNi_(0.83)Co_(0.11)Mn_(0.06)O_(2)particles that are pre-treated with pore construction.The lithium-ion conductive lithium borate in grain gaps functions as the grain binder that can bear the strain/stress from anisotropic contraction/expansion,and provides more pathways for lithium-ion diffusion.As a result,the intergranular cracks are ameliorated and the lithium-ion diffusion kinetics is improved.Moreover,the coating layer separates the sensitive cathode surface and electrolyte,helping to suppress the parasitic reactions and related gas evolution.In addition,the enhanced structural stability is acquired by strong B-O bonds with trace boron doping.As a result,the boron-modified sample with an optimized boron content of 0.5%(B5-NCM)exhibits a higher initial discharge capacity of 205.5 mAh g^(−1)at 0.1C(1C=200 mA g^(−1))and improved capacity retention of 81.7%after 100 cycles at 1C.Furthermore,the rate performance is distinctly enhanced by high lithium-ion conductive LBO(175.6 mAh g^(−1)for B5-NCM and 154.6 mAh g^(−1)for B0-NCM at 5C)

关键词： Nickel-rich layered oxides Lithium borates Intergranular cracks Lithium-ion diffusion kinetics Trace boron doping Gas evolution

基于骨外科仿生治疗理念探讨寰枢椎脱位的临床分型及治疗策略

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中华骨与关节外科杂志 2024年第2期17卷 170-174页

作者：许正伟夏虹郝定均西安交通大学附属红会医院脊柱病医院西安710054 中国人民解放军南部战区总医院骨科广州510010

寰枢椎脱位是一种具有临床挑战性的脊柱外科疾病,可引起患者四肢麻木无力、大小便功能障碍,严重者可致循环紊乱和呼吸功能障碍。传统治疗主要是松解复位,解除压迫,局部坚强固定融合,术后常伴有颈椎活动受限。与传统治疗理念不同,骨外科... 详细信息

寰枢椎脱位是一种具有临床挑战性的脊柱外科疾病,可引起患者四肢麻木无力、大小便功能障碍,严重者可致循环紊乱和呼吸功能障碍。传统治疗主要是松解复位,解除压迫,局部坚强固定融合,术后常伴有颈椎活动受限。与传统治疗理念不同,骨外科仿生治疗理念主张尽可能保留脊柱活动功能,遵循结构稳定、功能最优的仿生学治疗理念,在实现寰枢椎脱位解剖复位的同时,最大限度保留上颈椎运动功能。本文旨在从仿生骨外科学的角度出发,对寰枢椎脱位的临床分型、治疗的选择和内固定技术的演变进行简明阐述,以期为寰枢椎脱位治疗策略的选择提供新的思路和见解。

关键词：寰枢椎脱位分型手术治疗仿生学治疗

加服温阳利水汤治疗心肾阳虚型心力衰竭临床观察

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广西中医药 2024年第2期47卷 10-12页

作者：徐正伟刘金艾昌吉回族自治州中医医院新疆昌吉831100

目的:观察温阳利水汤治疗心肾阳虚型心力衰竭的临床疗效。方法:选取72例心肾阳虚型心力衰竭患者,随机分为两组,每组36例。对照组予常规西药治疗,观察组在对照组治疗的基础上口服温阳利水汤治疗,两组疗程均为14d。结果:观察组总有效率为8... 详细信息

目的:观察温阳利水汤治疗心肾阳虚型心力衰竭的临床疗效。方法:选取72例心肾阳虚型心力衰竭患者,随机分为两组,每组36例。对照组予常规西药治疗,观察组在对照组治疗的基础上口服温阳利水汤治疗,两组疗程均为14d。结果:观察组总有效率为83.33%,高于对照组的61.11%(P<0.05)。与治疗前比较,两组患者Lee氏心衰评分、血清N末端B型钠尿肽前体(NT-proBNP)水平降低,左室舒张末期内径(LVEDd)缩短,左心室射血分数(LVEF)增高,差异均有统计学意义(P<0.05);且观察组各项指标改善程度均优于对照组(P<0.05)。结论:温阳利水汤联合西药治疗心肾阳虚型心力衰竭患者可改善临床症状及心功能,降低血清NT-proBNP水平。

