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The mechanisms of melanogenesis inhibition by glabridin:molecular docking,PKA/MITF and MAPK/MITF pathways

Food Science and Human Wellness 2023年第1期12卷 212-222页

作者： Chunxing Pan Xiaoying Liu Yating Zheng Zejun Zhang Yongliang Li Biao Che Guangrong Liu Lanyue Zhang Changzhi Dong Haji Akber Aisa Zhiyun Du zhengqiang yuan School of Biomedical and Pharmaceutical Sciences Guangdong University of TechnologyGuangzhou 510006China Infinitus(China)Company Ltd. Guangzhou 510663China Foshan Allen Conney Biological Technology Co. Ltd.Foshan 528225China UniversitéParis Diderot Sorbonne Paris CitéITODYSUMR 7086 CNRSFrance The Key Laboratory of Plant Resources and Chemistry of Arid Zone Xinjiang Technical Institute of Physics and ChemistryChinese Academy of SciencesÜrümqi 830011China

Glabridin is the main ingredient of hydrophobic fraction in licorice extract and has been shown to have anti-melanogenesis activity in ***,the underlying mechanism(s)remain not completely *** aim of this study is thus to elucidate the possible mechanisms related to the melanogenesis suppression by glabridin in cultured B16 murine melanoma cells and in UVA radiation induced hyperpigmentation model of BALB/c mice as *** docking simulations revealed that between catalytic core residues and the *** treatment by glabridin significantly downregulated both transcriptional and/or protein expression of melanogenesis-related factors including melanocyte stimulating hormone receptor(MC1R),microphthalmia-associated transcription factor(MITF),tyrosinase(TYR),TYR-related protein-1(TRP-1)and TRP-2 in B16 *** PKA/MITF and MAPK/MITF signaling pathways were found to be involved in the suppression of melanogenesis by glabridin in B16 *** in vivo glabridin therapy significantly reduced hyperpigmentation,epidermal thickening,roughness and inflammation induced by frequent UVA exposure in mice skins,thus beneficial for skin *** data further look insights into the molecular mechanisms of melanogenesis suppression by glabridin,rationalizing the application of the natural compound for skin healthcare.

关键词： Glabridin Melanogenesis Molecular docking PKA/MITF pathway MAPK/MITF pathway

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Advances in methane emissions from agricultural sources:Part *** and mitigation

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Journal of Environmental Sciences 2024年第6期140卷 279-291页

作者： Xiaokun Wu Ying Zhang Yinghui Han Yagang Zhang Yuhang Zhang Xiaodan Cheng Pei Zhong Xue yuan yuanxun Zhang zhengqiang Li State Key Laboratory of Alternate Electrical Power System with Renewable Energy Sources North China Electric Power UniversityBeijing 102206China Hebei Key Laboratory of Physics and Energy Technology North China Electric Power UniversityBaoding 071003China College of Resources and Environment University of Chinese Academy of SciencesBeijing 101408China Interdisciplinary Mathematics Institute University of South CarolinaColumbiaSC 29208United States Aerospace Information Research Institute Chinese Academy of SciencesBeijing 100094China

Methane is one of the major greenhouse gases(GHGs)and agriculture is recognized as its primary *** accounting is a prerequisite for developing effective agriculture mitigation *** this review,methane accounting methods and research status for various agricultural emission source including rice fields,animal enteric fermentation and livestock and poultry manure management were overview,and the influencing factors of each emission source were analyzed and *** the same time,it analyzes the different research efforts involving agricultural methane accounting and makes recommendations based on the actual ***,mitigation strategies based on accounting results and actual situation are *** review aims to provide basic data and reference for agriculture-oriented countries and regions to actively participate in climate action and carry out effective methane emission mitigation.

关键词： Methane emission Agricultural sources Accounting methodology Mitigation Emission influencing factors

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Independent integration and innovation of the first domestically-integrated 60000 m^3/h air separation unit

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Baosteel Technical Research 2009年第3期3卷 3-12页

作者： yuan Jilie QIAN Feng LI zhengqiang GAO yuan CHENG Yuzhi Energy ＆ Environment Department Baoshan Iron ＆ Steel Co.Ltd. Shanghai 200941 China

Baosteel＇s 60000 m……3/h air separation unit （ASU）, the first domestically-integrated unit of its class, is a milestone in the Chinese air separation industry. In this paper,the process characteristics of the unit and the application of the original techniques are expatiated. Some difficulties in the process design, the risk control, the quality control, the control system integration and the system commissioning are analyzed and appraised. The mode of the project integration and innovation, the cooperation among industries and the user-orientated project management mode are introduced. Finally,the successful experiences in innovation are summarized with the focus on the integration of the project.

