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Endoplasmic reticulum stress and autophagy in cerebral ischemia/reperfusion injury:PERK as a potential target for intervention

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Neural Regeneration Research 2025年第5期20卷 1455-1466页

作者： Ju Zheng Yixin Li Ting Zhang Yanlin Fu Peiyan Long Xiao Gao zhengwei wang Zhizhong Guan Xiaolan Qi Wei Hong Yan Xiao Key Laboratory of Endemic and Ethnic Diseases Ministry of Education&Key Laboratory of Medical Molecular Biology of Guizhou ProvinceGuizhou Medical UniversityGuiyangGuizhou ProvinceChina Guizhou Center for Disease Control and Prevention GuiyangGuizhou ProvinceChina Department of Histology and Embryology Guizhou Medical UniversityGuiyangGuizhou ProvinceChina Collaborative Innovation Center for Prevention and Control of Endemic and Ethnic Regional Diseases Co-constructed by the Province and Ministry GuiyangGuizhou ProvinceChina

Several studies have shown that activation of unfolded protein response and endoplasmic reticulum(ER)stress plays a crucial role in severe cerebral ischemia/reperfusion *** occurs within hours after cerebral ischemia,but the relationship between ER stress and autophagy remains *** this study,we established experimental models using oxygen-glucose deprivation/reoxygenation in PC12 cells and primary neurons to simulate cerebral ischemia/reperfusion *** found that prolongation of oxygen-glucose deprivation activated the ER stress pathway protein kinase-like endoplasmic reticulum kinase(PERK)/eukaryotic translation initiation factor 2 subunit alpha(e IF2α)-activating transcription factor 4(ATF4)-C/EBP homologous protein(CHOP),increased neuronal apoptosis,and induced ***,inhibition of ER stress using inhibitors or by si RNA knockdown of the PERK gene significantly attenuated excessive autophagy and neuronal apoptosis,indicating an interaction between autophagy and ER stress and suggesting PERK as an essential target for regulating *** autophagy with chloroquine exacerbated ER stress-induced apoptosis,indicating that normal levels of autophagy play a protective role in neuronal injury following cerebral ischemia/reperfusion *** from this study indicate that cerebral ischemia/reperfusion injury can trigger neuronal ER stress and promote autophagy,and suggest that PERK is a possible target for inhibiting excessive autophagy in cerebral ischemia/reperfusion injury.

关键词： apoptosis ATF4 autophagy C/EBP homologous protein cerebral ischemia/reperfusion injury eIF2α endoplasmic reticulum stress PERK

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A novel task-oriented framework for dual-arm robotic assembly task

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Frontiers of Mechanical Engineering 2021年第3期16卷 528-545页

作者： zhengwei wang Yahui GAN Xianzhong DAI School of Automation Southeast UniversityNanjing 210096China Key Laboratory of Measurement and Control of Complex Systems of Engineering Ministry of EducationNanjing 210096China

In industrial manufacturing,the deployment of dual-arm robots in assembly tasks has become a ***,making the dual-arm robots more intelligent in such applications is still an open,challenging *** paper proposes a novel framework that combines task-oriented motion planning with visual perception to facilitate robot deployment from perception to execution and finish assembly problems by using dual-arm *** this framework,visual perception is first employed to track the effects of the robot behaviors and observe states of the workpieces,where the performance of tasks can be abstracted as a high-level state for intelligent *** assembly task and manipulation sequences can be obtained by analyzing and reasoning the state transition trajectory of the environment as well as the ***,the corresponding assembly manipulation can be generated and parameterized according to the differences between adjacent states by combining with the prebuilt knowledge of the *** are set up with a dual-arm robotic system(ABB YuMi and an RGB-D camera)to validate the proposed *** results demonstrate the effectiveness of the proposed framework and the promising value of its practical application.