关键词：心力衰竭心肾阳虚证温阳利水汤中西医结合疗法

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橡胶树体胚苗质量调查与分析

热带作物学报 2024年第6期45卷 1219-1225页

作者：彭素娜徐正伟华玉伟顾晓川成镜黄华孙黄天带中国热带农业科学院橡胶研究所/海口市热带植物种苗创新重点实验室海南海口571101

天然橡胶是我国重要的战略物资和工业原料,主要来源于橡胶树。橡胶树生长周期长,其苗木质量直接影响天然橡胶产业的发展,橡胶树体胚苗在前期研究中表现一致性好,且具有速生、高产的优势。海南省天然橡胶新型种植材料创新基地是当前规模... 详细信息

天然橡胶是我国重要的战略物资和工业原料,主要来源于橡胶树。橡胶树生长周期长,其苗木质量直接影响天然橡胶产业的发展,橡胶树体胚苗在前期研究中表现一致性好,且具有速生、高产的优势。海南省天然橡胶新型种植材料创新基地是当前规模生产的橡胶树体胚苗的基地,现生产品种有热研73397和热研917。本研究分析比较了热研73397体胚试管苗在2018—2020年间的株高、茎粗、叶片数、主根长等指标的差异性,比较了2020年2个品种各指标的差异性,并对不同年份不同品种进行分级比较,以期阐明橡胶树体胚苗规模生产的情况。结果表明:(1)2018—2020年,热研73397的株高、茎粗、叶片数、主根长度在各区间的比例相当;株高、叶片数、主根长度在3 a间的差异不显著;茎粗在2018和2019年之间差异显著,且3 a均值均在2.00 mm以上,最大值和最小值的差值仅为0.09 mm。(2)2020年,热研73397和热研917体胚苗的株高一致,均值均为8.0 cm,且大部分集中在5.0~10.0 cm,分别占66.13%、66.91%;热研73397和热研917的茎粗范围分别为0.80~4.23 mm、1.13~3.73 mm,均值分别为2.11 mm和2.18 mm,2个品种的茎粗在1.50~3.00 mm之间高度集中,分别占85.94%、83.82%;热研73397和热研917叶片数范围分别为0~6片和1~4片,2个品种叶片数绝大多数为1~3片,分别占88.82%、96.32%,其中热研917叶片数为2片的占比高达52.94%;热研73397的主根长度均值为9.5 cm,而热研917的为9.1 cm,2个品种的主根长度多数集中在8.0~12.0 cm之间,分别占74.12%、79.41%;方差分析结果表明,2020年2个品种的株高、茎粗、叶片数差异不显著,主根长度差异显著(P<0.05)。(3)2018—2020年调查的橡胶树体胚苗中,不同年份不同品种的橡胶树体胚苗,一级苗比例为19%~22%,二级苗比例为56%~62%。据此,规模化生产橡胶树体胚试管苗质量稳定,为橡胶树体胚苗生产工艺的推广应用提供参考。

关键词：橡胶树体胚苗质量指标种苗质量

激素浓度组合对成熟油梨枝条伸长和生根的影响

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热带农业科学 2024年第3期44卷 15-22页

作者：成镜汤倩黄天带顾晓川徐正伟彭素娜海南天然橡胶与热带林木研究院海南海口571101 中国热带农业科学院橡胶研究所/农业农村部橡胶树生物学与遗传资源利用重点实验室/省部共建国家重点实验室培育基地/海南省热带作物栽培生理学重点实验室/热带林木种子种苗工程中心/海口市热带植物种苗创新重点实验室海南海口571101 海南大学林学院海南儋州571737

为了建立抗根腐病成熟油梨砧木的快繁技术体系,通过设置不同浓度(0.1、0.5、1.0、1.5、2.0、2.5、3.0 mg/L)的细胞分裂素(meta-topolin,MT)与不同浓度(0.1、0.5、1.0、1.5 mg/L)的赤霉素(gibberellin,GA3)的组合试验,研究适宜于成熟油... 详细信息

