检索结果-南通市图书馆

A Flexible Smart Healthcare Platform Conjugated with Artificial Epidermis Assembled by Three‑Dimensionally Conductive MOF Network for Gas and Pressure Sensing

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Nano-Micro Letters 2025年第2期17卷 601-620页

作者： Qingqing Zhou Qihang ding Zixun Geng Chencheng Hu Long Yang Zitong Kan Biao Dong Miae Won Hongwei Song Lin Xu Jong Seung Kim State Key Laboratory of Integrated Optoelectronics College of Electronic Science and EngineeringJilin UniversityChangchun 130012People’s Republic of China Department of Chemistry Korea UniversitySeoul 02841Republic of Korea TheranoChem Incorporation Seoul 02856Republic of Korea

The rising flexible and intelligent electronics greatly facilitate the noninvasive and timely tracking of physiological information in telemedicine *** building bionic-sensitive moieties is vital for designing efficient electronic skin with advanced cognitive functionalities to pluralistically capture external ***,realistic mimesis,both in the skin’s three-dimensional interlocked hierarchical structures and synchronous encoding multistimuli information capacities,remains a challenging yet vital need for simplifying the design of flexible logic ***,we construct an artificial epidermal device by in situ growing Cu_(3)(HHTP)_(2) particles onto the hollow spherical Ti_(3)C_(2)T_(x) surface,aiming to concurrently emulate the spinous and granular layers of the skin’s *** bionic Ti_(3)C_(2)T_(x)@Cu_(3)(HHTP)_(2) exhibits independent NO_(2) and pressure response,as well as novel functionalities such as acoustic signature perception and Morse code-encrypted message ***,a wearable alarming system with a mobile application terminal is self-developed by integrating the bimodular senor into flexible printed *** system can assess risk factors related with asthmatic,such as stimulation of external NO_(2) gas,abnormal expiratory behavior and exertion degrees of fingers,achieving a recognition accuracy of 97.6%as assisted by a machine learning *** work provides a feasible routine to develop intelligent multifunctional healthcare equipment for burgeoning transformative telemedicine diagnosis.

关键词： Ti_(3)C_(2)T_(x)@Cu_(3)(HHTP)_(2)composites NO_(2)/pressure flexible sensors Health-monitoring Machine learning

Lattice expansion enables interstitial doping to achieve a high average ZT in n-type PbS

在线全文

学校读者我要写书评

暂无评论

Interdisciplinary Materials 2023年第1期2卷 161-170页

作者： zhengtao Liu Tao Hong Liqing Xu Sining Wang Xiang Gao Cheng Chang Xiangdong ding Yu Xiao Li-Dong Zhao State Key Laboratory for Mechanical Behavior of Materials Xi'an Jiaotong UniversityXi'anChina School of Materials Science and Engineering Beihang UniversityBeijingChina Center for High Pressure Science and Technology Advanced Research(HPSTAR) BeijingChina Institute of Science and Technology Austria KlosterneuburgAustria

Lead sulfide(PbS)presents large potential in thermoelectric application due to its earth-abundant S ***,its inferior average ZT(ZTave)value makes PbS less competitive with its analogs PbTe and *** promote its thermoelectric performance,this study implements strategies of continuous Se alloying and Cu interstitial doping to synergistically tune thermal and electrical transport properties in n-type ***,the lattice parameter of 5.93Åin PbS is linearly expanded to 6.03Åin PbS_(0.5)Se_(0.5)with increasing Se alloying *** expanded lattice in Se-alloyed PbS not only intensifies phonon scattering but also facilitates the formation of Cu *** on the PbS_(0.6)Se_(0.4)content with the minimal lattice thermal conductivity,Cu interstitials are introduced to improve the electron density,thus boosting the peak power factor,from 3.88μW cm^(−1)K^(−2)in PbS_(0.6)Se_(0.4)to 20.58μW cm^(−1)K^(−2)in PbS0.6Se0.4−1%***,the lattice thermal conductivity in PbS_(0.6)Se_(0.4)−x%Cu(x=0-2)is further suppressed due to the strong strain field caused by Cu ***,with the lowered thermal conductivity and high electrical transport properties,a peak ZT~1.1 and ZTave~0.82 can be achieved in PbS_(0.6)Se_(0.4)−1%Cu at 300–773K,which outperforms previously reported n-type PbS.