关键词： dual-arm assembly Al reasoning intelligent system task-oriented motion planning visual perception

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Turbine efficiency test on a large hydraulic turbine unit

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Science China(Technological Sciences) 2012年第8期55卷 2199-2205页

作者： YAN ZongGuo ZHOU LingJiu wang zhengwei College of Water Conservancy and Civil Engineering China Agricultural UniversityBeijing 100083China State Key Laboratory of Hydroscience and Engineering Department of Thermal EngineeringTsinghua UniversityBeijing 100084China.

The flow rate measurements are the most difficult part of efficiency tests on prototype hydraulic *** the numerous flow rate measurement methods,the Winter Kennedy method is preferred for measuring turbine flow rates,since it is convenient,practical and *** paper describes efficiency tests on a large 300 MW Francis turbine,with the flow rate measured using the Winter Kennedy method and the Winter Kennedy flow rate coefficient calibrated using the Gibson *** measured turbine efficiency curve is then compared with the curve provided by the *** CFD calculations including the spiral case are then used to analyze the influence with the coefficient K and index n in the Winter Kennedy flow rate formula on the flow rate *** uncertainty values of n and K are a key reason for the differences between the curves obtained from the efficiency test and the curves provided by the manufacturer.

关键词： hydraulic turbine efficiency test flow rate measurement CFD calculations measurement uncertainty

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3D Two-way Coupled TEHD Analysis on the Lubricating Characteristics of Thrust Bearings in Pump-turbine Units by Combining CFD and FEA

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Chinese Journal of Mechanical Engineering 2016年第1期29卷 112-123页

作者： ZHAI Liming LUO Yongyao wang zhengwei LIU Xin State Key Laboratory of Hydroscience and Engineering Tsinghua University Beijing 100084 China Department of Thermal Engineering Tsinghua University Beijing 100084 China

The thermal elastic hydro dynamic （TEHD） lubrication analysis for the thrust bearing is usually conducted by combining Reynolds equation with finite element analysis （FEA）. But it is still a problem to conduct the computation by combining computational fluid dynamics （CFD） and FEA which can simulate the TEHD more accurately. In this paper, by using both direct and separate coupled solutions together, steady TEHD lubrication considering the viscosity-temperature effect for a bidirectional thrust bearing in a pump-turbine unit is simulated combining a 3D CFD model for the oil film with a 3D FEA model for the pad and mirror plate. Cyclic symmetry condition is used in the oil film flow as more reasonable boundary conditions which avoids the oil temperature assumption at the leading and trailing edge. Deformations of the pad and mirror plate are predicted and discussed as well as the distributions of oil film thickness, pressure, temperature. The predicted temperature shows good agreement with measurements, while the pressure shows a reasonable distribution comparing with previous studies. Further analysis of the three-coupled-field reveals the reason of the high pressure and high temperature generated in the film. Finally, the influence of rotational speed of the mirror plate on the lubrication characteristics is illustrated which shows the thrust load should be balanced against the oil film temperature and pressure in optimized designs. This research proposes a thrust bearing computation method by combining CFD and FEA which can do the TEHD analysis more accurately.

关键词： pump-turbine thrust bearing TEHD lubrication two-way coupled CFD FEA

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Nonlinear Vibration Induced by the Water-film Whirl and Whip in a Sliding Bearing Rotor System

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Chinese Journal of Mechanical Engineering 2016年第2期29卷 260-270页

作者： ZHAI Liming LUO Yongyao wang zhengwei KITAUCHI Seishiro MIYAGAWA Kazuyoshi State Key Laboratory of Hydroscience and Engineering Tsinghua University Department of Thermal Engineering Tsinghua University Department of Applied Mechanics and Aerospace Engineering Waseda University

