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Molecular mechanism of Xuebijing in treating pyogenic liver abscess complicated with sepsis

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World Journal of Emergency Medicine 2024年第1期15卷 35-40页

作者： Wei Zhou Maiying fan Xiang Li fang Yu En Zhou Xiaotong Han Department of Emergency Medicine the First Affi liated Hospital of Hunan Normal University/Hunan Provincial People’s HospitalChangsha 410005China Department of Otolaryngology-head and Neck Surgery the First Affi liated Hospital of Hunan Normal University/Hunan Provincial People’s HospitalChangsha 410005China

BACKGROUND:Xuebijing(XBJ)can alleviate the inflammatory response,improve organ function,and shorten the intensive care unit(ICU)stay in patients with pyogenic liver abscess(PLA)complicated with sepsis,but the molecular mechanisms have not been *** study aimed to explore the molecular mechanism of XBJ in treating PLA complicated with sepsis using a network pharmacology ***:The active ingredients and targets of XBJ were retrieved from the ETCM *** targets related to PLA and sepsis were retrieved from the GeneCards,PharmGKB,DisGeNet,Online Mendelian Inheritance in Man(OMIM),Therapeutic Targets Database(TTD),and DrugBank *** targets of PLA complicated with sepsis were mapped to the targets of XBJ to identify potential treatment ***-protein interaction networks were analyzed using the STRING *** treatment targets were imported into the Metascape platform for Gene Ontology(GO)functional enrichment and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichment *** docking was performed to validate the interactions between active ingredients and core ***:XBJ was found to have 54 potential treatment targets for PLA complicated with ***-1β(IL-1β),interleukin-6(IL-6),and tumor necrosis factor(TNF)were identifi ed as core *** enrichment analysis revealed important pathways,including the interleukin-17(IL-17)signaling pathway,the TNF signaling pathway,the nuclear factor-kappa B(NF-κB)signaling pathway,and the Toll-like receptor(TLR)signaling *** docking experiments indicated stable binding between XBJ active ingredients and core ***:XBJ may exert therapeutic eff ects on PLA complicated with sepsis by modulating signaling pathways,such as the IL-17,TNF,NF-κB,and TLR pathways,and targeting IL-1β,IL-6,and TNF.

关键词： Xuebijing injection Pyogenic liver abscess Sepsis

The Mineral Composition and Sources of the Fine-Grained Sediments from the 49.6?E Hydrothermal Field at the SWIR

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Journal of Ocean University of China 2020年第1期19卷 60-68页

作者： ZHANG Wenqiang SUN Xiaoxia fan Dejiang LIU Ming JIA Qi YANG Zuosheng Key Laboratory of Submarine Geosciences and Technology MOEOcean University of ChinaQingdao 266100China Laboratory for Marine Geology Qingdao National Laboratory for Marine Science and TechnologyQingdao 266061China

We used the X-ray diffraction method to determine systematically the mineral phases in bulk sediment samples and acid undissolved residuals of the fine-grained fraction of the surface sediments from the 49.6°E hydrothermal field at the Southwest Indian Ridge(SWIR)and discussed the mineral sources of the surface *** results showed that the surface sediments in this region were composed of calcareous ooze,and calcite was the dominant *** sediments also contained quartz,feldspar,clay minerals,pyroxene,sphalerite,barite,serpentine,and *** quartz,feldspar,and clay minerals were exogenous minerals that mainly originated from the Namib and Kalahari deserts in southern *** pyroxene,serpentine,magnetite,sphalerite,calcite,and barite were endogenous minerals from weathering of seafloor basement rocks and seafloor hydrothermal *** sulfide particles in the sediments were mainly deposited from upwelling plumes.