关键词： electrical transport properties interstitial doping PbS thermal conductivity ZT_(ave)

X射线透视引导下不同方式建立兔椎间盘退变模型的结果对比

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国组织工程研究 2025年第5期29卷 995-1002页

作者：丁至立黄杰蒋强李土胜刘江丁宇安徽医科大学海军临床学院北京市100048 安徽医科大学第五临床医学院安徽省合肥市230032 解放军总医院第六医学中心中医医学部骨伤科北京市100048

背景:国内外学者认为新西兰大白兔腰椎解剖形态与人类腰椎更为相似,是理想的模型动物。在X射线引导下采用不同方式建立兔椎间盘退变模型目前尚缺乏系统性比较。目的:基于X射线引导采用针刺法、终板注射法以及改良终板注射法建立兔腰椎... 详细信息

背景:国内外学者认为新西兰大白兔腰椎解剖形态与人类腰椎更为相似,是理想的模型动物。在X射线引导下采用不同方式建立兔椎间盘退变模型目前尚缺乏系统性比较。目的:基于X射线引导采用针刺法、终板注射法以及改良终板注射法建立兔腰椎间盘退变模型,比较3种方法造模的效果。方法:6月龄新西兰大白兔16只随机分为4组,分别为针刺组、终板注射组、改良终板注射组及空白对照组,针刺组对3个连续节段(L2/3、L3/4、L4/5)椎间盘进行针刺造模,终板注射组在3个连续节段终板单点注射50μL无水乙醇,改良终板注射组对3个连续节段椎间盘进行针刺并在相应节段终板4个方位点注射50μL无水乙醇,空白对照组不进行干预。术后2,4,8周进行X射线检查,测量椎间隙高度指数,然后取椎间盘组织进行解剖学观察、病理学检查。结果与结论:①解剖学观察显示,针刺组以纤维环破溃为主要表现,终板注射组主要以髓核退变为主要表现,改良终板注射组以全椎间盘结构紊乱为主要表现;②与空白对照组相比,针刺组术后2周椎间隙高度指数降低最明显,终板注射组术后2,4周椎间隙高度指数降低明显,改良终板注射组术后2,4,8周椎间隙高度指数均显著降低;③病理学检查显示,针刺组纤维环结构出现破损,内层纤维环向内凸入,终板注射组表现为终板裂隙、排列混乱及细胞核丢失,改良终板注射组表现为整体椎间盘结构紊乱,髓核失水皱缩,与破损的纤维环无明显边界。结果表明,针刺法、终板注射法及改良终板注射法均能建立兔椎间盘退变模型,改良终板注射法较单一方法可大幅加快并加重椎间盘退变,可有效缩短实验周期。

关键词：组织工程椎间盘退变纤维环穿刺法终板注射法 X射线新西兰大白兔

Notoginsenoside Ft1 acts as a TGR5 agonist but FXR antagonist to alleviate high fat diet-induced obesity and insulin resistance in mice

在线全文

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2021年第6期11卷 1541-1554页

作者： Lili ding Qiaoling Yang Eryun Zhang Yangmeng Wang Siming Sun Yingbo Yang Tong Tian Zhengcai Ju Linshan Jiang Xunjiang Wang zhengtao Wang Wendong Huang Li Yang Shanghai Key Laboratory of Complex Prescriptions and MOE Key Laboratory for Standardization of Chinese Medicines Institute of Chinese Materia MedicaShanghai University of Traditional Chinese MedicineShanghai 201203China Department of Diabetes Complications and Metabolism Diabetes and Metabolism Research InstituteBeckman Research InstituteCity of Hope National Medical CenterDuarteCA 91010USA Department of Pharmacy Shanghai Children's HospitalShanghai Jiao Tong UniversityShanghai 200040China Graduate School of Biological Science City of Hope National Medical CenterDuarteCA 91010USA Institute of Interdisciplinary Integrative Medicine Research Shanghai University of Traditional Chinese MedicineShanghai 201203China Jiangsu Kanion Pharmaceutical Co. Ltd.Lianyungang 222001China