Many industrial applications and experiments have shown that sliding bearings often experience fluid film whip due to nonlinear fluid film forces which can cause rotor-stator rub-impact failures. The oil-film whips have attracted many studies while the water-film whips in the water lubricated sliding bearing have been little researched with the mechanism still an open problem. The dynamic fluid film forces in a water sliding bearing are investigated numerically with rotational, whirling and squeezing motions of the journal using a nonlinear model to identify the relationships between the three motions. Rotor speed-up and slow-down experiments are then conducted with the rotor system supported by a water lubricated sliding bearing to induce the water-film whirl/whip and verify the relationship. The experimental results show that the vibrations of the journal alternated between increasing and decreasing rather than continuously increasing as the rotational speed increased to twice the first critical speed, which can be explained well by the nonlinear model. The radial growth rate of the whirl motion greatly affects the whirl frequency of the journal and is responsible for the frequency lock in the water-film whip. Further analysis shows that increasing the lubricating water flow rate changes the water-film whirl/whip characteristics, reduces the first critical speed, advances the time when significant water-film whirling motion occurs, and also increases the vibration amplitude at the bearing center which may lead to the rotor-stator rub-impact. The study gives the insight into the water-film whirl and whip in the water lubricated sliding bearing.

关键词： rotor system sliding bearing vibration water-film whip nonlinear

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Stereotactic surgery for refractory epilepsy complicated by mental disorders A retrospective case analysis

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Neural Regeneration Research 2008年第6期3卷 690-693页

作者： Yifang wang Aigang Xu Qifu Tan zhengwei wang Dongsheng Jiao Hao Zhu KaidongLiu Department of Neurosurgery the 454 Hospital of Chinese PLA Nanjing 210002 Jiangsu Province China Departrnent of Neurosurgery Nanjing General Hospital of Nanjing Military Area Command of Chinese PLA Nanjing 210002 Jiangsu Province China

BACKGROUND： Anti-epilepsy and anti-psychosis drugs have traditionally been used in the clinic to treat epilepsy complicated by mental disorders. However, there is still no effective therapy for refractory epilepsy patients suffering from persistent mental disorders. OBJECTIVE： To explore the therapeutic effects of stereotactic multi-element localization and multi-target radiofrequency ablation on patients with refractory primary epilepsy and mental disorders. DESIGN： A retrospective case analysis. SETTING： Department of Neurosurgery, the 454 Hospital of Chinese PLA. PARTICIPANTS： Between June and November 2004, 13 patients with refractory primary epilepsy complicated by persistent mental disorders were admitted to the Department of Neurosurgery, the 454 Hospital of Chinese PLA. The patient group consisted of nine males and four females, with an average age of 25 years （range 18-39 years）, and a course of disease ranging 3-11 years. Diagnosis of mental disorders was in accordance with Chinese Classification of Mental Disorders. Written informed consent was obtained from all patients and their families, and the treatment protocol was approved by the Ethics Committee of the Hospital. METHODS： Under venous inhalation anesthesia, the disease targets, including bilateral corpus callosum, bilateral amygdala, and bilateral medial septal area, as well as unilateral Forel-H area, were coagulated by RFG-3CF radiofrequency thermocoagnlation at 75-80 ℃ for 60-70 seconds. During thermocoagulation, the targets were identified using deep-brain microelectrodes and localized according to electrophysiology and electric resistance values. MAIN OUTCOME MEASURES： One year post-surgery, epileptic seizures were assessed on the basis of the Tan classification, and psychogenic （non-epileptic） seizures were evaluated using a 5-grade system. RESULTS： All enrolled 13 epileptic patients were included in the final analysis. The results of follow-up evaluations demonstrated that epilepsy was well-

关键词： epilepsy metal disorders retrospective studies

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Research on the Properties of a Surface-Type Infrared Decoy and Effect of Multiple Launching

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Journal of Harbin Institute of Technology(New Series) 2017年第2期24卷 72-79页

作者： zhengwei wang Huijun Ning Jinlong wang Hao wang Cheng Zhang School of Energy and Power Engineering Nanjing University of Science and Technology Nanjing 210094 China