关键词： air separation unit localization independent integration project management

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有限元复合单元的构造方法研究

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重庆大学学报（自然科学版） 2017年第6期40卷 15-25页

作者：袁政强熊光亮马宁宁重庆大学土木工程学院重庆400044

传统有限单元法中每一种单元都由单一的材料组成,虽然只考虑一种材料的性质给软件编程带来了极大的方便,但是这比利用复合单元进行建模,需要更多的工作量。为此,笔者提出从4节点矩形单元与2节点线单元的虚功原理出发,运用能量方程,来整... 详细信息

传统有限单元法中每一种单元都由单一的材料组成,虽然只考虑一种材料的性质给软件编程带来了极大的方便,但是这比利用复合单元进行建模,需要更多的工作量。为此,笔者提出从4节点矩形单元与2节点线单元的虚功原理出发,运用能量方程,来整合两种不同单元。以VC++作为开发工具,利用等参元的特性,根据逆矩阵形函数构造方法编写平面单元的形函数程序,采用高斯数值积分方法,形成普通单元的单元刚度矩阵。然后根据线单元与面单元的节点位移编号,进行单元刚度的整合,进而得到一种包含面单元和线单元的复合单元。同时,通过对平面矩形单元和平面三角形单元与线单元进行复合,用得到的两种复合单元分别对悬臂梁作用端部集中荷载的简单算例进行位移求解,得到的结果与同等条件下ANSYS计算结果进行对比验证。结果表明:两种情况的计算结果都非常接近,复合单元的构造方法正确、可靠,同时也能够减少单元个数。

关键词：有限元复合单元逆矩阵形函数高斯数值积分单元刚度矩阵

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The origin and evolution of Earth's nitrogen

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National Science Review 2024年第6期11卷 56-75页

作者： yuan Li State Key Laboratory of Isotope Geochemistry Guangzhou Institute of GeochemistryChinese Academy of Sciences Bayerisches Geoinstitut Universit?t Bayreuth

Nitrogen is a vital element for life on Earth. Its cycling between the surface(atmosphere + crust) and the mantle has a profound influence on the atmosphere and climate. However, our understanding of the origin and evolution of Earth's nitrogen is still incomplete. This review presents an overview of the current understanding of Earth's nitrogen budget and the isotope composition of different reservoirs, laboratory constraints on deep nitrogen geochemistry, and our understanding of the origin of Earth's nitrogen and the deep nitrogen cycle through plate subduction and volcanism. The Earth may have acquired its nitrogen heterogeneously during the main accretion phase, initially from reduced, enstatite-chondrite-like impactors,and subsequently from increasingly oxidized impactors and minimal CI-chondrite-like materials. Like Earth's surface, the mantle and core are also significant nitrogen reservoirs. The nitrogen abundance and isotope composition of these three reservoirs may have been fundamentally established during the main accretion phase and have been insignificantly modified afterwards by the deep nitrogen cycle, although there is a net nitrogen ingassing into Earth's mantle in modern subduction zones. However, it is estimated that the early atmosphere of Earth may have contained ～1.4 times the present-day atmospheric nitrogen(PAN),with ～0.4 PAN being sequestered into the crust via biotic nitrogen fixation. In order to gain a better understanding of the origin and evolution of Earth's nitrogen, directions for future research are suggested.

关键词： nitrogen isotopes silicate Earth atmosphere magma ocean

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Robustness of the octupole collectivity in 144Ba within the cranking covariant density functional theory in 3D lattice

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Nuclear Science and Techniques 2024年第8期35卷 124-131页

作者： Ze‑Kai Li yuan‑yuan Wang Mathematics and Physics Department North China Electric Power UniversityBeijing 102206China Hebei Key Laboratory of Physics and Energy Technology North China Electric Power UniversityBaoding 071000China

The octupole deformation and collectivity in octupole double-magic nucleus 144Ba are investigated using the Cranking covariant density functional theory in a three-dimensional lattice *** reduced B(E3)transition probability is implemented for the first time in semiclassical approximation based on the microscopically calculated electric octupole *** available data,including the I-ωrelation and electric transitional probabilities B(E2)and B(E3)are well ***,it is shown that the ground state of 144Ba exhibits axial octupole and quadrupole deformations that persist up to high spins(I≈24h).

关键词： Octupole collectivity Cranking covariant density functional theory Rotational spectrum Electric transitional probabilities

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The Performance of the Tension Region of the Box-Column and H Beam Joint and Nonlinear Finite Element Method Analysis

The Performance of the Tension Region of the Box-Column and ...

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中国钢结构协会结构稳定与疲劳分会2006年学术交流会暨钢结构教学研讨会

作者： LENG Gang, CUI Jia, yuan zhengqiang (College of Civil Engineering, Chongqing University, Chongqing, P.R.China, 400045)

The performance of the box-column(without stiffing plates inside) and H beam joint at the tension region of the beam flange was first *** the simplified model for analysis was established and twenty models were analysed with the nonlinear finite element *** the impact of the width of the beam flange,the thickness of the column flange and the axial load ratio of the column on the behavior of the joint were also discussed. Finally,the ruling condition of the load-carrying capacity of the joint was established,according to which the formula to calculate the bearing capacity of the joint was suggested and the results from the suggested formula and FEM analysis were compared.