Obesity and its associated complications are highly related to a current public health crisis around the world.A growing body of evidence has indicated that G-protein coupled bile acid(BA) receptor TGR5(also known as Gpbar-1) is a potential drug target to treat obesity and associated metabolic *** have identified notoginsenoside Ftl(Ftl) from Panax notoginseng as an agonist of TGR5 in ***,the pharmacological effects of Ftl on diet-induced obese(DIO) mice and the underlying mechanisms are still *** we show that Ftl(100 mg/100 diet) increased adipose lipolysis,promoted fat browning in inguinal adipose tissue and induced glucagon-like peptide-1(GLP-1) secretion in the ileum of wild type but not Tgr5^(-/-) obese *** addition,Ftl elevated serum free and taurineconjugated bile acids(BAs) by antagonizing Fxr transcriptional activities in the ileum to activate Tgr5 in the adipose *** metabolic benefits of Ftl were abolished in Cyp27 al^(-/-) mice which have much lower BA *** results identify Ftl as a single compound with opposite activities on two key BA receptors to alleviate high fat diet-induced obesity and insulin resistance in mice.

关键词： Notoginsenoside Ft1 Obesity Insulin resistance Bile acids TGR5 FXR GLP-1 Metabolic disorders

新时代大学生爱国主义教育的现实境遇与实践理路——基于《爱国主义教育法》实施视角

在线全文

学校读者我要写书评

暂无评论

高校辅导员学刊 2025年第1期17卷 15-19,95,96页

作者：丁露江西陶瓷工艺美术职业技术学院马克思主义学院江西景德镇333300

在“两个大局”背景下,西方强势的意识形态输出、国家经济社会发展的新矛盾新问题、碎片化和去中心化的“信息茧房”给新时代大学生爱国主义教育带来严峻挑战。《中华人民共和国爱国主义教育法》应运而生,为新时代大学生爱国主义教育的... 详细信息

在“两个大局”背景下,西方强势的意识形态输出、国家经济社会发展的新矛盾新问题、碎片化和去中心化的“信息茧房”给新时代大学生爱国主义教育带来严峻挑战。《中华人民共和国爱国主义教育法》应运而生,为新时代大学生爱国主义教育的现实境遇提供了规范——“教什么”、创新——“怎么教”、落实——“谁来教”的价值指向,同时通过尊法、学法、守法、用法、执法、护法的“六维”方式找到了涵养大学生爱国主义教育法治思维、规范大学生爱国主义教育法治行动、保障大学生爱国主义教育运行的实践理路。

关键词：《中华人民共和国爱国主义教育法》大学生爱国主义教育现实境遇实践理路

Online Fault-Tolerant Tracking Control With Adaptive Critic for Nonaffine Nonlinear Systems

在线全文

学校读者我要写书评

暂无评论

IEEE/CAA Journal of Automatica Sinica 2025年第1期 215-227页

作者： ding Wang Lingzhi Hu Xiaoli Li Junfei Qiao IEEE the School of Information Science and Technology Beijing Key Laboratory of Computational Intelligence and Intelligent SystemBeijing Laboratory of Smart Environmental Protection and Beijing Institute of Artificial Intelligence Beijing University of Technology