为了建立抗根腐病成熟油梨砧木的快繁技术体系,通过设置不同浓度(0.1、0.5、1.0、1.5、2.0、2.5、3.0 mg/L)的细胞分裂素(meta-topolin,MT)与不同浓度(0.1、0.5、1.0、1.5 mg/L)的赤霉素(gibberellin,GA3)的组合试验,研究适宜于成熟油梨外植体伸长的培养条件;同时设置不同浓度(0.5、1.0、1.5、2.0、2.5、3.0 mg/L)的吲哚-3-丁酸(indole-3-butyric acid,IBA)的生根培养基,探究最适油梨外植体生根的培养条件。研究发现,伸长试验30 d时(D30)油梨外植体株高增量和茎粗增量的效应量依次是MT浓度×GA_(3)浓度>MT浓度>GA_(3)浓度;对D30叶片增量的效应量依次是MT浓度>MT浓度×GA_(3)浓度>GA_(3)浓度。结果表明,在该研究的测试范围内,最适于伸长的激素浓度组合是MT 2 mg/L、GA_(3)(0.5~1.0)mg/L,而在测试的IBA浓度范围内均没有观察到根系的生长。通过显微结构观察发现,MT浓度为1 mg/L处理的油梨外植体茎木质部(木质部厚度为171.6μm)生长优于MT浓度为0.1 mg/L的处理(木质部厚度为95.3μm),这对后期的成功驯化有一定积极作用。本研究结果可为成熟油梨快繁体系建立提供借鉴。

关键词：成熟油梨激素抗根腐病砧木伸长生根驯化

超声引导下选择性神经根封闭术在手术治疗多节段腰椎退变中的指导价值

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国际外科学杂志 2024年第3期51卷 174-180,F0004页

作者：葛朝元杨文龙钱立雄杨小卫郝定均许正伟西安交通大学附属红会医院脊柱外科西安710054

目的评估超声引导下选择性神经根封闭术在手术治疗多节段腰椎退变中的指导价值。方法采用回顾性病例对照研究的方法分析2019年1月—2021年12月于西安交通大学附属红会医院收治的47例接受减压手术治疗的多节段腰椎退变患者的临床资料。... 详细信息

目的评估超声引导下选择性神经根封闭术在手术治疗多节段腰椎退变中的指导价值。方法采用回顾性病例对照研究的方法分析2019年1月—2021年12月于西安交通大学附属红会医院收治的47例接受减压手术治疗的多节段腰椎退变患者的临床资料。根据术前是否行超声引导下选择性神经根封闭术分为神经根封闭组(n=22)及非神经根封闭组(n=25)。记录并比较两组患者的手术时间、术中出血量、减压椎板数、术后引流量及住院天数,比较两组患者术前及随访期间腰痛视觉模拟评分(VAS)、腿痛VAS、日本骨科协会(JOA)评分及Oswestry功能障碍(ODI)评分等。正态分布的计量资料以均数±标准差(x±s)表示,组间比较采用配对t检验,计数资料组间比较采用χ^(2)检验。结果47例患者均顺利完成手术,术中未发生神经血管损伤等严重并发症,所有患者获得(27.6±7.5)个月随访。神经根封闭组手术时间、术中出血量、减压椎板数、术后引流量、住院天数分别为(90.5±12.6)min、(110.5±15.8)mL、(1.2±0.8)个、(85.6±15.8)mL、(6.2±2.8)d,非神经根封闭组分别为(190.6±25.5)min、(450.5±24.8)mL、(3.8±1.6)个、(210.5±16.8)mL、(9.5±2.2)d,神经根封闭组均显著少于非神经根封闭组,两组相比差异具有统计学意义(P0.05)。末次随访时两组患者内固定位置良好,无松动移位,植骨均融合良好。结论对于多节段腰椎退变患者,术前行超声引导下选择性神经根封闭术可以明确责任节段,依此进行的选择性减压融合术,可有效减少手术创伤,同时改善患者腰腿痛及身体功能,具有重要的手术指导价值。

关键词：超声检查腰椎减压术,外科脊柱融合术选择性神经根封闭术多节段腰椎退变