关键词： box-column beam-column joint the tension region of the beam flange nonlinear FEM analysis

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Collective Molecular Machines: Multidimensionality and Reconfigurability

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Nano-Micro Letters 2024年第8期16卷 309-340页

作者： Bin Wang yuan Lu Department of Chemical Engineering Tsinghua UniversityBeijing 100084People’s Republic of China Key Laboratory of Industrial Biocatalysis Ministry of EducationTsinghua UniversityBeijing 100084People’s Republic of China

Molecular machines are key to cellular activity where they are involved in converting chemical and light energy into efficient mechanical *** the last 60 years,designing molecular structures capable of generating unidirectional mechanical motion at the nanoscale has been the topic of intense *** progress has been made,attributed to advances in various fields such as supramolecular chemistry,biology and nanotechnology,and ***,individual molecular machines are only capable of producing nanometer work and generally have only a single *** order to address these problems,collective behaviors realized by integrating several or more of these individual mechanical units in space and time have become a new *** this review,we comprehensively discuss recent developments in the collective behaviors of molecular *** particular,collective behavior is divided into two *** is the appropriate integration of molecular machines to efficiently amplify molecular motions and deformations to construct novel functional *** other is the construction of swarming modes at the supramolecular level to perform nanoscale or microscale *** discuss design strategies for both modes and focus on the modulation of features and ***,in order to address existing challenges,the idea of transferring experience gained in the field of micro/nano robotics is presented,offering prospects for future developments in the collective behavior of molecular machines.

关键词： Molecular machines Collective control Collective behaviors DNA Biomolecular motors

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Global adaptive output-feedback tracking with prescribed performance for uncertain nonlinear systems

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Science China(Information Sciences) 2024年第5期67卷 150-164页

作者： yuan WANG Yungang LIU School of Control Science and Engineering Shandong University

At present, one typical control strategy for guaranteeing transient and steady-state performance is funnel control and prescribed performance control. The strategy features completely discarding the system nonlinearities, even if they are completely known and available. Such an intrinsic feature requires the controller to produce a larger control effect to eliminate the negative impact caused by the high nonlinearities, leading to a conservative controller. In this paper, we fully take advantage of known information on nonlinearities in control design, instead of completely discarding it as done in funnel control. Particularly, we leverage adaptive techniques(i.e., high-gain dynamic compensation) to deal with unknown system nonlinearities. Meanwhile, we integrate the tools of output feedback, tracking control, and the performance *** such, an adaptive output-feedback scheme is developed for global tracking with spatiotemporal performance specifications: arbitrarily given tracking accuracy and accuracy-ensured time. A simulation example supports the developed approach.

关键词： uncertain nonlinear systems output feedback prescribed performance unknown control direction dynamic high gain global tracking

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Theoretical study on the synergistic mechanism of Fe–Mn in sodium-ion batteries

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Particuology 2024年第10期93卷 284-290页

作者： Yang You Mingliang yuan School of Mineral Processing and Bioengineering Central South UniversityChangsha410083China

This article conducts first-principles calculations to initially explore the construction of two configurations,NaFeO_(2)(NFO)and NaMnO_(2)(NMO),and studies the mixing enthalpies under different Fe–Mn *** results indicate that NaFe3/8Mn5/8O_(2)(NFMO)exhibits the most thermodynamically stable *** calculations on the mixing enthalpies and volume changes during the sodium extraction process for NFO,NMO,and NFMO configurations are presented,along with the partial density of states(PDOS)and Bader charges of transition metals(TM)and *** calculations reveal the synergistic mechanism of Fe and *** and Mn can engage in more complex electron exchanges during sodium extraction,optimizing the internal electron density distribution and overall charge balance,thereby stabilizing the crystal structure and reducing the migration of Fe^(3+)to the sodium layers during deep sodium *** interaction between Fe’s 3d electrons and Mn’s 3d electrons through the shared oxygen atoms’2p orbitals occurs in the Fe–Mn–O *** interaction can lead to a rebalancing of the electron density around Mn³⁺atoms,mitigating the asymmetric electron density distribution caused by the d4 configuration of the lone Mn³⁺and suppressing the Jahn-Teller effect of Mn^(3+).Moreover,the synergistic effects between Fe and Mn can provide a more balanced charge distribution,reducing extreme changes to the charge state of oxygen atoms and decreasing the irreversible oxygen release caused by anionic redox reactions during deep sodium extraction,thereby enhancing the material’s *** in-depth study of the interaction mechanism at the microscopic level when co-doping Fe and Mn offers valuable insights for the rational design and development of high-performance cathode materials.

关键词： First-principles calculations Sodium-ionbatteries Layered oxides NaFe_(3/8)Mn_(3/8)O_(2)

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