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结直肠息肉的规范化诊疗

中华胃肠外科杂志 2024年第6期27卷 583-590页

作者：王人杰张晓兰蔡继东王铭河刘建强徐烨复旦大学附属肿瘤医院大肠外1科、复旦大学上海医学院肿瘤学系上海200032 复旦大学附属肿瘤医院内镜科、复旦大学上海医学院肿瘤学系上海200032

结直肠息肉的规范化处理,包括分型、治疗、随访和预防控制等多个方面。针对不同类型的息肉需采用相应的治疗方案,包括内镜下切除和外科手术。目前对于pT1期的“恶性息肉”是选择内镜下切除还是外科手术还有所争议。本文结合最新文献及... 详细信息

结直肠息肉的规范化处理,包括分型、治疗、随访和预防控制等多个方面。针对不同类型的息肉需采用相应的治疗方案,包括内镜下切除和外科手术。目前对于pT1期的“恶性息肉”是选择内镜下切除还是外科手术还有所争议。本文结合最新文献及指南就息肉的分型及治疗方式、随访及预防控制分别进行阐述。规范化处理结直肠息肉对于降低结直肠癌的发病率、提高早期结直肠癌的治愈率,具有重大意义。

关键词：结直肠息肉分型治疗随访

Target threat estimation based on discrete dynamic Bayesian networks with small samples

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Journal of Systems Engineering and Electronics 2022年第5期33卷 1135-1142页

作者： ye Fang MAO Ying LI Yibing LIU Xinrui College of Information and Communication Engineering Harbin Engineering UniversityHarbin 150001China Key Laboratory of Advanced Marine Communication and Information Technology Ministry of Industry and Information TechnologyHarbin Engineering UniversityHarbin 150001China

The accuracy of target threat estimation has a great impact on command *** Bayesian network,as an effective way to deal with the problem of uncertainty,can be used to track the change of the target threat ***,the traditional discrete dynamic Bayesian network(DDBN)has the problems of poor parameter learning and poor reasoning accuracy in a small sample environment with partial prior information *** the finiteness and discreteness of DDBN parameters,a fuzzy k-nearest neighbor(KNN)algorithm based on correlation of feature quantities(CF-FKNN)is proposed for DDBN parameter ***,the correlation between feature quantities is calculated,and then the KNN algorithm with fuzzy weight is introduced to fill the missing *** this basis,a reasonable DDBN structure is constructed by using expert experience to complete DDBN parameter learning and *** results show that the CF-FKNN algorithm can accurately fill in the data when the samples are seriously missing,and improve the effect of DDBN parameter learning in the case of serious sample *** the proposed method,the final target threat assessment results are reasonable,which meets the needs of engineering applications.

关键词： discrete dynamic Bayesian network(DDBN) parameter learning missing data filling Bayesian estimation

小陷胸汤对5-FU介导小鼠心肌纤维化及HIF-1α/VEGF信号通路蛋白表达的影响

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中国实验方剂学杂志 2024年第16期30卷 1-9页

作者：叶倩倩秦美洁丁芮方海雁陈建黄金玲安徽中医药大学合肥230012 中药复方安徽省重点实验室合肥230012

目的:观察小陷胸汤对5-氟尿嘧啶(5-FU)介导小鼠心肌纤维化及缺氧诱导因子-1α(HIF-1α)/血管内皮生长因子(VEGF)信号通路的影响,探讨其减轻5-FU心脏损伤的可能机制。方法:将100只SPF级雄性ICR小鼠随机分为正常组、模型组、小陷胸汤低、... 详细信息