To study the properties of a new surface-type infrared decoy,the numerical dispersion model and the infrared radiance model of the plates are established. In addition,the temperature of a single plate was measured during combustion experiment,and the spatial position and infrared radiance of each plate are calculated in plate cloud by the two models respectively. Furthermore,the radar images of the plate cloud are simulated and analyzed in dependence of time and direction for single and multiple launching. The result shows that the surface-type infrared decoy can be a point source of interference when the missile is remote tracking. In the meanwhile,the plates cloud shelters the infrared characteristics of the plume and jets of aircraft when the missile is on IR imaging guidance mode. Moreover,With the analysis of the plate cloud dispersion at different intervals and the infrared radiation intensity in the case of different launching number,it can be concluded that a comfortable launching interval can maintain a continuous plate cloud,launching the decoys simultaneously increase the increment of the radiation intensity obviously,the multiple launching is an effective way to enhance the interference property of the decoy.

关键词： ordnance science and technology surface-type infrared decoy radiation intensity multiple launching

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Influence of N doping and the functional groups of graphene on a RGO/TiO2 composite photocatalyst

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Science China(Technological Sciences) 2020年第6期63卷 1045-1054页

作者： TANG Bo HE YanFeng ZHANG ZhenYu wang zhengwei JI Li MA TingTing LI Sen DAI YuanZhe ZHANG GuoLiang School of Petroleum Engineering Changzhou UniversityChangzhou 213016China

Reduced graphene oxide(RGO)assisted TiO2 composite photocatalysts have attracted increased attention because of their high photocatalytic performance under both UV-and visible-light ***,the corresponding properties under the long wavelength irradiation is far from *** this study,a series of RGO samples with well-designed N impurity and optimized surface functional groups are prepared and employed during hybridization with TiO2(named N-RGO/TiO2).The coupling between the doped N atoms and surface functional groups is analyzed based on the resulting photocatalytic performances,and the specific mechanism is revealed by the EPR,IR and lifetime of the photoinduced *** comparing the corresponding performances of the RGO/TiO2 and RGO/N-TiO2 specimens,the results show that the surface functional groups of the RGO serve as a precondition to achieveπ-d coupling between the graphene basal plane and TiO2 nanoparticles,while N atoms in the RGO enhance the resulting photoactivity under a long wavelength range(>510 nm).The findings provide a potential approach to promote the photocatalytic properties of graphene-based composite photocatalysts with the low-energy incident photons.

关键词： graphene surface functional group N doping coupling photocatalyst

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The Active Participation of Ethnic Minority Areas in the Belt and Road Initiative

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Qiu Shi 2016年第1期8卷 79-84页

作者： wang zhengwei Vice Chairman National Committee of the Chinese People's Political Consultative Conference DeT)uty Director United Front Work Devartment of the CPC

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Ni-catalyzed carbon–carbon bonds cleavage of mixed polyolefin plastics waste

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Journal of Energy Chemistry 2023年第10期85卷 562-569,I0014页

作者： Xiaoqin Si Jiali Chen zhengwei wang Yue Hu Zhiwen Ren Rui Lu Lu Liu Jing Zhang Liwei Pan Rui Cai Fang Lu State Key Laboratory of Catalysis Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023LiaoningChina Research Center for Energy Strategy Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023LiaoningChina College of Environmental and Chemical Engineering Dalian UniversityDalian 116622LiaoningChina

The inert carbon–carbon(C–C) bonds cleavage is a main bottleneck in the chemical upcycling of recalcitrant polyolefin plastics waste. Here we develop an efficient strategy to catalyze the complete cleavage of C–C bonds in mixed polyolefin plastics over non-noble metal catalysts under mild conditions. The nickelbased catalyst involving Ni_(2)Al_(3) phase enables the direct transformation of mixed polyolefin plastics into natural gas, and the gas carbon yield reaches up to 89.6%. Reaction pathway investigation reveals that natural gas comes from the stepwise catalytic cleavage of C–C bonds in polypropylene, and the catalyst prefers catalytic cleavage of terminal C–C bond in the side-chain with the low energy ***, our developed approach is evaluated by the technical economic analysis for an economically competitive production process.

关键词： Ni-based catalyst Mixed polyolefin plastics C–C bonds cleavage

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