关键词： Southwest Indian Ridge surface sediment mineral source hydrothermal

Dynamic features of near-inertial oscillations in the Northwestern Pacific derived from mooring observations from^2015 to 2018

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Journal of Oceanology and Limnology 2020年第4期38卷 1092-1107页

作者： HU Shijian LIU Lingling GUAN Cong ZHANG Linlin WANG Jianing WANG Qingye MA Jie WANG Fujun JIA fan FENG Junqiao LU Xi WANG fan HU Dunxin CAS Key Laboratory of Ocean Circulation and Waves Institute of OceanologyChinese Academy of SciencesQingdao 266071China Center for Ocean Mega-Science Chinese Academy of SciencesQingdao 266071China Pilot National Laboratory for Marine Science and Technology(Qingdao) Qingdao 266237China College of Marine Science University of Chinese Academy of SciencesQingdao 266071China

Near-inertial oscillation is an important physical process transferring surface wind energy into deep *** investigated the near-inertial kinetic energy(NIKE)variability using acoustic Doppler current profiler measurements from a mooring array deployed in the tropical western Pacific Ocean along 130°E at 8.5°N,11°N,12.6°N,15°N,and 17.5°N from September 2015 to January *** features,decay timescales,and significant seasonal variability of the observed NIKE were *** the mooring sites of 17.5°N,15°N,and 12.6°N,the NIKE peaks occurred in boreal autumn and the NIKE troughs were observed in boreal *** contrast,the NIKE at 11°N and 8.5°N showed peaks in winter and troughs in *** cyclones and strong wind events played an important role in the emergence of high-NIKE events and explained the seasonality and latitudinal characteristics of the observed NIKE.

关键词： near-inertial kinetic energy western Pacific Ocean tropical cyclones mooring array seasonal variability

An ultrafast carrier dynamics system from oxygen vacancies modified SnO_(2)QDs and Zn_(2)SnO_(4)heterojunction for deeply photocatalytic oxidation of NO

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Journal of Materials Science & Technology 2023年第34期165卷 85-93页

作者： Yuhan Li Min Zhang Bangfu Chen Ping Ouyang Youyu Duan Kangle Lv fan Dong Engineering Research Center for Waste Oil Recovery Technology and Equipment Ministry of EducationChongqing Key Laboratory of Catalysis and New Environmental MaterialsChongqing Technology and Business UniversityChongqing 400067China Nanchang Institute of Technology Nanchang 33044China College of Physics and Center of Quantum Materials and Devices Chongqing UniversityChongqing 401331China Key Laboratory of Resources Conversion and Pollution Control of the State Ethnic Affairs Commission College of Resources and Environmental ScienceSouth-Central Minzu UniversityWuhan 430074China

Deeply photocatalytic oxidation of NO-to-NO_(3)holds great promise for alleviating NO_(x) *** major challenge of NO photo-oxidation is the highly in-situ generated NO_(2) concentration,and the formation of unstable nitrate species causes desorption to release NO_(2).In this study,SnO_(2) quantum dots and oxygen vacancies co-modified Zn_(2)SnO_(4)(ZSO-SnO_(2)-OVs)were prepared by a one-step hydrothermal procedure,the NO photo-oxidation was investigated by a combination of solid experimental and theoretical ***,spectroscopic measurements indicate that fast carrier dynamics can be achieved due to the electron transfer efficiency of ZSO-SnO_(2)-OVs reaching 99.99%,far outperforming the counterpart and previously reported *** NO oxidation,molecular NO/O_(2) and H2O are efficiently adsorbed/activated around OVs and SnO_(2) QDs,***-situ infrared measurements and calculated electron localized function disclose two main findings:(1)richly electrons enable NO promptly form NOinstead of toxic NO_(2) or NO^(+);(2)the generation of stable and undecomposed bidentate NO_(3)rather than bridging or monodentate one benefits the deep oxidation of NO via shifting reaction sites from O terminals for original ZSO to Sn ones for ZSO-SnO_(2)-*** synergistic action of SnO_(2) QDs and OVs positively contributes to the NO oxidation performance enhancement(60.6%,0.1 g of sample)and high selectivity of NO to NO_(3)(99.2%).Results from this study advance the mechanistic understanding of NO photooxidation and its selectivity to NO_(3)over photocatalysts.