目的:观察小陷胸汤对5-氟尿嘧啶(5-FU)介导小鼠心肌纤维化及缺氧诱导因子-1α(HIF-1α)/血管内皮生长因子(VEGF)信号通路的影响,探讨其减轻5-FU心脏损伤的可能机制。方法:将100只SPF级雄性ICR小鼠随机分为正常组、模型组、小陷胸汤低、中、高剂量(8.3、16.6、33.2 g·kg^(-1))组,每组20只。除正常组外,其余各组均采用腹腔注射5-FU(30 mg·kg^(-1))连续7 d建立心肌损伤模型小鼠。小陷胸汤低、中、高组造模同时灌胃相应剂量小陷胸汤,正常组和模型组给予等容积生理盐水,连续处理7 d。采用彩色多普勒超声心动仪检测左心室舒张末期内径(LVIDd)、左室收缩末期内径(LVIDs)、左室射血分数(LVEF)、左室短轴缩短率(LVFS);苏木素-伊红(HE)及马松(Masson)染色观察心肌组织病理形态学改变;免疫组化法测定心肌组织α-平滑肌肌动蛋白(α-SMA)表达;采用酶联免疫吸附测定法(ELISA)检测血清丙二醛(MDA)、超氧化物歧化酶(SOD)水平;实时荧光定量聚合酶链式反应(Real-time PCR)检测心肌组织HIF-1α、VEGF mRNA表达;蛋白免疫印迹法(Western blot)检测心肌组织HIF-1α、VEGF、Ⅰ型胶原蛋白(ColⅠ)及Ⅲ型胶原蛋白(ColⅢ)蛋白的表达。结果:与正常组比较,模型组小鼠LVIDd、LVIDs显著升高(P<0.01),LVEF、LVFS显著降低(P<0.01),心肌组织出现明显排列紊乱、炎性细胞浸润及间质纤维化等病理变化,心肌胶原容积分数%(CVF%)显著升高(P<0.01),α-SMA、ColⅠ、ColⅢ蛋白表达显著升高(P<0.01),MDA水平升高(P<0.01),SOD水平降低(P<0.01),HIF-1α、VEGF mRNA及蛋白表达显著升高(P<0.01)。与模型组比较,小陷胸汤中、高剂量组LVIDd、LVIDs明显降低(P<0.05,P<0.01),LVEF、LVFS明显升高(P<0.05,P<0.01),小陷胸汤各剂量组心肌组织损伤、炎性细胞浸润与心肌纤维化均明显减轻,CVF%明显降低(P<0.05,P<0.01),小陷胸汤中、高剂量组α-SMA、ColⅠ、ColⅢ蛋白表达显著降低(P<0.01),MDA显著降低(P<0.01),SOD显著升高(P<0.01),HIF-1α、VEGF mRNA及蛋白表达明显降低(P<0.05,P<0.01)。结论:小陷胸汤能够减轻5-FU介导的小鼠心肌氧化应激损伤,抑制心肌纤维化,改善小鼠心功能,减轻5-FU心脏毒性,该作用可能与其调节HIF-1α/VEGF信号通路有关。

关键词：小陷胸汤 5-氟尿嘧啶心脏毒性缺氧诱导因子-1α 血管内皮生长因子

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金属铂氧化物还原反应温度的模拟研究

石油炼制与化工 2024年第7期55卷 91-98页

作者：任强袁海鸥张成喜叶蔚甄李永祥中石化石油化工科学研究院有限公司北京100083

采用第一性原理的分子动力学对H_(2)和金属铂氧化物的还原反应温度进行了模拟计算,同时对其反应机理进行了探讨。计算结果表明,从减少能耗的角度出发,金属铂氧化物还原反应发生的适合温度在250℃左右。PtO_(2)的还原反应路径有两条:一是... 详细信息

采用第一性原理的分子动力学对H_(2)和金属铂氧化物的还原反应温度进行了模拟计算,同时对其反应机理进行了探讨。计算结果表明,从减少能耗的角度出发,金属铂氧化物还原反应发生的适合温度在250℃左右。PtO_(2)的还原反应路径有两条:一是由H_(2)先还原为PtO,再进一步还原为金属Pt;另外一种路径是PtO_(2)由H2直接还原为金属Pt,反应路径的选择与反应压力有关。PtO还原为Pt的活化能垒高于PtO_(2)还原为金属Pt的活化能垒,其原因是PtO与H_(2)的反应轨道能级差高于PtO_(2)与H_(2)的反应轨道能级差,因此PtO与H_(2)间电子跃迁所需要的能量要高于PtO_(2)与H_(2)。