In this paper, a fault-tolerant-based online critic learning algorithm is developed to solve the optimal tracking control issue for nonaffine nonlinear systems with actuator ***, a novel augmented plant is constructed by fusing the system state and the reference trajectory, which aims to transform the optimal fault-tolerant tracking control design with actuator faults into the optimal regulation problem of the conventional nonlinear error system. Subsequently, in order to ensure the normal execution of the online learning algorithm, a stability criterion condition is created to obtain an initial admissible tracking policy. Then, the constructed model neural network(NN) is pretrained to recognize the system dynamics and calculate trajectory control. The critic and action NNs are constructed to output the approximate cost function and approximate tracking control,respectively. The Hamilton-Jacobi-Bellman equation of the error system is solved online through the action-critic framework. In theoretical analysis, it is proved that all concerned signals are uniformly ultimately bounded according to the Lyapunov *** tracking control law can approach the optimal tracking control within a finite approximation error. Finally, two experimental examples are conducted to indicate the effectiveness and superiority of the developed fault-tolerant tracking control scheme.

关键词：

A data-driven rolling optimization method for trajectory tracking error prediction of CNC machine tools

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Science China Technological Sciences 2025年第1期 274-289页

作者： Yinxin GUAN Jixiang YANG Shizhong TAN Han ding School of Mechanical Science and Engineering State Key Laboratory of Intelligent Manufacturing Equipment and TechnologyHuazhong University of Science and Technology

The dynamic performance of the feed-drive system in CNC machine tools directly influences the accuracy of machined parts. To enhance the motion control performance of CNC machine tools, a high-precision model of the feed-drive system is critical. However, current modeling methods for feed-drive systems seldom consider time-varying factors such as loads, wear, and lubrication. As a result, the model accuracy degrades when the system characteristics are affected by these time-varying factors. In this paper, a rolling optimization method with partial weights frozen is developed to realize quick iterative learning of a data-driven model for a feed drive system with time-varying characteristics using a small amount of ***, the long short-term memory fully connected(LSTM-FC) network is built and divided into feature extraction and output fitting parts based on their functions. Then, a weight freezing-based rolling optimization method is applied. The weights in the feature extraction part are frozen, which preserves the learned common knowledge and patterns by solidifying the way that high-dimensional features are extracted from the input. By adjusting the weights in the output fitting part, the extracted highdimensional features are remapped to the new data distribution changed by time-varying factors. Finally, the performance of the developed rolling optimization method is confirmed by experiments. The results show that the proposed rolling optimization method reduces the maximum prediction errors by 49.5% and the total training time by 96.3% compared with existing methods,which demonstrates that the proposed method can restore model accuracy when the system characteristics change due to timevarying factors, and significantly accelerate the optimization process by rolling optimization.

关键词：

AAV-mediated expression of p65shRNA and bone morphogenetic protein 4 synergistically enhances chondrocyte regeneration

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

中国组织工程研究 2025年第17期29卷 3537-3547页

作者： Yu Yangyi Song Zhuoyue Lian Qiang ding Kang Li Guangheng Shenzhen Key Laboratory of Musculoskeletal Tissue Reconstruction and Function Restoration Division of Adult Joint Reconstruction and Sports MedicineDepartment of Orthopedic SurgeryShenzhen People’s Hospital(The Second Clinical Medical College Jinan UniversityThe First Affiliated HospitalSouthern University of Science and Technology)Shenzhen 518020Guangdong ProvinceChina Department of Orthopedics Zhengzhou Orthopedics HospitalZhengzhou 450000Henan ProvinceChina Department of Orthopedics Shenzhen Pingle Orthopedics HospitalShenzhen 518000Guangdong ProvinceChina