关键词： Zn_(2)SnO_(4) Modification NO photo-oxidation Charge transfer efficiency Reaction mechanism

Antimicrobial hydrogel with multiple pH-responsiveness for infected burn wound healing

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Nano Research 2023年第8期16卷 11139-11148页

作者： Na Li Wan Liu Xiaoyan Zheng Qing Wang Lixin Shen Junfeng Hui Daidi fan Shaanxi Key Laboratory of Degradable Biomedical Materials Shaanxi R&D Center of Biomaterials and Fermentation EngineeringSchool of Chemical EngineeringNorthwest UniversityXi’an 710069China Biotech.&Biomed.Research Institute Northwest UniversityXi’an 710069China The college of life sciences Northwest UniversityXi’an 710069China

Burns are a common medical problem globally,and wound infection is one of the major causes of inducing related *** antibiotics effectively prevent wound infections,the misuse of antibiotics has created a new problem of ***,we propose a new strategy to obtain pH-responsive antimicrobial P-ZIF(ZIF:zeolitic imidazolate framework)by loading polyhexamethylenebiguanide(PHMB)into the framework of ZIF-8 *** will enable PHMB to be released in the weak acid environment of an infected *** address burn infections,P-ZIF nanoparticles were loaded into a hydrogel system made of sodium alginate(SA)and 3-aminophenylboronic acid modified human-like collagen(H-A)through borate ester *** resulting H-A/SA/P-ZIF(HASPZ)hydrogel dressing not only possesses antibacterial and wound healing properties but also has dual pH responsiveness to prevent the overuse of medication while effectively treat deep second-degree ***,P-ZIF nanoparticles and the corresponding HASPZ hydrogel dressing are considered of significant importance in antimicrobial,drug delivery,and wound repair.

关键词： P-ZIF nanoparticles hydrogel dressing antibacterial pH-responsive burn wound healing

Biocompatible Multifunctional E-Skins with Excellent Self-Healing Ability Enabled by Clean and Scalable Fabrication

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Nano-Micro Letters 2021年第12期13卷 221-234页

作者： Xiuzhu Lin fan Li Yu Bing Teng Fei Sen Liu Hongran Zhao Tong Zhang State Key Laboratory of Integrated Optoelectronics College of Electronic Science and EngineeringJilin UniversityChangchun 130012People’s Republic of China

Electronic skins(e-skins) with an excellent sensing performance have been widely developed over the last few ***,wearability,biocompatibility,environmental friendliness and scalability have become new limitations. Self-healing ability can improve the long-term robustness and reliability of e-skins. However,self-healing ability and integration are hardly balanced in classical structures of self-healable devices. Here,cellulose nanofiber/poly(vinyl alcohol)(CNF/PVA),a biocompatible moisture-inspired self-healable composite,was applied both as the binder in functional layers and the substrate. Various functional layers comprising particular carbon materials and CNF/PVA were patterned on the substrate. A planar structure was beneficial for integration,and the active self-healing ability of the functional layers endowed self-healed e-skins with a higher toughness. Water served as both the only solvent throughout the fabrication process and the trigger of the self-healing process,which avoids the pollution and bioincompatibility caused by the application of noxious additives. Our e-skins could achieve real-time monitoring of whole-body physiological signals and environmental temperature and humidity. Cross-interference between di erent external stimuli was suppressed through reasonable material selection and structural design. Combined with conventional electronics,data could be transmitted to a nearby smartphone for post-processing. This work provides a previously unexplored strategy for multifunctional e-skins with an excellent practicality.

关键词： Self-healing electronics Strain sensors Environmental friendly method Multifunctional e-skins Scalability

Growth kinetics of titanium carbide coating by molten salt synthesis process on graphite sheet surface

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International Journal of Minerals,Metallurgy and Materials 2024年第8期31卷 1858-1864页

作者： Xiaoyu Shi Chongxiao Guo Jiamiao Ni Songsong Yao Liqiang Wang Yue Liu Tongxiang fan State Key Lab of Metal Matrix Composites School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240China