关键词：铂氧化物氧化还原反应分子模拟

Experimental Study on Ultrasonic Cavitation Intensity Based on Fluorescence Analysis

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Chinese Journal of Mechanical Engineering 2023年第4期36卷 196-204页

作者： Linzheng ye Shida Chuai Xijing Zhu Dong Wang Shanxi Key Laboratory of Advanced Manufacturing Technology School of Mechanical EngineeringNorth University of ChinaTaiyuan 030051China College of Engineering Mathematics and Physical SciencesUniversity of ExeterExeter EX44QFUK

The Ultrasonic cavitation effect has been widely used in mechanical engineering,chemical engineering,biomedicine,and many other *** quantitative characterization of ultrasonic cavitation intensity has always been a *** on this,a fluorescence analysis method has been adopted to explore ultrasonic cavitation intensity in this *** the experiment of fluorescence intensity measurement,terephthalic acid(TA)was used as the fluorescent probe,ultrasonic power,ultrasonic frequency,and irradiation time were independent variables,and fluorescence intensity and fluorescence peak area were used as experimental *** collapse of cavitation bubble will cause molecular bond breakage and release·OH,and the non-fluorescent substance TA will form the strong fluorescent substance TAOH with·*** spectra of the treated samples were measured by a F-7000 fluorescence *** results showed that the fluorescence intensity and fluorescence peak area increased rapidly after ultrasonic cavitation treatment,and then increased slowly with the increase of ultrasonic power,which gradually increased with the increase of irradiation *** first decreased and then increased with the increase of ultrasonic frequency from 20 kHz to 40 *** irradiation time was the most influential factor,and the cavitation intensity of low frequency was higher *** fluorescence intensity and fluorescence peak area of the samples increased by 2-20 times after ultrasonic treatment,which could increase from 69 and 5238 to 1387 and 95451,*** the irradiation time exceeded 25 min,the growth rate of fluorescence intensity slowed down,which was caused by the decrease of gas content and TA concentration in the *** study quantitatively characterized the cavitation intensity,reflecting the advantages of fluorescence analysis,and provided a basis for the further study of ultra-sonic cavitation.

关键词： Ultrasonic cavitation Cavitation intensity Fluorescence intensity Fluorescence peak area

基于3种降水产流方案的洪水过程模拟研究——以西南地区孙水河流域为例

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西北大学学报（自然科学版） 2024年第3期54卷 366-377页

作者：吕小余李占玲李昕潼叶瀛韬水资源与环境学院北京100083 北京100083

精确模拟洪峰流量和洪水过程线对防洪减灾分析至关重要,其中涉及的降雨损失和产汇流计算往往对洪水过程的模拟最为关键。为评估不同降雨损失模型和产流模型在我国西南地区孙水河流域的适用性,设计了3套降雨产流方案。方案1:SCS曲线数法+... 详细信息

精确模拟洪峰流量和洪水过程线对防洪减灾分析至关重要,其中涉及的降雨损失和产汇流计算往往对洪水过程的模拟最为关键。为评估不同降雨损失模型和产流模型在我国西南地区孙水河流域的适用性,设计了3套降雨产流方案。方案1:SCS曲线数法+Sndyer单位线法;方案2:初始常速率法+Clark单位线法;方案3:Green-Ampt法+SCS单位线法,使用HEC-HMS模型对我国西南地区孙水河流域2007—2018年15场洪水过程进行模拟和分析。结果表明,方案1、方案2对研究区洪水过程线的模拟效果最优,其中方案1对单峰洪水过程的模拟效果更好,方案2对复峰洪水过程的模拟效果更好;方案3模拟效果偏差。论文结果可为相似地区的洪水模拟、预报预警提供参考。