BACKGROUND:Adeno-associated virus(AAV)gene therapy has been proven to be reliable and safe for the treatment of osteoarthritis in recent ***,given the complexity of osteoarthritis pathogenesis,single gene manipulation for the treatment of osteoarthritis may not produce satisfactory *** studies have shown that nuclear factorκB could promote the inflammatory pathway in osteoarthritic chondrocytes,and bone morphogenetic protein 4(BMP4)could promote cartilage ***:To test whether combined application of AAV-p65shRNA and AAV-BMP4 will yield the synergistic effect on chondrocytes regeneration and osteoarthritis ***:Viral particles containing AAV-p65-shRNA and AAV-BMP4 were *** efficacy in inhibiting inflammation in chondrocytes and promoting chondrogenesis was assessed in vitro and in vivo by transfecting AAV-p65-shRNA or AAV-BMP4 into *** experiments were divided into five groups:PBS group;osteoarthritis group;AAV-BMP4 group;AAV-p65shRNA group;and BMP4-p65shRNA 1:1 *** were collected at 4,12,and 24 weeks *** staining,including safranin O and Alcian blue,was applied after collecting articular ***,the optimal ratio between the two types of transfected viral particles was further investigated to improve the chondrogenic potential of mixed cells in *** AND CONCLUSION:The combined application of AAV-p65shRNA and AAV-BMP4 together showed a synergistic effect on cartilage regeneration and osteoarthritis *** cells transfected with AAV-p65shRNA and AAV-BMP4 at a 1:1 ratio produced the most extracellular matrix synthesis(P<0.05).In vivo results also revealed that the combination of the two viruses had the highest regenerative potential for osteoarthritic cartilage(P<0.05).In the present study,we also discovered that the combined therapy had the maximum effect when the two viruses were administered in equal *** either p65shRNA or BMP4

关键词： osteoarthritis adeno-associated virus bone morphogenetic protein 4 p65-short hairpin RNA gene therapy short hairpin RNA transforming growth factor-β1 extracellular matrix articular cartilage chondrocytes.

miRNA-21-5p is an important contributor to the promotion of injured peripheral nerve regeneration using hypoxia-pretreated bone marrow-derived neural crest cells

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第1期20卷 277-290页

作者： Meng Cong Jing-Jing Hu Yan Yu Xiao-Li Li Xiao-Ting Sun Li-Ting Wang Xia Wu Ling-Jie Zhu Xiao-Jia Yang Qian-Ru He Fei ding Hai-Yan Shi School of Medicine Nantong UniversityNantongJiangsu ProvinceChina Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education and Coinnovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Physiology Jiangsu Health Vocational CollegeNanjingJiangsu ProvinceChina Department of Pathology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina

Our previous study found that rat bone marrow–derived neural crest cells(acting as Schwann cell progenitors)have the potential to promote long-distance nerve ***-based therapy can enhance peripheral nerve repair and regeneration through paracrine bioactive factors and intercellular ***,the complex contributions of various types of soluble cytokines and extracellular vesicle cargos to the secretome remain *** investigate the role of the secretome and extracellular vesicles in repairing damaged peripheral nerves,we collected conditioned culture medium from hypoxia-pretreated neural crest cells,and found that it significantly promoted the repair of sensory neurons damaged by oxygen-glucose *** mRNA expression of trophic factors was highly expressed in hypoxia-pretreated neural crest *** performed RNA sequencing and bioinformatics analysis and found that miR-21-5p was enriched in hypoxia-pretreated extracellular vesicles of neural crest ***,to further clarify the role of hypoxia-pretreated neural crest cell extracellular vesicles rich in miR-21-5p in axonal growth and regeneration of sensory neurons,we used a microfluidic axonal dissociation model of sensory neurons in vitro,and found that hypoxia-pretreated neural crest cell extracellular vesicles promoted axonal growth and regeneration of sensory neurons,which was greatly dependent on loaded ***,we constructed a miR-21-5p-loaded neural conduit to repair the sciatic nerve defect in rats and found that the motor and sensory functions of injured rat hind limb,as well as muscle tissue morphology of the hind limbs,were obviously *** findings suggest that hypoxia-pretreated neural crest extracellular vesicles are natural nanoparticles rich in ***-21-5p is one of the main contributors to promoting nerve regeneration by the neural crest cell *** helps to explain the mechanism of action of the secretome and e

关键词： axotomy cell-free therapy conditioned medium extracellular vesicles hypoxic preconditioning microRNA oxygen-glucose deprivation peripheral nerve injury Schwann cell precursors