The synthesis of carbide coatings on graphite substrates using molten salt synthesis(MSS),has garnered significant interest due to its cost-effective *** study investigates the reaction process and growth kinetics involved in MSS,shedding light on key aspects of the *** involvement of Ti powder through liquid-phase mass transfer is revealed,where the diffusion distance and quantity of Ti powder play a crucial role in determining the reaction rate by influencing the C content gradient on both sides of the ***,the growth kinetics of the carbide coating are predominantly governed by the diffusion behavior of C within the carbide layer,rather than the chemical reaction *** analyze the kinetics,the thickness of the carbide layer is measured with respect to heat treatment time and temperature,unveiling a parabolic relationship within the temperature range of 700-1300℃.The estimated activation energy for the reaction is determined to be 179283 J·mol^(-1).These findings offer valuable insights into the synthesis of carbide coatings via MSS,facilitating their optimization and enhancing our understanding of their growth mechanisms and properties for various applications.

关键词： titanium carbide graphite molten salt kinetic analysis

Virus-induced gene silencing(VIGS)in Chinese narcissus and its use in functional analysis of NtMYB3

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Horticultural Plant Journal 2021年第6期7卷 565-572页

作者： Ping Zhou Jiayu Peng Minjie Zeng Lixuan Wu Yuxin fan Lihui Zeng College of Horticulture Fujian Agriculture and Forestry UniversityFuzhou 35002China College of Horticulture Nanjing Agriculture UniversityNanjing 210095China

Virus-induced gene silencing(VIGS)is a natural defense mechanism of plants,which can cause sequence-specific degradation of viral RNA and is often used for studying the functional *** present,the VIGS system mediated by Tobacco rattle virus(TRV)has been successfully established in many plant ***,the VIGS system in Chinese narcissus had not been reported *** this paper,the first use of the TRV-VIGS system in Chinese narcissus is described in *** injecting pTRV2-GFP into narcissus leaves,we confirmed that TRV could infect narcissus and move in narcissus *** the inoculation of pTRV2-Nt PDS by two methods,phenomena such as photo-bleaching appeared in narcissus leaves and qRT-PCR results proved that PDS gene of narcissus was successfully ***,pTRV2-NtMYB3 was inoculated into basal plates of narcissus to study the function of NtMYB3;the results showed that NtMYB3 is an inhibitor of flavonoids biosynthesis,which can increase the content of proanthocyanidins in basal plates of narcissus by repressing the expression level of *** results indicate that the TRV-VIGS system has been successfully established in Chinese narcissus and successfully applied to the functional study of NtMYB3.

关键词： Chinese narcissus VIGS Tobacco rattle virus(TRV) NtPDS NtMYB3

Preliminary calibration results for Jason-3 and Sentinel-3 altimeters in the Wanshan Islands

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Journal of Oceanology and Limnology 2021年第2期39卷 458-471页

作者： Wanlin ZHAI Jianhua ZHU Xiaohui fan Longhao YAN Chuntao CHEN Zhen TIAN National Ocean Technology Center Tianjin 300112China Tianjin Guohai Marine Engineering Survey Co.Ltd. Tianjin 300000China

We present preliminary calibration results for Jason-3 and Sentinel-3A altimeters that we set up in the Wanshan Islands in Guandong Province,*** campaigns were carried out in 2018,from March 8 to April 16 and from November 3 to December 11,*** GPS reference stations and tide gauges were established on the islands of Zhiwan,Dangan,and Wailingding during the *** in-situ sea surface height(SSH)of the altimeter footprint was determined using the tide *** tidal and geoid connection between the tide gauge locations and the altimeter footprints were computed with the NAO.99Jb tidal prediction system and the EGM 2008 geoid,*** data of the tide gauges were defi ned using the GPS buoy and GPS reference stations during the *** results show that the waveform of the altimeters was slightly contaminated by the small *** bias associated with Jason-3 and Sentinel-3A amounted to approximately+20.7±49.7 mm and+30.1±39.4 mm,respectively,which agreed well with the results from other in-situ calibration fi *** indicates that the Wanshan area was very suitable as an in-situ calibration/validation fi *** wet zenith delay(WZD)determined from the Microwave Radiometer(MWR)and the GPS measurements diff ered from each other for the Jason-3 and Sentinel-3A by−6.6±7.4 mm and 0±6.8 mm,respectively.

关键词： altimeter calibration tide gauge GPS buoy wet zenith delay