关键词： HEC-HMS 孙水河降雨损失产汇流模型

A multi-point collaborative DDoS defense mechanism for IIoT environment

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Digital Communications and Networks 2023年第2期9卷 590-601页

作者： Hongcheng Huang Peixin ye Min Hu Jun Wu School of Communication and Information Engineering Chongqing University of Posts and TelecommunicationsChongqing400065China Chongqing Engineering Research Center of Communication Software Chongqing400065China

Nowadays,a large number of intelligent devices involved in the Industrial Internet of Things(IIoT)environment are posing unprecedented cybersecurity *** to the limited budget for security protection,the IIoT devices are vulnerable and easily compromised to launch Distributed Denial-of-Service(DDoS)attacks,resulting in disastrous ***,considering the particularity of the IIoT environment,most of the defense solutions in traditional networks cannot be directly applied to IIoT with acceptable security ***,in this work,we propose a multi-point collaborative defense mechanism against DDoS attacks for ***,for the single point DDoS defense,we design an edge-centric mechanism termed EdgeDefense for the detection,identification,classification,and mitigation of DDoS attacks and the generation of defense *** the practical multi-point scenario,we propose a collaborative defense model against DDoS attacks to securely share the defense information across the network through the ***,a fast defense information sharing mechanism is designed to reduce the delay of defense information sharing and provide a responsive cybersecurity *** simulation results indicate that the identification and classification performance of the two machine learning models designed for EdgeDefense are better than those of the state-of-the-art baseline models,and therefore EdgeDefense can defend against DDoS attacks *** results also verify that the proposed fast sharing mechanism can reduce the propagation delay of the defense information blocks effectively,thereby improving the responsiveness of the multi-point collaborative DDoS defense.

关键词： Industrial internet of things(IIoT) DDoS Deep learning Blockchain Edge computing

Nonparametric Two-Step Estimation of Drift Function in the Jump-Diffusion Model with Noisy Data

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Journal of Systems Science & Complexity 2022年第6期35卷 2398-2429页

作者： ye Xuguo ZHAO Yanyong LIN Jinguan LONG Weifang School of Science Kaili UniversityKaili 556011China Department of Statistics Nanjing Audit UniversityNanjing 211815China

This paper considers a nonparametric diffusion process whose drift and diffusion coefficients are nonparametric functions of the state variable.A two-step approach to estimate the drift function of a jump-diffusion model in noisy settings is *** proposed estimator is shown to be consistent and asymptotically normal in the presence of finite activity *** experiments and a real data application are undertaken to assess the finite sample performance of the newly proposed method.

关键词： Drift function jump-diffusion processes microstructure noise nonparametric estimation

多维乡村空间治理体系的建构与差异化实施路径

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规划师 2024年第5期40卷 106-113页

作者：叶丹陈树荣陈艳华杨培峰福建理工大学建筑与城乡规划学院福建省城乡规划设计研究院福建省自然资源厅耕地保护监督处

针对当前乡村空间治理面临的治理目标有限性、治理要素片面性、治理手段局限性和治理主体单一性的现实困境,明确新时期乡村空间治理的目标指引,构建涵括治理目标、治理要素、治理手段和治理主体等维度的多维乡村空间治理体系,并针对福... 详细信息

针对当前乡村空间治理面临的治理目标有限性、治理要素片面性、治理手段局限性和治理主体单一性的现实困境,明确新时期乡村空间治理的目标指引,构建涵括治理目标、治理要素、治理手段和治理主体等维度的多维乡村空间治理体系,并针对福建省提出的集聚提升中心类、转型融合城郊类、保护开发特色类和搬迁撤并衰退类等村庄类型,因地制宜、因村施策,探索不同类型村庄的差异化乡村空间治理路径,以促进乡村振兴战略的落实与乡村治理水平的提升。

关键词：多维差异化空间治理体系乡村福建省